International Ophthalmology最新文献

{"title":"Clinical and histologic characterization of vitamin A deficiency in children undergoing penetrating keratoplasty.","authors":"Dara R Baker, Dilip Kumar Misra, Divya Sree Ramya Achanta, Deepak Paul Edward, Muralidhar Ramappa","doi":"10.1007/s10792-025-03703-2","DOIUrl":"https://doi.org/10.1007/s10792-025-03703-2","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the spectrum of clinical and histologic findings in a large cohort of children in India with anterior segment findings associated with vitamin A deficiency (VAD). This study presents the clinical findings of children with VAD who underwent penetrating keratoplasty (PK) and examines the histological features of corneal buttons.</p><p><strong>Methods: </strong>This retrospective review identified children with VAD who underwent penetrating keratoplasty at a tertiary eye care center in India. The study analyzed demographics, inciting factors, and clinical and pathological corneal findings.</p><p><strong>Results: </strong>A total of 41 eyes from 21 children (median age 2.78 years) with documented VAD were identified from an institutional database. Clinically, 25 out of 41 eyes (60%) presented with corneal opacity and adherent leucoma, 7 eyes (16.7%) had corneal perforation or infiltrate with shallow anterior chamber and iris prolapse, 5 eyes (12%) showed anterior staphyloma, 3 eyes (7.1%) were phthisical, and 1 eye (2.4%) had a pseudo-cornea. Histologically, 15 out of 22 corneas that underwent PK displayed severe stromal scarring and neovascularization (100%), with surface keratinization observed in 2 cases (13.3%), focal epithelial down growth in 2 cases (13.3%), epithelial hyperplasia in 1 case (6.7%), and band keratopathy in 1 case (6.7%). At a median follow-up of 0.35 years (IQR 0.09-2.5), 12 of 22 eyes (54%) had a clear graft.</p><p><strong>Conclusions: </strong>These findings indicate that children with VAD who underwent keratoplasty at a tertiary eye institute showed clinical and histologic signs of long-standing, severe, and irreversible corneal damage. Corneal surgery for VAD-related morbidity generally had poor long-term outcomes.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"331"},"PeriodicalIF":1.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 pandemic on the incidence and recurrence of central serous chorioretinopathy in Greece: a multicenter study.","authors":"Alexandros Rouvas, Ioannis Datseris, Ilias Georgalas, Miltiadis Tsilimbaris, Paris Tranos, Panagiotis Theodosiadis, Malvina-Efthimia Tzanidaki, Marina Kardara, Konstantinos Tyrlis, Dimitrios Spyropoulos, Rafaela Datseri, Anastasios Stavrakakis, Marianna Tranou, Pavlina Kazantzidou, Nikolaos Gouliopoulos","doi":"10.1007/s10792-025-03704-1","DOIUrl":"10.1007/s10792-025-03704-1","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the impact of the COVID-19 pandemic on the incidence and recurrence of central serous chorioretinopathy (CSCR) in Greece, analyzing data from 2017 to 2023.</p><p><strong>Methods: </strong>A retrospective, observational, cross-sectional study was conducted, including patients diagnosed with either new-onset or recurrent CSCR at five ophthalmology departments in Greece from January 2017 to December 2023. Data were categorized into \"pre-COVID\" (2017-2019) and \"COVID\" (2021-2023) periods, excluding cases from 2020 due to lockdown restrictions. Patient demographics, disease recurrence, and COVID-19 infection history were recorded. Statistical analyses included chi-square tests, Spearman's rank correlation, and Student's t-test.</p><p><strong>Results: </strong>A total of 730 CSCR cases were analyzed (435 new-onset, 295 recurrent). The participants' mean age was 46.8 ± 7.5 years. The overall number of cases significantly increased during the COVID-19 period (462 cases) compared to the pre-COVID period (268 cases) (p < 0.001). Both new-onset (164 vs. 271, p < 0.001) and recurrent cases (104 vs. 191, p < 0.001) showed a significant rise. Among patients from 2021 to 2023, those with a confirmed COVID-19 infection had significantly higher CSCR rates compared to non-infected individuals (p < 0.001).</p><p><strong>Conclusion: </strong>The COVID-19 pandemic was associated with a significant increase in CSCR incidence and recurrence in Greece. This rise may be attributed to heightened psychological stress and endogenous cortisol elevation during the pandemic, as well as direct viral effects and corticosteroid use in infected patients. Further studies are needed to explore underlying mechanisms and long-term consequences.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"329"},"PeriodicalIF":1.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of cataract surgery in patients with previous corneal transplantation for keratoconus: comparison of PK and DALK.","authors":"Kia Bayat, Mohammad Ali Javadi, Sepehr Feizi, Ghazal Izadi-Jorshari, Parisa Pooyan","doi":"10.1007/s10792-025-03705-0","DOIUrl":"https://doi.org/10.1007/s10792-025-03705-0","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the visual and refractive outcomes of cataract surgery in patients with previous deep anterior lamellar keratoplasty (DALK) or penetrating keratoplasty (PK) performed for keratoconus.</p><p><strong>Methods: </strong>This cross-sectional study evaluated patients with a history of corneal transplantation who underwent cataract surgery. Corrected distance visual acuity (CDVA) and manifest refraction were assessed postoperatively. Pre- and postoperative outcomes were compared using paired t-tests and Wilcoxon signed-rank tests, while intergroup (PK vs. DALK) differences were analyzed using independent t-tests and Mann-Whitney U tests. Finally, multivariable linear regression analysis was performed to adjust for potential confounding variables.</p><p><strong>Results: </strong>A total of 24 eyes from 24 keratoconus-affected patients were included, comprising 12 patients in each of the DALK and PK groups. Following cataract surgery, CDVA, spherical refractive error, and spherical equivalent (SE) showed significant improvement (p = 0.023, < 0.001, and < 0.001, respectively), while cylindrical refractive error remained unchanged (p = 0.943). Patients in the DALK group demonstrated better CDVA compared to those in the PK group (p = 0.028), a difference that remained significant after adjusting for confounders (p = 0.004). However, refractive outcomes, including spherical refractive error, cylindrical refractive error, and SE did not differ between the two groups (p = 0.127, 0.247 and 0.347, respectively). Graft survival was excellent in both groups at final follow-up.</p><p><strong>Conclusion: </strong>Although the sample size is small, the results of this study show that cataract surgery yields favorable visual and refractive outcomes in post-keratoplasty patients, with superior results observed in DALK cases compared to PK.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"330"},"PeriodicalIF":1.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aqueous humor cytokine profile in insufficient responder to aflibercept for neovascular age-related macular degeneration.","authors":"Ryo Terao, Ryo Obata, Atsushi Okubo, Shuichiro Aoki, Keiko Azuma, Satoru Inoda, Yuto Hashimoto, Hana Yoshida, Manami Misawa, Hironori Takahashi, Hidenori Takahashi","doi":"10.1007/s10792-025-03678-0","DOIUrl":"https://doi.org/10.1007/s10792-025-03678-0","url":null,"abstract":"<p><strong>Purpose: </strong>To identify cytokines associated with insufficient response to aflibercept against neovascular age-related macular degeneration.</p><p><strong>Methods: </strong>This prospective, comparative control study enrolled 40 eyes of 40 patients with nAMD. Aqueous humor (AH) samples were collected at the baseline before the intravitreal administration of aflibercept. The patients were further classified into responder and non-responder groups based on the clinical course. Patients were classified as \"responders\" if they required three or fewer additional injections after the three initial monthly loading doses within one year, and as non-responders, if they required four or more injections after the initial three-monthly loading doses or were switched to alternative anti-VEGF agents or treatments such as photodynamic therapy. The concentration of Angiopoietin 1, angiopoietin like 4 (ANGPTL4), interferon gamma-induced protein 10, hepatocyte growth factor, interleukin 10, platelet derived growth factor BB, plasminogen activator inhibitor 1 (PAI1), vascular endothelial growth factor A, angiopoietin 2, monocyte chemotactic protein 1, IL8, IL12, platelet-derived growth factor (PlGF), and vascular cell adhesion molecule 1 in AH samples were analyzed using a multiplex immunoassay, in order to compare between responders and non-responders.</p><p><strong>Results: </strong>21 eyes were defined as responders, and 19 eyes were defined as non-responders. There were no significant differences in baseline characteristics. Multiple variate analysis using logistic regression analysis found that PAI1 (p = 0.023, coefficient = 0.025), PlGF (p = 0.016, coefficient = - 1.4), and ANGPTL4 (p = 0.032, coefficient = - 0.00070) at the baseline were significantly associated with the resistance to aflibercept.</p><p><strong>Conclusion: </strong>Baseline higher PAI1 and lower PlGF and ANGPTL4 were associated with insufficient response to aflibercept in 1 year. These cytokines can potentially predict the treatment effect against nAMD.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"326"},"PeriodicalIF":1.4,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-24-3p mediates Keap1/Nrf2 axis to promote autophagy and thereby inhibit lens epithelial cell early senescence.","authors":"Fang Hou, Xuya An, Yaping Zhao","doi":"10.1007/s10792-025-03701-4","DOIUrl":"https://doi.org/10.1007/s10792-025-03701-4","url":null,"abstract":"<p><strong>Background: </strong>microRNA-24-3p (miR-24-3p) has been identified as a diagnostic biomarker for age-related cataracts (ARC) and is implicated in the apoptosis of lens epithelial cells (LECs). However, its role in LECs senescence and the underlying regulatory mechanisms remain poorly understood. In this study, we investigated the functional involvement of miR-24-3p in ARC pathogenesis and elucidated its molecular mechanisms.</p><p><strong>Methods: </strong>Thirty specimens of lens anterior capsule tissues were collected from patients diagnosed with ARC to assess miR-24-3p expression. Autophagic vesicles in LECs were visualized using monodansylcadaverine (MDC) staining, while cellular senescence was evaluated via senescence-associated β-galactosidase (SA-β-gal) staining.</p><p><strong>Results: </strong>Reverse transcription quantitative polymerase chain reaction (RT-qPCR) revealed significant downregulation of miR-24-3p in LECs of ARC patients, which exhibited an inverse correlation with senescence. The direct targeting interaction between miR-24-3p and the 3'-UTR region of Keap1 mRNA was confirmed using a dual-luciferase reporter assay. Mechanistically, miR-24-3p was demonstrated to activate autophagic flux through modulation of the kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 (Keap1/Nrf2) signaling axis. Functional studies showed that miR-24-3p overexpression suppressed Keap1 protein levels while enhancing nuclear translocation of Nrf2. Notably, the anti-senescence effect of miR-24-3p was abolished following Nrf2 knockdown or pharmacological autophagy inhibition with 3-methyladenine (3-MA).</p><p><strong>Conclusions: </strong>A novel miR-24-3p/Keap1/Nrf2 signaling axis implicated in the senescence of LECs. miR-24-3p may be a promising therapeutic target for cataract intervention.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"327"},"PeriodicalIF":1.4,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gonioscopy-assisted transluminal trabeculotomy for intractable ocular hypertension after repeated intravitreal dexamethasone implant injections.","authors":"Rukiye Kilic Ucgul, Ahmet Ozan Olgun, Zeynep Beyza Akdeniz, Pınar Inan, Zeynep Aktas, Ahmet Yucel Ucgul","doi":"10.1007/s10792-025-03698-w","DOIUrl":"https://doi.org/10.1007/s10792-025-03698-w","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) in managing intractable ocular hypertension (OHT) following repeated intravitreal dexamethasone implant (DI) injections.</p><p><strong>Methods: </strong>This retrospective study included patients with steroid-induced OHT unresponsive to maximum tolerated medical therapy who underwent GATT. Primary outcome measures were intraocular pressure (IOP) reduction and surgical success (qualified and complete), number of DI injections.</p><p><strong>Results: </strong>Fourteen eyes of 14 patients (mean age: 66.2 ± 8.3 years) with steroid-induced OHT following repeated DI injections were analyzed. The mean number of DI injections before surgery was 4.2 ± 1.1 over a median period of 18.4 months (range: 12-36 months). The mean preoperative IOP was 33.6 ± 4.1 mmHg, which significantly decreased to 13.5 ± 2.9 mmHg at the first postoperative month (59.8% reduction, p < 0.001) and remained stable at 14.2 ± 3.1 mmHg at final visit. Qualified success was achieved in 100% of cases, while complete success was 71.4%. The mean number of glaucoma medications decreased from 3.1 ± 0.4 preoperatively to 0.4 ± 0.8 postoperatively.</p><p><strong>Conclusion: </strong>GATT is a highly effective surgical option for treating intractable steroid-induced OHT following repeated DI injections, achieving significant and sustained IOP reduction while minimizing medication dependence.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"325"},"PeriodicalIF":1.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and classification framework of polypoidal choroidal vasculopathy in Saudi populations.","authors":"Wael A Alsakran, Adhwa Abdullah Alsadoon, Bena Alsayed, Moustafa S Magliyah, Hani Basher ALBalawi","doi":"10.1007/s10792-025-03685-1","DOIUrl":"https://doi.org/10.1007/s10792-025-03685-1","url":null,"abstract":"<p><strong>Introduction: </strong>The Changes in visual acuity(VA) can be caused by polypoidal choroidal vasculopathy(PCV), a subtype of macular neovascularization which is characterized by the formation of polyp-like structures under the retinal pigment epithelium. PCV has been commonly found concurrent with the neovascular age-related macular degeneration (nAMD), which has led to the debate regarding whether, it should be viewed as an independent entity or as a subset of nAMD. The insight into the clinical features of PCV and its therapeutic response such as understanding the prognosis of this disease is very crucial for management and better outcomes. This study aims to differentiate the different types of PCV, and assess its clinical features, disease progression, and treatment options available for Saudi patients and also examine the effectiveness of different treatment modalities.</p><p><strong>Materials and methods: </strong>A retrospective study was conducted in Saudi Arabia among 39 PCV diagnosed patients, using multimodal imaging technique for assessment such as fundus imaging, OCT and ICGA. Patients were classified into three subtypes: age-related macular degeneration-associated PCV(PCV-AMD, Type A), a group with posterior-capsule-vitreous neovascularization-associated PCV (PCV-BVN, Type B), and idiopathic PCV (Type C). The treatment options available were photodynamic therapy(PDT), thermal laser therapy and anti-vascular endothelial growth factor (anti-VEGF) therapy. The clinical and visual outcomes were evaluated at the end of 1 year. SPSS version 23 was used to conduct statistical analysis, including chi-square, ANOVA and Kruskal-Wallis tests (p < 0.05).</p><p><strong>Results: </strong>PCV-AMD was the most common subtype(75.7%), followed by PCV-BVN (13.5%) and idiopathic PCV (10.8%). The median age was 68 years, with idiopathic PCV patients being significantly younger (p = 0.012). Most lesions were macular (94.6%) with peaked/dome-shaped RPE elevations (94.6%). Anti-VEGF therapy was administered in 94.6% of cases, with aflibercept usage differing significantly across subtypes (p = 0.018). Complete lesion resolution was achieved in 45.9%, with PCV-BVN showing the highest resolution rate (80%) and idiopathic PCV the lowest at(0%).</p><p><strong>Conclusion: </strong>PCV is predominantly presents as a variant of nAMD, with significant differences in subtype characteristics and treatment response. While anti-VEGF therapy remains the mainstay of treatment, idiopathic PCV appears more refractory, necessitating the individualized therapeutic strategies. Additional future studies are required to enhance management strategies for this condition.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"323"},"PeriodicalIF":1.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal image-based disease classification using hybrid deep architecture with improved image features.","authors":"L B Lisha, Sylaja Vallee Narayan S R","doi":"10.1007/s10792-025-03660-w","DOIUrl":"https://doi.org/10.1007/s10792-025-03660-w","url":null,"abstract":"<p><strong>Objective: </strong>Ophthalmologists use retinal fundus imaging as a useful tool to diagnose retinal issues. Recently, research on machine learning has concentrated on disease diagnosis. However, disease detection is less accurate, more likely to be misidentified, and often takes a long time to get the right conclusions. This study suggested a new hybrid Deep Learning (DL) approach for retinal illness classification using retinal images to overcome these problems. Three crucial stages are included in this proposed study: preprocessing, feature extraction, and disease classification.</p><p><strong>Methods: </strong>At first, the retinal images are preprocessed using the Modified Gaussian Filtering technique to enhance the quality of the image. Subsequently, ResNet, VGG16-based feature descriptors are applied to the preprocessed image along with Improved Multi-Texton features, and statistical features are derived to obtain the most pertinent characteristics and minimize the dimensionality to boost the performance of the model. Then, these obtained features are employed in the hybrid classification model, which is a combination of an Improved LinkNet (ILinkNet) and SqueezeNet models. These models independently process the features for effective classification of disease. Lastly, the final classification results are obtained by averaging the outcomes of both classifiers.</p><p><strong>Results: </strong>Additionally, the efficiency of the proposed ILink-SqNet model is assessed in comparison to the current techniques. As a result, the ILink-SqNet model achieved a precision of 0.951, which surpasses the result of MobileNet (0.846), SpinalNet (0.821), CNN-Trans (0.836), and LinkNet (0.859), SqueezeNet (0.794) and Fundus-DeepNet (0.762) respectively.</p><p><strong>Conclusion: </strong>Therefore, the suggested ILink-SqNet method provides a robust and effective solution for disease classification, ultimately contributing to better patient outcomes and more efficient clinical practices.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"324"},"PeriodicalIF":1.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capacity of health facilities to diagnose and manage keratoconus: a Kilimanjaro region case study.","authors":"Focus P Maro, Vanessa R Moodley","doi":"10.1007/s10792-025-03653-9","DOIUrl":"10.1007/s10792-025-03653-9","url":null,"abstract":"<p><strong>Introduction: </strong>Keratoconus (KC), is a corneal disease that causes visual impairment, which diminishes thequality of life (QoL) of affected individuals. Although most eye care practitioners in Tanzania anecdotally report a significant number of patients presenting with KC symptoms,little is known on how KC is managed at differentlevels of the healthcare system.</p><p><strong>Purpose: </strong>To conduct a survey to assess health facility capacity and optometrists' capability to diagnose and manage KC in Kilimanjaro region, Tanzania.</p><p><strong>Methods: </strong>A mixed-method, cross-sectional study was conducted. Health facilities providing eye care services and their employed optometristswere purposivelyselected. TheWHO Service Availability and Readiness Assessment (SARA) tool was applied to obtain eye health care service delivery data and in-depth interviews were conducted to investigate optometrists' knowledge on the diagnosis and management modalities of KC at their respective facilities.</p><p><strong>Results: </strong>Nine multi-level health facilitieswere included in the SARA assessment.The majority of SARA respondents were female (56%) and ten optometrists participated in in-depth interviews. Only 44% of facilities were both ready to provide and had KC services available. Although all optometrists reported being aware of KC, some did not know how to comprehensively diagnose and manage KC. Barriers to optimal patient care were a lack of equipment and supplies and no practitioner training on KC.</p><p><strong>Conclusion: </strong>Findings indicate a lack of KC service availability and/or inadequate service readiness in the majority of health facilities in Kilimanjaro. Recommended remedies include general KC advocacy and a health leadership intervention to remedy reported facility and human resource deficiencies towards improved KC patient care.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"322"},"PeriodicalIF":1.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Long non-coding RNA nuclear paraspeckle assembly transcript 1 downregulation protects lens epithelial cells from oxidative stress-induced apoptosis by regulating the microRNA-124-3p/death-associated protein kinase 1 axis in age-related cataract.","authors":"Xuanni Guo, Chunyan Li, Yongbin Wang, Chunhui Jiang, Li Yang","doi":"10.1007/s10792-025-03697-x","DOIUrl":"https://doi.org/10.1007/s10792-025-03697-x","url":null,"abstract":"","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"321"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}