Zeynep Akgun, Cumali Degirmenci, Mehmet Sezai Tasbakan, Ozen K Basoglu, Melis Palamar
{"title":"阻塞性睡眠呼吸暂停患者视网膜血管结构的光学相干断层扫描评价。","authors":"Zeynep Akgun, Cumali Degirmenci, Mehmet Sezai Tasbakan, Ozen K Basoglu, Melis Palamar","doi":"10.1007/s10792-025-03724-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Evaluation of the retinal vascular structure with optic coherence tomography angiography (OCT-A) in patients with obstructive sleep apnea (OSA).</p><p><strong>Materials and methods: </strong>A total of 47 severe (Group 1), 30 moderate (Group 2), and 25 mild (Group 3) OSA patients and 51 healthy volunteers (Group 4) were included. Total, parafoveal, perifoveal superficial (SCP), and deep capillary plexus (DCP) vascular densities, foveal avascular zone (FAZ) and blood flow of choriocapillaris and outer retina were evaluated. Results were examined comparatively, and their correlation with hypoxia parameters (minSpO<sub>2</sub>, meanSpO<sub>2</sub>, T90%) in polysomnography was investigated.</p><p><strong>Results: </strong>There was no difference in terms of age and gender (p = 0.155, p = 0.313, respectively). No difference was detected between the groups in terms of SCP and DCP (p > 0.005 for all parameters). FAZ were 0.28 ± 0.28, 0.26 ± 0.08, 0.25 ± 0.09, and 0.28 ± 0.98 mm<sup>2</sup> for Group 1-4, respectively (p = 0.880). For Group 1-4; blood flow areas of outer retinal layer were 8.38 ± 4.5 (4.5-17.1), 8.18 ± 1.9 (5-16.8), 8.62 ± 2.1 (5.5-17.2), 8.44 ± 3.2 (5.1-17.5) mm<sup>2</sup> and blood flow areas of choriocapillaris were 19.96 ± 1.4 (17.6-31.2), 19.98 ± 0.8 (18.5-21.6), 19.98 ± 1.1 (17.7-22.2), 19.97 ± 1.1 (18.1-23.2) mm<sup>2</sup>, respectively (p = 0.622, 0.558, respectively). Total, parafoveal and perifoveal DCP densities were correlated with meanSpO<sub>2</sub> (ρ = 0.269, 261, and 0.277, respectively); total and perifoveal DCP densities were correlated with meanSpO<sub>2</sub> (r = 0.028, 0.042, respectively). No correlation was detected between T90% and any OCT-A parameters.</p><p><strong>Conclusion: </strong>After considering confounding factors, no significant difference was observed in the retinochoroidal circulation between the study group and healthy volunteers, or across different stages of OSA. The weak to moderate correlation between hypoxia parameters and DCP density may suggest that the microvascular structure could be impacted in the early stages.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"371"},"PeriodicalIF":1.4000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of retinal vascular structure via optic coherence tomography angiography in obstructive sleep apnea.\",\"authors\":\"Zeynep Akgun, Cumali Degirmenci, Mehmet Sezai Tasbakan, Ozen K Basoglu, Melis Palamar\",\"doi\":\"10.1007/s10792-025-03724-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Evaluation of the retinal vascular structure with optic coherence tomography angiography (OCT-A) in patients with obstructive sleep apnea (OSA).</p><p><strong>Materials and methods: </strong>A total of 47 severe (Group 1), 30 moderate (Group 2), and 25 mild (Group 3) OSA patients and 51 healthy volunteers (Group 4) were included. Total, parafoveal, perifoveal superficial (SCP), and deep capillary plexus (DCP) vascular densities, foveal avascular zone (FAZ) and blood flow of choriocapillaris and outer retina were evaluated. Results were examined comparatively, and their correlation with hypoxia parameters (minSpO<sub>2</sub>, meanSpO<sub>2</sub>, T90%) in polysomnography was investigated.</p><p><strong>Results: </strong>There was no difference in terms of age and gender (p = 0.155, p = 0.313, respectively). No difference was detected between the groups in terms of SCP and DCP (p > 0.005 for all parameters). FAZ were 0.28 ± 0.28, 0.26 ± 0.08, 0.25 ± 0.09, and 0.28 ± 0.98 mm<sup>2</sup> for Group 1-4, respectively (p = 0.880). For Group 1-4; blood flow areas of outer retinal layer were 8.38 ± 4.5 (4.5-17.1), 8.18 ± 1.9 (5-16.8), 8.62 ± 2.1 (5.5-17.2), 8.44 ± 3.2 (5.1-17.5) mm<sup>2</sup> and blood flow areas of choriocapillaris were 19.96 ± 1.4 (17.6-31.2), 19.98 ± 0.8 (18.5-21.6), 19.98 ± 1.1 (17.7-22.2), 19.97 ± 1.1 (18.1-23.2) mm<sup>2</sup>, respectively (p = 0.622, 0.558, respectively). Total, parafoveal and perifoveal DCP densities were correlated with meanSpO<sub>2</sub> (ρ = 0.269, 261, and 0.277, respectively); total and perifoveal DCP densities were correlated with meanSpO<sub>2</sub> (r = 0.028, 0.042, respectively). No correlation was detected between T90% and any OCT-A parameters.</p><p><strong>Conclusion: </strong>After considering confounding factors, no significant difference was observed in the retinochoroidal circulation between the study group and healthy volunteers, or across different stages of OSA. The weak to moderate correlation between hypoxia parameters and DCP density may suggest that the microvascular structure could be impacted in the early stages.</p>\",\"PeriodicalId\":14473,\"journal\":{\"name\":\"International Ophthalmology\",\"volume\":\"45 1\",\"pages\":\"371\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10792-025-03724-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10792-025-03724-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Evaluation of retinal vascular structure via optic coherence tomography angiography in obstructive sleep apnea.
Objectives: Evaluation of the retinal vascular structure with optic coherence tomography angiography (OCT-A) in patients with obstructive sleep apnea (OSA).
Materials and methods: A total of 47 severe (Group 1), 30 moderate (Group 2), and 25 mild (Group 3) OSA patients and 51 healthy volunteers (Group 4) were included. Total, parafoveal, perifoveal superficial (SCP), and deep capillary plexus (DCP) vascular densities, foveal avascular zone (FAZ) and blood flow of choriocapillaris and outer retina were evaluated. Results were examined comparatively, and their correlation with hypoxia parameters (minSpO2, meanSpO2, T90%) in polysomnography was investigated.
Results: There was no difference in terms of age and gender (p = 0.155, p = 0.313, respectively). No difference was detected between the groups in terms of SCP and DCP (p > 0.005 for all parameters). FAZ were 0.28 ± 0.28, 0.26 ± 0.08, 0.25 ± 0.09, and 0.28 ± 0.98 mm2 for Group 1-4, respectively (p = 0.880). For Group 1-4; blood flow areas of outer retinal layer were 8.38 ± 4.5 (4.5-17.1), 8.18 ± 1.9 (5-16.8), 8.62 ± 2.1 (5.5-17.2), 8.44 ± 3.2 (5.1-17.5) mm2 and blood flow areas of choriocapillaris were 19.96 ± 1.4 (17.6-31.2), 19.98 ± 0.8 (18.5-21.6), 19.98 ± 1.1 (17.7-22.2), 19.97 ± 1.1 (18.1-23.2) mm2, respectively (p = 0.622, 0.558, respectively). Total, parafoveal and perifoveal DCP densities were correlated with meanSpO2 (ρ = 0.269, 261, and 0.277, respectively); total and perifoveal DCP densities were correlated with meanSpO2 (r = 0.028, 0.042, respectively). No correlation was detected between T90% and any OCT-A parameters.
Conclusion: After considering confounding factors, no significant difference was observed in the retinochoroidal circulation between the study group and healthy volunteers, or across different stages of OSA. The weak to moderate correlation between hypoxia parameters and DCP density may suggest that the microvascular structure could be impacted in the early stages.
期刊介绍：
International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.
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