International Ophthalmology最新文献_第2页

Comparative efficacy of subretinal and intravitreal conbercept injections in polypoidal choroidal vasculopathy. 视网膜下注射与玻璃体内注射治疗息肉样脉络膜血管病变的疗效比较。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-30 DOI: 10.1007/s10792-025-03747-4

Kaiyuan Xu, Xiaojun Zhang

{"title":"Comparative efficacy of subretinal and intravitreal conbercept injections in polypoidal choroidal vasculopathy.","authors":"Kaiyuan Xu, Xiaojun Zhang","doi":"10.1007/s10792-025-03747-4","DOIUrl":"https://doi.org/10.1007/s10792-025-03747-4","url":null,"abstract":"Purpose: To compare the clinical efficacy of subretinal versus intravitreal conbercept injections in the treatment of polypoidal choroidal vasculopathy (PCV).Methods: In this retrospective, single-center study, 102 consecutive PCV patients treated between July 2022 and October 2023 were divided into two groups based on the injection regimen: subretinal injections (n = 55, 1 + PRN regimen) and intravitreal injections (n = 47, 3 + PRN regimen) of conbercept. Comprehensive assessments-including best-corrected visual acuity (BCVA), optical coherence tomography (OCT), and indocyanine green angiography (ICGA)-were performed at baseline and at 1, 2, 3, 6, 9, and 12 months. Outcome measures included changes in BCVA, macular retinal thickness (MRT), subfoveal choroidal thickness (SFCT), pigment epithelial detachment (PED) height, number of injections, and polyp regression rates.Results: Baseline characteristics were comparable between the two groups (all P > 0.05). Over the 12-month follow-up, the subretinal injection group showed significantly greater improvement in BCVA (Month 12: 0.21 ± 0.23 logMAR vs. 0.49 ± 0.42 logMAR; P < 0.001). Additionally, reductions in MRT, SFCT, and PED height were significantly more pronounced in the subretinal group compared with the intravitreal group (all P < 0.001). The subretinal group also required fewer injections (1.82 ± 0.94 vs. 3.85 ± 2.11; P < 0.001) and achieved a significantly higher rate of polyp regression (69.1% vs. 42.6%; P = 0.007). No significant ocular or systemic complications were reported in either group.Conclusion: Subretinal conbercept provides superior and more durable anatomical and functional outcomes compared to intravitreal injection in patients with PCV. It also reduces treatment burden and enhances lesion regression, supporting its potential as a promising alternative therapeutic approach.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"400"},"PeriodicalIF":1.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Culture positivity of anterior chamber exudate in cases of fungal keratitis. 真菌性角膜炎前房渗出液培养阳性。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-30 DOI: 10.1007/s10792-025-03746-5

Amanjot Kaur, Smruti Rekha Priyadarshini, Srikant Kumar Sahu, Himansu Sekhar Behera, Sujata Das

{"title":"Culture positivity of anterior chamber exudate in cases of fungal keratitis.","authors":"Amanjot Kaur, Smruti Rekha Priyadarshini, Srikant Kumar Sahu, Himansu Sekhar Behera, Sujata Das","doi":"10.1007/s10792-025-03746-5","DOIUrl":"https://doi.org/10.1007/s10792-025-03746-5","url":null,"abstract":"Purpose: To describe the nature of anterior chamber (AC) exudates in cases of fungal keratitis, and to determine whether these are inflammatory or infective.Methodology: Twenty-six patients with culture-proven fungal keratitis and anterior chamber exudate, worsening due to medical management and who underwent therapeutic penetrating keratoplasty (TPK), were included in the study. Patients with mixed infections, prior surgical intervention, perforation, or absence of hypopyon/AC exudates were excluded from the study. AC exudates were plated on one/two solid culture media during surgery after excision of the corneal button. The corneal buttons were bisected into half and sent for microbiological and histopathological examinations.Results: Among the 26 patients, 14 were male, and most of them were farmers. Most patients (73%) had a history of trauma with vegetative matter and presented within 17.8 ± 11.7 days from the appearance of the first symptom. All patients had visual acuity less than counting fingers at 2 m. Corneal scraping confirmed fungal keratitis in all patients, with Aspergillus flavus (57.7%) being the predominant species. Despite medical treatment, all patients worsened and required TPK within a fortnight. Samples from AC exudates grew fungus only in 4/26 (15.4%) cases, and the bisected corneal buttons grew fungus in 7/26 (26.9%). Histopathology revealed fungal filaments in all samples, with 19 (79.2%) cases involving the posterior stroma and Descemet's membrane.Conclusion: AC exudates in fungal keratitis are usually sterile if there is no perforation or prior intervention, and therefore, most of the AC exudates were inflammatory.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"399"},"PeriodicalIF":1.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blinded by the drug? A vigilyze signal linking semaglutide to NAION. 药物致盲？一个连接semaglutide和NAION的警戒信号。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-30 DOI: 10.1007/s10792-025-03760-7

Jaishree Suresh, Kalaiselvan Vivekanandan

{"title":"Blinded by the drug? A vigilyze signal linking semaglutide to NAION.","authors":"Jaishree Suresh, Kalaiselvan Vivekanandan","doi":"10.1007/s10792-025-03760-7","DOIUrl":"https://doi.org/10.1007/s10792-025-03760-7","url":null,"abstract":"Introduction: Semaglutide, available widely as Ozempic, Wegovy, and Rybelsus, has significantly improved the management of type 2 diabetes and obesity due to its beneficial adverse drug reactions and safer use in diverse population. However, as its use grows widely, rare but serious side effects are coming to light. One such emerging concern is Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION), a condition causing sudden, often irreversible vision loss.Methodology: A retrospective, post-market observational study was conducted using data collected from VigiBase® until June 2025, using mapped terms under Medical Dictionary for Regulatory Activities (MedDRA).Result: Of 73,636 global Individual Case Safety Reports (ICSRs) related to Semaglutide reported adverse reactions globally, 91 were associated with the adverse reaction NAION. The cases were reported globally with increased number of cases reported by Denmark (N = 38, 41.80%), Australia (N = 9, 9.90%) and France (N = 7, 7.70%), primarily affected patients aged 45-74 years (N = 50, 54.90%). Most cases (97.80%) were classified as serious with a significant of the cases reported of males. The co-reported reactions involved serious 'eye-related' conditions like Visual Impairment (N = 12,13.20%), Blindness (N = 9, 9.90%), Visual field defect (N = 5, 5.50%), Optic atrophy (N = 4, 4.40%), Vision blurred (N = 4, 4.40%) among other serious reactions.Conclusion: This study raises awareness of a rare yet significant safety concern with Semaglutide. Early detection of NAION symptoms and timely drug discontinuation may be critical in preventing permanent vision loss. Moreover, the reaction should be mentioned in the patient information leaflet/ summary of the product characteristic of the drug to create awareness among the healthcare providers as well as the consumers taking the drug.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"398"},"PeriodicalIF":1.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of fluid flow posterior capsule polishing in reducing capsule rupture and enhancing visual recovery during phacoemulsification cataract surgery. 白内障超声乳化术中后囊膜抛光液对减少囊破裂和提高视力恢复的疗效。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-29 DOI: 10.1007/s10792-025-03748-3

Nan Xu, Anbing Peng, Shanwei He, Ting Wu, Xiali Zhang

{"title":"Efficacy of fluid flow posterior capsule polishing in reducing capsule rupture and enhancing visual recovery during phacoemulsification cataract surgery.","authors":"Nan Xu, Anbing Peng, Shanwei He, Ting Wu, Xiali Zhang","doi":"10.1007/s10792-025-03748-3","DOIUrl":"10.1007/s10792-025-03748-3","url":null,"abstract":"Objective: Cataracts remain the leading cause of blindness worldwide, and phacoemulsification cataract surgery is the gold standard for cataract treatment. However, complications such as posterior capsule rupture (PCR) and posterior capsule opacification (PCO) continue to affect success of the procedure. This study investigates effect of fluid flow posterior capsule polishing in reducing the incidence of PCR and PCO during phacoemulsification cataract surgery, with the goal of improving surgical outcomes and postoperative recovery.Methods: A total of 290 eyes from cataract patients were randomly assigned to two groups: the fluid flow polishing group (n = 144) and the mechanical polishing group (n = 146). The incidence of posterior capsule rupture and other postoperative outcomes were compared.Results: The posterior capsule rupture rate in the fluid flow polishing group was 0%, compared to 15.38% in the mechanical polishing group (p < 0.05). The best-corrected visual acuity (BCVA) at 1 day and 1 month post-surgery was significantly higher in the fluid flow group (p < 0.05). Furthermore, the incidence of posterior capsule opacification (PCO) at 1 month was significantly lower in the fluid flow polishing group compared to the mechanical polishing group (p < 0.05). In subgroup analysis, patients older than 60 years exhibited a statistically significant difference in posterior capsule rupture rates (p < 0.05).Conclusion: Fluid flow posterior capsule polishing significantly reduces the incidence of posterior capsule rupture in phacoemulsification cataract surgery, particularly in elderly patients, and contributes to better visual recovery postoperatively. This technique can be considered a safe and effective modification in cataract surgery to improve patient outcomes and reduce complications.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"397"},"PeriodicalIF":1.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metaheuristic-optimized swin transformer with SHAP explainability for keratoconus classification from corneal topography maps. 基于SHAP可解释性的元启发式优化swin变压器在角膜地形图中对圆锥角膜进行分类。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-29 DOI: 10.1007/s10792-025-03744-7

S Maria Seraphin Sujitha, S Subiramoniyan, J Mahil, T Jarin

{"title":"Metaheuristic-optimized swin transformer with SHAP explainability for keratoconus classification from corneal topography maps.","authors":"S Maria Seraphin Sujitha, S Subiramoniyan, J Mahil, T Jarin","doi":"10.1007/s10792-025-03744-7","DOIUrl":"https://doi.org/10.1007/s10792-025-03744-7","url":null,"abstract":"Keratoconus (KCN) is an uncommon corneal disorder where the central cornea undergoes advanced thinning and causes non-uniform astigmatism. This results in metamorphopsia and potential vision loss if it is left untreated. Early detection of KCN is major to provide timely intervention and address severe visual impairment. But, conventional diagnostic tools corneal topography and slit-lamp examinations are based on expert interpretation; they are subjective and insufficient to find early KCN. To overcome these challenges, this work presents an automated and scalable deep learning (DL) model for KCN detection using corneal imaging data. The model combines Improved Swin Transformer Blocks (ISTB) with Residual Multi-Layer Perceptrons (R-MLP) for capturing local microstructural irregularities and global curvature patterns in corneal topography images. Then, the metaheuristic algorithm Polar Fox Optimizer (PFO) is presented for enhancing model convergence and robustness. Moreover, the suggested work combines SHapley additive exPlanations (SHAP) explainability for providing insights into the decision making that enhances understanding of the detection. Experimental outcomes on the benchmark dataset show that the suggested model attained high accuracy (99.4%), and outperformed other models. The approach has significant ability for deployment in clinical environments in low-resource settings, by providing understandable, real-time, and expert independent diagnosis of KCN.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"396"},"PeriodicalIF":1.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: accuracy of 12 IOL power calculation formulas in highly myopic eyes. 12种高度近视眼人工晶状体度数计算公式的准确性评价。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-29 DOI: 10.1007/s10792-025-03779-w

Filippo Maria Vollaro, Matteo Savo, Isabella Pellegrino, Enrica Sarnicola

引用次数: 0

Nigrospora oryzae keratitis: a rare fungal etiology. 米黑孢子虫角膜炎：一种罕见的真菌病因。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-27 DOI: 10.1007/s10792-025-03774-1

Huong Duong Nguyen Viet, Huy Tran Ngoc, Vinh Lam Minh, Mai Nguyen Thi Truc, Simon Fung

{"title":"Nigrospora oryzae keratitis: a rare fungal etiology.","authors":"Huong Duong Nguyen Viet, Huy Tran Ngoc, Vinh Lam Minh, Mai Nguyen Thi Truc, Simon Fung","doi":"10.1007/s10792-025-03774-1","DOIUrl":"https://doi.org/10.1007/s10792-025-03774-1","url":null,"abstract":"Purpose: To report a rare case of fungal keratitis caused by Nigrospora oryzae in an immunocompetent patient without a history of ocular trauma, and to compare its clinical and microbiological features with a previously published case.Methods: A 62-year-old female farmer presented in December 2019 with a two-week history of ocular pain, redness, and visual loss in the right eye. Initial treatment by a local provider was unsuccessful. On presentation, slit-lamp examination revealed a raised central corneal infiltrate with feathery margins, associated with corneal neovascularization and hypopyon, but without epithelial defect. Corneal scraping was performed, and the specimen was analyzed by fungal staining, culture, and DNA sequencing.Results: Staining revealed septate hyphae, suggestive of a filamentous fungus. Culture confirmed Nigrospora oryzae with susceptibility to amphotericin B, itraconazole, and fluconazole. The patient was treated with oral itraconazole, topical amphotericin B 0.15%, and fortified povidone-iodine 5%. Complete resolution was achieved without recurrence, but with residual central scarring. No prophylactic antibiotics or corticosteroids were used. A comparative review with the only other reported case revealed differences in ulcer characteristics, treatment protocols, and antifungal susceptibility.Conclusion: Nigrospora oryzae is a rare cause of fungal keratitis that can present in immunocompetent individuals without apparent trauma. In resource-limited settings like Vietnam, delayed diagnosis due to limited microbiological support may obscure detection of uncommon pathogens. This case underscores the need for enhanced diagnostic capacity and awareness of atypical fungal agents in cases of infectious keratitis.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"392"},"PeriodicalIF":1.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of topical ramucirumab in experimental corneal neovascularization model. 外用ramucirumab对实验性角膜新生血管模型的影响。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-27 DOI: 10.1007/s10792-025-03780-3

Mustafa Bülbül, Onur Çatak, Murat Erdağ, Tuncay Kuloğlu, Serhat Hançer

{"title":"Effect of topical ramucirumab in experimental corneal neovascularization model.","authors":"Mustafa Bülbül, Onur Çatak, Murat Erdağ, Tuncay Kuloğlu, Serhat Hançer","doi":"10.1007/s10792-025-03780-3","DOIUrl":"https://doi.org/10.1007/s10792-025-03780-3","url":null,"abstract":"Purpose: This study aimed to compare the efficacy of topical Bevacizumab and Ramucirumab in an experimental corneal neovascularization model and to find the most effective Ramucirumab dose.Materials and methods: In the experiments, 42 Sprague Dawley rats were randomly divided into six groups (n = 7). Corneal cauterization was applied to all groups except Group 1. Group 1 did not receive any treatment. The sham group (group 2) was applied topical dimethylsulfoxide twice daily. Group 3 was administered topical bevacizumab drops (5 mg/ml) twice daily. Groups 4, 5 and 6 received topical ramucirumab drops at a dose of 2.5, 5 and 10 mg/ml twice daily, respectively. On the 14th day, corneal photographs of all rats were taken under general anesthesia and the percentage of corneal neovascular area was calculated. VEGF, VEGFR-2 and TRPM2 immune reactivity in corneas taken after decapitation was evaluated by immunohistochemical scoring method. TAS and TOS levels were measured in blood taken from rats, and apoptosis was evaluated using the TUNEL staining method.Results: The percentage of corneal neovascularization areas to the entire cornea was lower in groups 3, 4, 5 and 6 compared to the sham group. VEGF, VEGFR-2 and TRPM2 immunoreactivity was observed to be statistically significantly increased in the sham group compared to the control group (p < 0.05), It was observed that there was a statistically significant decrease in groups 3, 4, 5 and 6 compared with the sham group (p < 0.05), no statistically significant difference was observed between groups 3, 4, 5 and 6 (p > 0.05).Conclusion: Ramucirumab can be used as a new agent in the treatment of CNV by reducing the levels of VEGF and VEGFR-2, which are CNV markers. In addition, since TRPM2 was affected statistically significantly, we think that it may be a new proangiogenic factor in CNV.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"394"},"PeriodicalIF":1.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ellipsoid zone reflectivity changes after idiopathic epiretinal membrane peeling: a pilot study. 特发性视网膜前膜剥离后椭球区反射率的变化：一项初步研究。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-27 DOI: 10.1007/s10792-025-03778-x

Alba Chiara Termite, Pasquale Viggiano, Giacomo Boscia, Lorenzo Accurso Tagano, Marta Zerbinati, Tommaso Festa, Giulia Fracchiolla, Antonio Fracchiolla, Ermete Giancipoli, Iaculli Cristiana, Francesco Pignatelli, Maria Grazia Pignataro, Federico Moscara, Pasquale Puzo, Nicola Recchimurzo, Giovanni Alessio, Francesco Boscia

{"title":"Ellipsoid zone reflectivity changes after idiopathic epiretinal membrane peeling: a pilot study.","authors":"Alba Chiara Termite, Pasquale Viggiano, Giacomo Boscia, Lorenzo Accurso Tagano, Marta Zerbinati, Tommaso Festa, Giulia Fracchiolla, Antonio Fracchiolla, Ermete Giancipoli, Iaculli Cristiana, Francesco Pignatelli, Maria Grazia Pignataro, Federico Moscara, Pasquale Puzo, Nicola Recchimurzo, Giovanni Alessio, Francesco Boscia","doi":"10.1007/s10792-025-03778-x","DOIUrl":"https://doi.org/10.1007/s10792-025-03778-x","url":null,"abstract":"Objective: This pilot study aimed to evaluate changes in ellipsoid zone (EZ) reflectivity and best-corrected visual acuity (BCVA) following epiretinal membrane (ERM) peeling surgery in patients with stage 2 and 3 ERM.Methods: Thirty-five patients with stage 2 and 3 ERM underwent surgical intervention. Preoperative and three-month postoperative measurements of BCVA and EZ reflectivity were taken using spectral-domain optical coherence tomography (SD-OCT). The correlation between changes in BCVA and EZ reflectivity was analyzed.Results: BCVA significantly improved from baseline (0.67 ± 0.23 LogMAR) to three months post-surgery (0.20 ± 0.20 LogMAR) (p < 0.0001). EZ reflectivity also showed a significant increase from baseline (0.62 ± 0.18) to the follow-up visit (0.99 ± 0.30) (p < 0.0001). A significant negative correlation was observed between BCVA (logMAR) and EZ reflectivity (r = - 0.758, p = 0.001).Conclusions: This pilot study provides preliminary evidence that EZ reflectivity correlates with visual recovery after ERM peeling surgery and suggests potential utility as a biomarker for assessing photoreceptor health. Despite the small sample size, the significant correlation between improved BCVA and increased EZ reflectivity warrants further investigation in larger, longitudinal studies.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"393"},"PeriodicalIF":1.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in macular microvasculature after Nd:YAG laser capsulotomy: an OCT-A study. Nd:YAG激光包膜切开术后黄斑微血管的变化：OCT-A研究。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-09-27 DOI: 10.1007/s10792-025-03751-8

Yusuf Samet Atlıhan, Çisil Erkan Pota, Aslı Çetinkaya Yaprak

{"title":"Changes in macular microvasculature after Nd:YAG laser capsulotomy: an OCT-A study.","authors":"Yusuf Samet Atlıhan, Çisil Erkan Pota, Aslı Çetinkaya Yaprak","doi":"10.1007/s10792-025-03751-8","DOIUrl":"https://doi.org/10.1007/s10792-025-03751-8","url":null,"abstract":"Purpose: To investigate microvascular changes in the retina and choriocapillaris using optical coherence tomography angiography (OCT-A) following neodymium:yttrium-aluminium-garnet (Nd:YAG) laser capsulotomy for posterior capsule opacification (PCO), a delayed finding that can be commonly observed after cataract surgery.Methods: Thirty-four eyes of 34 patients undergoing Nd:YAG laser capsulotomy were included. Comprehensive ophthalmologic examination and OCT-A imaging were performed before, one week, and one month after the procedure. Retinal thickness, ganglion cell layer (GCL), retinal nerve fiber layer (RNFL), and vessel densities in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) were evaluated.Results: Following laser treatment, anterior chamber depth (ACD) increased, the foveal avascular zone (FAZ) enlarged, and vessel densities in the central regions of both the SCP and DCP decreased significantly (p = 0.002, p < 0.001, p < 0.001, and p < 0.001, respectively). Additional reductions were also observed in some parafoveal and CC quadrants (Table 4). No statistically significant changes were observed in intraocular pressure (IOP), spherical equivalent (SE), axial length (AL), macular thickness, or choroidal thickness (all p > 0.05).Discussion: Our findings indicate that retinal blood flow and vessel density may decrease following Nd:YAG laser capsulotomy; however, the clinical significance of these microvascular changes remains unclear. OCT-A appears to be a promising, non-invasive modality for monitoring retinal microcirculation in patients undergoing this procedure. Nonetheless, further prospective and longitudinal studies are necessary to clarify the long-term consequences and potential functional outcomes of these vascular alterations.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"391"},"PeriodicalIF":1.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0