International Ophthalmology最新文献

{"title":"Demographic and topographic findings suggesting poor response to crosslinking-iontophoresis in patients with progressive keratoconus.","authors":"Rosario Touriño-Peralba, Julio Rodríguez-Lago, David Lamas-Francis, Laura Martínez-Pérez, Teresa Rodríguez-Ares","doi":"10.1007/s10792-025-03421-9","DOIUrl":"10.1007/s10792-025-03421-9","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate demographic and tomographical parameters in predicting treatment response following transepithelial iontophoresis-assisted corneal cross-linking (I-CXL) for progressive keratoconus.</p><p><strong>Methods: </strong>Forty eyes (20 aged < 19 years and 20 aged ≥ 19 years) underwent I-CXL treatment between 2016 and 2022. Progression criteria based on the ABCD system, changes in asphericity (Q), demographic factors and keratoconus phenotypes were evaluated. Subjects were followed for 24 months after procedure.</p><p><strong>Results: </strong>Sixty percent of participants were male. The mean age at the time of treatment was 21.0 ± 6.0 years. All tomographical values showed progression after 2 years of follow-up (p < 0.05), particularly during the first 6 months, except for anterior curvature. Within the ABCD grading system, we observed: A) an increase in anterior curvature, more evident with lower initial values; B) an increase in posterior curvature, more pronounced with higher initial values. Two years after I-CXL, 20% of subjects met progression criteria in two or more parameters, with 62.5% being under 19 years of age. Patients with a family history of corneal ectasia exhibited a mean KMax progression of 1.94D ± 1.88, (p = 0.046). Only phenotypes 3 and 4 showed progression. Although patients under 19 years showed greater progression in all tomographical variables at the end of the study, this difference was not statistically significant.</p><p><strong>Conclusion: </strong>Treatment with I-CXL did not stop progression in the variables studied two years after the procedure in an effective manner, especially in patients younger than 19 years. A family history of corneal ectasia and subtype 4 keratoconus predicted a less favourable response to I-CXL.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"69"},"PeriodicalIF":1.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the therapeutic efficacy of low-temperature plasma ablation in treating fungal keratitis caused by various strains.","authors":"Tao Sun, Bo-Wen Zhang, Guo-Fu Wu, Lin Liu, Hong-Yan Song, Pei-Wei Liu, Rui Xiong, Xian Liu","doi":"10.1007/s10792-025-03440-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03440-6","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to assess the therapeutic efficacy of low-temperature plasma ablation (LTP) combined with drug treatment in the treatment of fungal keratitis (FK) caused by various pathogens, thereby establishing a clinical foundation for the use of LTP in treating FK.</p><p><strong>Methods: </strong>A retrospective study was performed, including 76 patients (76 eyes) with FK diagnosed at the Affiliated Eye Hospital of Nanchang University. The patients were categorized into the Fusarium group, Alternaria group, Aspergillus group, and other genus groups based on positive results from biological cultures. Key clinical parameters, including best-corrected visual acuity (BCVA), maximum ulcer lesion diameter, and healing grades, were assessed and compared at baseline (pre-treatment), on postoperative day 3, and at postoperative week 3.</p><p><strong>Results: </strong>The study demonstrated that the BCVA (LogMAR) of all patients revealed no significant differences at postoperative day 3 (F = 2.54, p = 0.063) and week 3 (F = 1.86, p = 0.143). Although BCVA improved to varying degrees compared to preoperative levels, the changes were not statistically significant (p > 0.05). After treatment with LTP combined with pharmacotherapy across all four groups, an average of 53 patients (69.74%) achieved grade I healing, with the group effect being nonsignificant (F = 2.85, p = 0.071), while the effect of time post-treatment was significant (F = 67.85, p < 0.001). Additionally, the corneal scar diameter at postoperative week 3 was significantly smaller compared to the preoperative lesion diameter (p < 0.05). Multiple comparisons revealed significant differences in scar diameter among patients with grade I healing at postoperative week 3 (F = 3.48, p = 0.023), with notable differences observed between the Alternaria and Fusarium groups (p = 0.017). The average rate of grade III healing, defined by the occurrence of corneal perforation and/or the need for therapeutic penetrating keratoplasty, was 7.89%.</p><p><strong>Conclusion: </strong>Low-temperature plasma ablation demonstrates effective therapeutic outcomes for FK caused by various pathogens that are unresponsive to pharmacological treatments, with no significant complications.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"68"},"PeriodicalIF":1.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitreous hemorrhage in patients with uveitis: a comparative study between adults and children.","authors":"Nesrine Abroug, Tarek Dridi, Mootez Mourali, Wijdene Nabi, Imen Ksiaa, Melek Kechida, Sana Khochtali, Bechir Jelliti, Moncef Khairallah","doi":"10.1007/s10792-024-03403-3","DOIUrl":"https://doi.org/10.1007/s10792-024-03403-3","url":null,"abstract":"<p><strong>Purpose: </strong>To compare clinical findings and visual outcomes of vitreous hemorrhage (VH) associated with uveitis in adults versus children.</p><p><strong>Methods: </strong>A retrospective comparative study.</p><p><strong>Results: </strong>There were 36 adults (44 eyes) and 10 children (12 eyes). Median age was 35 years in the adult group and 9.5 years in the pediatric group. VH was the presenting manifestation of the underlying uveitis in 45.7% of patients. VH in the adult group was more frequently associated with vascular sheathing, retinal hemorrhages, and extensive peripheral retinal ischemia on fluorescein angiography (FA), whereas VH in the pediatric group was associated with a significantly lower presenting visual acuity, and more frequently with vitritis and non-occlusive retinal vasculitis with fern-like retinal capillaritis. The most common source of bleeding was ischemia-driven retinal or optic disc neovascularization in the adult group (81.8%, p ≤ 0.001) and inflammation-driven optic disc neovascularization in the pediatric group (66.6%, p ≤ 0.001). A retinal vasoproliferative tumor was the cause of VH in one child (1.8%). Tuberculosis and Behçet's uveitis were the most common etiologies of uveitis in the adult group. Idiopathic intermediate uveitis/pars planitis was the leading cause of VH in the pediatric group. The mean final visual acuity was significantly higher in the pediatric group (20/25) than in the adult group (20/50) (p = 0.045).</p><p><strong>Conclusions: </strong>VH associated with uveitis has a distinctive clinical and etiological profile between adults and children. The main source of bleeding was ischemia-driven neovascularization in adults and inflammation-driven neovascularization in children.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"60"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation of the Standardized Patient Evaluation of Eye Dryness Questionnaire in European Portuguese in a non-clinical sample.","authors":"Eva Ramalho, Ivo Soares, Francisco Miguel Brardo, Amélia Fernandes Nunes","doi":"10.1007/s10792-025-03437-1","DOIUrl":"10.1007/s10792-025-03437-1","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study is to determine the best cut-off value for the Standardized Patient Evaluation of Eye Dryness Portuguese version questionnaire and verify possible differences between the questionnaire score and different age groups.</p><p><strong>Methods: </strong>The clinical validation of the Standardized Patient Evaluation of Eye Dryness Portuguese version was performed by completing this and the Ocular Surface Disease Index in Portuguese version questionnaire, in 180 volunteers (68.9% female), with an age range of 19-96 years.</p><p><strong>Results: </strong>An excellent degree of reliability was found between the Standardized Patient Evaluation of Eye Dryness Portuguese version and the Ocular Surface Disease Index Portuguese version questionnaires (Cronbach's Alpha = 0.824). The Receiver Operating Characteristic curve analysis revealed a cut-off of 8 points (Sensitivity of 71.2% and Specificity of 71%). Furthermore, the area under the curve of the Receiver Operating Characteristic curve was 0.813, indicating that Standardized Patient Evaluation of Eye Dryness Portuguese version questionnaire is a good diagnostic tool and interchangeable with the Ocular Surface Disease Index questionnaire.</p><p><strong>Conclusion: </strong>The Standardized Patient Evaluation of Eye Dryness Portuguese version questionnaire is a reliable tool for the detection of dry eye symptoms in the Portuguese population with a broad age range.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"64"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of peripheral neuropathy with dry eye disease and meibomian gland dysfunction in patients with type 1 diabetes.","authors":"Meryem Altin Ekin, Hazan Gul Kahraman, Emine Deniz Egrilmez, Sehnaz Arici, Guzide Gonca Oruk","doi":"10.1007/s10792-025-03420-w","DOIUrl":"10.1007/s10792-025-03420-w","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the relationship between dry eye disease and type 1 diabetes mellitus (DM) and also to identify whether diabetic peripheral neuropathy (DPN) was a significant predictor for the development of dry eye disease.</p><p><strong>Materials and methods: </strong>This prospective cross sectional study involved patients with type 1 DM and aged- and sex-matched healthy controls. All of the participants underwent dry eye tests including meibomian gland function. Based on neurologic examination and electromyography findings, diabetic patients were grouped as DPN + and DPN-. All findings were compared and predictive factors for dry eye disease were identified.</p><p><strong>Results: </strong>Of the 97 patients with type 1 DM, 42 (43.3%) were diagnosed as DPN. In patients with DM, there was a significant increase in the ocular surface disease index, corneal surface staining, eyelid margin abnormality and meibomian gland dysfunction and a significant decrease in tear break-up time and Schirmer's I test (p < 0.05). Measurements of dry eye tests were more severe with the presence of DPN (p < 0.05). Age of the patients, duration of DM and HbA1c level were significantly correlated with ocular surface and meibomian gland dysfunction parameters (p < 0.05). Age of the patients (p < 0.001), duration of DM (p = 0.001), HbA1c level (p = 0.036) and presence of DPN (p < 0.001) were found to be the independent and significant predictors of dry eye disease.</p><p><strong>Conclusion: </strong>Type 1 DM was found to be significantly associated with ocular surface abnormalities including meibomian gland dysfunction. Furthermore, age of the patients, duration of DM, HbA1c level and presence of DPN were predictive factors of dry eye disease in type 1 DM.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"61"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined pars plana vitrectomy and silicone oil injection for the treatment of acute postoperative infectious endophthalmitis.","authors":"Ahmed Nour Kotb, Ayman Lotfy, Ali Goda Ali, Marwa A Khairy","doi":"10.1007/s10792-025-03425-5","DOIUrl":"https://doi.org/10.1007/s10792-025-03425-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of early pars plana vitrectomy (PPV) and silicone oil (SO) tamponade for treating acute post-phacoemulsification infectious endophthalmitis.</p><p><strong>Methods: </strong>This retrospective study included 44 eyes of 44 patients who developed early endophthalmitis after uneventful phacoemulsification. PPV with SO tamponade was performed within 24 h of presentation.</p><p><strong>Results: </strong>A significant improvement in logMAR visual acuity (VA) was reported in our patients; (2.595 ± 0.249 at baseline compared to 1.052 ± 0.462 at final visit), with P value 0.0001. SO was removed in all cases after 4-9 months (6 ± 1.3) and all patients continued follow-up for at least 6 months after SO removal (15.4 ± 6.5). Postoperative complications included; three eyes (6.8%) developing severe proliferative vitreoretinopathy (PVR), four eyes (9.1%) developing inferior retinal detachment (RD) under SO, Two eyes (4.5%) developing pupillary block glaucoma and two eyes (4.5%) suffered from recurrent RD after SO removal.</p><p><strong>Conclusion: </strong>Early PPV with SO tamponade for the treatment of acute endophthalmitis after phacoemulsification has good visual outcomes and lower complication rates if performed early within 24 h of patient presentation.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"67"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manifestations of persistent pupillary membrane.","authors":"N F Bobrova, T V Romanova, O D Dovhan, N I Molchaniuk","doi":"10.1007/s10792-025-03436-2","DOIUrl":"https://doi.org/10.1007/s10792-025-03436-2","url":null,"abstract":"<p><strong>Purpose: </strong>To study the clinical and structural manifestations of persistent pupillary membranes (PPM) using light and electron microscopy.</p><p><strong>Materials and methods: </strong>This descriptive case series study included 32 children (38 eyes) with different clinical PPM types. The cases were collected between 2005 and 2023. The age of the patients ranged from 7 months to 13 years, with a mean age of 3 ± 2.6 years. All children underwent standard ophthalmological examinations, including biomicroscopy, keratometry, gonioscopy, ophthalmoscopy, tonometry, visometry, ultrasonic biometry, scanning, and photo and video recording. Surgical removal of PPM was performed in 15 children (17 eyes), and the removed PPMs were histologically and electron microscopically studied.</p><p><strong>Results: </strong>The PPMs were of different sizes, configurations, and volumes. The vast majority, 25 children (29 eyes, 76.3%), had type II PPM with iridolenticular attachment (Duke-Elder classification, 1964). Six children (8 eyes, 21.1%) had type I PPMs with iris-to-iris attachment. In one case (one eye, 2.67%), a combination of type I and type II PPM was observed. In the eyes with PPM, microphthalmia and microcornea were observed in 34.2% and 23.7% of cases, respectively. PPM affected the size and configuration of the pupil in 44.76% of cases and the anterior chamber angle structure in 26.3% of cases. The lens remained transparent in 84.2% of the cases. Congenital cataracts were observed in 15.89%. Visual acuity in the eyes with PPM varied from light perception to 0.4 logMAR. In 50.0% of cases, significant visual loss occurred in type II PPM. Histomorphological and electron microscopic studies showed that PPM was the remnant of the tunica vasculosa lentis, had a mesodermal origin, and did not penetrate the anterior lens capsule.</p><p><strong>Conclusion: </strong>For the first time, the clinical features of PPM were analyzed in a significantly large number of cases, and the analysis showed that PPMs with iridolenticular attachment were dominant. They were of different sizes and configurations and had a dense fit to the lens, causing significant visual loss and thus requiring surgical removal. In almost half of the cases, PPM caused pupil narrowing, decentration, and deformation, whereas the crystalline lens remained transparent in most cases (84.2%).</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"63"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of herpetic keratouveitis following cataract surgery.","authors":"Laura E Drew-Bear, Raul E Ruiz-Lozano, Kevin Wang, Alejandro Rodriguez-Garcia, Ashley Behrens, Everardo Hernandez-Quintela","doi":"10.1007/s10792-025-03438-0","DOIUrl":"10.1007/s10792-025-03438-0","url":null,"abstract":"<p><strong>Purpose: </strong>Herpetic eye disease (HED) is a leading cause of infectious vision loss worldwide. Cataract surgery is known to be implicated in triggering the recurrence of herpes keratouveitis. This study evaluates the current evidence on the association between HED and cataract surgery, focusing on the risk factors and potential pathogenic mechanisms and preventive strategies involved with reactivation or new-onset herpes-related keratitis, uveitis, or keratouveitis.</p><p><strong>Methods: </strong>A comprehensive search of databases (Cinahl, Embase, Scopus, ProQuest, Web of Science, and PubMed) was conducted to identify articles describing the association between new onset or reactivation of HED after cataract surgery up to March 2024. A total of 24 studies were included.</p><p><strong>Results: </strong>The heterogeneity of the studies precluded systematic analysis. However, the findings suggest that the herpetic recurrence rate, mainly in the form of keratitis, after cataract surgery is high (approximately 40%), mostly occurring ≤ 2 years after surgery, and can be influenced by factors such as topical corticosteroids, the quiescent time before surgery, and history of prior recurrences, and the patient's comorbidities, including diabetes and atopy. The current evidence for prescribing perioperative HED prophylaxis is of inadequate quality.</p><p><strong>Conclusions: </strong>Available evidence suggests that herpetic recurrences tend to occur in the first two years after cataract surgery. A longer quiescent time before surgery might reduce the risk of recurrence. Prospective studies analyzing the effects of perioperative prophylaxis are needed.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"65"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal transplant awareness in medical students by grade and the effect of subject-specific education on this awareness level.","authors":"Anil Kaplan, Atanur Ayas, Alperen Bilen, Aysegul Colak, Timur Köse, Ozlem Barut Selver","doi":"10.1007/s10792-025-03424-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03424-6","url":null,"abstract":"<p><strong>Purpose: </strong>Corneal transplantation is the most commonly performed transplant surgery. Medical students, doctors of the future, will educate the public about organ transplantation and raise public awareness on this issue. The first aim of this study is to evaluate the initial awareness of medical students about corneal transplantation, then to provide training to these students and finally to evaluate the change in their knowledge on this subject.</p><p><strong>Method: </strong>310 medical students from Ege University were asked to participate in a 20-question survey. Later, they were given education by a corneal transplant specialist. Immediately after the lessons, the survey was reapplied.</p><p><strong>Results: </strong>The number of students who said they had knowledge about corneal transplantation before the training was 25.5% (n = 79). The knowledge level of 1st grades was lower than the 5th and 6th grades. Final-test scores were significantly higher than pre-test scores in each year group (p < 0.001). The final-test scores were significantly higher than the pre-test scores in both groups, who said they had knowledge about corneal transplantation and who said they did not.</p><p><strong>Conclusion: </strong>Physicians' attitudes toward organ transplantation play a crucial role in influencing the public interest in organ donation. In addition, the physicians' level of knowledge about organ and tissue transplantation is the main determinant of their attitudes via answering the questions and clarifying the worries of the society. This article showed the level of knowledge about corneal transplantation does not increase linearly as the medical school year progresses. In addition, regardless of the initial level of knowledge, the education on corneal transplantation will increase the knowledge level of every student from the 1st grade to the 6th grade.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"62"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence with ChatGPT 4: a large language model in support of ocular oncology cases.","authors":"Federico Giannuzzi, Matteo Mario Carlà, Lorenzo Hu, Valentina Cestrone, Carmela Grazia Caputo, Maria Grazia Sammarco, Gustavo Savino, Stanislao Rizzo, Maria Antonietta Blasi, Monica Maria Pagliara","doi":"10.1007/s10792-024-03399-w","DOIUrl":"10.1007/s10792-024-03399-w","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate ChatGPT's ability to analyze comprehensive case descriptions of patients with uveal melanoma and provide recommendations for the most appropriate management.</p><p><strong>Design: </strong>Retrospective analysis of ocular oncology patients' medical records.</p><p><strong>Subjects: </strong>Forty patients treated for uveal melanoma between May 2019 and October 2023.</p><p><strong>Methods: </strong>We uploaded each case description into the ChatGPT interface (version 4.0) and asked the model to provide realistic treatment options by asking the question, \"What type of treatment do you recommend?\" The accuracy of decisions produced by ChatGPT was compared to those recorded in patients' files and the treatment recommendations provided by three ocular oncologists, each with more than 10 years of experience.</p><p><strong>Main outcome measures: </strong>The primary objective of this research was to assess the accuracy of ChatGPT replies in ocular oncology cases, analyzing its competence in both straightforward and intricate situations. Our secondary purpose was to assess the concordance between the responses of ChatGPT and those of ocular oncology specialists when faced with analogous clinical scenarios.</p><p><strong>Results: </strong>ChatGPT's surgical choices matched those in patients' files in 55% of cases (22 out of 40). ChatGPT options were agreed upon by 50%, 55%, and 57% of the three ocular oncology specialists. The investigation revealed significant differences between ChatGPT's responses and those of the three cancer specialists when compared to patients' files (p = 0.003, p = 0.001, and p = 0.001). ChatGPT's surgical responses matched with patient data in 18 out of 24 cases (75%), excluding enucleation cases. The decisions matched with the three ocular oncology specialists in 17/24, 18/24, and 18/24 cases, reflecting agreements of 70%, 75%, and 75%, respectively. The decisions made by ChatGPT were not significantly different from those of the three professionals in this cohort (p = 0.50, p = 0.36, and p = 0.36 for ChatGPT compared to specialists 1, 2, and 3).</p><p><strong>Conclusion: </strong>ChatGPT exhibited a level of proficiency that was comparable to that of trained ocular oncology specialists. However, it exhibited its limitations when evaluating more complex scenarios, such as extrascleral extension or infiltration of the optic nerve, when a comprehensive evaluation of the patient is therefore necessary.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"59"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}