International Ophthalmology最新文献_第10页

Carbonic anhydrase inhibitor alleviates retinal barrier toxicity in paclitaxel-induced retinopathy and macular edema by inhibiting CAXIV. 碳酸酐酶抑制剂通过抑制 CAXIV 减轻紫杉醇诱导的视网膜病变和黄斑水肿的视网膜屏障毒性。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-23 DOI: 10.1007/s10792-024-03362-9

Ya-Ting Ye, Ya-Li Niu, Zi-Yi Zhou, Yu Sun, Tian-Fang Chang, Yu-Tong Jing, Qian Bai, Zhao-Jie Chu

{"title":"Carbonic anhydrase inhibitor alleviates retinal barrier toxicity in paclitaxel-induced retinopathy and macular edema by inhibiting CAXIV.","authors":"Ya-Ting Ye, Ya-Li Niu, Zi-Yi Zhou, Yu Sun, Tian-Fang Chang, Yu-Tong Jing, Qian Bai, Zhao-Jie Chu","doi":"10.1007/s10792-024-03362-9","DOIUrl":"10.1007/s10792-024-03362-9","url":null,"abstract":"Purpose: To investigate the mechanism of paclitaxel (PTX)-induced macular edema and the therapeutic effect of carbonic anhydrase inhibitors (CAI) on this condition.Methods: The effect of PTX on cell morphology was detected by immunofluorescence. Cell barrier was measured by measuring cell resistance across the epithelium. Western blotting analysis and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were performed to investigate the effects of PTX or PTX + CAI on the expression of carbonic anhydrase XIV (CAXIV), aquaporin 4 (AQP4) and inflammatory factors. After intraperitoneal injection of PTX in vivo, retinal electrophysiology (ERG) was used to evaluate the effects of drugs on visual electrophysiology.Results: PTX inhibited the proliferation of ARPE-19 and Müller cells, promoting their apoptosis, changing their morphology and cell cycle, reducing the transepithelial resistance of ARPE-19 cells and promoting the expression of inflammatory factors; This process was alleviated after temporary withdrawal. CAI inhibited the upregulation of inflammatory factors. Following treatment with PTX, the expression levels of AQP4 and CAXIV were higher than control group; nevertheless, the levels of ZO-1 and OCLN were lower than control group. In vivo, the ERG analysis showed that the light- and dark-adapted 3.0 ERG, and dark-adapted 3.0 oscillatory potentials decreased to different degrees following treatment with PTX.Conclusion: PTX-induced macular edema is mainly due to Müller cell toxicity. The condition can be alleviated by regulating water channels and enhancing subretinal fluid absorption. Thus, CAI may provide a new therapeutic approach for PTX-induced macular edema.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"437"},"PeriodicalIF":1.4,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors and prognostic analysis of vitreous cavity opacification after silicone oil removal. 硅油去除后玻璃体腔不透明的风险因素和预后分析。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-23 DOI: 10.1007/s10792-024-03364-7

Jingsheng Yi, Zijing Huang, Wai Kit Chu, Dezhi Zheng, Jianlong Zheng, Weiqi Chen, Qihong Li, Dingguo Huang

{"title":"Risk factors and prognostic analysis of vitreous cavity opacification after silicone oil removal.","authors":"Jingsheng Yi, Zijing Huang, Wai Kit Chu, Dezhi Zheng, Jianlong Zheng, Weiqi Chen, Qihong Li, Dingguo Huang","doi":"10.1007/s10792-024-03364-7","DOIUrl":"https://doi.org/10.1007/s10792-024-03364-7","url":null,"abstract":"Purpose: This study aims to investigate the risk factors for postoperative vitreous cavity opacification following pars plana silicone oil removal and its impact on prognostic visual acuity.Methods: A retrospective case-control study was conducted. A total of 66 eyes from 66 patients were enrolled in the study. On the first postoperative day, all patients underwent a scanning laser ophthalmoscopy to assess the turbidity of the vitreous cavity. 42.42% (28/66) were categorized as Grade 0, 36% (24/66) as Grade I, and 21% (14/66) as Grade II, based on the visibility of posterior pole blood vessels. Ordered multiple classification logistic regression analysis was employed to investigate the impact of surgical and baseline factors on the occurrence and severity of vitreous cavity opacification.Results: The presence of high myopia and the intraoperative combination of epiretinal membrane peeling exhibited significant correlations with the development of postoperative vitreous cavity opacification (OR = 3.424, 95% CI 2.326-31.643, P = 0.023; OR = 3.612, 95% CI 1.263-14.676, P = 0.031, respectively). The best corrected visual acuity (BCVA) on the first day post-surgery was significantly reduced across all degrees of opacification compared to the preoperative level (p < 0.001). However, no significant difference in BCVA was detected between the preoperative period, one-week post-operation, and the last follow-up (P > 0.05).Conclusion: High myopia and intraoperative epiretinal membrane peeling may be associated with the development of more severe vitreous cavity opacity following silicone oil removal. This opacity generally resolves within one week post-surgery and does not appear to increase the risk of retinal re-detachment.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"438"},"PeriodicalIF":1.4,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated serum lipoprotein(a) levels as a potential risk factor for diabetic retinopathy in type 2 diabetes: a meta-analysis. 作为 2 型糖尿病视网膜病变潜在风险因素的血清脂蛋白（a）水平升高：一项荟萃分析。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-23 DOI: 10.1007/s10792-024-03360-x

Ying Pang, Chi Yi

{"title":"Elevated serum lipoprotein(a) levels as a potential risk factor for diabetic retinopathy in type 2 diabetes: a meta-analysis.","authors":"Ying Pang, Chi Yi","doi":"10.1007/s10792-024-03360-x","DOIUrl":"10.1007/s10792-024-03360-x","url":null,"abstract":"Purpose: This meta-analysis aimed to clarify the correlation between serum lipoprotein(a) [Lp(a)] levels and diabetic retinopathy (DR) in type 2 diabetes (T2D) individuals.Methods: We searched electronic databases, including PubMed, Web of Science, and Embase, for relevant observational studies evaluating the association between serum Lp(a) levels and the risk of DR. Odds ratios (ORs) with 95% confidence intervals (CIs) were summarized to indicate the association between a high Lp(a) and the risk of DR. Data were extracted and pooled using a random-effects model to account for variability among studies. Heterogeneity was assessed using the I2 statistic, and publication bias was evaluated through funnel plots and Egger's test.Results: Eleven observational studies were included. Compared to T2D patients of the lowest Lp(a) category, those of the highest Lp(a) category were associated with a higher risk of DR (OR: 2.05, 95% CI: 1.43-2.93, I2 = 83%, p < 0.001). Subgroup analyses suggested this association was predominantly observed in cross-sectional and case-control studies but not cohort studies (p for subgroup differences = 0.03). Additionally, the link between Lp(a) and DR was consistent across variables such as study country, Lp(a) cutoff values, analysis model (univariate or multivariate), and adjustment for concurrent medication use. A further meta-analysis suggested a significant relationship between elevated Lp(a) levels and proliferative DR (OR: 1.90, 95% CI: 1.03-3.48, I2 = 86%, p = 0.04).Conclusion: Elevated serum Lp(a) levels are associated with an increased risk of DR in individuals with T2D.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"439"},"PeriodicalIF":1.4,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances of IGF-1R inhibitors in Graves' ophthalmopathy. IGF-1R 抑制剂在巴塞杜氏眼病中的应用进展。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-22 DOI: 10.1007/s10792-024-03358-5

Meilan Wang, Lian Liu

引用次数: 0

A prospective study to evaluate the effectiveness of preventive aspects in relation to sports related ocular injuries. 一项前瞻性研究，旨在评估与运动相关的眼外伤预防措施的有效性。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-22 DOI: 10.1007/s10792-024-03357-6

Avinash Mishra, Atul Bhirud, Mohini Agrawal, Anchal Tripathi, V K Baranwal, Gaurav Kapoor

{"title":"A prospective study to evaluate the effectiveness of preventive aspects in relation to sports related ocular injuries.","authors":"Avinash Mishra, Atul Bhirud, Mohini Agrawal, Anchal Tripathi, V K Baranwal, Gaurav Kapoor","doi":"10.1007/s10792-024-03357-6","DOIUrl":"10.1007/s10792-024-03357-6","url":null,"abstract":"Background and objectives: Ocular trauma, a major cause of visual morbidity and unilateral blindness globally, sees sports as a prominent contributor. This study aims to assess the effectiveness of preventive measures, combining health education and ocular protective devices, in reducing sports-induced ocular injuries over 5 years.Methods: Conducted in a large military hospital in India, this prospective observational study spanned from January 2010 to December 2018. Preventive strategies included pre-participation eye examinations, health education targeting players, parents, and coaches, and the mandatory use of ocular protective gear. Ocular injuries were classified using The Birmingham Eye Trauma Terminology.Results: Over the study period, ocular injuries reduced significantly by more than 70%. The reduction was observed across various sports, with an 80% decrease in some. Notably, sports with compulsory ocular protection, such as swimming and squash, showed a 100% reduction in eye injuries (p < 0.01).Conclusion: This study underscores the success of a combined approach involving health education and mandatory use of ocular protective gear in preventing sports-related ocular injuries. The results highlight the need for continued efforts, including governmental initiatives, to achieve the ultimate goal of 90% prevention and alleviate the burden on healthcare resources.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"436"},"PeriodicalIF":1.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total keratometry versus standard keratometry for intraocular lens power calculation in eyes with keratoconus. 在计算角膜病患者眼内晶状体功率时，全角膜测量法与标准角膜测量法的比较。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-18 DOI: 10.1007/s10792-024-03332-1

Cinthya Parra-Bernal, Rocío Villaseñor-García, Erika Fernández-Muñoz, Miguel Castro-Monreal, Roberto González-Salinas

{"title":"Total keratometry versus standard keratometry for intraocular lens power calculation in eyes with keratoconus.","authors":"Cinthya Parra-Bernal, Rocío Villaseñor-García, Erika Fernández-Muñoz, Miguel Castro-Monreal, Roberto González-Salinas","doi":"10.1007/s10792-024-03332-1","DOIUrl":"10.1007/s10792-024-03332-1","url":null,"abstract":"Purpose: To describe the accuracy of monofocal intraocular lens power calculation in patients with keratoconus using total keratometry (TK) and standard keratometry (K) with conventional and keratoconus-modified formulas.Setting: Asociación Para Evitar la Ceguera en México, Mexico City, Mexico.Design: Observational, retrospective, non-randomized, comparative study.Methods: Biometric data from IOL Master 700 and postoperative refraction were collected from patients with keratoconus who had undergone cataract surgery. Predicted refraction of each patient was calculated using K and TK with the following formulas: SRK/T, Barrett Universal II, Panacea, Kane, Kane keratoconus, and Barrett True-K keratoconus (predicted and measured posterior corneal astigmatism [PCA]). Refractive prediction error, mean absolute error, trimmed mean, median absolute error, standard deviation, and percentage of eyes within ± 0.50 D, ± 1.00 D, ± 1.50 D, ± 2.00, and > 2.00 D were determined.Results: 55 keratoconic eyes of 40 patients were included. RPE in patients with keratoconus was < 1.00 D with all formulas. Barrett True-K keratoconus with predicted PCA registered the lowest MAE and MedAE. All formulas showed a discrete increase in myopic error percentage when calculations were performed using TK as opposed to K.Conclusions: Barrett True-K for keratoconus showed the highest accuracy, closely followed by Kane KC. BTK KC pPCA or mPCA with standard keratometries could serve as the primary choice in eyes with keratoconus and steepness < 60 D. In the absence of keratoconus-modified formulas, TK input in conventional formulas improves the prediction outcome.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"434"},"PeriodicalIF":1.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of motor vehicle accident-associated ocular trauma. 机动车事故相关眼外伤的流行病学。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-18 DOI: 10.1007/s10792-024-03356-7

Nishay V Bhatnagar, Aditya Uppuluri, Neelakshi Bhagat, Paul D Langer

{"title":"Epidemiology of motor vehicle accident-associated ocular trauma.","authors":"Nishay V Bhatnagar, Aditya Uppuluri, Neelakshi Bhagat, Paul D Langer","doi":"10.1007/s10792-024-03356-7","DOIUrl":"10.1007/s10792-024-03356-7","url":null,"abstract":"Purpose: The objective is to investigate trends in cases of motor vehicle accident-associated (MVA-associated) ocular trauma in which the patient was the driver of the motor vehicle.Methods: The study utilizes data from the 2007-2014 National Trauma Databank (NTDB), a national trauma registry. Status as the driver of the motor vehicle was identified using E-Codes from the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). Trauma diagnoses were identified using D-Codes from the ICD-9-CM. Statistics were performed using IBM SPSS Version 23.Results: We identified 49,660 cases of ocular trauma secondary to an MVA with a 25.3% increase in injuries over the 8-year time period. Men comprised 68.6% (34,057) of cases. Orbital floor fractures (OFFs) were the most commonly observed ocular injury, occurring in 17,647 (35.5%) cases. There were 2,787 cases of open globe injury (OGI) with the highest proportion of cases in the 65 + age group (6.5%). OGIs were seen in 3.0% of cases with OFFs vs. 7.1% in those without. Drivers under 18 were more likely to have optic pathway/cranial nerve injuries (4.4%) and ocular/adnexal contusions (41.2%) than adult drivers. The mortality rate was 4.3% and was highest in the 65 + age group (9.4%).Conclusion: Men and young adults comprised the majority of cases of MVA-associated ocular trauma. OFFs were seen in approximately one-third of cases of ocular trauma. OGIs were less commonly observed when a concurrent OFF was observed. Though the overall mortality was 4.3%, there was significant variation by age group.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"433"},"PeriodicalIF":1.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics, progression patterns and treatment outcomes in microsporidial keratoconjunctivitis: a prospective study in Thailand. 小孢子菌性角结膜炎的临床特征、发展模式和治疗效果：泰国的一项前瞻性研究。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-17 DOI: 10.1007/s10792-024-03340-1

Manapon Lekskul, Nathamon Sasiprapha, Mathirut Mungthin, Toon Ruang-Areerate, Ram Rangsin, Ratanasuda Thongruay

{"title":"Clinical characteristics, progression patterns and treatment outcomes in microsporidial keratoconjunctivitis: a prospective study in Thailand.","authors":"Manapon Lekskul, Nathamon Sasiprapha, Mathirut Mungthin, Toon Ruang-Areerate, Ram Rangsin, Ratanasuda Thongruay","doi":"10.1007/s10792-024-03340-1","DOIUrl":"https://doi.org/10.1007/s10792-024-03340-1","url":null,"abstract":"Purpose: To assess the clinical characteristics, progression patterns, and treatment outcomes of microbiologically confirmed microsporidial keratoconjunctivitis (MKC).Methods: This prospective cross-sectional study included patients with superficial punctate epithelial keratitis clinically suspected of MKC. Comprehensive slit-lamp examinations were conducted, and corneal scraping was performed for Gram-chromotrope staining and polymerase chain reaction (PCR) analysis. A standardized questionnaire gathered demographic data, clinical features, and risk behaviors. Treatment regimens and corneal findings, including medication and frequency, were documented at each visit.Results: PCR confirmed the diagnosis of MKC in 96 out of 117 eyes (82.1%), identifying Vittaforma corneae in 93.7% of cases, Microsporidium sp. in 4.2%, and Encephalitozoon hellem in 2.1%. All cases exhibited similar characteristics and pattern of progression, including elevated epithelial lesions in diffused distribution (34.1%), typical target lesions (31.3%), and subepithelial infiltrations (41.7%). Treatment with topical moxifloxacin, with or without oral albendazole, followed by topical steroids for subepithelial infiltrates, led to clinical improvement within approximately two weeks, with 52% of patients achieving complete recovery.Conclusions: This study identifies key clinical features and progression patterns in MKC. Topical fluoroquinolone monotherapy, or its combination with topical steroids or oral albendazole, results in favorable visual outcomes without corneal scarring. These insights may inform and enhance clinical management of MKC.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"432"},"PeriodicalIF":1.4,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive factors of long-term visual outcomes after primary Descemet's membrane endothelial keratoplasty (DMEK): retrospective study. 原发性德斯梅尔膜内皮角膜移植术（DMEK）后长期视觉效果的预测因素：回顾性研究。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-14 DOI: 10.1007/s10792-024-03329-w

Nuno Moura-Coelho, Renato Papa-Vettorazzi, Arnaldo Dias-Santos, João Paulo Cunha, Marco Dutra-Medeiros, Felicidad Manero, José Luis Güell

{"title":"Predictive factors of long-term visual outcomes after primary Descemet's membrane endothelial keratoplasty (DMEK): retrospective study.","authors":"Nuno Moura-Coelho, Renato Papa-Vettorazzi, Arnaldo Dias-Santos, João Paulo Cunha, Marco Dutra-Medeiros, Felicidad Manero, José Luis Güell","doi":"10.1007/s10792-024-03329-w","DOIUrl":"10.1007/s10792-024-03329-w","url":null,"abstract":"Purpose: To determine predictive factors of higher levels of best-corrected visual acuity (BCVA) in the long-term after primary Descemet's membrane endothelial keratoplasty (DMEK).Methods: Retrospective, single-surgeon case series of 129 successful primary DMEK eyes without graft failure and with a minimum postoperative follow-up of 12 months. Mixed effect model for repeated measurements (MMRM) analysis was performed to determine recipient, donor, surgical and postoperative factors associated with BCVA ≤ 0.10 logMAR (≥ 20/25 Snellen).Results: After primary DMEK, there was a statistically significant improvement in BCVA with a global reduction in logMAR BCVA (p < 0.00001). There was also a global tendency towards increasing proportion of eyes with BCVA ≤ 0.10 logMAR at all time points (p < 0.00001), from 1.6% before DMEK to 64.4% in eyes with more than 5 years of F-U. Absence of retinal disease was associated with a decrease of 0.10 logMAR in postoperative BCVA after primary DMEK, maintaining constant the rest of variables (p < 0.001). The variables age (OR 0.960), postoperative time (OR 1.083), preoperative BCVA ≥ 0.375 logMAR (OR 0.162) and indication for DMEK (OR 5.412) were included in the predictive MMRM model of BCVA ≤ 0.10 logMAR.Conclusion: Primary DMEK is associated with statistically and clinically significant improvement in BCVA that occur early in the postoperative period and are continuous over time. Eyes with retinal comorbidities have increased risk of worse postoperative BCVA after DMEK. Younger recipient age, Fuchs' dystrophy eyes and eyes with better preoperative BCVA are more likely to achieve postoperative BCVA ≤ 0.10 logMAR.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"430"},"PeriodicalIF":1.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epi-off riboflavin with vitamin E TPGS (Ribocross®) cross-linking: one-year outcome. 外显子核黄素与维生素 E TPGS（Ribocross®）交联：一年的结果。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2024-11-14 DOI: 10.1007/s10792-024-03354-9

Pietro Paolo Saba, Alessandro Feo, Luca Pagano, Paolo Vinciguerra, Riccardo Vinciguerra

{"title":"Epi-off riboflavin with vitamin E TPGS (Ribocross®) cross-linking: one-year outcome.","authors":"Pietro Paolo Saba, Alessandro Feo, Luca Pagano, Paolo Vinciguerra, Riccardo Vinciguerra","doi":"10.1007/s10792-024-03354-9","DOIUrl":"https://doi.org/10.1007/s10792-024-03354-9","url":null,"abstract":"Purpose: To assess the short and mid-term outcomes of epithelium-off (epi-off) corneal collagen cross-linking using Riboflavin with Vitamin E TPGS (Epi-off Ribocross® CXL) for progressive keratoconus (KC).Design: Retrospective, single-center non-comparative interventional study.Methods: Patients with progressive keratoconus who underwent CXL using (Epi-off Ribocross® CXL) from May 2021 to May 2022 who completed at least 12 months of follow-up in Humanitas Clinical and Research Center, Rozzano, Milan, Italy. Corrected distance visual acuity with spectable (CDVA), tomographic parameters (Belin ABCD) and topographic parameters were evaluated at baseline and at last follow up.Results: Twenty eyes of twenty patients fulfilled inclusion criteria. CDVA remained stable at last follow up (0.88 ± 0.19 from 0.83 ± 0.21, p = 0.45) with a significant reduction in cylinder (1.97 ± 1.69 from 2.78 ± 2.19, p = 0.03). Kmax significantly improved from 53.18D ± 6.32 to 50.96 ± 5.3D (p = 0.005). At the last follow up, no case of progression was noted.Conclusions: Epi-off Ribocross® CXL proved to be a safe treatment for progressive KC, with a stabilization of all cases at the one year follow up. Further studies are needed to confirm long-term stability.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"44 1","pages":"429"},"PeriodicalIF":1.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0