International Ophthalmology最新文献

{"title":"Development of a scoring model integrating inflammatory markers for predicting ROP in preterm neonates.","authors":"Şahin Hamilçıkan, Hatice Erolur, Ceren Can, Yakup Karakurt, Emrah Can","doi":"10.1007/s10792-025-03572-9","DOIUrl":"10.1007/s10792-025-03572-9","url":null,"abstract":"<p><strong>Purpose: </strong>ROP is a leading cause of blindness in preterm infants worldwide. ROP diagnosis is made through a detailed eye examination and supportive methods are required, especially in limited centers. ROP diagnosis primarily relies on frequent ophthalmological examinations; however, complementary diagnostic tools may significantly aid clinicians, particularly in centers with limited resources. This study introduces an innovative scoring model integrating systemic inflammatory markers for its early prediction of ROP.</p><p><strong>Methods: </strong>A retrospective case-control study involving 120 preterm infants (≤ 32 weeks, ≤ 1500 g) was conducted. Hemogram-based inflammatory indices, including the Systemic Inflammatory Response Index (SIRI), Platelet-to- Lymphocyte Ratio (PLR), and Pan-Immun Inflammatory Value (PIV), were calculated from blood samples obtained within the first 24 h of life and before ROP diagnosis. Logistic regression and ROC analyses informed the scoring model.</p><p><strong>Results: </strong>Infants with ROP showed lower gestational ages and birth weights (p < 0.001, p = 0.02). SIRI-2 displayed the highest diagnostic accuracy (AUC = 0.704). A combined model using SIRI-2, PLR-2, and PIV-2 achieved superior performance (AUC = 0.802). Logistic regression identified SIRI-2 and PLR-2 as independent predictors, enhancing risk stratification.</p><p><strong>Conclusion: </strong>This scoring model not only enhances early risk stratification but also holds potential for widespread implementation in neonatal intensive care units, particularly in resource-limited settings. Future multicenter trials will further establish its role in optimizing neonatal outcomes globally.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"206"},"PeriodicalIF":1.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of the modified yamane technique in complicated cataract surgery: same session or second session?","authors":"Mehmet Icoz, Eyüp Erkan","doi":"10.1007/s10792-025-03571-w","DOIUrl":"https://doi.org/10.1007/s10792-025-03571-w","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the timing of the modified Yamane technique (MYT) in complicated cataract surgery where capsular support is lost.</p><p><strong>Methods: </strong>This retrospective study was conducted on 41 eyes of 41 patients. Participants who underwent the MYT during primary cataract surgery were classified as group P(n = 12),while those who underwent the technique in a second session after cataract surgery were classified as group S(n = 29).Preoperative and postoperative ophthalmological findings were examined in both groups.</p><p><strong>Results: </strong>In group S,the mean time between the two surgeries was 18 days (range:6-32 days).Preoperative intraocular pressure was 12.5 ± 2.9 mmHg in group P and 15.1 ± 1.9 mmHg in group S(p = 0.02).At the postoperative six-month follow-up, no significant differences were observed between the two groups in relation to visual acuity, refraction measurements, or intraocular pressure values(p > 0.05 for all). Central macular thickness was measured as 274 ± 18 microns(range:236-291 microns) in group P and 254 ± 11 microns (range:229-272 microns) in group S(p = 0.02).In the early postoperative period (< 1 month),cystoid macular edema occurred in two cases(16.6%) in group P, while one case(8.3%) of increased intraocular pressure and one case(8.3%) of severe corneal edema were observed. In group S, cystoid macular edema occurred in one case(3.4%).No complications were detected in either group during the late postoperative period.</p><p><strong>Conclusion: </strong>In cases of complicated cataract with loss of capsular support,the MYT,whether performed in the same session or in a second session, yielded comparable visual and refractive outcomes. While complications were more frequent in the early postoperative period in the group undergoing surgery in the same session,no complications were observed in either group during the late postoperative period.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"205"},"PeriodicalIF":1.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iris retractor-assisted cataract surgery with modified scleral fixation for treating subluxated lenses.","authors":"Tingkun Shi, Meiqing Yang, Yinglin Cheng, Haoyu Chen, Yuqiang Huang","doi":"10.1007/s10792-025-03524-3","DOIUrl":"https://doi.org/10.1007/s10792-025-03524-3","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficiency and safety of iris retractor-assisted cataract surgery with modified scleral fixation for treating subluxated lenses.</p><p><strong>Methods and analysis: </strong>We developed a modified technique combining iris retractors with intrascleral intraocular lens (IOL) fixation for the treatment of moderate or severe lens subluxation due to non-progressive or progressive zonular defects. A retrospective case series study was conducted, including patients diagnosed with severe zonular dialysis who underwent this technique. Clinical data were collected and analyzed, including comprehensive ophthalmic examinations, anterior segment optical coherence tomography, surgical procedures, and outcome measures such as visual acuity and IOL positioning.</p><p><strong>Results: </strong>Fourteen eyes from fourteen patients (four females and ten males), with a mean age of 56.36 ± 17.74 years and severe zonular loss, were enrolled in the study. All patients were followed up for a mean of 22.5 ± 15.4 months (range 4-49 months). The mean visual acuity improved significantly after surgery (p < 0.001), and the IOLs were well-centered. Postoperative transient intraocular hypertension was observed in one patient.</p><p><strong>Conclusion: </strong>This modified technique simplifies the surgical procedures for treating severe lens subluxation and reduces postoperative complications.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"204"},"PeriodicalIF":1.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of topical cyclosporine A in optimizing ocular surface and relieving dry eye symptoms after cataract surgery: a systematic review and meta-analysis of randomized controlled trials.","authors":"Min Lu, Huaifeng Li, Xiang Xiang","doi":"10.1007/s10792-025-03570-x","DOIUrl":"10.1007/s10792-025-03570-x","url":null,"abstract":"<p><strong>Purpose: </strong>Dry eye symptoms and signs are common following cataract surgery. Topical cyclosporine A (CsA) is an approved treatment of moderate-to-severe dry eye disease. However, its effectiveness in managing postoperative dry eye remains debated. This systematic review and meta-analysis aimed to evaluate the efficacy of topical CsA in managing dry eye symptoms and signs after cataract surgery.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) assessing topical CsA in cataract surgery patients were identified through searches of PubMed, EMBASE, Web of Science, ClinicalTrials.gov, the Cochrane Library, and Google Scholar up to August 31, 2024. Outcomes included postoperative tear break-up time (TBUT), Schirmer's test (with or without anesthesia), the Ocular Surface Disease Index (OSDI), corneal fluorescein staining, and treatment-related adverse events.</p><p><strong>Results: </strong>Nine RCTs involving 451 patients (558 eyes) were included. Topical CsA was significantly associated with prolonged TBUT (mean difference [MD] = 1.95 s, 95% confidence interval [CI]: 1.38 to 2.53, P < 0.001), improved Schirmer's test scores without anesthesia (MD = 2.14 mm, 95%CI: 0.68 to 3.59, P = 0.004), and reduced corneal fluorescein staining (standardized MD = - 1.62, 95%CI: - 3.16 to - 0.08, P = 0.039). However, CsA did not significantly improve Schirmer's test scores with anesthesia (MD = 1.73 mm, 95%CI: - 0.11 to 3.56 to 2.79, P = 0.066) or OSDI scores (MD = - 2.73, 95%CI: - 7.42 to 1.97, P = 0.255) compared to control. All treatment-related adverse events were mild.</p><p><strong>Conclusion: </strong>Topical CsA significantly improves ocular surface and tear film parameters following cataract surgery and may be considered for the postoperative management of ocular surface disturbance and dry eye. However, considering the very low to moderate certainty of evidence, further high-quality RCTs are needed to validate for these findings.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"201"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular pathway and mechanism responsible for the progress of thyroid-associated orbitopathy.","authors":"Jyotsana Dwivedi, Shubhi Kaushal, Poonam Arora, Pranay Wal, Ankita Wal, Amin Gasmi","doi":"10.1007/s10792-025-03564-9","DOIUrl":"https://doi.org/10.1007/s10792-025-03564-9","url":null,"abstract":"<p><strong>Purpose: </strong>Our study aims to summarize the current knowledge concerning the molecular pathway and mechanism responsible for the progress of orbitopathy in the thyroid.</p><p><strong>Method: </strong>A thorough investigation of the literature was conducted using Scopus, Elsevier, PubMed, ScienceDirect, and Web of Science databases, covering studies published between 2000 and 2024. The inclusion criteria focused on clinical trials, preclinical research, and ethnopharmacological studies that investigated the effects of traditional medicines on \"orbitopathy in thyroid,\" \"molecular pathway,\" \"mechanism,\" \"Medicinal Plants,\" \"Mechanism of Action,\" and \"Active Constituents.\" Studies were excluded if they lacked specific data on orbitopathy in thyroid, focused solely on orbitopathy in thyroid, or had inconclusive methodologies.</p><p><strong>Results: </strong>Our findings indicate that TSHR autoantibodies drive orbital fibroblast activation, leading to inflammation, adipogenesis, and glycosaminoglycan accumulation. Elevated IL-17 and TNF-α levels contribute to immune dysregulation, while IGF-1R signaling enhances fibroblast proliferation and cytokine release. Biomarker analysis suggests that miR-146a, miR-155, and HLA-DR3 polymorphisms may serve as potential indicators for disease severity and progression.</p><p><strong>Conclusion: </strong>Early diagnostic markers and targeted therapies, including offer promising avenues for improved TAO management. A multidisciplinary, personalized approach integrating biomarker-driven treatment decisions may help optimize patient outcomes.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"197"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of retinal and choroidal structures in patients with ulcerative colitis.","authors":"Burak Ören, Dilara Ozkoyuncu Kocabas, Hüseyin Kaçmaz, Hasan Kızıltoprak, Esat Yetkin","doi":"10.1007/s10792-025-03560-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03560-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the macula, peripapillary retinal nerve fiber layer (RNFL) thickness, retinal layers, and choroidal vascularity index (CVI) in patients with ulcerative colitis (UC).</p><p><strong>Methods: </strong>A total of 92 patients were included in this study, with 40 in the UC group and 52 in the control group. RNFL, retinal layer, and central macular thickness (CMT) measurements were performed using spectral-domain optical coherence tomography (SD-OCT) (Spectralis, Heidelberg Engineering, Heidelberg, Germany). Choroidal thickness (CT) and CVI were acquired using the enhanced depth imaging mode of SD-OCT. UC disease activity was assessed according to the Mayo endoscopic score.</p><p><strong>Results: </strong>The mean values of the CMT, ganglion cell layer, inner plexiform, and outer nuclear layer thickness in the UC group were significantly thinner than the control (p < 0.05, each). While CT values at three different areas were higher in the UC group, only the temporal CT value was significant between groups (p = 0.004). The luminal area (LA) and CVI were significantly lower in the UC group compared with the controls (p < 0.05, each). The stromal area was significantly higher in the UC group than controls (p < 0.001). Correlation analyses between the Mayo disease activity index and LA, subfoveal, and temporal CT values revealed moderate positive correlations (p = 0.009, r = 484; p = 0.003, r = 545; p = 0.007, r = 497, respectively).</p><p><strong>Conclusion: </strong>UC patients have altered retinal and choroidal structures. Further research on the association between disease activity and choroidal vascular structures may contribute to these findings.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"194"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracameral medications in cataract surgery.","authors":"Caglar Bektas, Erdem Yuksel","doi":"10.1007/s10792-025-03554-x","DOIUrl":"https://doi.org/10.1007/s10792-025-03554-x","url":null,"abstract":"<p><strong>Purpose: </strong>To review the indications, dosages, and safety profiles of intracameral drugs used during cataract surgery.</p><p><strong>Methods: </strong>A narrative review was conducted, evaluating published clinical studies, review articles, and guidelines related to intracameral drug use in cataract surgery. The analysis focused on drugs commonly used for anesthesia, mydriasis, inflammation control, and intraoperative complication management. Special consideration was given to their utility in high-risk surgical scenarios, such as small pupils, intraoperative floppy iris syndrome, white or pediatric cataracts, and cases with zonular weakness.</p><p><strong>Results: </strong>Intracameral drugs have proven beneficial in achieving effective anesthesia, maintaining pupil dilation, and controlling inflammation during cataract surgery. Their use is particularly advantageous in complex cases, including those with corneal opacity, posterior capsular rupture, or combined procedures like minimally invasive glaucoma surgery and premium IOL implantation. When prepared and administered properly, these agents contribute to safer and more efficient surgeries. However, improper preparation or dosing can lead to ocular toxicity, highlighting the importance of meticulous handling.</p><p><strong>Conclusion: </strong>Intracameral drug administration is a valuable adjunct in cataract surgery, enabling surgeons to manage routine and complex cases more effectively. Understanding their appropriate use and potential risks is essential to maximize patient safety and surgical success.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"192"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective evaluation of ocular injuries in fractures of the zygomaticoorbital complex in a level I trauma center: is primary specialized ophthalmologic examination always necessary?","authors":"Vanessa Kramer, Efstathios Vounotrypidis, Christian Steinkohl, Christel Weiß, Alexander Schramm, Frank Wilde, Marcel Ebeling, Andreas Sakkas","doi":"10.1007/s10792-025-03566-7","DOIUrl":"10.1007/s10792-025-03566-7","url":null,"abstract":"<p><strong>Purpose: </strong>The necessity of a specialized ophthalmological assessment following fractures of the zygomaticoorbital (ZMO) complex in an emergency setting is still debated in resource-limited health systems. The primary aim of this study was to determine the incidence and types of ocular and periocular injuries (OPIs) associated with different fracture patterns of the ZMO complex. The secondary aim was to investigate the association between patient- and trauma-specific variables with the different types of OPI and identify high-risk patients for severe OPI.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on patients with ZMO complex fractures over a seven-year period. All patients underwent a specialized ophthalmic assessment in the ophthalmology clinic within 24 h of initial admission. Visual acuity, extraocular eye movements, and pupillary reaction were examined to determine the type of OPI that occurred. Demographic and medical history data, clinical and radiological findings and specific OPIs were recorded. Demographics, fracture patterns and ophthalmological findings were presented using descriptive statistical analysis. A multivariable analysis was performed to identify associations between predictor factors (etiology of injury, fracture pattern, pre-traumatic ophthalmological conditions, antithrombotic therapy) and OPI severity.</p><p><strong>Results: </strong>489 patients with a mean age of 50.88 years and a total of 540 examined eyes met the inclusion criteria. Ground-level fall was the most common etiology of injury. Periocular hematomas (28.99%), subconjunctival hemorrhage (18.65%) and periorbital swelling (15.13%) were the most common ophthalmologic findings. Eye motility disorders (p = 0.0003) and diplopia (p = 0.0019) were significantly more common in isolated orbital wall fractures than in other midface fracture patterns. Chemosis was significantly more common in fractures of the zygomaticoorbital complex (p = 0.0199), while lid tears (p = 0.0470) and open globe injuries (p = 0.0002) were more common in Le Fort fractures. Optic disc hemorrhage occurred significantly more frequently in patients under single antithrombotic therapy (p = 0.0171). Blow from blunt objects and Le Fort fractures were associated with higher rates of severe OPI, while pre-traumatic ophthalmologic conditions and antithrombotic therapy were not.</p><p><strong>Conclusions: </strong>Within the limitations of the study, patients who experienced blows from blunt objects and those with Le Fort fractures are at a higher risk for severe OPIs. Early specialized ophthalmological consultation is recommended for patients with zygomatic fractures and orbital involvement, especially for those with visual alterations such as motility disorders and diplopia as well as those taking antithrombotic medication.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"199"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining ranibizumab with calcium dobesilate to reduce injection frequency in diabetic macular edema treatment.","authors":"Jian-Ying Chen, Hong-Wei Pan, Xiao-Ming Zhang, Jing-Min Liu, Sum-Yuet Chan, Ting-Ting Liu, Jian-Yi Ma, Qi Liu, Wan-Zhao Yi, Ya-Ni Wu, Shuo-Shuo Gu, Ling-Xiao Xia, Jing Meng","doi":"10.1007/s10792-025-03578-3","DOIUrl":"10.1007/s10792-025-03578-3","url":null,"abstract":"<p><strong>Background: </strong>This study explores the potential of calcium dobesilate combined with intravitreal ranibizumab injections to reduce the treatment frequency in patients with DME-induced visual impairment and observes the clinical outcomes.</p><p><strong>Methods: </strong>In this investigation involving 90 DME patients, a comparative analysis was conducted between a group treated with both ranibizumab injections and calcium dobesilate capsules (45 patients) and a control group receiving only the injections (45 patients). Treatment was monthly for 3 months, then adjusted as needed, with a follow-up at 12 months focusing on injection frequency, BCVA scores, and CMT to assess both treatment efficacy and safety.</p><p><strong>Results: </strong>In the 12-month trial, subjects receiving a new combination therapy experienced fewer required intravitreal injections (average 4.73) compared to those on standard monotherapy (average 6.02), showing a significant reduction (p < 0.05). Final assessments revealed substantial improvements in best corrected visual acuity (BCVA) and central macular thickness (CMT) for both groups from baseline (p < 0.05). The experimental group notably showed greater enhancements in BCVA and CMT, highlighting the superior effectiveness of the combination therapy in managing DME symptoms with reduced treatment frequency.</p><p><strong>Conclusion: </strong>Combination therapy with calcium dobesilate and ranibizumab decreased the frequency of intravitreal injections and led to greater improvements in BCVA and CMT compared to ranibizumab alone over 12 months. Both treatments were well-tolerated, with the combination therapy demonstrating a favorable safety profile.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"203"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Malay-vision disability assessment (VDA) questionnaire and its application to assess the functional disability among cataract patients of a tertiary medical centre in Malaysia.","authors":"Yi Wen Lim, Nor Fadhilah Mohamad, Foong Ming Moy, Tengku Ain Kamalden","doi":"10.1007/s10792-025-03552-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03552-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to translate, culturally adapt, and validate the Malay-Visual Disability Assessment (VDA) questionnaire and to assess its applicability in evaluating functional disability among cataract patients of a tertiary medical centre in Malaysia.</p><p><strong>Methods: </strong>This cross-sectional, questionnaire-based study was divided into two phases. In Phase I, the pre-final version of Malay-VDA was validated by a panel of six experts, followed by cognitive debriefing with 10 respondents. Test-retest reliability was assessed using 35 participants. The reliability and validity of the Malay-VDA was tested using intraclass correlation coefficient (ICC) and content validity index (CVI). Phase II evaluated the visual function among 200 cataract patients using the validated Malay-VDA. Additionally, self-administered questionnaire was used to collect sociodemographic data of the respondents.</p><p><strong>Results: </strong>In Phase I, all items in Malay-VDA achieved an item-level CVI of > 0.8 for relevance and > 0.7 for clarity, with an overall CVI > 0.9. The test-retest reliability analysis demonstrated excellent reliability, with a single measures ICC of 0.998 (95% CI: 0.995-0.999, p < 0.001) and an average measures ICC of 0.999 (95% CI: 0.998-0.999, p < 0.001). In Phase II, out of the 200 respondents, they were more Chinese, females, had completed primary education and aged between 70 to 79 years. The respondents had higher VDA scores in distance domain with the mean (SD) scores of 16.57 (5.11), showing worst functional disability in distant activities, followed by difficulties in the mobility domain (mean (SD) scores of 10.15 (3.72)) and near domain (mean (SD) scores of 9.98 (2.76)). The mean score was found to be significantly higher in the poor vision group for all three domains. A positive correlation with moderate strength was found between total VDA score and best-corrected visual acuity (BCVA) with age adjusted (r = 0.575, p < 0.001).</p><p><strong>Conclusion: </strong>The Malay-VDA demonstrated good reliability and validity, making it a suitable tool for local adaptation. This study highlighted that visual function was not solely determined by visual acuity, underscoring the importance of comprehensive functional assessment in cataract patients. Therefore, integrating visual function assessment into preoperative evaluations could enhance surgical decision-making.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"191"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}