International Ophthalmology最新文献

{"title":"A retrospective analysis of treatment switch from faricimab to aflibercept 8 mg in nAMD.","authors":"Sarah Nermin Mehany, Pia Veronika Vécsei-Marlovits, Agnes Boltz","doi":"10.1007/s10792-026-04237-x","DOIUrl":"https://doi.org/10.1007/s10792-026-04237-x","url":null,"abstract":"<p><strong>Purpose: </strong>Macular neovascularization is one of the most common causes of irreversible vision loss. Intravitreal injections with anti-vascular endothelial growth factor are the treatment of choice. In recent years, new drugs such as faricimab and aflibercept 8 mg have paved the way for longer intervals between intravitreal injections. However, there are currently very few comparative studies on these longer-acting drugs.</p><p><strong>Methods: </strong>This retrospective analysis included patients with at least three consecutive intravitreal injections of faricimab due to neovascular age-related macular degeneration who were subsequently switched from faricimab to aflibercept 8 mg in 2024. The primary outcome was the change in central retinal thickness as measured by optical coherence tomography. The secondary outcome was best-corrected visual acuity.</p><p><strong>Results: </strong>41 eyes of 38 patients were included. There were no statistically significant changes in retinal thickness. Best-corrected visual acuity showed a trend towards deterioration, however not statistically significant. One patient experienced a tear of the retinal pigment epithelium after receiving the first injection of aflibercept 8 mg.</p><p><strong>Conclusion: </strong>This retrospective analysis did not show statistically significant changes in central retinal thickness or best-corrected visual acuity after treatment switch from faricimab to aflibercept 8 mg.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and imaging characterization of ocular toxoplasmosis in a Central-West Brazilian population.","authors":"Alexsandra Passarelli Giabardo Marques, Luiza Roschel Zaunrith, Danilo Donizete da Silva, Aparecida Perpétuo Silveira Carvalho, Fernando Henrique Antunes Murata, Rubens Camargo Siqueira, Lucas Gazarini, Edis Belini Júnior, Julie Massayo Maeda Oda, Christiane Maria Ayo, Luiz Carlos de Mattos, Cinara Cássia Brandão","doi":"10.1007/s10792-026-04302-5","DOIUrl":"10.1007/s10792-026-04302-5","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and characterize patients with presumed ocular toxoplasmosis using combined clinical and serological approaches in the municipality of Três Lagoas, Mato Grosso do Sul, Brazil.</p><p><strong>Methods: </strong>This cross-sectional quantitative study included 85 patients with presumed Toxoplasma gondii related retinochoroiditis referred from the public healthcare system. Participants underwent ophthalmologic examination and serological testing for anti-T. gondii IgG and IgM antibodies. Patients were classified into control (G1), active lesion (G2), and cicatricial lesion (G3) groups.</p><p><strong>Results: </strong>Overall, 76.5% of patients were positive for anti-T. gondii IgG, while 3.5% were positive for IgM. Most patients with cicatricial lesions (G3) were IgG-positive (31/33). In contrast, IgM positivity was restricted to a small subset of patients (3/13) with active lesions (G2). Ophthalmologic evaluation demonstrated that unilateral disease predominated (78.2%), with lesions mainly located in the posterior pole (52.8%). Morphologically, round-to-ovoid lesions were most frequent (60.0%), followed by amoeboid (16.0%), placoid (8.0%), and wedge-shaped and punctate (4.0% each) patterns. Mean lesion size among evaluable eyes was 16.2 mm².</p><p><strong>Conclusion: </strong>The analyses provide data that contribute to the understanding of the clinical characteristics of the disease, ocular behavior, and serological findings. Consequently, preventive measures may be implemented, reducing risk factors and improving patients' quality of life.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal and choroidal microvascular changes in hemodialysis and peritoneal dialysis: a comparative OCT and OCTA study.","authors":"Binhan Aslan Akbulut, Ahmet Altıntaş, Emine Alyamaç Sukgen, Tayyibe Saler, Lina Elmas","doi":"10.1007/s10792-026-04293-3","DOIUrl":"10.1007/s10792-026-04293-3","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate retinal and choroidal structural and microvascular parameters using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in patients undergoing hemodialysis (HD) and peritoneal dialysis (PD). Furthermore, it aimed to compare short-term dialysis-associated ocular changes between the two dialysis modalities.</p><p><strong>Methods: </strong>This prospective observational study encompassed 84 eyes from 46 patients undergoing either HD or PD. Ocular measurements were conducted at two time points according to the dialysis modality. Measurements for HD patients were taken before and after dialysis, whereas for PD patients, measurements were performed after dialysate drainage and following refilling. Comprehensive ophthalmologic assessments and OCT/OCTA imaging were performed. Statistical analyses were used to compare pre- and post-dialysis measurements and changes between the HD and PD groups.</p><p><strong>Results: </strong>CMT significantly increased after dialysis, whereas subfoveal choroidal thickness significantly decreased. Systolic and diastolic blood pressures also decreased significantly. No significant changes were observed in OCTA-derived retinal microvascular parameters, including vessel density and FAZ parameters. A significant difference in ΔCMT was observed between the HD and PD groups (p = 0.002). Correlation analysis showed a moderate negative correlation between ΔCMT and the change in systolic blood pressure and a moderate positive correlation between ΔCMT and dialysis session duration.</p><p><strong>Conclusion: </strong>Most OCTA-derived retinal microvascular parameters remained stable following dialysis, whereas small but statistically significant structural changes were observed in CMT and subfoveal choroidal thickness. The magnitude of short-term CMT change differed between HD and PD; however, the mechanism underlying this difference remains uncertain. OCT and OCTA may serve as useful non-invasive tools for evaluating ocular structural and microvascular changes in patients with ESRD undergoing dialysis.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-surgical management of thyroid eye disease: a pilot survey of oculoplastic surgeons.","authors":"Shiqi Hui, Lihua Luo, Dongmei Li","doi":"10.1007/s10792-026-04296-0","DOIUrl":"https://doi.org/10.1007/s10792-026-04296-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate real-world practices in the non-surgical management of thyroid eye disease (TED) among oculoplastic surgeons across participating Asia-Pacific clinical settings.</p><p><strong>Methods: </strong>A structured 39-item online questionnaire was distributed between August and October 2023 to 40 eligible oculoplastic surgeons identified through the Asia Pacific Society of Ophthalmic Plastic and Reconstructive Surgery. The questionnaire assessed clinical experience, TED patient volume, and preferred non-surgical therapeutic approaches, including corticosteroids, immunosuppressive agents, orbital radiotherapy (ORT), biologic therapies, periocular injections, and micronutrient supplementation. Descriptive statistics were used because of the exploratory nature and small sample size of the survey.</p><p><strong>Results: </strong>Seventeen physicians completed the questionnaire, corresponding to a response rate of 42.5%. All respondents reported using glucocorticoids, and intravenous methylprednisolone was the predominant systemic treatment. A cumulative dose of 4.5 g, administered as 6 weekly infusions of 500 mg followed by 6 weekly infusions of 250 mg, was selected by 13 respondents (76.5%). Periocular injections were used by 11 respondents (64.7%), with triamcinolone acetonide being the most frequently used agent. Ten respondents (58.8%) reported using ORT. Immunosuppressive agents were used less frequently, with mycophenolate mofetil and methotrexate each reported by 3 respondents (17.7%). Biologic therapies included tocilizumab (4, 23.5%), rituximab (3, 17.7%), and teprotumumab (1, 5.9%). Selenium supplementation was reported only sporadically.</p><p><strong>Conclusions: </strong>This exploratory survey demonstrates substantial variability in the non-surgical management of TED across participating Asia-Pacific settings. Given the small, non-random sample and uneven country representation, these findings should be interpreted as preliminary and hypothesis-generating rather than representative of the Asia-Pacific region as a whole.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing surgical residual deviation and their impact on higher-order aberrations after SMILE surgery.","authors":"Xujie Deng, Rong Huang, Fangfang Lu, Shigang Xia, Jia Zhang, Jing Lu, Yu Wang, Jiahuan Yi, Xinxin Song, Lijing Deng, Qiguo Xiao, Zhi Wang","doi":"10.1007/s10792-026-04301-6","DOIUrl":"10.1007/s10792-026-04301-6","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the factors influencing the surgical residual deviation after Small Incision Lenticule Extraction (SMILE) and its impact on postoperative higher-order aberrations (HOAs).</p><p><strong>Methods: </strong>This retrospective study included 77 patients (146 eyes) who underwent SMILE surgery at our Eye and Vision Center from February 2021 to June 2022. Surgical data collected included uncorrected distance visual acuity (UDVA), refraction, spherical equivalent (SE), corneal curvature, central corneal thickness (CCT), axial length (AL), intraoperative actual refractive correction, posterior corneal surface height (PME), total corneal HOAs, spherical aberration (SA), coma aberration (CA), and trefoil aberration. Changes in central corneal thickness were observed preoperatively and at 1 and 3 months postoperatively. The actual lenticular thickness removed during surgery was compared with the predicted lenticular thickness, and statistical analysis was performed using SPSS version 26.0.</p><p><strong>Results: </strong>The average deviation of CCT at 1 month postoperative was - 7.11±9.933 µm, and at 3 months postoperative was - 13.37±9.665 µm. The difference between actual and predicted lenticular thickness showed statistical significance (P<0.05). At 1 month and 3 months postoperative, the ratio of eyes with negative deviation to positive deviation was 113:33 and 137:9, respectively. Statistically significant differences were observed in preoperative CCT, with the negative deviation group positively correlating with preoperative refraction, SE, intraoperative actual refractive correction, curvature, CCT, and PME (P<0.05). Conversely, the positive deviation group showed a negative correlation with preoperative curvature, CCT, and PME (P<0.05). At 1 month and 3 months postoperative, HOAs, SA, CA, and trefoil aberration increased compared to preoperative values, with UDVA, SE, HOAs, SA, and CA showing statistically significant differences (P<0.05). In the negative deviation group at 1 month postoperative, deviation values positively correlated with SE (P<0.05). In the negative deviation group at 3 months postoperative, deviation values were positively correlated with HOAs, SA, and CA (P<0.05). No significant correlation was found between deviation values and UDVA, SE, HOAs, SA, CA, or trefoil aberration in the positive deviation group at both 1 and 3 months postoperative.</p><p><strong>Conclusion: </strong>There is a difference between the actual lenticular thickness removed during SMILE and the predicted lenticular thickness. Central corneal thickness gradually increases over time postoperatively. The cutting deviation after SMILE is correlated with preoperative refraction, curvature, and PME, and has a certain impact on postoperative HOAs.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative safety and complication profiles of two three-piece intraocular lenses in Yamane technique.","authors":"Erdi Karadağ, Güzide Akçay, Burak Tanyıldız, Ulviye Kıvrak, Esengül Kuş Solmaz","doi":"10.1007/s10792-026-04289-z","DOIUrl":"https://doi.org/10.1007/s10792-026-04289-z","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the mechanical behavior, intraoperative events, and postoperative outcomes of two three-piece intraocular lenses (IOLs) with different haptic materials-polymethyl methacrylate (PMMA) and polyvinylidene fluoride (PVDF)-implanted using the Yamane fixation technique.</p><p><strong>Methods: </strong>This retrospective comparative study included eyes undergoing Yamane scleral fixation with either a PMMA-haptic IOL (Alcon MA60AC) or a PVDF-haptic IOL (Eyecryl Plus TP613). Preoperative and postoperative month 6 best-corrected visual acuity (BCVA), intraocular pressure (IOP), and cylindrical refraction, as well as intraoperative haptic-related complications including haptic tip breakage and optic-haptic junction separation, postoperative IOL dislocation, and other postoperative complications were recorded and analyzed.</p><p><strong>Results: </strong>Seventy-four eyes (37 per group) were included. Baseline demographic and preoperative clinical characteristics were similar between groups. At 6 months, BCVA improved significantly in both groups without a significant intergroup difference, and postoperative IOP values and cylindrical refraction were comparable. Intraoperative complications were more frequent in the Alcon group (32.4%, 95% CI 19.6-48.5% vs. 5.4%, 95% CI 1.5-17.7%; p = 0.003), with haptic-related complications occurring exclusively in this group. Overall postoperative complication rates were similar; however, IOL dislocation occurred only in the Alcon group (16.2%, 95% CI 7.7-31.1% vs. 0%; p = 0.025). Other postoperative complications did not differ significantly.</p><p><strong>Conclusion: </strong>Both IOLs yielded comparable improvements in visual acuity; however, all haptic-related complications and IOL dislocations occurred exclusively in the Alcon MA60AC group. These findings suggest that IOL selection is an important consideration in Yamane fixation, and the Eyecryl Plus TP613 with its PVDF haptics and more favorable design profile may offer greater biomechanical reliability.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual, refractive, and tomographic outcomes after mitomycin-free manual superficial keratectomy for Salzmann nodular degeneration and peripheral hypertrophic subepithelial corneal degeneration: a retrospective cohort study.","authors":"Sofie Mourisse, Isabeau Houben, Thierry Derveaux, Ineke van Gremberghe, Elke O Kreps, Dimitri Roels","doi":"10.1007/s10792-026-04292-4","DOIUrl":"https://doi.org/10.1007/s10792-026-04292-4","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate visual, refractive, keratometric, aberrometric, and densitometric outcomes after manual superficial keratectomy (MSK) without adjuvant mitomycin C (MMC) for Salzmann nodular degeneration (SND) and peripheral hypertrophic subepithelial corneal degeneration (PHSCD).</p><p><strong>Methods: </strong>Retrospective cohort study of patients treated with MSK without adjuvant MMC at Ghent University Hospital. Outcomes included best-corrected visual acuity (BCVA), refraction, and Scheimpflug-based tomography, aberrometry, and densitometry (Pentacam HR). Recurrence and complications were recorded throughout follow-up.</p><p><strong>Results: </strong>Pre- and postoperative outcomes were compared in 56 eyes of 38 patients (50 SND, 6 PHSCD) over a median follow-up of 4.6 (mean 13.8) months (maximum 6.4 years). BCVA improved from 0.20 to 0.08 logMAR, spherical equivalent from + 1.51 to - 0.85 D, refractive cylinder from - 4.56 to - 1.24 D, and corneal astigmatism from 4.31 to 1.40 D (all P < 0.001). K1 increased from 38.92 to 42.26 D (P < 0.001), with a smaller increase in K2 (43.25 to 43.67 D; P = 0.009). Higher-order root-mean-square aberrations decreased from 2.79 to 1.12 µm (P < 0.001) and total root-mean-square aberrations from 7.30 to 3.27 µm (P < 0.001). Corneal densitometry did not change significantly in any prespecified zone. Nodular recurrence occurred in one eye (1.8%); secondary pterygia developed in 4 eyes (7.1%); no intraoperative complications occurred.</p><p><strong>Conclusions: </strong>In this retrospective cohort of eyes with SND or PHSCD, MSK without adjuvant MMC was associated with significant visual, refractive, keratometric, and aberrometric improvement. We consider this approach an effective first-line surgical option in symptomatic or visually significant SND and PHSCD.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical outcomes, cost, and patient perceptions between delayed and immediate sequential bilateral cataract surgery in Thailand: a retrospective case-control study.","authors":"Aim-On Saengsirinavin, Thiti Wichayachiwin, Thanida Voraviwat, Frances Andrea Anover, Ngoc Trong Tuong Than, Negin Yavari, Jia-Horung Hung, Jingli Gou, Christopher Or, Quan Dong Nguyen, Prin Rojanapongpun","doi":"10.1007/s10792-026-04271-9","DOIUrl":"10.1007/s10792-026-04271-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare clinical outcomes, complication rates, costs, and patient perceptions-encompassing satisfaction, anxiety, pain, and visual function-between delayed sequential bilateral cataract surgery (DSBCS) and immediately sequential bilateral cataract surgery (ISBCS) in Thailand.</p><p><strong>Setting: </strong>King Chulalongkorn Memorial Hospital (KCMH) and Sukhumvit Hospital, Bangkok, Thailand.</p><p><strong>Methods: </strong>A retrospective comparative study was performed, including 201 adult patients (402 eyes) who underwent DSBCS (n = 99) or ISBCS (n = 102), performed by a single surgeon between January 2016 and December 2023. Patient perceptions were assessed through structured interviews.</p><p><strong>Results: </strong>No major intraoperative or postoperative complications-including posterior capsule rupture or endophthalmitis-were observed in either group. Postoperative visual acuity (LogMAR) and refraction within ±0.5D of target were comparable between groups (61.6% DSBCS vs 65.5% ISBCS, p = 0.485). ISBCS patients reported significantly higher anxiety scores (median 3 vs 2, p = 0.002) and lower satisfaction scores (median 8 vs 10, p < 0.001) than DSBCS patients. ISBCS patients also reported significantly higher pain during surgery (p < 0.001). DSBCS patients demonstrated greater improvement in near visual function, specifically reading (median improvement 3 vs 2, p = 0.021) and computer use (p < 0.001). The total healthcare cost was significantly higher for DSBCS (USD 1,624 [IQR 1,492-4,029]) compared to ISBCS (USD 1,012 [IQR 910-1,839]) (p < 0.001).</p><p><strong>Conclusion: </strong>Safety and efficacy outcomes were equivalent for DSBCS and ISBCS. However, ISBCS patients reported higher anxiety, greater pain during surgery, and lower satisfaction compared to DSBCS. DSBCS patients demonstrated greater improvement in near visual function. The overall cost was significantly lower for ISBCS, a finding consistent across both government and private hospital settings. These results highlight the need for interventions to reduce perioperative anxiety and pain in ISBCS patients, and provide Thai-specific evidence to inform healthcare policy decisions regarding the wider implementation of ISBCS.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual outcomes and short-term complication profile following Yamane scleral fixation of intraocular lenses across different surgical indications.","authors":"Ahmad Kunbaz, Esma Ecem Ersoy, Fatime Ucdag, Batuhan Borucu, Fehim Esen, Ebubekir Durmus, Halit Oguz, Veysel Aykut","doi":"10.1007/s10792-026-04294-2","DOIUrl":"https://doi.org/10.1007/s10792-026-04294-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate visual and safety outcomes of double-flanged (Yamane) intrascleral intraocular lens fixation across different clinical scenarios of capsular support loss.</p><p><strong>Methods: </strong>This retrospective cohort study included 55 eyes undergoing Yamane scleral fixation. Eyes were stratified by surgical indication into aphakia (10), dislocated intraocular lens (12), complicated phacoemulsification (15), and dropped intraocular lens managed with pars plana vitrectomy (18). Best-corrected visual acuity, intraocular pressure, and postoperative complications were assessed preoperatively and at 1-week, 1-month, and 3-month follow-up. Multivariable regression analysis was performed to evaluate associations between clinical factors and final visual acuity.</p><p><strong>Results: </strong>Best-corrected visual acuity improved significantly in all groups (p < 0.001), with no intergroup differences at any postoperative time point (all p > 0.05). Postoperative intraocular pressure remained comparable across groups (p > 0.05). Early postoperative complications were more frequent in the phacoemulsification with scleral fixation group (p = 0.01), primarily transient corneal edema (93.3%) and transient intraocular pressure elevation (53.3%). Lens-related complications, including iris optic capture, intraocular lens tilt, and intraocular lens dislocation, each occurred in 6.7% and required surgical repositioning. Later postoperative complication rates at 1 and 3 months were comparable among groups. Postoperative refractive outcomes, including spherical equivalent and prediction error, were comparable across all surgical indications, with no significant intergroup differences (all p > 0.05).</p><p><strong>Conclusions: </strong>Yamane scleral fixation was associated with consistent short-term visual improvement and an acceptable short-term complication profile across a broad range of clinical indications in eyes without capsular support. Combined cataract extraction with scleral fixation was associated with visual outcomes comparable to isolated secondary intraocular lens fixation but was associated with a higher incidence of early postoperative complications.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral eplerenone in first-episode acute central serous chorioretinopathy: results of a double-masked randomized trial.","authors":"Ghodsieh Zamani, Roozbeh Asghari, Nasser Shoeibi, Majid Abrishami, Seyedeh Maryam Hoseini, Mohammad-Reza Ansari-Astaneh, Mojtaba Abrishami, Elham Bakhtiari, Mehrdad Motamed Shariati","doi":"10.1007/s10792-026-04287-1","DOIUrl":"10.1007/s10792-026-04287-1","url":null,"abstract":"<p><strong>Background: </strong>Central serous chorioretinopathy (CSCR) is a pachychoroid disorder characterized by serous retinal detachment driven by choroidal vascular dysfunction and mineralocorticoid receptor (MR) overactivation. Eplerenone, a selective MR antagonist, has been proposed as a therapeutic option, although clinical evidence remains inconsistent.</p><p><strong>Methods: </strong>In a randomized, double-blind, placebo-controlled trial, 44 patients with first-episode acute CSCR received either oral eplerenone (25 mg twice daily) or placebo for three months. Outcomes included best-corrected visual acuity (BCVA), central macular thickness (CMT), subretinal fluid (SRF) height, subfoveal choroidal thickness (CT), and OCT-angiography parameters of retinal and choroidal microvasculature.</p><p><strong>Results: </strong>Both groups demonstrated significant reductions in CMT and SRF over time, but SRF absorption was significantly greater in the eplerenone group at 3 months (P < 0.05). Choriocapillaris vessel density and flow index improved significantly with eplerenone (P < 0.001), while superficial, deep, and radial peripapillary plexus densities did not differ between groups. BCVA improved similarly in both groups.</p><p><strong>Conclusion: </strong>Eplerenone accelerates SRF resolution and enhances choriocapillaris perfusion in acute CSCR, although visual outcomes remain comparable to placebo. Early MR antagonism may offer anatomical and microvascular benefits in CSCR management.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}