International Ophthalmology最新文献_第9页

Effects of toric intraocular lens in cataract patients with axial myopia and regular corneal astigmatism at primary hospitals. 环形人工晶状体在基层医院轴型近视伴角膜散光白内障患者中的应用效果。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-05 DOI: 10.1007/s10792-025-03530-5

Zhijian Jiang, Nan Zhang, Maoli Zhu, Liang Huang, Jianhong Dong

{"title":"Effects of toric intraocular lens in cataract patients with axial myopia and regular corneal astigmatism at primary hospitals.","authors":"Zhijian Jiang, Nan Zhang, Maoli Zhu, Liang Huang, Jianhong Dong","doi":"10.1007/s10792-025-03530-5","DOIUrl":"https://doi.org/10.1007/s10792-025-03530-5","url":null,"abstract":"Purpose: To explore the long-term clinical efficacy of AcrySof toric intraocular lens (IOL) implantation to correct regular corneal astigmatism in cataract patients with axial myopia at primary hospitals.Methods: A total of 78 cataract patients (78 eyes) with regular corneal astigmatism and axial myopia were enrolled in the retrospective cohort study and were divided into two groups according to axial length (AL) (group 1: 24‒27 mm; group 2: 27‒30 mm). Best-corrected visual acuity (BCVA; in logarithms of the minimum angle of resolution), astigmatism value, and the lens axis deviation (LAD) were determined before and at 3 and 12 months after operation.Results: BCVA (LogMAR) and residual refractive astigmatism (RAS) at 3 and 12 months after IOL implantation were significantly lower than those before implantation in each group (p < 0.05). The differences of LAD at 3 and 12 months between the two groups were not significant (p > 0.05). The proportion of eyes with LAD exceeding 10° at 12 months was significantly lower in group 1 than in group 2 (p = 0.043). AL was closely correlated with LAD (r = 0.360, p = 0.001), and AL (odds ratio 2.527, 95% confidence interval 1.110-5.751) was a significant, independent risk factor for LAD at 12 months.Conclusion: These data suggested that implantation of an AcrySof toric IOL is effective for correcting regular corneal astigmatism in eyes with axial myopia and cataract at primary hospitals. AL was an independent risk factor for toric IOL rotation.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"172"},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adopting machine learning to predict nomogram for small incision lenticule extraction (SMILE). 采用机器学习预测小切口晶状体提取术（SMILE）的形态图。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-05 DOI: 10.1007/s10792-025-03520-7

Pan Liu, Xiaochen Gu, Yexuan Jiao, Xinqi Ye, Yu-Hang Zhou, Xinlin Wang, Yongjin Zhou, Zhengbo Shao

{"title":"Adopting machine learning to predict nomogram for small incision lenticule extraction (SMILE).","authors":"Pan Liu, Xiaochen Gu, Yexuan Jiao, Xinqi Ye, Yu-Hang Zhou, Xinlin Wang, Yongjin Zhou, Zhengbo Shao","doi":"10.1007/s10792-025-03520-7","DOIUrl":"https://doi.org/10.1007/s10792-025-03520-7","url":null,"abstract":"Purpose: To predict nomogram for small incision lenticule extraction (SMILE) using machine learning technology and preoperative clinical data.Methods: A total of 1025 eyes with postoperative spherical equivalent within ± 0.50D after SMILE were included in this study. The XGBoost, gradient boosting regression (GBR), random forest (RF), LightGBM, linear regression (LR) and support vector regression (SVR) were applied to predict the nomogram. The performance of six machine learning methods was assessed by calculating the root mean absolute error (RMSE) and the mean absolute error (MAE). Four junior residents were selected to design the nomogram based on preoperative clinical data in testing set, and were compared with the machine learning models by calculating the accuracy of eyes within three specific thresholds (± 0.05D, ± 0.15D, ± 0.25D).Results: The actual nomogram was not significantly different from the nomogram predicted machine learning methods (P > 0.05). The RMSE of six models ranged from 0.075 to 0.110, and MAE were 0.055 to 0.085 on nomogram prediction. The XGBoost provided significantly higher accuracy within 0.05 to 0.25 D than the SVR and junior residents (McNemar test, P < 0.001). However, there were no statistically significant differences in accuracy within 0.05 to 0.25 D that the XGBoost, GBR, RF, LightGBM, and LR achieved (P > 0.05).Conclusions: Machine learning of the preoperative clinical data could accurately predict nomogram for SMILE. The machine learning methods may assist the refractive surgeons and shorten the learning curve of junior residents while making the nomogram adjustment.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"175"},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and managements of severe corneal ulcers in patients with end-stage glaucoma. 终末期青光眼患者严重角膜溃疡的临床特点和处理。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-05 DOI: 10.1007/s10792-025-03527-0

Yan Li, Xin Zhong, Di Ma

{"title":"Clinical characteristics and managements of severe corneal ulcers in patients with end-stage glaucoma.","authors":"Yan Li, Xin Zhong, Di Ma","doi":"10.1007/s10792-025-03527-0","DOIUrl":"https://doi.org/10.1007/s10792-025-03527-0","url":null,"abstract":"Purpose: To review the clinical characteristics and managements of severe corneal ulcers in patients with end-stage glaucoma.Methods: Retrospectively reviewed the medical records of patients diagnosed with severe corneal ulcers who had a history of end-stage glaucoma, including demographic profiles, medical histories, clinical features, and treatments.Results: Thirty patients (30 eyes) were included. The median age at presentation was 73.00 years (interquartile range [IQR]: 64.25-77.25 years). The majority of patients were previously diagnosed with primary angle-closure glaucoma (11/30, 36.67%). Nineteen patients (63.33%) were still using antiglaucoma medications within 6 months before the onset of corneal ulcer. Visual acuity was already severely impaired in these patients before the onset of corneal ulcer. At last visit before the onset, 20 eyes (66.67%) had intraocular pressure (IOP) greater than 21 mmHg. Corneal perforation occurred in 13 eyes (43.33%). Eleven eyes (36.67%) underwent debridement of corneal ulcer and conjunctival flap covering surgery, while 13 eyes (43.33%) eventually underwent evisceration. Patients without corneal perforation had received a greater variety of surgical or laser treatments in the past compared to those with corneal perforation (P = 0.047). A significantly larger proportion of patients with corneal perforation underwent evisceration (9/13 vs 4/17, P = 0.012).Conclusion: Severe corneal ulcers in patients with end-stage glaucoma were characterized by advanced age, long-term use of topical antiglaucoma medications and poor IOP control. Nearly half of the patients lost their eyes. Active treatment of underlying diseases and careful attention to ocular surface condition are crucial in preventing corneal perforation and improving prognosis.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"173"},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Klebsiella endogenous endophthalmitis treated with initial systemic and intravitreal therapy: a 10-year retrospective cohort study. 最初全身和玻璃体内治疗克雷伯氏菌内源性眼内炎的结果：一项10年回顾性队列研究。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-05 DOI: 10.1007/s10792-025-03518-1

Daniel Ho Tak Wong, Jennifer Chien Hui Hung, Kenneth Kai Wang Li

{"title":"Outcomes of Klebsiella endogenous endophthalmitis treated with initial systemic and intravitreal therapy: a 10-year retrospective cohort study.","authors":"Daniel Ho Tak Wong, Jennifer Chien Hui Hung, Kenneth Kai Wang Li","doi":"10.1007/s10792-025-03518-1","DOIUrl":"https://doi.org/10.1007/s10792-025-03518-1","url":null,"abstract":"Background: Management of endogenous endophthalmitis (EE) is challenging. Klebsiella EE, in particular, carries a guarded prognosis and poor visual outcome. We aimed to test the hypothesis that a certain group of Klebsiella EE would carry a better prognosis when presenting with specific signs, compared to the worse-performing group when treated with initial systemic and intravitreal therapy.Methods: A retrospective cohort study was conducted across two local tertiary hospitals to review all cases of Klebsiella EE from January 2013 to December 2022. Anatomical success was defined by retention of the globe, without intractable retinal detachment or phthisis bulbi. Functional success was defined as achieving a visual acuity of better than 1.3 logMAR.Results: A total of 56 proven cases of EE were identified. 31 subjects (55.4%) had Klebsiella EE. Of those, 31 eyes of 21 subjects met the inclusion criteria. 4 subjects were unconscious or cognitively impaired at initial presentation. The factors that predict a higher chance of successful treatment with systemic antibiotics and intravitreal antibiotics only, in the Klebsiella EE group, were a better visual acuity at presentation, lack of conjunctival injection, absence of corneal edema, hypopyon, panophthalmitis, and the presence of a fundal view (p < 0.02). The probability of overall treatment success was greater than 50% if the initial visual acuity was better than or close to finger counting at one meter (p = 0.006).Conclusion: Universal screening of patients with Klebsiella infection and the identification of earlier EE presentation with these prognostic factors that predict a positive or less severe outcome are crucial for the prompt initiation of treatment within this narrow therapeutic window.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"176"},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of corneal mapping with anterior segment optical coherence tomography in severe obstructive sleep apnea syndrome patients. 重度阻塞性睡眠呼吸暂停综合征患者角膜前段光学相干断层成像分析。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-05 DOI: 10.1007/s10792-025-03553-y

Halil Ibrahim Sonmezoglu, Burcin Cakır, Samet Oncel, Busra Guner Sonmezoglu

{"title":"Analysis of corneal mapping with anterior segment optical coherence tomography in severe obstructive sleep apnea syndrome patients.","authors":"Halil Ibrahim Sonmezoglu, Burcin Cakır, Samet Oncel, Busra Guner Sonmezoglu","doi":"10.1007/s10792-025-03553-y","DOIUrl":"https://doi.org/10.1007/s10792-025-03553-y","url":null,"abstract":"Purpose: We aimed to compare corneal thickness maps and ocular surface parameters with anterior segment optical coherence tomography (AS-OCT) between severe obstructive sleep apnea syndrome (OSAS) patients and healthy controls.Methods: The study included patients with severe OSAS and healthy subjects. Ocular surface parameters (Schirmer, Tear break-up time (TBUT)), Oxford corneal staining score(OCSS), and Ocular surface disease index (OSDI) score were evaluated, and corneal thickness maps (total and epithelial) were obtained by AS-OCT in all participants.Results: The mean ages of the control (n:30) and patient (n:30) groups were 44.80 ± 6.5 and 48.3 ± 8.9 years, respectively (p:0.09). The mean Apnea hypopnea index (AHI) in the patient group was 64.53 ± 21.25, mean body mass index (BMI) was 31.33 ± 3.66. TBUT, Schirmer tests, OCSS and OSDI score were statistically significantly different between the groups (p < 0.001, p:0.037, p < 0.001, p < 0.001, respectively). There was no significant difference between the groups in the parameters in the corneal thickness maps using OCT.Conclusion: Ocular surface parameters may worsen in OSAS. There were no significant differences among groups in corneal epithelial thickness mapping using AS-OCT. Further research is needed to explore the long-term effects of the disease on corneal morphology.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"170"},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification and management of myopic traction maculopathy: a vitrectomy-based consensus from taiwanese experts. 近视牵引性黄斑病变的分类与治疗：台湾专家以玻璃体切除为基础的共识。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-05 DOI: 10.1007/s10792-025-03526-1

Cheng-Yung Lee, Tzyy-Chang Ho, San-Ni Chen, Shih-Jen Chen, Tsung-Tien Wu, Yi-Ting Hsieh, Wei-Chi Wu, Cheng-Kuo Cheng, Pei-Chang Wu, Shu-Chun Kuo, Chung-May Yang

{"title":"Classification and management of myopic traction maculopathy: a vitrectomy-based consensus from taiwanese experts.","authors":"Cheng-Yung Lee, Tzyy-Chang Ho, San-Ni Chen, Shih-Jen Chen, Tsung-Tien Wu, Yi-Ting Hsieh, Wei-Chi Wu, Cheng-Kuo Cheng, Pei-Chang Wu, Shu-Chun Kuo, Chung-May Yang","doi":"10.1007/s10792-025-03526-1","DOIUrl":"https://doi.org/10.1007/s10792-025-03526-1","url":null,"abstract":"Purpose: To develop a vitrectomy-based consensus on the definition, diagnosis, and management of myopic traction maculopathy (MTM).Methods: Relevant literature was initially reviewed. Six key questions and six consensus statements were developed based on reference articles. Ten panelists then voted on the statements for consensus development.Results: MTM was defined as maculoschisis or maculoschisis with foveal disruption, including a lamellar macular hole (LMH), full-thickness macular hole (FTMH), and macular hole with retinal detachment (MHRD). A classification combining the status of maculoschisis and the type of foveal pathology was formulated. MHRD was regarded as the end stage of the MTM. Modern optical coherence tomography images of the macula, standard color fundus photography, periodical axial length measurement, and regular visual function tests with best-corrected visual acuity and Amsler's grid were four essential tools used for the diagnosis and follow-up of MTM. FTMH and MHRD are reliable surgical indications. Surgery may be indicated for maculoschisis, with or without LMH, if visual deterioration is observed. A visual acuity of less than 20/40 was set as the relative empirical requirement for surgery. The panel reached a consensus on the use of fovea-sparing ILM peeling and the inverted ILM flap technique for MTM with various structural changes.Conclusions: The proposed consensus on the six important aspects of the MTM may serve as a valuable reference for clinicians in relevant fields in daily practice.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"174"},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal incision contracture: literature review and report of a novel therapeutic strategy using intrastromal corneal ring segments. 角膜切口挛缩：文献回顾和报告一种新的治疗策略，使用角膜间环段。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-05 DOI: 10.1007/s10792-025-03551-0

Juan J Prados-Carmona, Manuel Arias-Alcalá, Álvaro Prados-Carmona, M Ángeles Herrador-Montiel, María Hernando-Molina, Javier Giménez-Almenara-Amo

{"title":"Corneal incision contracture: literature review and report of a novel therapeutic strategy using intrastromal corneal ring segments.","authors":"Juan J Prados-Carmona, Manuel Arias-Alcalá, Álvaro Prados-Carmona, M Ángeles Herrador-Montiel, María Hernando-Molina, Javier Giménez-Almenara-Amo","doi":"10.1007/s10792-025-03551-0","DOIUrl":"https://doi.org/10.1007/s10792-025-03551-0","url":null,"abstract":"Purpose: This review summarizes key aspects of corneal incision contracture (CIC), also known as wound burn. CIC is a rare complication of phacoemulsification, which can significantly compromise surgical outcomes, leading to delayed healing, suboptimal functional results, and patient dissatisfaction.Methods: A comprehensive literature review was conducted across multiple databases, encompassing full-length studies, case series, and reports. A total of 52 studies were selected, focusing either on the etiopathogenesis and risk factors of CIC or on different treatment strategies.Results: Although preventing CIC remains challenging, key risk factors include excessive ultrasound energy, the use of high-viscosity ophthalmic viscosurgical devices (OVDs), and narrower, longer incisions, particularly in shallow anterior chambers. Additionally, this review highlights therapeutic approaches for managing both the acute and chronic phases of CIC. A critical analysis of previous reports reveals a lack of consensus on management and limited attention to long-term rehabilitation, contributing to suboptimal visual outcomes in the majority of patients. Finally, we propose a novel treatment for the chronic phase of CIC: the implantation of intracorneal ring segments (ICRS), a technique not previously described. This method was successfully applied in a patient with severe CIC-induced astigmatism (> 23 diopters), achieving a plano spherical equivalent and a final visual acuity (VA) of 0.8 decimal (0.1 logMAR). This outcome surpasses those reported in previous literature.Conclusion: This study highlights the significant challenges associated with CIC and introduces a promising therapeutic strategy using ICRS implantation, potentially improving outcomes for these complex cases.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"171"},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of ocular ischemic syndrome in patients with asymptomatic severe internal carotid artery stenosis. 无症状重度颈内动脉狭窄患者眼缺血综合征的发生率。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-03 DOI: 10.1007/s10792-025-03537-y

Yanli Hou, Simeng Tang, Zhaoyang Meng, Yingying Zhao, Jing Li, Hongyang Li, Yanling Wang

{"title":"Incidence of ocular ischemic syndrome in patients with asymptomatic severe internal carotid artery stenosis.","authors":"Yanli Hou, Simeng Tang, Zhaoyang Meng, Yingying Zhao, Jing Li, Hongyang Li, Yanling Wang","doi":"10.1007/s10792-025-03537-y","DOIUrl":"https://doi.org/10.1007/s10792-025-03537-y","url":null,"abstract":"Objectives: To evaluate the incidence of ocular ischemic syndrome (OIS) in patients with asymptomatic Severe Internal Carotid Artery Stenosis or occluded (ipICA-SO).Design and methods: 260 patients with ipICA stenosis ≥ 70%, 120 patients with ipsilateral OIS, and 140 with normal ocular condition. The logistic regression analysis was conducted to establish risk prediction models of OIS/Neovascular-OIS/Chronic-OIS for patients with ipICA-SO. The area under the receiver operating characteristic curve (AUC) was used to test the application value of the prediction models.Results: In ipICA-SO patients, OIS patients showed significantly higher incidence of ipICA occlusion (p < 0.001), plaque unstable (p < 0.001 ipsilateral/contralateral) or plaque located at both the primary and siphon section (p = 0.004 in ipsilateral), contralateral ICA or anterior/middle cerebral artery severe stenosis (p = 0.001, 0.016, 0.040, respectively), and ipsilateral OphAr low /reflux blood flow (p < 0.001). The hypertension was significantly higher in the control group (p = 0.002). The AUC of the prediction model of OIS was 0.834. Diabetes mellitus (DM) and OphAr reflux blood flow are risk factors for Neovascular-OIS. The AUC of Neovascular-OIS was 0.724. Chronic progress is likely in OIS patients with ipICA occlusion and DM. The AUC of Chronic-OIS was 0.673.Conclusions: The ipICA-SO patients without sufficient collateral flow are more likely to develop OIS. IpICA-SO patients with hypertension had a lower risk of developing OIS. Neovascular was commonly found in OIS patients with DM and reversed OphAr blood flow. Chronic OIS was associated with ipICA total occlude and DM.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"161"},"PeriodicalIF":1.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombolytic activity of recombinant tissue-type plasminogen activator (rtPA) in in-vitro model for subretinal hemorrhages. 重组组织型纤溶酶原激活剂（rtPA）在视网膜下出血体外模型中的溶栓活性。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-03 DOI: 10.1007/s10792-025-03545-y

Anne-Cécile Vandebroek, Annekatrin Rickmann, Karl T Boden, Berthold Seitz, Peter Szurman, André Schulz

{"title":"Thrombolytic activity of recombinant tissue-type plasminogen activator (rtPA) in in-vitro model for subretinal hemorrhages.","authors":"Anne-Cécile Vandebroek, Annekatrin Rickmann, Karl T Boden, Berthold Seitz, Peter Szurman, André Schulz","doi":"10.1007/s10792-025-03545-y","DOIUrl":"https://doi.org/10.1007/s10792-025-03545-y","url":null,"abstract":"Purpose: Recombinant tissue-type plasminogen activator (rtPA) has become central to the treatment of subretinal hemorrhages. However, individual results show highly variable and unpredictable efficacy of thrombolytic function. The aim of this study is to investigate the thrombolytic activity of rtPA in an in-vitro model for submacular hemorrhages.Methods: Using UV/Vis spectroscopy, the thrombolytic activity of rtPA was analyzed in an in-vitro model for subretinal hemorrhages with citrated human venous blood from 24 volunteers. The effects of blood clot volume (20 µL and 100 µL) and age (1d and 4d), rtPA concentration (0, 10, 50, 100, 150, and 200 µg/mL), and incubation time (30 min, 1d, and 2d) on thrombolysis was analyzed on blood clots prepared through different synthesis routes (tube vs. hanging droplet).Results: For each period of incubation with rtPA, thrombolysis was significantly reduced for large blood clots with a volume of 100 μL compared with 20 μL blood clots. We found significantly more thrombolysis in 4-day-old clots than in 1-day-old clots after 30 min incubation with rtPA for each blood clot size studied. For each blood clot size and age as well as rtPA incubation time, thrombolysis did not increase linearly across the tested concentrations. Thrombolysis was significantly lower after 30 min than after 1d and 2d rtPA incubations.Conclusion: The effectiveness of thrombolysis with rtPA increases with smaller clot size (20 µL), increasing clot age (4d), and increasing incubation time (1-2d). Within the range of biocompatible rtPA concentrations, there was no concentration effect of rtPA on thrombolysis.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"164"},"PeriodicalIF":1.4,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors affecting the refractive error after cataract surgery. 影响白内障术后屈光不正的因素。

IF 1.4 4区医学

International Ophthalmology Pub Date : 2025-05-03 DOI: 10.1007/s10792-025-03543-0

Dong-Yan Xu, Jing Wang

引用次数: 0