International Ophthalmology最新文献

{"title":"Validation of Malay-vision disability assessment (VDA) questionnaire and its application to assess the functional disability among cataract patients of a tertiary medical centre in Malaysia.","authors":"Yi Wen Lim, Nor Fadhilah Mohamad, Foong Ming Moy, Tengku Ain Kamalden","doi":"10.1007/s10792-025-03552-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03552-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to translate, culturally adapt, and validate the Malay-Visual Disability Assessment (VDA) questionnaire and to assess its applicability in evaluating functional disability among cataract patients of a tertiary medical centre in Malaysia.</p><p><strong>Methods: </strong>This cross-sectional, questionnaire-based study was divided into two phases. In Phase I, the pre-final version of Malay-VDA was validated by a panel of six experts, followed by cognitive debriefing with 10 respondents. Test-retest reliability was assessed using 35 participants. The reliability and validity of the Malay-VDA was tested using intraclass correlation coefficient (ICC) and content validity index (CVI). Phase II evaluated the visual function among 200 cataract patients using the validated Malay-VDA. Additionally, self-administered questionnaire was used to collect sociodemographic data of the respondents.</p><p><strong>Results: </strong>In Phase I, all items in Malay-VDA achieved an item-level CVI of > 0.8 for relevance and > 0.7 for clarity, with an overall CVI > 0.9. The test-retest reliability analysis demonstrated excellent reliability, with a single measures ICC of 0.998 (95% CI: 0.995-0.999, p < 0.001) and an average measures ICC of 0.999 (95% CI: 0.998-0.999, p < 0.001). In Phase II, out of the 200 respondents, they were more Chinese, females, had completed primary education and aged between 70 to 79 years. The respondents had higher VDA scores in distance domain with the mean (SD) scores of 16.57 (5.11), showing worst functional disability in distant activities, followed by difficulties in the mobility domain (mean (SD) scores of 10.15 (3.72)) and near domain (mean (SD) scores of 9.98 (2.76)). The mean score was found to be significantly higher in the poor vision group for all three domains. A positive correlation with moderate strength was found between total VDA score and best-corrected visual acuity (BCVA) with age adjusted (r = 0.575, p < 0.001).</p><p><strong>Conclusion: </strong>The Malay-VDA demonstrated good reliability and validity, making it a suitable tool for local adaptation. This study highlighted that visual function was not solely determined by visual acuity, underscoring the importance of comprehensive functional assessment in cataract patients. Therefore, integrating visual function assessment into preoperative evaluations could enhance surgical decision-making.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"191"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular manifestations and treatment progress of Parry-Romberg syndrome.","authors":"Dengfeng Zhang, Shuting Huang, Xin Zhang, Le Ling, Bei Li","doi":"10.1007/s10792-025-03574-7","DOIUrl":"https://doi.org/10.1007/s10792-025-03574-7","url":null,"abstract":"<p><strong>Purposes: </strong>Parry-Romberg syndrome is a rare degenerative disease. This article focuses on the ocular aspects of Parry-Romberg syndrome to help diagnose and further explore more effective treatments.</p><p><strong>Methods: </strong>A combined systematic search of PubMed electronic database by using Boolean operators AND and OR was conducted, choosing the following keywords: \"Parry-Romberg syndrome\", \"Progressive hemifacial atrophy\", \"eye\", \"oculus\", \"ophthalmic\", \"ophthalmologic\", \"ophthalmology\" and \"global\", etc. After the initial screening of these articles, repetitive literatures were excluded.</p><p><strong>Results: </strong>69 articles were selected. This study introduces the ocular manifestations, possible pathogenesis, and treatment progress of Parry-Romberg syndrome.</p><p><strong>Conclusion: </strong>There is currently no clear pathogenesis and effective treatment for Parry-Romberg syndrome. Understanding its pathological mechanism in the context of autoimmune etiology and exploring its phenotype-genotype correlation may help find more valuable treatments.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"202"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repositioning of the completely prolapsed lacrimal tube after bicanalicular intubation: a novel technique.","authors":"Ahmed N Kotb, Sahar Hemeda, Sherif Sharaf El Deen, Reem Amir Kamal Dessouky","doi":"10.1007/s10792-025-03565-8","DOIUrl":"https://doi.org/10.1007/s10792-025-03565-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the outcomes of a novel technique for repositioning a completely prolapsed lacrimal tube after bicanalicular intubation for congenital nasolacrimal duct obstruction.</p><p><strong>Methods: </strong>This retrospective study included 18 children with complete lacrimal tube prolapse that could not be repositioned from the nose during the period from July 2020 to August 2023. Medical records were reviewed for demographic data, date and details of the initial intubation surgery, and the time till tube prolapse was calculated. Description of the repositioning procedure including the duration, intraoperative complications and success rate were reported. Postoperative follow-up visits were scheduled weekly for 1 month then monthly till tube removal to record tube stability and any postoperative complications. After tube removal, follow up was continued for 3 months to detect recurrent epiphora.</p><p><strong>Results: </strong>18 eyes of 18 children were included with a mean age of 1.36 ± 0.24 years. Mean time till tube prolapse was 23.6 ± 17.1 days. The success rate of the novel repositioning technique was 83.3%. The mean duration of the procedure was 11.8 ± 1.8 min. 2 (13.3%) cases had mild intraoperative nasal bleeding that did not prevent repositioning. No other intraoperative complications were reported. Postoperatively, 2 (13.3%) children showed recurrent partial tube prolapse.</p><p><strong>Conclusion: </strong>The novel repositioning technique is safe and effective in children with complete tube prolapse after bicanalicular intubation. It salvages the existing tube avoiding the added cost and burden of a new intubation. Trial registration ZU-IRB#11052-13-9-2023, 13/9/2023 'retrospectively registered'.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"198"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of moxifloxacin penetration into corneal lenticules extracted during SMILE surgery.","authors":"Mehmet Altun, Mevlut Celal Ocal, Husna Topcu, Dilek Yasa, Gönül Karatas Durusoy, Bulent Kose, Yasar Sakarya","doi":"10.1007/s10792-025-03562-x","DOIUrl":"https://doi.org/10.1007/s10792-025-03562-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the penetration of topically applied moxifloxacin 0.5% in corneal lenticule tissue collected from healthy patients undergoing the Kerato Lenticule Extraction (KLEx) surgery.</p><p><strong>Methods: </strong>Thirty-seven eyes of 37 patients received a single drop of moxifloxacin 0.5% before corneal lenticule tissue collection in KLEx surgery. The lenticule samples were divided into three groups according to collection time. Eight lenticules (21.6%) were included in group 1 (0.5 to 1.0 h), 19 lenticules (51.3%) in group 2 (1.0 to 1.5 h), and 10 lenticules (27.0%) in group 3 (1.5 to 2.0 h). The lenticules were stored at -80 °C until analysis. Moxifloxacin concentration in the lenticule tissue was measured using a validated liquid chromatography mass spectrometry (LC-MS/MS) technique.</p><p><strong>Results: </strong>The mean corneal lenticule concentration of moxifloxacin was 22.54 ± 13.63 μg/g in group 1, 17.8 ± 10.88 μg/g in group 2, and 9.88 ± 4.2 μg/g in group 3. These concentrations were higher than the minimum inhibitory concentration (MIC) values of bacterial isolates, except Pseudomonas aeruginosa.</p><p><strong>Conclusion: </strong>This study demonstrates that a single preoperative drop of moxifloxacin 0.5% achieves corneal tissue concentrations above the MIC for most bacterial pathogens except Pseudomonas aeruginosa. These results suggest that such prophylactic administration may effectively reduce the risk of post-operative infection in patients undergoing KLEx surgery.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"196"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive quality and reliability assessment of SMILE (small incision lenticule extraction) laser surgery videos on youtube.","authors":"Ali Hakim Reyhan, İrfan Uzun, Çağrı Mutaf, Mehmet Eryavuz","doi":"10.1007/s10792-025-03568-5","DOIUrl":"https://doi.org/10.1007/s10792-025-03568-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the quality and reliability of YouTube videos involving SMILE (Small Incision Lenticule Extraction) laser surgery and to assess the differences between physician-authored and patient-generated content.</p><p><strong>Methods: </strong>A comprehensive search was conducted on YouTube for SMILE laser surgery videos. The top 100 English-language videos were evaluated using validated scoring systems including DISCERN, JAMA, Global Quality Score (GQS), and Patient Education Materials Assessment Tool for Audio Visual (PEMAT-A/V).</p><p><strong>Results: </strong>The average quality scores were moderate across all metrics (DISCERN: 45.1, PEMAT-AV Understandability: 68.8, PEMAT-AV Actionability: 49.9, JAMA: 2.39, GQS: 2.99). Physician-authored videos scored significantly higher on reliability, treatment choices, and overall quality (p < 0.05). Patient-generated videos demonstrated higher viewer engagement, with more views (23,973 vs. 15,467) and comments (28 vs. 8). Positive correlations were determined between video length, likes, comments, and quality metrics (p < 0.05).</p><p><strong>Conclusions: </strong>The SMILE laser surgery information on YouTube is of moderate quality. While physician-authored videos provide higher quality content, patient-generated videos offer unique perspectives and greater engagement. There is a need for balanced, high-quality video content that incorporates both professional expertise and patient experiences to provide comprehensive and reliable online information about SMILE laser surgery.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"200"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of trabeculectomy and gonioscopy-assisted transluminal trabeculotomy results in long eyes wıth open-angle glaucoma.","authors":"Gulsah Gumus Akgun, Selahattin Emirhan Kanik, Cigdem Altan, Nese Alagoz, Ihsan Cakir, Tekin Yasar","doi":"10.1007/s10792-025-03561-y","DOIUrl":"https://doi.org/10.1007/s10792-025-03561-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to compare one-year results and success rates of trabeculectomy and gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with long axial length (AL) and glaucoma.</p><p><strong>Method: </strong>This retrospective study included patients with an AL greater than 24 mm who underwent trabeculectomy (29 eyes) or GATT surgery (33 eyes) in our hospital and had at least a one-year follow-up. Complete success was defined as achieving an IOP > 5 and ≤ 21 mmHg (criterion A), > 5 and ≤ 18 mmHg (criterion B), or > 5 and ≤ 15 mmHg (criterion C), without the use of antiglaucoma medications or additional surgical interventions, except for bleb needling. The same IOP levels with or without medication were considered as overall success.</p><p><strong>Results: </strong>The GATT group required significantly more antiglaucoma medications at the 1-week, 1-month, and 3-month follow-ups (p < 0.05 for all). Complete success rates were higher in the trabeculectomy group based on criteria A, B, and C (p < 0.05 for each), and the overall success rates based on criteria A, B, and C were similar in both groups in one-year follow-up (p > 0.05 for each). The failure rates based on all three criteria were similar in both groups (p > 0.05 for each). The cumulative probability of overall success based on criterion B was 93.1, 86.2 and 79.3% at 3, 6 and 12 months in the trabeculectomy group and 90.9, 84.5 and 81.8% at 3, 6 and 12 months in the GATT group. The incidence of postoperative complications was higher in the GATT group, and the majority of complications were haemorrhage-related.</p><p><strong>Conclusion: </strong>In eyes with long AL, the requirement for antiglaucoma medications is reduced in the first three months following trabeculectomy compared to GATT. Although the overall success rate was similar in both groups, the complete success rates of criteria A, B and C were higher in the trabeculectomy group. GATT may be considered an alternative in eyes with long AL.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"195"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual outcomes of aberration neutral versus monofocal plus IOLs in triple DMEK surgery.","authors":"Karanpreet Multani, Liam Redden, David Hoang, Scott Vadala, Nitin Rangu, Justin D Dvorak, Kai Ding, Jascha Wendelstein, Kamran M Riaz","doi":"10.1007/s10792-025-03558-7","DOIUrl":"https://doi.org/10.1007/s10792-025-03558-7","url":null,"abstract":"<p><strong>Purpose: </strong>To compare visual acuity outcomes of two monofocal IOL models, a zero-aberration monofocal IOL (Envista MX60E; Bausch and Lomb) and a monofocal plus IOL (Eyhance DIB00; Johnson and Johnson), in eyes undergoing combined cataract surgery and Descemet membrane endothelial keratoplasty (DMEK) (triple DMEK).</p><p><strong>Methods: </strong>Retrospective, single-center case series of 91 eyes (66 patients) undergoing triple DMEK with either IOL between 2019 and 2023 at a tertiary academic center. Eyes were divided into 2 groups: zero-aberration IOL (49 eyes) and monofocal plus IOL (42 eyes). Among these, 20 eyes received a zero-aberration IOL, and 26 eyes received a monofocal plus IOL in both eyes. Visual acuity measurements at 3-6 months and 6-12 months postoperatively included uncorrected distance, intermediate, and near (UDVA, UIVA, UNVA) and distance-corrected distance, intermediate, and near (CDVA, DCIVA, DCNVA) visual acuities for monocular (Uni) and binocular (Bi) assessments. Patients were administered the Intraocular Lens Satisfaction questionnaire to assess their level of spectacle independence at the 3-6 month visit. Statistical analysis was performed using Wilcoxon rank-sum and Fisher's exact tests.</p><p><strong>Results: </strong>UDVA_Uni, CDVA_Uni, and UNVA_Uni were favorable and comparable between the two groups. At the 3-6 month timepoint, the Eyhance group had significantly better UIVA_Uni (0.17 ± 0.12 vs. 0.23 ± 0.13, p = 0.03), DCIVA_Uni (0.23 ± 0.08 vs. 0.31 ± 0.08, p < 0.001), and DCNVA_Uni (0.36 ± 0.09 vs. 0.40 ± 0.08, p = 0.04). However, at 6-12 months, all six VA measurements were similar between the 2 groups. Bilateral cases at the 3-6 month timepoint demonstrated superior DCNVA_Bi in the Eyhance group versus the Envista group (0.31 ± 0.08 vs. 0.41 ± 0.03, p = 0.008). The spherical equivalent refractive error (- 0.51 ± 0.94D vs. - 0.55 ± 1.05D, p = 0.89) for all eyes and inter-eye refractive error in the binocular subgroup (0.29 ± 1.36D vs. 0.42 ± 1.11D, p = 0.80) was similar for both groups. Postoperative complications and patient satisfaction were comparable between the two groups.</p><p><strong>Conclusion: </strong>Both IOLs can provide favorable corrected and uncorrected VA in triple DMEK eyes. Eyhance may provide better DCIVA_Uni and UIVA_Uni in single eyes and better DCNVA_Uni/Bi in all eyes up to six months postoperatively.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"193"},"PeriodicalIF":1.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of periocular scars after blepharoplasty and external dacryocystorhinostomy according to Manchester and modified Vancouver scar score.","authors":"Çisil Erkan Pota, Aslı Bilgiç, Aslı Çetinkaya Yaprak, Hatice Deniz İlhan, Uğur Kahraman","doi":"10.1007/s10792-025-03567-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03567-6","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate and compare the scars of two groups of patients who underwent different periorbital surgical procedures, blepharoplasty and external dacryocystorhinostomy (DCR), using established scar scales. We aimed to compare the cosmetic outcomes of incisions parallel and perpendicular to the skin lines and to evaluate the relationship between patient satisfaction, skin aging, skin phototypes, and scar scores.</p><p><strong>Methods: </strong>This cross-sectional study included 55 patients who underwent upper eyelid blepharoplasty and 50 patients who underwent external DCR. Patients' postoperative scars were assessed between 12 and 36 months after surgery using the fitzpatrick skin type scoring (Type I white skin-Type VI dark brown/black skin), Modified Fitzpatrick Wrinkle Scale (MFWS) (Class 0 no wrinkle-Class 3 deep wrinkle), modified vancouver scar scale (MVSS) (pigmentation, vascularity, pliability, height) and the Manchester Scar Scale (MSS) (visual analog scale, color, matte/glossy, contour, distortion, texture) by an ophthalmologist and a dermatologist. The assessment was blinded. Finally, all participants answered a patient satisfaction scale consisting of three questions [(1) Can you see the wound (2) Is the scar important to you? (3) Would you undergo the same operation again regarding the scar?].</p><p><strong>Results: </strong>Both MSS and MVSS scores were higher in the blepharoplasty group than in the external DCR group (p = 0.041, p = 0.029). As patient dissatisfaction increased, a significant increase in both MSS and MVSS scoreswas observed (p = 0.001, r = 0.308; p = 0.025, r = 0.219).</p><p><strong>Conclusion: </strong>According to the patient satisfaction scale, blepharoplasty and external DCR were not significantly different, but external DCR resulted in less scarring than blepharoplasty according to MSS and MVSS (performed by a dermatologist and an ophthalmologist). We found that the scar score was influenced by the amount of wrinkles, but not by age or skin color. To our knowledge, this is the first study to compare both the MSS and MVSS scar scores with patient satisfaction after periocular surgery. Finally, both the MSS and MVSS scar scores provide an objective and useful method of assessing postoperative scarring and can therefore help surgical teams optimize their procedure and achieve a better outcome.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"190"},"PeriodicalIF":1.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cataract surgery on macular and peripapillary optical coherence tomography values.","authors":"Mona Pournaghi, Aidin Meshksar, Sadra Ashrafi, Kiana Hassanpour, Hossein Mohammad-Rabie, Shahin Yazdani, Bahareh Kheiri, Diba Idani, Farideh Sharifipour","doi":"10.1007/s10792-025-03557-8","DOIUrl":"https://doi.org/10.1007/s10792-025-03557-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of cataract surgery on peripapillary retinal nerve fiber layer (pp-RNFL) and macular thickness measurements, obtained by optical coherence tomography (OCT).</p><p><strong>Methods: </strong>In this prospective before-after study, both pp- and macular scans were obtained within two days before and then two weeks after surgery. Cataract density was graded using the Lens Opacities Classification System (LOCS) III. Pre- and postoperative quality scores and thicknesses were compared.</p><p><strong>Results: </strong>In 100 studied eyes of 100 patients, quality scores and thickness values increased postoperatively. (all P < 0.001). The greatest change was observed at the nasal superior sector of pp-OCT (5.28 ± 11.11µm) and the temporal quadrant of 3-mm-diameter circle (7.40 ± 9.13 µm) of macular scans. Changes in the quality score were significantly correlated with changes in global, nasal, and temporal-inferior pp-RNFL thicknesses and none of macular sectors. The greatest changes in pp-RNFL and macular thicknesses were observed with posterior subcapsular and the least with cortical cataracts. In 14 eyes, the increase in pp-RNFL thickness measurements resulted in a change in color display of pie charts. In this subset of patients, significant positive correlation was observed between global thickness change and quality change. (r = 0.217, P = 0.033).</p><p><strong>Conclusion: </strong>Cataract surgery significantly improves the quality score and thickness values of both pp- and macular OCT. Correcting OCT-derived pp-RNFL thicknesses in eyes with significant cataracts is needed to prevent misdiagnosis of glaucoma.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"189"},"PeriodicalIF":1.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating clues of cystoid macular edema from a vascular perspective under long-term latanoprost usage.","authors":"Cansu Yuksel Elgin, Ilayda Kaner Savci, Yildiz Birisik, Mustafa Hepokur","doi":"10.1007/s10792-025-03556-9","DOIUrl":"https://doi.org/10.1007/s10792-025-03556-9","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the macular vascular effects of prolonged use of latanoprost compared to the dorzolamide-timolol fixed combination in patients with very early-stage glaucoma, where glaucoma-specific damage has been minimized.</p><p><strong>Methods: </strong>The retinal vascular effects of latanoprost versus the dorzolamide-timolol fixed combination were evaluated using Optical Coherence Tomography Angiography (OCT-A) in a case-control study design. A total of 71 eyes from 71 individuals were included in the study: 28 eyes receiving latanoprost (Group 1), 20 eyes receiving the dorzolamide-timolol combination (Group 2), and 23 eyes from healthy individuals (Group 3). Superficial, deep, and radial peripapillary capillary plexus vascular density (SCP-vd, DCP-vd, RPCP-vd) and foveal avascular zone (FAZ) measurements were taken with OCT-A. The comparative analysis between groups was performed with SPSS V.26.</p><p><strong>Results: </strong>Across the groups (from 1 to 3), whole image vascular density (vd) measurements were as follows: SCP-vd: 45.86 ± 3.99, 44.58 ± 4.58, 48.35 ± 4.04; DCP-vd: 44.86 ± 5.75, 44.02 ± 6.87, 49.74 ± 4.84; and RPCP-vd: 46.97 ± 3.81, 47.07 ± 5.49, 49.90 ± 2.43. All these measurements were significantly decreased in both glaucoma groups (groups 1 and 2) compared to healthy subjects (group 3). In subgroup analyses of the macular region, including the fovea, parafovea, and perifovea, vd measurements were decreased in all areas except the fovea in glaucoma patients. However, no statistically significant differences were found between the latanoprost and dorzolamide-timolol groups regarding retinal vascular structure. In FAZ measurements, no significant differences were found in any anatomical location among the three groups.</p><p><strong>Conclusion: </strong>This study demonstrates that latanoprost, the first prostaglandin analog known for its edema-inducing effect on the macula, does not have a long-term impact on macular vascularity. However, this result should be supported with longer and larger studies.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"188"},"PeriodicalIF":1.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}