International Ophthalmology最新文献

{"title":"Recurrence of herpetic keratouveitis following cataract surgery.","authors":"Laura E Drew-Bear, Raul E Ruiz-Lozano, Kevin Wang, Alejandro Rodriguez-Garcia, Ashley Behrens, Everardo Hernandez-Quintela","doi":"10.1007/s10792-025-03438-0","DOIUrl":"10.1007/s10792-025-03438-0","url":null,"abstract":"<p><strong>Purpose: </strong>Herpetic eye disease (HED) is a leading cause of infectious vision loss worldwide. Cataract surgery is known to be implicated in triggering the recurrence of herpes keratouveitis. This study evaluates the current evidence on the association between HED and cataract surgery, focusing on the risk factors and potential pathogenic mechanisms and preventive strategies involved with reactivation or new-onset herpes-related keratitis, uveitis, or keratouveitis.</p><p><strong>Methods: </strong>A comprehensive search of databases (Cinahl, Embase, Scopus, ProQuest, Web of Science, and PubMed) was conducted to identify articles describing the association between new onset or reactivation of HED after cataract surgery up to March 2024. A total of 24 studies were included.</p><p><strong>Results: </strong>The heterogeneity of the studies precluded systematic analysis. However, the findings suggest that the herpetic recurrence rate, mainly in the form of keratitis, after cataract surgery is high (approximately 40%), mostly occurring ≤ 2 years after surgery, and can be influenced by factors such as topical corticosteroids, the quiescent time before surgery, and history of prior recurrences, and the patient's comorbidities, including diabetes and atopy. The current evidence for prescribing perioperative HED prophylaxis is of inadequate quality.</p><p><strong>Conclusions: </strong>Available evidence suggests that herpetic recurrences tend to occur in the first two years after cataract surgery. A longer quiescent time before surgery might reduce the risk of recurrence. Prospective studies analyzing the effects of perioperative prophylaxis are needed.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"65"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal transplant awareness in medical students by grade and the effect of subject-specific education on this awareness level.","authors":"Anil Kaplan, Atanur Ayas, Alperen Bilen, Aysegul Colak, Timur Köse, Ozlem Barut Selver","doi":"10.1007/s10792-025-03424-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03424-6","url":null,"abstract":"<p><strong>Purpose: </strong>Corneal transplantation is the most commonly performed transplant surgery. Medical students, doctors of the future, will educate the public about organ transplantation and raise public awareness on this issue. The first aim of this study is to evaluate the initial awareness of medical students about corneal transplantation, then to provide training to these students and finally to evaluate the change in their knowledge on this subject.</p><p><strong>Method: </strong>310 medical students from Ege University were asked to participate in a 20-question survey. Later, they were given education by a corneal transplant specialist. Immediately after the lessons, the survey was reapplied.</p><p><strong>Results: </strong>The number of students who said they had knowledge about corneal transplantation before the training was 25.5% (n = 79). The knowledge level of 1st grades was lower than the 5th and 6th grades. Final-test scores were significantly higher than pre-test scores in each year group (p < 0.001). The final-test scores were significantly higher than the pre-test scores in both groups, who said they had knowledge about corneal transplantation and who said they did not.</p><p><strong>Conclusion: </strong>Physicians' attitudes toward organ transplantation play a crucial role in influencing the public interest in organ donation. In addition, the physicians' level of knowledge about organ and tissue transplantation is the main determinant of their attitudes via answering the questions and clarifying the worries of the society. This article showed the level of knowledge about corneal transplantation does not increase linearly as the medical school year progresses. In addition, regardless of the initial level of knowledge, the education on corneal transplantation will increase the knowledge level of every student from the 1st grade to the 6th grade.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"62"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence with ChatGPT 4: a large language model in support of ocular oncology cases.","authors":"Federico Giannuzzi, Matteo Mario Carlà, Lorenzo Hu, Valentina Cestrone, Carmela Grazia Caputo, Maria Grazia Sammarco, Gustavo Savino, Stanislao Rizzo, Maria Antonietta Blasi, Monica Maria Pagliara","doi":"10.1007/s10792-024-03399-w","DOIUrl":"10.1007/s10792-024-03399-w","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate ChatGPT's ability to analyze comprehensive case descriptions of patients with uveal melanoma and provide recommendations for the most appropriate management.</p><p><strong>Design: </strong>Retrospective analysis of ocular oncology patients' medical records.</p><p><strong>Subjects: </strong>Forty patients treated for uveal melanoma between May 2019 and October 2023.</p><p><strong>Methods: </strong>We uploaded each case description into the ChatGPT interface (version 4.0) and asked the model to provide realistic treatment options by asking the question, \"What type of treatment do you recommend?\" The accuracy of decisions produced by ChatGPT was compared to those recorded in patients' files and the treatment recommendations provided by three ocular oncologists, each with more than 10 years of experience.</p><p><strong>Main outcome measures: </strong>The primary objective of this research was to assess the accuracy of ChatGPT replies in ocular oncology cases, analyzing its competence in both straightforward and intricate situations. Our secondary purpose was to assess the concordance between the responses of ChatGPT and those of ocular oncology specialists when faced with analogous clinical scenarios.</p><p><strong>Results: </strong>ChatGPT's surgical choices matched those in patients' files in 55% of cases (22 out of 40). ChatGPT options were agreed upon by 50%, 55%, and 57% of the three ocular oncology specialists. The investigation revealed significant differences between ChatGPT's responses and those of the three cancer specialists when compared to patients' files (p = 0.003, p = 0.001, and p = 0.001). ChatGPT's surgical responses matched with patient data in 18 out of 24 cases (75%), excluding enucleation cases. The decisions matched with the three ocular oncology specialists in 17/24, 18/24, and 18/24 cases, reflecting agreements of 70%, 75%, and 75%, respectively. The decisions made by ChatGPT were not significantly different from those of the three professionals in this cohort (p = 0.50, p = 0.36, and p = 0.36 for ChatGPT compared to specialists 1, 2, and 3).</p><p><strong>Conclusion: </strong>ChatGPT exhibited a level of proficiency that was comparable to that of trained ocular oncology specialists. However, it exhibited its limitations when evaluating more complex scenarios, such as extrascleral extension or infiltration of the optic nerve, when a comprehensive evaluation of the patient is therefore necessary.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"59"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of differences between keratometric astigmatism and total corneal astigmatism measured by IOLMaster 700.","authors":"Chunxia Yu, Xiaoling Fang, Jinhua Tao, Yiping Dong, Shenyu Ben, Yulan Wang","doi":"10.1007/s10792-024-03394-1","DOIUrl":"10.1007/s10792-024-03394-1","url":null,"abstract":"<p><strong>Purpose: </strong>To compare keratometric astigmatism (ΔK) and total corneal astigmatism (ΔTK) calculated by the IOLMaster 700 in cataract cases with regular corneal astigmatism ≥ 0.75 diopters (D).</p><p><strong>Methods: </strong>This study was a secondary analysis of a database of cataract patients who had undergone examination with IOLMaster 700 between May 2021 and March 2022 at Shanghai Eye Disease Prevention and Treatment Center. The Surgically Induced Astigmatism Calculator v2.1 was used to examine vector errors between ΔK and ΔTK. Subgroup analyses were performed based on ΔK axis, ΔK magnitude, age, gender, mean simulated keratometry (Km), and white-to-white corneal diameter (WTW).</p><p><strong>Results: </strong>In total, 580 eyes in 580 cases were included. The centroid values of ΔK and ΔTK were 0.28 D at 4° ± 1.55 D and 0.51 D at 4° ± 1.60 D, respectively. ΔTK (1.38 [1.02-1.85] D) was significantly larger than ΔK (1.25 [0.98-1.69] D) (P < 0.0001). The absolute value of the vector error between ΔK and ΔTK (|ΔTK - ΔK|) was 0.24 (0.18-0.31) D. Among groups categorized based on ΔK axis, the |ΔTK - ΔK| was markedly reduced in the with-the-rule (WTR) astigmatism group compared with other groups; ΔTK was starkly lower than ΔK in the WTR astigmatism group (P = 0.0006), while ΔTK was larger than ΔK in the against-the-rule (ATR) astigmatism (P < 0.0001). The |ΔTK - ΔK| increased with the magnitude of ΔK and with age. The difference between ΔK and ΔTK showed no correlations with gender, Km, and WTW (all P > 0.05).</p><p><strong>Conclusions: </strong>A significant difference between ΔK and ΔTK obtained by IOLMaster 700 was found in cataract cases with regular corneal astigmatism ≥ 0.75 D. Such a difference was markedly reduced in the WTR astigmatism group. In contrast, this difference increased with the magnitude of ΔK and age. Moreover, this difference was not associated with gender, Km, and WTW.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"66"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal rhythm-modulated transcriptome analysis of meibomian gland in hyperlipidemic mice using RNA sequencing.","authors":"Qing Zhang, Jinxing Su, Jing Chen, Sainan Wu, Xiaoxuan Qi, Min Chu, Shangquan Jiang, Kan He","doi":"10.1007/s10792-025-03431-7","DOIUrl":"https://doi.org/10.1007/s10792-025-03431-7","url":null,"abstract":"<p><strong>Aim: </strong>To explore the regulatory mechanism of meibomian gland (MG) in hyperlipidemic mice under a diurnal rhythm by transcriptomic analysis based on high-throughput sequencing.</p><p><strong>Methods: </strong>The mouse model of hyperlipidemia induced by four months of high-fat diet (HFD) feeding to a regular light-dark (LD) cycle for 2 weeks was used in this study. Phenotypic observation and RNA sequencing (RNA-seq) of MGs of the experimental mice were then performed to investigate transcriptional changes due to hyperlipidemia and the diurnal rhythm and their effects on meibomian gland dysfunction (MGD).</p><p><strong>Results: </strong>The expression levels of the identified dysregulated genes were then validated by qRT-PCR. Several significantly regulated genes and enriched pathways were identified as associated with MGD in hyperlipidemic mice under a diurnal rhythm; these genes included some core diurnal clock genes, e.g., Clock, Per2 and Per3. Phenotypic and histological analysis reveals abnormal morphology concomitantly with a modification of the transcriptional landscape of MG caused by HFD.</p><p><strong>Conclusion: </strong>Our findings provide us with a deeper understanding of the diurnal rhythm regulation of MG in hyperlipidemic mice altered by daily nutritional challenge.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"57"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of higher pain in possible open globe injury emergency medical services activations.","authors":"Hassaam S Choudhry, David Mothy, Aneesh Reddy, Aman M Patel, Skyler Peterson, Benjamin Fisher, Mohammad H Dastjerdi","doi":"10.1007/s10792-025-03418-4","DOIUrl":"10.1007/s10792-025-03418-4","url":null,"abstract":"<p><strong>Purpose: </strong>To determine predictors of high pain in open globe injury (OGI) cases treated and transported by Emergency Medical Services.</p><p><strong>Methods: </strong>The National Emergency Medical Services Information System database was queried for activations of OGI between 2017 and 2021. Demographic, location, medication, and date and time information was collected. Cases were divided based on the intensity of maximum pain reported (low pain: below 5/10, high pain: above 5/10). Logistic regression was used to identify significant predictors of high maximum pain.</p><p><strong>Results: </strong>Of 53,589 cases of OGI, 20,766 reported high levels of pain. Females were more likely to report high pain than males (OR 1.24, CI 1.195-1.285). All age groups between 16 and 75 years old were more likely to report high pain than patients below 15, while all age groups above 75 were less likely. American Indians/Alaska Natives, Black, and Hispanic Americans were all more likely to report high pain than White Americans (American Indian, OR 1.249, CI 1.067-1.461; Black, OR 1.332, CI 1.277-1.390; Hispanic, OR 1.133, CI 1.064-1.207). OGI cases in the Midwest and South regions were less likely to report high pain than those in the West (Midwest, OR 0.868, CI 0.807-0.933; South, OR 0.800, CI 0.748-0.855). Compared to low pain patients, a greater percentage of high pain patients received opioid analgesia (10.04% vs. 0.44%).</p><p><strong>Conclusions: </strong>Demographic factors and location may contribute to higher pain in OGI patients. This information may prove useful in the management of OGI and may warrant further investigation into the nature of open globe trauma.Kindly check and confirm the inserted city is correct for affiliation 3.Correct.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"53"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of endothelial cell count, central corneal thickness and intraocular pressure in different ethnic groups in the Western Cape, South Africa.","authors":"Raquel Bhika, Moleen Zunza, Derrick Smit","doi":"10.1007/s10792-025-03426-4","DOIUrl":"10.1007/s10792-025-03426-4","url":null,"abstract":"<p><strong>Purpose: </strong>To compare endothelial cell counts (ECC), central corneal thickness (CCT) and intraocular pressure (IOP) in different ethnic groups.</p><p><strong>Methods: </strong>Between January 2019 and December 2021, we enrolled 373 patients who self-identified as native African (116), ethnically diverse (157) or of European descent (100). Mean intraocular pressure (IOP), CCT and ECC were recorded.</p><p><strong>Results: </strong>IOP was similar between the groups (African mean IOP 15.7 ± 2.2 mmHg, ethnically diverse 15.8 ± 2.2 mmHg, European 16.0 ± 2.0 mmHg, p = 0.48). There were age differences but no gender differences between ethnic groups. Mean CCT was 503.6 ± 30.0 µm (African), 516.8 ± 30.0 µm (ethnically diverse) and 539.1 ± 34.2 µm (European) (p < 0.002 for all). Mean ECC was 2775 ± 272 cells/mm² (African), 2678 ± 233 cells/mm² (ethnically diverse) and 2639 ± 313 cells/mm² (European). These differences were significant between Africans and Europeans (p = 0.001) and Africans and ethnically diverse groups (p = 0.01).</p><p><strong>Conclusion: </strong>ECC was highest in Africans with lowest CCT and conversely, Europeans demonstrated lowest ECC and highest CCT. Ethnically diverse participants demonstrated values between those of Africans and Europeans. We hypothesize that genomic research is required to determine if these differences have a genetic basis.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"56"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing early detection of keratoconus suspects using interocular corneal tomography asymmetry.","authors":"Shuangcheng Li, Yan Huo, Ruisi Xie, Yimei Han, Haohan Zou, Yan Wang","doi":"10.1007/s10792-025-03423-7","DOIUrl":"https://doi.org/10.1007/s10792-025-03423-7","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate corneal tomography asymmetry of both eyes in keratoconus (KC), keratoconus suspects (KCS), and normal (NL) eyes, and to introduce an interocular asymmetry index (IAI) for early diagnosis of keratoconus.</p><p><strong>Methods: </strong>This prospective case-control study included 210 NL eyes, 140 eyes with KCS, and 40 eyes with KC. New Scheimpflug imaging scans were performed to obtain corneal tomographic parameters. Based on the high and low values of tomographic parameters, each eye was categorized as \"worse\" or \"better.\" Intragroup correlation coefficients (ICC) were used to compare interocular asymmetry. Logistic regression indices were constructed using interocular differences. Receiver operating characteristic (ROC) curves were used to analyze the sensitivity, specificity, and cutoff values of the IAI.</p><p><strong>Results: </strong>In the KC group, 86.7% of the parameters significantly differed between the worse and better eyes. In the KCS group, 66.7% of the parameters showed significant differences between the worse and better eyes, with high consistency between the central and thinnest corneal thickness groups (ICC > 0.6). Strong intragroup correlations were observed in the NL group (ICC > 0.6). IAI effectively distinguished the NL from the KCS group (area under the ROC [AUROC] = 0.891), reaching 67.1% sensitivity and 97.1% specificity at a cutoff value of 0.494. At a cutoff value of 0.778, the IAI reached 95.0% sensitivity and 96.2% specificity in distinguishing NL from KC (AUROC = 0.954).</p><p><strong>Conclusion: </strong>Interocular asymmetry in keratoconus suspects can be detected in the early stages, with increased asymmetry compared to NL eyes observed as keratoconus progresses. Interocular asymmetry can complement monocular diagnostic parameters.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"55"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological profiles of infectious corneal ulcers in Derbyshire and North Nottinghamshire-a 10-year analysis.","authors":"Balázs Fazekas, Delicia Jayakumar, Harminder Singh Dua, Lana Faraj","doi":"10.1007/s10792-025-03432-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03432-6","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the spectrum of organisms causing microbial keratitis and their in-vitro anti-microbial sensitivities out of 2 hospitals in the East Midlands Region of the United Kingdom.</p><p><strong>Methods: </strong>A retrospective review was undertaken of all patients who underwent corneal scrapes for infectious keratitis between 2011 and 2021 at Royal Derby Hospital (RDH) in Derby and between 2009 and 2021 at King's Mill Hospital in Mansfield.</p><p><strong>Results: </strong>In total, the results of 645 corneal scrapes (from 622 patients) were analysed after exclusions. Of these, 307 (47.6%) yielded positive cultures. The mean patient age was 52.6 ± 22.1 years (Mean ± St Dev) across both sites and 332 (51.4%) were from female patients. At RDH, there were 195 positive corneal scrape cultures, from which 250 species of organisms were isolated. At RDH, 64% (160/250) were Gram-positive bacteria, 32% (81/250) were Gram-negative bacteria, 2.4% (6/250) were Acanthamoeba species and 1.2% were fungi (3/250). At KMH, there were 112 positive cultures, from which 128 species of organisms were isolated. 14 corneal scrapes from KMH were polymicrobial. At KMH, 96% (123/128) were bacterial (51% Gram positive, 45% Gram negative), 3/128 (2.3%) were fungi and 2/128 (1.6%) were Acanthamoeba. Sensitivity testing confirmed that the fluoroquinolone class of antibiotics appeared to be effective against the majority isolates across the two hospital sites.</p><p><strong>Conclusion: </strong>There are differences in microbiological profiles between these neighbouring hospitals covering neighbouring populations. Despite these differences, reassuringly, the current first-line fluoroquinolone monotherapy treatment is an appropriate first-line treatment for both hospital sites.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"58"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can the combination of citicoline and vitamin B12 be beneficial in the healing of corneal nerves after corneal cross-linking?","authors":"Metin Unlu, Furkan Ozer, Esra Sahin Aslan, Hidayet Sener, Kuddusi Erkilic","doi":"10.1007/s10792-025-03433-5","DOIUrl":"https://doi.org/10.1007/s10792-025-03433-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of topical citicoline, vitamin B12 and hyaluronic acid (OMK2 eye drops; Omikron Italia Srl, Italy) on the healing of corneal nerve after corneal cross-linking (CXL) treatment in patients with keratoconus (KC).</p><p><strong>Methods: </strong>A total of 44 eyes of 22 patients with KC who underwent CXL were included in this prospective study. After CXL, one eye of these patients received OMK2 eye drop and standard post-CXL treatment (OMK2 group), while the fellow eye received only standard post-CXL treatment (control group). The following parameters were analyzed in the pre- and post-CXL procedure periods (1st, 3rd and 6th months): corneal sensitivity, tear film stability, central corneal thickness (CCT), and the corneal sub-basal nerve plexus (sbNP) parameters (including corneal nerve fiber density [CNFD], corneal nerve branch density [CNBD], corneal nerve fiber length [CNFL], corneal total branch density [CTBD], corneal nerve fiber area [CNFA], corneal nerve fiber width [CNFW]).</p><p><strong>Results: </strong>Following CXL, a comparison of the baseline and month 6 data revealed that CNFA decreased in the control group (p < 0.001) and did not differ in the OMK2 group (p = 0.283). Other corneal sbNP parameters exhibited a decrease when comparing baseline and 6 months in each group (all p < 0.05). In addition, CCT in the OMK2 group was not significantly different between baseline and month 6 (p = 0.052). However, a decline in CCT of the control groups was observed during this specified time interval (p = 0.009). Corneal sensitivity or tear film stability parameters did not differ significantly between groups at any time point or over time within each group (all p > 0.05).</p><p><strong>Conclusion: </strong>The use of OMK2 eye drop after CXL may provide more stable CNFA. In addition, it may also provide faster recovery in CCT.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"54"},"PeriodicalIF":1.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}