International Ophthalmology最新文献

{"title":"An optimized multi-scale dilated attention layer for keratoconus disease classification.","authors":"K Balaji, N Gobalakrishnan","doi":"10.1007/s10792-025-03688-y","DOIUrl":"https://doi.org/10.1007/s10792-025-03688-y","url":null,"abstract":"<p><strong>Introduction: </strong>Keratoconus (KCN) is a progressive and non-inflammatory corneal disorder characterized by thinning and conical deformation of the cornea, resulting in visual impairment. Early and accurate detection is crucial to prevent disease progression. Conventional diagnostic methods are time-consuming and depend on expert evaluation. This study introduces an advanced deep learning (DL) model aimed at automating KCN detection using corneal topography images.</p><p><strong>Materials and methods: </strong>The proposed model, Optimized MSDALNet, integrates a Multi-Scale Dilated Attention Layer (MSDAL) to capture local and global corneal features at varying spatial resolutions. Training is optimized using Arctic Puffin Optimization (APO), a metaheuristic algorithm inspired by puffin foraging behavior. The model includes Explainable AI (XAI) capabilities using Grad-CAM for visual interpretability. Experiments were conducted using a public KCN dataset with over 1,100 labeled corneal topography images categorized into Normal, Suspect, and KCN classes. Standard pre-processing, data augmentation, and performance evaluation metrics (accuracy, precision, recall, specificity, FNR, MCC, AUC) were applied.</p><p><strong>Results: </strong>The Optimized MSDALNet achieved superior classification performance with an accuracy of 99.5%, precision of 99.4%, and specificity of 98.4%. The proposed model outperformed existing methods such as CNN, ViT, and Swin Transformer in terms of accuracy, computational cost (1.2 GFLOPs), and inference speed (8.4 ms/image). Grad-CAM visualization confirmed the model's focus on clinically relevant corneal regions. An ablation study demonstrated the impact of each component in the proposed framework.</p><p><strong>Conclusion: </strong>The Optimized MSDALNet combined with APO delivers an effective and interpretable solution for KCN detection. The model excels in feature extraction, computational efficiency, and clinical transparency. Limitations include dataset size and lack of multimodal inputs. Future work will focus on incorporating diverse datasets and additional patient data to enhance generalizability and diagnostic robustness.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"318"},"PeriodicalIF":1.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing central visual field loss representation with a hybrid unsupervised approach.","authors":"Seungtae Yoo, Sang Wook Jin, Jung Lim Kim, Jonghoon Shin, Seung Uk Lee, EunAh Kim, Jiwon Lee, Giltae Song, Jiwoong Lee","doi":"10.1007/s10792-025-03672-6","DOIUrl":"10.1007/s10792-025-03672-6","url":null,"abstract":"<p><strong>Purpose: </strong>To effectively represent central visual field (VF) loss for individual patients using a hybrid unsupervised approach.</p><p><strong>Methods: </strong>We obtained 7927 10-2 VF test data from 3328 patients in 5 hospitals. We propose a hybrid approach that combines archetypal analysis (AA) and fuzzy c-means (FCM) to identify characteristic patterns and decompose 10-2 VF without loss. To compare the performance between hybrid approach using FCM and AA single approach, mean deviation (MD) change prediction was performed through supervised learning using decomposition coefficient changes and a linear mixed-effects model was built to investigate the relationship between the MD slope and baseline decomposition coefficients.</p><p><strong>Results: </strong>We identified 10 representative archetypes for 10-2 VF test. The hybrid approach using FCM outperformed the AA single approach in predicting MD change, achieving lower mean squared error and higher pearson correlation coefficient (all P ≤ 0.039). According to the linear mixed-effects model, the hybrid approach using FCM provides a better fit for predicting MD slope compared to the AA single approach, as reflected by lower akaike information criterion (AIC) and bayesian information criterion (BIC) scores (AIC decrease: 20.31, BIC decrease: 13.33). Eyes with baseline VFs with more inferior and both hemifield loss and less intact field and nearly total loss were associated with faster central VF progression (all P ≤ 0.026).</p><p><strong>Conclusion: </strong>A hybrid approach combining AA and FCM to analyze 10-2 VF can visualize central VF tests in characteristic patterns and enhance prediction of central VF progression with minimized projection loss decomposition compared with AA single approach.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"317"},"PeriodicalIF":1.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of eight intraocular lens power calculation formulas in patients with ciliary sulcus implantation.","authors":"Pusheng Xu, Xinyu Zhang, Zhangkai Lian, Zhenzhen Liu, Charlotte Aimee Young, Siyuan Liu, Danying Zheng, Guangming Jin","doi":"10.1007/s10792-025-03684-2","DOIUrl":"10.1007/s10792-025-03684-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the accuracy of intraocular lens (IOL) power calculation for ciliary sulcus-implanted IOL.</p><p><strong>Methods: </strong>Patients with IOL (Tecnis ZA9003) implanted in the ciliary sulcus were reviewed from March 1, 2021 to November 1, 2024 at Zhongshan Ophthalmic Center, Guangzhou, China. Optic capture was used at all case. The prediction error (PE) and mean absolute error (MAE) of eight new and old formulas including Barrett Universal II (BUII), Emmetropia Verifying Optical (EVO), Haigis, Hoffer QST, Holladay 1, Kane, Radial Basis Function 3.0 (RBF 3.0), and SRK/T formula were compared. The second-generation Wang-Koch adjustment (WK2) for axial length (AL) > 26.5 mm and adjusted surgeon factor for IOL implanted in the ciliary sulcus (SF_cs) were used to modify Holladay 1 formula.</p><p><strong>Results: </strong>56 eyes from 56 patients were enrolled. The performance of each formula ranked by mean PE from lowest to highest were Holladay 1 (- 0.42 D), BUII (- 0.47 D), EVO (- 0.49 D), Haigis (- 0.49 D), RBF 3.0 (- 0.52 D), SRK/T (- 0.53 D), Kane (- 0.56 D), and Hoffer QST (- 0.58 D). BUII formula reached the lowest MAE (0.68 D), while Hoffer QST and Kane formula had the highest MAE (0.75 D). Holladay 1, modified with WK2 and a SF_sc of 1.37, achieved a mean PE of 0 ± 0.67 D, the lowest MAE (0.52) and MedAE (0.40), as well as the highest percentage of eyes with PE within ± 0.25 D, ± 0.50 D, and ± 1.00 D.</p><p><strong>Conclusion: </strong>Among the eight included formulas, Holladay 1 formula modified with WK2 adjustment and a SF_cs of 1.37 was recommended for patients with sulcus-implanted optic-captured ZA9003 IOL.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"316"},"PeriodicalIF":1.4,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory response index as a predictive biomarker for Irvine-Gass syndrome.","authors":"Serdar Bilici, Tuba Gültekin Erol, Numan Küçük, Suat Hayri Uğurbaş","doi":"10.1007/s10792-025-03680-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03680-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate systemic inflammatory marker levels in Irvine-Gass Syndrome (IGS) cases and to compare with uncomplicated cataract (control) cases.</p><p><strong>Methods: </strong>Medical records of 25 IGS cases and 30 control cases were retrospectively analyzed. Levels of neutrophils, monocytes, lymphocytes, and thrombocytes were obtained from blood samples. Systemic inflammatory markers, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated and compared between the two groups. In case of significant difference presence, the receiver operating characteristic curve (ROC) analysis was performed to determine the best cutoff value of systemic inflammatory markers in IGS.</p><p><strong>Results: </strong>The medians (min-max) of NLR, PLR, SII, and SIRI were 2.59 (0.13-16.50), 118.42 (5.49-297.69), 525.18 (22.5-3217.5), and 1.44 (0.06-10.11) in IGS group; 1.62 (0.93-8.50), 98.69 (70.0-400.0), 380.60 (161.0-2040.0), and 0.79 (0.37-5.10) in control group, respectively. SIRI was significantly higher in the IGS group (p = 0.036) in comparison to the control group. NLR, PLR, and SII were also found higher in the IGS group, but this difference couldn't reach statistical significance level (p = 0.101, p = 0.600, and p = 0.176, respectively). The ROC analysis revealed that the area under the curve for SIRI to distinguish IGS found to be 0.665. The best cutoff value of SIRI was 0.95, with a sensitivity of 64% and specificity 73%.</p><p><strong>Conclusion: </strong>Higher levels of SIRI in IGS cases may indicate the potential association between subclinical systemic inflammation and pseudophakic cystoid edema formation. The current results highlight the potential utility of SIRI as a predictive factor for IGS following cataract surgery.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"315"},"PeriodicalIF":1.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the genetic spectrum of achromatopsia: novel CNGA3 and CNGB3 variants.","authors":"Zehra Manav Yigit, Nurdamla Sandal Filikci, Erol Erkan, Gozde Sahin Vural, Mehmet Altay Unal, Evren Gumus","doi":"10.1007/s10792-025-03650-y","DOIUrl":"https://doi.org/10.1007/s10792-025-03650-y","url":null,"abstract":"<p><strong>Purpose: </strong>Achromatopsia is a rare autosomal recessive disorder characterised by congenital pendular nystagmus, photophobia, decreased visual acuity, and impaired colour vision. Variants in the CNGA3 (Achromatopsia 2, MIM#216900) and CNGB3 (Achromatopsia 3, MIM#262300) genes account for the majority (more than 2/3) of cases, but genotype-phenotype correlations remain incompletely understood.</p><p><strong>Methods: </strong>This study aims to expand the clinical and genetic spectrum of achromatopsia by analysing five patients from three families, including two novel variants in the CNGA3 and CNGB3. Comprehensive ophthalmological and genetic evaluations were performed, including best corrected visual acuity, electroretinography, optical coherence tomography, and clinical exome sequencing. Segregation analysis was conducted to confirm the inheritance pattern.</p><p><strong>Results: </strong>We identified a novel missense variant in CNGA3 (c.1710C > A p.(Ser570Arg)) and a novel frameshift variant in CNGB3 (c.739_754del p.(Ala247Thrfs*27)).</p><p><strong>Conclusion: </strong>Molecular dynamics simulations suggest that the CNGA3 c.1710C > A p.(Ser570Arg) variant may act as a gain-of-function variant, leading to altered cyclic nucleotide-gated channel activity in cone photoreceptors. This finding provides new insights into the functional consequences of CNGA3 variants in the pathophysiology of achromatopsia. Our findings provide new insights into genotype-phenotype correlations in achromatopsia and highlight the importance of early genetic diagnosis in improving disease management and genetic counselling. The identification of novel variants enhances our understanding of the genetic basis of achromatopsia and highlights the clinical utility of next-generation sequencing in the diagnosing of inherited retinal diseases.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"313"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in machine learning for ABCA4-related retinopathy: segmentation and phenotyping.","authors":"Yousif J Shwetar, Brian P Brooks, Brett G Jeffrey, Benjamin D Solomon, Melissa A Haendel","doi":"10.1007/s10792-025-03690-4","DOIUrl":"10.1007/s10792-025-03690-4","url":null,"abstract":"<p><strong>Purpose: </strong>Stargardt disease, also called ABCA4-related retinopathy (ABCA4R), is the most common form of juvenile-onset macular dystrophy and yet lacks an FDA approved treatment. Substantial progress has been made through landmark studies like that of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar), but tasks like image segmentation and phenotyping still pose major challenges in terms of monitoring disease progression and categorizing patient subgroups. Furthermore, these methods are subjective and laborious. Recent advancements in machine learning (ML) and deep learning show considerable promise in automating these processes.</p><p><strong>Methods: </strong>This scoping review explores ML applications in ABCA4R, with a focus on segmentation and phenotyping. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) methodology, 15 articles were selected from 264, with 12 focused on the task of segmenting atrophic lesions, retinal flecks, retinal layer boundaries, or en-face imaging. Three studies addressed phenotyping based on electroretinography (ERG), visual acuity, and microperimetry.</p><p><strong>Results: </strong>Several effective approaches were implemented in these studies, including ensemble modeling, self-attention mechanisms, soft-label approaches, and dynamic frameworks that consider extent of tissue damage. Excellent model performance includes segmentation DICE performances of 0.99 and ERG phenotyping accuracies 90% and greater. Smaller datasets and variable presentations present as significant challenges, while advanced methods like Monte Carlo dropout and active learning improve pipeline efficiency and performance.</p><p><strong>Conclusion: </strong>ML techniques are well on their way to automate key steps in ABCA4R evaluation with excellent performance. These emerging methods have the potential to expedite therapeutic innovation and enhance our understanding of ABCA4R.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"314"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior chamber alterations in fellow eyes of face-down positioned patients after pars plana vitrectomy: a prospective longitudinal study.","authors":"Gozde Sahın Vural, Yurdagul Gırgın, Yucel Yıgıt, Eyyup Karahan","doi":"10.1007/s10792-025-03663-7","DOIUrl":"10.1007/s10792-025-03663-7","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the anterior chamber (AC) changes in fellow eyes of patients who were directed to a face-down position after pars plana vitrectomy (PPV).</p><p><strong>Methods: </strong>The bilaterally phakic patients who had PPV, and were advised prone position due to intraocular tamponade for at least three days were included. The AC properties such as central anterior chamber depth (ACD), and ACD and anterior chamber angle (ACA) in nasal, and temporal quadrants and the intraocular pressure (IOP) were recorded at the preoperative visit, 1st-day, last day of prone position, and 1st-month visits in both eyes.</p><p><strong>Results: </strong>The study included 51 eyes of 51 patients with a mean age of 60.3 ± 13.5 years. Mean IOP had a significant increase on 1st day (Preoperative IOP 14.9 ± 3.5 mmHg, and IOP on 1st day: 16.4 ± 3.7 mmHg (p = 0.021)). Mean ACD in all quadrants were significantly narrowed on 1st day and last face-down day (p < 0.001, for all) while ACA in all quadrants were significantly narrowed similarly (p < 0.001, for all parameters) compared to the preoperative period.</p><p><strong>Conclusion: </strong>The face-down position in fellow eyes of PPV-operated patients may lead to significant anterior chamber narrowing resulting in IOP peaks. The patients should be carefully monitored for possible angle-closure glaucoma. This study was approved by the institutional review board (Registration Number and Date: 2021/60 and 24.02.2021).</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"312"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of cardiopulmonary coupled sleep monitoring technology in sleep analysis of glaucoma patients.","authors":"Cuijuan Liu, Jing Ma, Pengfen Wang, Wei Liu, Miaomiao Zhang","doi":"10.1007/s10792-025-03689-x","DOIUrl":"https://doi.org/10.1007/s10792-025-03689-x","url":null,"abstract":"<p><strong>Objective: </strong>To assess sleep quality of glaucoma patients using cardiopulmonary coupled CPC monitoring.</p><p><strong>Methods: </strong>276 patients from July 2021 to May 2022 were continuously collected. 176 patients including 95 patients with acute angle-closure glaucoma (group A) and 81 patients with chronic angle-closure glaucoma (group B) were enrolled, 100 cataract patients (group C) as the control group. The CPC monitoring was performed on the enrolled patients. According to diseases types and CPC results, the sleep quality of the glaucoma patients was analyzed.</p><p><strong>Results: </strong>The total sleep time (TST) of group A was 6.91 ± 1.471 h, while Group B's TST was 7.14 ± 0.637 h. Group C's TST was 7.45 ± 0.852 h. The sleep efficiency (TIB) of group A was 80.128 ± 10.959, and group B's TIB was 80.246 ± 9.936. Group C's TIB was 85.451 ± 6.534. The Apnea-Hypopnea Index (AHI) of group A was 17.923 ± 19.901, and group B's AHI was 15.438 ± 15.818. Group C's AHI was 9.481 ± 10.494. The difference between the group A and group B was statistically significant, and the differences among the group A, B and the group C was statistically significant in the three sets of data.</p><p><strong>Conclusions: </strong>PACG patients, especially with acute presentation (PAACG), demonstrate significantly disrupted sleep and higher AHI versus controls via CPC monitoring. These findings advocate for embedding sleep-disordered breathing screening into routine glaucoma management using CPC as a practical triage tool.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"308"},"PeriodicalIF":1.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of central visual field deterioration by sector-wise peripapillary vessel density measurement in eyes with retinitis pigmentosa.","authors":"Kazuyoshi Okawa, Yume Iwashita, Tatsuya Inoue, Shohei Kawasaki, Yuna Uechi, Misa Miyazato, Kentaro Nakamura, Ryo Asaoka, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono","doi":"10.1007/s10792-025-03677-1","DOIUrl":"https://doi.org/10.1007/s10792-025-03677-1","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between the visual field (VF) deterioration and vessel density (VD) around the optic nerve head (ONH) in a sector-wise manner in eyes with retinitis pigmentosa (RP).</p><p><strong>Methods: </strong>The present study enrolled the RP patients who demonstrated VF constriction within central 10°. The VD around the ONH was measured with optical coherence tomography angiography (OCTA), using three binarization methods and the relationships between VD and the mean deviation (MD) value were investigated, respectively. Then, the VD in each quadrant (superior, temporal, inferior, nasal) around the ONH was calculated using Otsu method (OVDs: vessel density measured with Otsu method in the superior region, OVDt: vessel density measured with Otsu method in the temporal region, OVDi: vessel density measured with Otsu method in the inferior region, OVDn: vessel density measured with Otsu method in the nasal region). Considering the foveal position relative to the optic disc, angle-corrected binarized OCTA images were created and the VD was measured in each sector (AcOVDs: angle-corrected OVDs, AcOVDt: angle-corrected OVDt, AcOVDi: angle-corrected OVDi, and AcOVDn: angle-corrected OVDn). We investigated the relationship between the MD value and OVDs, OVDt, OVDi and OVDn. Furthermore, the correlation between the MD value and AcOVDs, AcOVDt, AcOVDi and AcOVDn was analyzed.</p><p><strong>Results: </strong>Thirty-six eyes were examined in the current study. Among Niblack, Bernsen and Otsu methods, the VD measured with Otsu method was closely related to the MD value. Among OVDs, OVDt, OVDi and OVDn, the optimal model for the MD value included OVDt and OVDi. On the other hand, among AcOVDs, AcOVDt, AcOVDi and AcOVDn, the optimal model for the MD value included only AcOVDt.</p><p><strong>Conclusions: </strong>The sector-wise VD around the ONH reflects VF deficit severity and is a candidate for improving the assessment of VF deterioration in eyes with RP.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"310"},"PeriodicalIF":1.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of suture thickness on clinical outcomes in gonioscopy-assisted transluminal trabeculotomy: a comparative analysis of 5-0 and 6-0 polypropylene sutures.","authors":"Enver Mirza, Gunsu Deniz Mirza, Selman Belviranli, Mehmet Okka","doi":"10.1007/s10792-025-03682-4","DOIUrl":"https://doi.org/10.1007/s10792-025-03682-4","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical results of Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) performed with 5-0 or 6-0 polypropylene sutures and whether it makes a difference in anterior chamber (AC) morphology.</p><p><strong>Methods: </strong>The file records of patients with primary open-angle glaucoma or pseudoexfoliation glaucoma who underwent GATT with 5-0 or 6-0 polypropylene sutures were reviewed. Patients were divided into two groups (GATT with 5-0 polypropylene suture: Group 1 vs. GATT with 6-0 polypropylene suture: Group 2). The clinical results of GATT, intraocular pressure (IOP) values, and parameters measured with Pentacam HR Scheimpflug camera system including anterior chamber angle (ACA), anterior chamber depth (ACD), anterior chamber volume (ACV), central corneal thickness (CCT), and pupil diameter (PD) of two groups at preoperative period, postoperative 1st, 3rd, and 6th months were compared.</p><p><strong>Results: </strong>A total of 41 patients were included in the study (Group 1: n = 21, Group 2: n = 20). Approximately 60% reduction in IOP was detected in both groups and the rate of IOP reduction at each visit was similar between the two groups (p > 0.05 in all). It was determined that there were no differences in AC parameters including ACA, ACD, ACV, CCT, and PD at any visit in either group. (p > 0.05 in all). Also, there was no significant difference in the complication rates between the two groups.</p><p><strong>Conclusion: </strong>It was observed that there were no significant differences in terms of success rate, complication rate, and the effect on AC morphology between performing GATT with 5-0 or 6-0 polypropylene sutures.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"311"},"PeriodicalIF":1.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}