Alba Chiara Termite, Pasquale Viggiano, Giacomo Boscia, Lorenzo Accurso Tagano, Marta Zerbinati, Tommaso Festa, Giulia Fracchiolla, Antonio Fracchiolla, Ermete Giancipoli, Iaculli Cristiana, Francesco Pignatelli, Maria Grazia Pignataro, Federico Moscara, Pasquale Puzo, Nicola Recchimurzo, Giovanni Alessio, Francesco Boscia
{"title":"特发性视网膜前膜剥离后椭球区反射率的变化：一项初步研究。","authors":"Alba Chiara Termite, Pasquale Viggiano, Giacomo Boscia, Lorenzo Accurso Tagano, Marta Zerbinati, Tommaso Festa, Giulia Fracchiolla, Antonio Fracchiolla, Ermete Giancipoli, Iaculli Cristiana, Francesco Pignatelli, Maria Grazia Pignataro, Federico Moscara, Pasquale Puzo, Nicola Recchimurzo, Giovanni Alessio, Francesco Boscia","doi":"10.1007/s10792-025-03778-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This pilot study aimed to evaluate changes in ellipsoid zone (EZ) reflectivity and best-corrected visual acuity (BCVA) following epiretinal membrane (ERM) peeling surgery in patients with stage 2 and 3 ERM.</p><p><strong>Methods: </strong>Thirty-five patients with stage 2 and 3 ERM underwent surgical intervention. Preoperative and three-month postoperative measurements of BCVA and EZ reflectivity were taken using spectral-domain optical coherence tomography (SD-OCT). The correlation between changes in BCVA and EZ reflectivity was analyzed.</p><p><strong>Results: </strong>BCVA significantly improved from baseline (0.67 ± 0.23 LogMAR) to three months post-surgery (0.20 ± 0.20 LogMAR) (p < 0.0001). EZ reflectivity also showed a significant increase from baseline (0.62 ± 0.18) to the follow-up visit (0.99 ± 0.30) (p < 0.0001). A significant negative correlation was observed between BCVA (logMAR) and EZ reflectivity (r = - 0.758, p = 0.001).</p><p><strong>Conclusions: </strong>This pilot study provides preliminary evidence that EZ reflectivity correlates with visual recovery after ERM peeling surgery and suggests potential utility as a biomarker for assessing photoreceptor health. Despite the small sample size, the significant correlation between improved BCVA and increased EZ reflectivity warrants further investigation in larger, longitudinal studies.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"393"},"PeriodicalIF":1.4000,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ellipsoid zone reflectivity changes after idiopathic epiretinal membrane peeling: a pilot study.\",\"authors\":\"Alba Chiara Termite, Pasquale Viggiano, Giacomo Boscia, Lorenzo Accurso Tagano, Marta Zerbinati, Tommaso Festa, Giulia Fracchiolla, Antonio Fracchiolla, Ermete Giancipoli, Iaculli Cristiana, Francesco Pignatelli, Maria Grazia Pignataro, Federico Moscara, Pasquale Puzo, Nicola Recchimurzo, Giovanni Alessio, Francesco Boscia\",\"doi\":\"10.1007/s10792-025-03778-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This pilot study aimed to evaluate changes in ellipsoid zone (EZ) reflectivity and best-corrected visual acuity (BCVA) following epiretinal membrane (ERM) peeling surgery in patients with stage 2 and 3 ERM.</p><p><strong>Methods: </strong>Thirty-five patients with stage 2 and 3 ERM underwent surgical intervention. Preoperative and three-month postoperative measurements of BCVA and EZ reflectivity were taken using spectral-domain optical coherence tomography (SD-OCT). The correlation between changes in BCVA and EZ reflectivity was analyzed.</p><p><strong>Results: </strong>BCVA significantly improved from baseline (0.67 ± 0.23 LogMAR) to three months post-surgery (0.20 ± 0.20 LogMAR) (p < 0.0001). EZ reflectivity also showed a significant increase from baseline (0.62 ± 0.18) to the follow-up visit (0.99 ± 0.30) (p < 0.0001). A significant negative correlation was observed between BCVA (logMAR) and EZ reflectivity (r = - 0.758, p = 0.001).</p><p><strong>Conclusions: </strong>This pilot study provides preliminary evidence that EZ reflectivity correlates with visual recovery after ERM peeling surgery and suggests potential utility as a biomarker for assessing photoreceptor health. Despite the small sample size, the significant correlation between improved BCVA and increased EZ reflectivity warrants further investigation in larger, longitudinal studies.</p>\",\"PeriodicalId\":14473,\"journal\":{\"name\":\"International Ophthalmology\",\"volume\":\"45 1\",\"pages\":\"393\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10792-025-03778-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10792-025-03778-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Ellipsoid zone reflectivity changes after idiopathic epiretinal membrane peeling: a pilot study.
Objective: This pilot study aimed to evaluate changes in ellipsoid zone (EZ) reflectivity and best-corrected visual acuity (BCVA) following epiretinal membrane (ERM) peeling surgery in patients with stage 2 and 3 ERM.
Methods: Thirty-five patients with stage 2 and 3 ERM underwent surgical intervention. Preoperative and three-month postoperative measurements of BCVA and EZ reflectivity were taken using spectral-domain optical coherence tomography (SD-OCT). The correlation between changes in BCVA and EZ reflectivity was analyzed.
Results: BCVA significantly improved from baseline (0.67 ± 0.23 LogMAR) to three months post-surgery (0.20 ± 0.20 LogMAR) (p < 0.0001). EZ reflectivity also showed a significant increase from baseline (0.62 ± 0.18) to the follow-up visit (0.99 ± 0.30) (p < 0.0001). A significant negative correlation was observed between BCVA (logMAR) and EZ reflectivity (r = - 0.758, p = 0.001).
Conclusions: This pilot study provides preliminary evidence that EZ reflectivity correlates with visual recovery after ERM peeling surgery and suggests potential utility as a biomarker for assessing photoreceptor health. Despite the small sample size, the significant correlation between improved BCVA and increased EZ reflectivity warrants further investigation in larger, longitudinal studies.
期刊介绍：
International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.
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