International Ophthalmology最新文献

{"title":"Capsule network-based deep learning for early and accurate diabetic retinopathy detection.","authors":"I Govindharaj, R Rampriya, G Michael, S Yazhinian, K Dinesh Kumar, R Anandh","doi":"10.1007/s10792-024-03391-4","DOIUrl":"https://doi.org/10.1007/s10792-024-03391-4","url":null,"abstract":"<p><p>Glaucoma, an optic nerve disease resulting in blindness if left untreated, is a difficult condition in healthcare in view of its diagnostic difficulties. Past approaches are based on assessment of the fundus images and the size of the cup and the disc, thickness of the rim and other abnormalities present in the eyes. Multifaceted developing AI prospects have potential to improve glaucoma identification. This research aims at implementing the best of feature learning on UNet +  + and Capsule Network (CapsNet) for better diagnostic results. For semantic segmentation, UNet +  + is used to accurately outline ODs and OCs-significant features in glaucoma diagnosis. CapsNet further performs this by capturing hierarchical structures and proves to be more sensitive towards the glaucomatous changes than the conventional Convolutional Neural Networks. To get improved image quality and features, a standard pre-processing method, such as Histogram Equalization and Contrast Limited Adaptive Histogram Equalization (CLAHE), are used in this paper to preprocess retinal images. The proposed hybrid model is then trained and tested on ten benchmark sets and achieves high accuracy in optic disc and cup segmentation and better performance in glaucoma detection than other presented approaches. Performance evaluation suggests good diagnostic ability which opens up the possibility of an automated system that helps clinicians diagnose early glaucoma. This application of UNet +  + and CapsNet shows the current possibility of glaucoma diagnosis using a new and more efficient method and a relatively small but powerful potential to prevent blindness by diagnosing glaucoma at an early stage. However, the study notes that the application of AI has revolutionized ophthalmic health care.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"78"},"PeriodicalIF":1.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between Scheimpflug-Placido topographer (Sirius^®) and anterior-segment swept-source optical coherence tomography (ANTERİON^®) devices for corneal high order aberrations in keratoconic and healthy eyes.","authors":"Furkan Ozer, Metin Unlu, Kubra Erdogan, Kuddusi Erkilic","doi":"10.1007/s10792-025-03434-4","DOIUrl":"https://doi.org/10.1007/s10792-025-03434-4","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the Scheimpflug-Placido Topographer (SP-T; Sirius^®) and anterior-segment Swept-Source Optical Coherence Tomography (asSS-OCT; ANTERİON^®) for high order corneal aberrations in healthy subjects and patients diagnosed with stage 1 and 2 keratoconus.</p><p><strong>Methods: </strong>The 125 eyes of 125 patients were included in the study and were divided into four groups based on their stage of keratoconus (KC) and the presence or absence of corneal cross-linking (CXL). The first group (KC1 group, n = 33) consisted of patients with stage 1 KC who underwent CXL, while the second group (ncKC1 group, n = 33) comprised patients with stage 1 KC who did not receive CXL. The third group (KC2 group, n = 26) included patients with stage 2 KC who underwent CXL, and the final group (control group, n = 33) consisted of healthy subjects. Root mean square (RMS) HOA (High-order aberration), horizontal trefoil (TrA), spherical aberration (SpA) and horizontal coma were compared between the SP-T and asSS-OCT to determine differences and agreement.</p><p><strong>Results: </strong>A notable difference was observed between the devices in the control group for RMS HOA, horizontal TrA, and coma (p = 0.001, p = 0.026 and p < 0.001, respectively). In the KC1 group, a proportional bias was identified with regard to horizontal coma and RMS HOA (p = 0.025 and p = 0.043). For SpA, a proportional and fixed bias was observed in both the ncKC1 and control groups.</p><p><strong>Conclusions: </strong>In the KC2 group, all parameters were in agreement, proving interchangeability between the SP-T and asSS-OCT devices. However, horizontal coma and HOA in KC1, as well as SpA in the control and ncKC1 groups, did not demonstrate this agreement. The interchangeability between devices may change according to the KC stage or CXL status.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"75"},"PeriodicalIF":1.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the immunological underpinnings of allergic conjunctivitis: the role of CD4 + T Cells and SLAM expression in ocular surface disease.","authors":"Xinyan Dou, Wei Zhang, Xi Zhang","doi":"10.1007/s10792-025-03443-3","DOIUrl":"https://doi.org/10.1007/s10792-025-03443-3","url":null,"abstract":"<p><strong>Background: </strong>Allergic conjunctivitis is a common ocular disease characterized by inflammation of the conjunctiva, often associated with environmental allergens. CD4 + T cells and signal lymphocyte activation molecule (SLAM) expression has been implicated in the pathogenesis of allergic conjunctivitis, but their roles and interactions remain unclear.</p><p><strong>Methods: </strong>This prospective cross-sectional observational study enrolled 100 participants, 50 with allergic conjunctivitis and 50 healthy controls, to investigate the relationship between peripheral blood CD4 + T cells, SLAM expression, and allergic conjunctivitis. Participants were evaluated using the Aston university allergy questionnaire (AUAQ), ocular surface disease index (OSDI), and dry eye questionnaire (DEQ-5). Peripheral blood mononuclear cells were isolated and analyzed for SLAM expression on CD4 + T cells using flow cytometry. Total serum IgE levels were measured using ELISA.</p><p><strong>Results: </strong>The allergic group demonstrated significantly higher AUAQ, OSDI, and DEQ-5 scores compared to the control group, indicating a more severe allergic and ocular surface disease burden. Flow cytometry analysis revealed a significant increase in SLAM expression on CD4 + T cells in the allergic group (22.6% ± 5.3%) compared to the control group (15.2% ± 4.7%) (p < 0.001). Total serum IgE levels were also significantly higher in the allergic group (255.3 ± 131.2 IU/mL) compared to the control group (36.7 ± 19.8 IU/mL) (p < 0.001). Spearman's rank correlation analysis indicated significant correlations between AUAQ and OSDI scores (R = 0.38, p < 0.001), and between TBUT and OSDI scores (R = 0.21, p = 0.008), suggesting that reduced tear film stability is associated with more severe ocular surface symptoms.</p><p><strong>Conclusion: </strong>The study findings suggest a significant association between allergic symptoms, ocular surface disease, and immunological markers in individuals with allergic conjunctivitis. The increased SLAM expression on CD4 + T cells and elevated total serum IgE levels in the allergic group may play a pivotal role in the pathophysiology of allergic conjunctivitis. These insights could inform the development of targeted therapies that address both the allergic and ocular surface components of the disease, potentially improving management and outcomes for patients with allergic conjunctivitis.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"77"},"PeriodicalIF":1.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reabsorption of vitreomacular traction syndrome-related acquired vitelliform lesions after pars plana vitrectomy.","authors":"Zeynep Eylul Ercan, Rengin Aslıhan Kurt, Caner Ozturk, Sezin Akca Bayar, Imren Akkoyun, Gursel Yılmaz","doi":"10.1007/s10792-025-03451-3","DOIUrl":"https://doi.org/10.1007/s10792-025-03451-3","url":null,"abstract":"<p><strong>Purpose: </strong>Acquired vitelliform lesions are mainly progressive retinal pigment epithelium alterations and lipofuscin accumulation in the macular region. They may occur due to many different etiologies including vitreoretinal interface disorders. While vitreomacular traction can cause vitelliform lesions, the lesions then may also cause photoreceptor atrophy. We aimed to demonstrate the reabsorption of acquired vitelliform lesions after 25-gauge pars plana vitrectomy to treat patients with vitreomacular traction syndrome.</p><p><strong>Methods: </strong>Nine eyes of eight patients, who were diagnosed with vitreomacular traction syndrome accompanied by acquired vitelliform lesions, were included in this institutional study. Patients with symptoms such as metamorphopsia, distorted vision of any kind or a decrease in visual acuity underwent 3-port 25-gauge pars plana vitrectomy and internal limiting membrane peeling with air or sulphur hexafluoride used as the endotamponade agent. During each preoperative and postoperative visit, the patients underwent a detailed ophthalmological examination. The differences in the median best-corrected visual acuity (BCVA) between the preoperative, postoperative second week, first,third and sixth months, first year and last follow-up were statistically compared using the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>The median (interquartile range IQR) preoperative BCVA was 0.40 0.30-0.45 LogMAR. During the second postoperative week, when intravitreal gas reabsorption occurred, the size of the vitelliform deposits decreased, and a median BCVA of 0.30 0.20-0.35 LogMAR was observed (p = 0.014). During the first month control vitelliform lesions were completely reabsorbed, and the BCVA was 0.20 0.15-0.35 LogMAR (p = 0.016).</p><p><strong>Conclusion: </strong>The presence of vitelliform lesions alongside vitreoretinal interface problems may indicate the need for early surgical intervention to address potential photoreceptor damage due to additive photoreceptor stress results of traction and deposit accumulation.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"76"},"PeriodicalIF":1.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of anterior segment optical coherence tomography in post-cataract surgery Descemet membrane detachment.","authors":"Francesco Ruggeri, Daria Rullo, Elisa Maugliani, Nicola Trotta, Chiara Ciancimino, Mariachiara Di Pippo, Fabio Guglielmelli, Solmaz Abdolrahimzadeh","doi":"10.1007/s10792-024-03397-y","DOIUrl":"10.1007/s10792-024-03397-y","url":null,"abstract":"<p><p>This review seeks to evaluate anterior segment optical coherence tomography (AS-OCT) in the diagnostic procedure and management of Descemet's membrane detachment (DMD) in cataract surgery. DMD may present diagnostic challenges, particularly in pronounced corneal edema where traditional methods such as slit lamp biomicroscopy may be inadequate in evaluating the corneal layers. The role of AS-OCT in providing high-resolution images in the preoperative, intraoperative, and postoperative phases of cataract surgery is analyzed with a focus on its role in the early diagnosis of DMD and in evaluating the extent, morphology, and topographic localization of DMD allowing for immediate intervention during surgery and precise pneumodescemetopexy procedures where conservative treatment has failed. This review explores the integration of AS-OCT into the standard perioperative diagnostic workflow, highlighting its potential role in the prevention, accurate diagnosis, and prompt management of DMD, a complication of cataract surgery that, while low in incidence, can be highly disruptive when it occurs. The emerging role of artificial intelligence (AI) in AS-OCT analysis of anterior segment conditions and surgical procedures is discussed, though refinement of AI algorithms is warranted.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"74"},"PeriodicalIF":1.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing diabetic retinopathy diagnosis: automatic segmentation of hyperreflective foci in OCT via deep learning.","authors":"Yixiao Li, Boyu Yu, Mingwei Si, Mengyao Yang, Wenxuan Cui, Yi Zhou, Shujun Fu, Hong Wang, Xuya Liu, Han Zhang","doi":"10.1007/s10792-025-03439-z","DOIUrl":"10.1007/s10792-025-03439-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Hyperreflective foci (HRF) are small, punctate lesions ranging from 20 to 50 &lt;math&gt;&lt;mi&gt;μ&lt;/mi&gt;&lt;/math&gt; m and exhibiting high reflective intensity in optical coherence tomography (OCT) images of patients with diabetic retinopathy (DR). The purpose of the model proposed in this paper is to precisely identify and segment the HRF in OCT images of patients with DR. This method is essential for assisting ophthalmologists in the early diagnosis and assessing the effectiveness of treatment and prognosis. In this study, we introduce an HRF segmentation algorithm based on KiU-Net, the algorithm that comprises the Kite-Net branch using up-sampling coding to collect more detailed information and a three-layer U-Net branch to extract high-level semantic information. To enhance the capacity of a single-branch network, we also design a cross-attention block (CAB) which combines the information extracted from two branches. The experimental results demonstrate that the number of parameters of our model is significantly reduced, and the sensitivity (SE) and the dice similarity coefficient (DSC) are respectively improved to 72.90 &lt;math&gt;&lt;mo&gt;%&lt;/mo&gt;&lt;/math&gt; and 66.84 &lt;math&gt;&lt;mo&gt;%&lt;/mo&gt;&lt;/math&gt; . Considering the SE and precision(P) of the segmentation, as well as the recall ratio and recall P of HRF, we believe that this model outperforms most advanced medical image segmentation algorithms and significantly relieves the strain on ophthalmologists.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;Hyperreflective foci (HRF) are small, punctate lesions ranging from 20 to 50 μm with high reflective intensity in optical coherence tomography (OCT) images of patients with diabetic retinopathy (DR). This study aims to develop a model that precisely identifies and segments HRF in OCT images of DR patients. Accurate segmentation of HRF is essential for assisting ophthalmologists in early diagnosis and in assessing the effectiveness of treatment and prognosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We introduce an HRF segmentation algorithm based on the KiU-Net architecture. The model comprises two branches: a Kite-Net branch that uses up-sampling coding to capture detailed information, and a three-layer U-Net branch that extracts high-level semantic information. To enhance the capacity of the network, we designed a cross-attention block (CAB) that combines the information extracted from both branches, effectively integrating detail and semantic features.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Experimental results demonstrate that our model significantly reduces the number of parameters while improving performance. The sensitivity (SE) and Dice Similarity Coefficient (DSC) of our model are improved to 72.90% and 66.84%, respectively. Considering the SE and precision (P) of the segmentation, as well as the recall ratio and precision of HRF detection, our model outperforms most advanced medical image segmentation algorithms CONCLUSION: The proposed HRF segmentation algorithm effectively ","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"79"},"PeriodicalIF":1.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Junctional proliferative vitreoretinopathy in rhegmatogenous retinal detachment secondary to viral retinitis in HIV.","authors":"Anup Kelgaonkar, Anamika Patel, Avinash Pathengay","doi":"10.1007/s10792-025-03448-y","DOIUrl":"https://doi.org/10.1007/s10792-025-03448-y","url":null,"abstract":"<p><strong>Introduction: </strong>Rhegmatogenous retinal detachment (RRD) is a vision-threatening complication of viral retinitis, at times compounded by proliferative vitreoretinopathy (PVR) at the junction of the necrotic and unaffected retina.</p><p><strong>Methods: </strong>Retrospective review of eyes with 'junctional PVR' in RRD after viral retinitis. We define junctional PVR as presence of stiffness, transverse traction, epiretinal membrane and/or pucker at the junction of normal and necrotic retina.</p><p><strong>Results: </strong>Five eyes of four patients with a mean age at presentation of 46.5 ± 10.96 years were included. Immunosuppression due to Human immunodeficiency virus (HIV) was the underlying condition in all the cases. Posterior hyaloid removal and epiretinal membrane removal at the junctional PVR was performed in all cases. Favourable outcomes were observed in seven sites where epiretinal membrane (ERM) removal with inner limiting membrane (ILM) peeling was performed; however, one site developed localised RRD requiring re-surgery. The mean logMAR best-corrected visual acuity (BCVA) improved from 1.84 before surgery to 0.64 during the last follow-up. All patients had undergone 23 G vitrectomy and silicone oil tamponade 1500 Centistokes (cSt) was used in all patients for a mean duration of 6.8 months.</p><p><strong>Conclusion: </strong>Management of posterior hyaloid coupled with ERM removal and localised ILM peeling may be used to address junctional PVR in the eyes with RRD after viral retinitis.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"70"},"PeriodicalIF":1.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METTL14-mediated m⁶A modification of LINC00340 exerts oncogenic role in retinoblastoma by regulating Notch signaling pathway.","authors":"Jing Chen, Bo Zeng","doi":"10.1007/s10792-025-03449-x","DOIUrl":"https://doi.org/10.1007/s10792-025-03449-x","url":null,"abstract":"<p><strong>Purpose: </strong>Retinoblastoma (RB) is a common primary intraocular cancer developed in early childhood. The N6-methyladenosine (m⁶A) modification of long non-coding RNAs (lncRNAs) have been reported to participate in tumorigenesis. However, the study on the m⁶A modification of lncRNA in RB is still limited. This study proposed to reveal the role of lncRNA LINC00340 in RB depending on m⁶A modification.</p><p><strong>Methods: </strong>The levels of LINC00340 and methyltransferase-like 14 (METTL14) were detected using qRT-PCR. The effects of LINC00340 interacting with METTL14 on RB cells were assessed by CCK8, colony formation, and flow cytometry assays. The changes of proteins associated with Notch signaling pathway were detected using western blotting. The regulatory mechanism of LINC00340 interacting with METTL14 in RB cells was confirmed by MeRIP, qRT-PCR, and actinomycin D treatment assays.</p><p><strong>Results: </strong>The expression of LINC00340 and METTL14 in RB samples were elevated, as well as their levels in RB samples showed the positive correlation. Silencing LINC00340 in RB cells could impair RB cell growth and enhance apoptosis via activating Notch signaling pathway, but overexpressing LINC00340 in RB cells showed the opposite effects. In addition, upregulating METTL14 effectively relieved the repressive effects of silencing LINC00340 on RB cells due to METTL14-mediated m⁶A modification of LINC00340.</p><p><strong>Conclusions: </strong>The findings of study reveal that METTL14-mediated m⁶A modification of LINC00340 exerts oncogenic function in RB via Notch signaling pathway, which may uncover a novel molecular mechanism driving RB progression and identify a potential therapeutic target for RB.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"73"},"PeriodicalIF":1.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice patterns and preferences in the management of age-related macular degeneration among vitreoretinal surgeons in the Philippines.","authors":"Reny Rose S Sabado, Kristine Corpus-Velasquez, Romulo N Aguilar","doi":"10.1007/s10792-025-03441-5","DOIUrl":"https://doi.org/10.1007/s10792-025-03441-5","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the practice patterns and preferences in the management of age-related macular degeneration (AMD) among vitreoretinal surgeons in the Philippines.</p><p><strong>Methods: </strong>This is a descriptive cross-sectional study. A validated online survey regarding practices in AMD management was sent to the members of the Vitreo-Retina Society of the Philippines (VRSP). Data were analyzed using frequency and percent distributions.</p><p><strong>Results: </strong>A total of 114 vitreoretinal surgeons participated in the study. Majority (97.4%) inquired about patients' smoking habits and advised cessation (99.1%). Dietary advice (94.7%) focused on omega-3-rich foods and green, leafy vegetables. Oral antioxidant supplements were prescribed for unilateral intermediate AMD (83.3%), with the age-related eye disease studies formula most commonly used (25.7%). Anti-vascular endothelial growth factor (anti-VEGF) was preferred for subfoveal (99.1%), juxtafoveal (94.7%), and extrafoveal (73.5%) choroidal neovascularization, with bevacizumab being the most frequently administered agent (72.6%) and aflibercept (83.2%) the most preferred due to cost considerations. The treat-and-extend protocol was followed by 58.4%, while 38.9% used a pro re nata approach. Treatment response was primarily evaluated by fluid reduction on optical coherence tomography, with intraretinal fluid being the most critical (48.7%). Most surgeons (86.7%) switched anti-VEGF agents for poor response, and 80.5% did so when no response was seen. Referral to low vision specialists was most often based on difficulty performing daily activities regardless of visual acuity.</p><p><strong>Conclusion: </strong>Real-world practice patterns and preferences of the members of the VRSP generally align with globally recognized management standards for AMD. They displayed remarkable knowledge and attitudes with regards to smoking, diet, and nutrition in relation to AMD care. Anti-VEGF drugs have been used widely for neovascular AMD in accordance with international guidelines. A significant proportion acknowledge the advantages of referral to a low vision specialist.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"71"},"PeriodicalIF":1.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous reconstruction of medial canthus deformity and traumatic nasolacrimal duct obstruction using micro-anchors.","authors":"Xueru Liu, Wenyue Zhang, Leilei Zhang, Lunhao Li, Yuanhui Han, Mohammad Javed Ali, Caiwen Xiao","doi":"10.1007/s10792-025-03444-2","DOIUrl":"10.1007/s10792-025-03444-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficiency and safety profiles of a technique of simultaneous reconstruction of traumatic lacrimal duct obstruction and medial canthus deformity using micro-anchors.</p><p><strong>Methods: </strong>A retrospective interventional study was performed from 2018 to 2022 on 26 consecutive patients who presented with medial canthal deformities and traumatic nasolacrimal duct obstruction. All patients underwent medial canthoplasty using micro-anchors combined with dacryocystorhinostomy to address the traumatic nasolacrimal duct obstruction. Preoperative and postoperative measurements of telecanthus, the superior or the inferior displacement of the medial canthal tendon (MCT), surgical technique of MCT fixation, advantages and limitations of using micro-anchors, functional and cosmetic outcomes were recorded and compared.</p><p><strong>Results: </strong>Satisfactory and symmetrical medial canthal fixation outcomes were achieved in 96% (25/26) patients using the micro-anchors. The surgical technique was easy and offered secure and reliable reattachment of the MCT in long-term. The DCR surgery was anatomically and functionally patent in 92% (24/26) patients. One patient had unsatisfactory medial canthal outcomes where the canthus remained partly lateral, and inferior compared to the uninjured side. The two failures following DCR surgery were secondary to complete cicatricial closure and had persistent epiphora.</p><p><strong>Conclusion: </strong>The present study noted that micro-anchors can correct the medial canthal deformity and leave more space for the DCR osteotomy simultaneously.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"72"},"PeriodicalIF":1.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}