International Ophthalmology最新文献

{"title":"Evaluatıon of the protective role of melatonın ın methanol ınduced optıc neuropathy.","authors":"Şerife Gülhan Konuk, Süleyman Özdemir, Raşit Kılıç, Gamze Bektur, Alper Güneş, Ender Şener","doi":"10.1007/s10792-025-03539-w","DOIUrl":"https://doi.org/10.1007/s10792-025-03539-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of intraperitoneal melatonin administration on the optic nerve and retina following acute methanol exposure.</p><p><strong>Materials and methods: </strong>Twenty-four female albino Wistar rats weighing 200-300 g and aged between 3 and 6 months were utilized. The rats were divided into three groups, each consisting of eight rats: healthy control (C), methanol (M), and methanol + melatonin (MM) groups. Initially, rats in groups M and MM were administered intraperitoneal methotrexate at a dose of 0.3 mg/kg. One week later, the same groups were orally given methanol at a concentration of 20% and a dose of 3 g/kg to induce methanol toxicity. To ensure survival, four hours after oral methanol administration, ethanol was orally administered at a concentration of 20% and a dose of 0.5 g/kg. Additionally, starting from the next day, the MM group received intraperitoneal melatonin at a dose of 20 mg/kg/day for 14 days. On the 14th day, rats were sacrificed, and their eyes, including the optic nerves, were enucleated for histopathological examinations. Myelin basic protein (MBP), retinal ganglion cell (RGC), glial cell degeneration and optic nerve thickness were evaluated.</p><p><strong>Results: </strong>The experiment was completed with a total of twenty-four rats, with each group consisting of eight rats. When evaluating RGC, glial cell degeneration, and optic nerve thickness, the results for Group MM were significantly better than those for Group M (p < 0.0001, p < 0.0001, p < 0.0001, respectively). There was no significant difference between Group MM and Group C, which was not subjected to alcohol intoxication (p: 0.89, p: 0.82, p: 0.77, respectively). There was no significant difference in MBP values ​​between the groups (p: 0.44, p: 0.17, p: 0.80, respectively).</p><p><strong>Conclusion: </strong>Intraperitoneal administration of melatonin has a significant positive effect on the structure of the retina and optic nerve resulting from methanol exposure. Melatonin should be considered in future studies as a potential therapy for methanol-induced toxic optic neuropathy.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"182"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of blepharoptosis surgery on vision-related quality of life and its correlation with contrast sensitivity changes.","authors":"M C Bruzual-Lezama, P Peña-Urbina, C Berrozpe-Villabona, N Ibáñez-Flores","doi":"10.1007/s10792-025-03563-w","DOIUrl":"https://doi.org/10.1007/s10792-025-03563-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation between contrast sensitivity changes and post-surgical improvement in visual function perception and health-related quality of life among patients with blepharoptosis.</p><p><strong>Methods: </strong>This prospective cohort studied 55 patients with blepharoptosis surgical indication, one eye per patient was considered for analysis. Refraction, visual acuity (VA), eyelash ptosis and contrast sensitivity (CS) test were evaluated. The National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ25), concerning vision-related activities and symptoms, was used to assess the patient´s quality of life pre and postoperatively. Patients were analyzed globally and divided according to the severity of ptosis, lens opacity and the co-existence of glaucoma.</p><p><strong>Results: </strong>55 eyes underwent ptosis surgery. VA significantly improved without notable refractive changes (p = 0.0044). CS demonstrated significant enhancement in all patients and groups. The NEI-VFQ 25 overall score significantly improved from baseline to 3 months postoperatively (p < 0.001). General vision (p = 0.0319), near and peripheral vision (p < 0.001 and p = 0.0188, respectively), color vision (0.0177), ocular pain (p < 0.001), dependence (p = 0.0093) and mental health (p = 0.0341) exhibited significant improvement. All groups experienced a significant increase in the overall score postoperatively. They all concurred on the improvement of the subscale near vision, except for the glaucoma group, which showed no improvement in either of the subscales.</p><p><strong>Conclusion: </strong>Ptosis surgery significantly improves contrast sensitivity, visual function, and quality of life in patients, including those with ocular comorbidities such as lens opacity and glaucoma. NEI-VFQ 25 assessment revealed an important enhancement in near and peripheral vision, ocular pain, and dependence; which highlight the broad benefits of the surgery, increasing autonomy in daily activities.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"187"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering hemorrhagic risks in external dacryocystorhinostomy: a comprehensive analysis of associated factors.","authors":"Bita Karimi, Masoomeh Eghtedari, Behzad Khademi, Mohammad Hossein Nowroozzadeh","doi":"10.1007/s10792-025-03544-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03544-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the impact of herbs (Ginger, Garlic and Green tea) and perioperative factors on intraoperative and postoperative hemorrhage as well as ecchymosis in external dacryocystorhinostomy.</p><p><strong>Methods: </strong>This was a case series study that included 50 external DCR procedures performed on adults. Patients' herbal use and other risk factors were questioned before the surgery. During the procedure, intraoperative hemorrhage volume and other parameters were documented. Postoperative hemorrhage and ecchymosis were evaluated on the day following the surgery. We used Regression analysis to assess the factors associated with hemorrhage complications in external DCR.</p><p><strong>Results: </strong>The average amount of intraoperative hemorrhage was 81.66 ml. Moderate to severe postoperative hemorrhage and ecchymosis occurred in 27.7 and 40.8% of cases, respectively. Upon conducting linear regression analysis, intraoperative MAP was the only factor associated with intraoperative hemorrhage. A significant association of ginger and intraoperative MAP with postoperative hemorrhage was revealed through multiple regression analysis. Additionally, the factors associated with postoperative ecchymosis were older age and urban residence.</p><p><strong>Conclusions: </strong>We identified several factors associated with hemorrhage complications in external DCR procedure, including ginger use, intraoperative MAP, older age, and urban residence. Based on our findings that ginger intake before surgery can increase the hemorrhage risk, patients should be meticulously questioned about ginger use prior to external DCR and be recommended to cease its use.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"185"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-infectious uveitis: a multicenter study from Argentina.","authors":"Belén María Virasoro, Alex Kostianovsky, Florencia Milesi, Marcela Bellón, Víctor Morales Roldan, Liliana Martínez, Emmanuel Bertiller, Milagros Heredia, Paula Aquino, Luz María De Zavalia, Luis Zeman, Santiago Catalán Pellet, María Marcela García, Marcelo Bursztyn, Eliana Flavia Emma Segretin Gutiérrez, Leandro Ferreyra Garrott, Eduardo Jorge Premoli, Javier Eduardo Rosa, Enrique Roberto Soriano, María Beatriz Marcantoni, Sebastián Andrés Muñoz, Ramiro Adrian Gómez, Andrea Smichowski, Federico Ceccato, Sophia Lutgen, Ariana Ringer, Silvina Auteri, Gustavo Budmann, Emilio María Dodds, Ariel Schlaen, Ignacio Javier Gandino","doi":"10.1007/s10792-025-03555-w","DOIUrl":"10.1007/s10792-025-03555-w","url":null,"abstract":"<p><strong>Purpose: </strong>To describe etiologies and clinical characteristics of patients from Argentina with non-infectious uveitis (NIU). Differences between the anatomic segments involved were described as well.</p><p><strong>Methods: </strong>This is a multicentric, cross-sectional study from January 2008 to March 2021. We included patients with NIU from private and public institutions. Uveitis diagnosis was made by ophthalmologists specializing in uveitis, and rheumatologists diagnosed the autoimmune conditions. Patients were classified according to the International Uveitis Study Group classification system. RESULTS°: We included 468 patients with NIU. Most of them were female (64.1%), with a mean age at diagnosis of 37.9 years (SD 17.2). Idiopathic uveitis and Vogt-Koyanagi-Harada disease (VKH) were the most frequent causes. Among anterior uveitis, the most prevalent causes were idiopathic, spondyloarthritis, juvenile idiopathic arthritis, and sarcoidosis. VKH and Behçet were predominant within the panuveitis group. Over half of the patients (57%) required immunosuppressants. Methotrexate (20.6%) and azathioprine (8.9%) were mostly used. Eleven percent of the patients needed biologics, mostly adalimumab (9.4%). Two hundred fifty-six (54.7%) patients had eye complications, and cataracts were the most frequent (30%). A comparative analysis was performed between public and private institutions. There was no difference in the causes of uveitis or complications (p = 0.38; p = 0.06, respectively).</p><p><strong>Conclusion: </strong>The most prevalent causes of uveitis were VKH and idiopathic uveitis, different from the etiologies observed in the United States and Europe.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"186"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-6837-3p protected retinal epithelial cells from oxidative stress by targeting E2F6.","authors":"Xin Zhao, Xinru Chen, Xiangyang Xin","doi":"10.1007/s10792-025-03540-3","DOIUrl":"https://doi.org/10.1007/s10792-025-03540-3","url":null,"abstract":"<p><strong>Aim: </strong>The mechanism of age-related macular degeneration (AMD) is a complex illness that is not fully understood. Therefore, the aim of this study was to investigate the expression patterns of miR-6837-3p in retinal epithelial cells.</p><p><strong>Methods: </strong>H₂O₂ was used to treat ARPE-19 cells for 2, 4 and 6 h to mimic the in vivo environment of AMD. MiR inhibitors and mimics were used to inhibit or overexpress miR-6837-3p in H₂O₂-treated ARPE-19 cells, respectively. Then, CCK8 assay, flow cytometry, and wound healing assays were conducted to assess the effects of miR-6837-3p on the behaviors of ARPE-19 cells, including cell growth, apoptosis, cycle progression, and migration. Finally, microRNA database prediction and luciferase reporter assays were used to demonstrate that miR-6837-3p targets the downstream gene E2F6.</p><p><strong>Results: </strong>H₂O₂ induced a decrease in cell viability and an increase in ROS levels in a time-dependent manner. Additionally, overexpression of miR-6837-3p increased cell viability and suppressed apoptosis in ARPE-19 cells treated with H₂O₂. Meanwhile, increased miR-6837-3p promoted cell cycle progression and cell migration of ARPE-19 cells. Finally, miR-6837-3p exerted anti-apoptosis and anti-oxidative stress effects by inhibiting the expression of E2F6 in ARPE-19 cells.</p><p><strong>Conclusions: </strong>The MiR-6837-3p/E2F6 axis might be a target for the treatment of AMD to improve ARPE-19 cell function.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"183"},"PeriodicalIF":1.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the choroidal vascularity index and choroidal thickness in patients with systemic sclerosis.","authors":"Esra Vural, Kemal Erol, Nurettin Bayram, Samet Karahan, Medine Gündoğan, Leyla Hazar","doi":"10.1007/s10792-025-03536-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03536-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the choroidal structural components using central macular thickness (CMT), choroidal thickness (CT) and the choroidal vascular index (CVI) and compare the results between patients with systemic sclerosis (SSc), causing both fibrotic and angiopathic changes in tissues and healthy controls.</p><p><strong>Methods: </strong>This prospective comparative study evaluated 22 patients with SSc (SSc group). The patients' choroidal thickness, CVI and choroidal area (CA) were compared with 21 healthy controls (control group). The patients' nailfold videocapillaroscopy (NVC) and modified Rodnan skin score (mRss) were evaluated by expert rheumatologists. In addition, the relationships between choroidal findings and NVC and mRss were assessed.</p><p><strong>Results: </strong>The central macular thickness in the SSc and control groups was 269.47 ± 26.78 µm and 261.19 ± 17.09 µm, respectively (p = 0.093). The subfoveal choroidal thickness was 295.38 ± 33.70 μm and 322.16 ± 70.24 μm, respectively (p = 0.026); the temporal choroidal thickness was 246.77 ± 21.83 μm and 265.26 ± 52.34 μm, respectively (p = 0.034); and the nasal choroidal thickness was 135.36 ± 28.10 μm and 158.88 ± 49.16 μm, respectively (p = 0.008). Total CA of 1.5 mm region centered on the fovea was 0.49 ± 0.08 mm² and 0.55 ± 0.09 mm², respectively (p = 0.002); total CVI of 1.5 mm region centered on the fovea was 63.66% ± 1.23 and 64.90% ± 1.07, respectively (p < 0.001); total CA of 6 mm region centered on the fovea was 1.61 ± 0.22 mm² and 1.80 ± 0.33 mm², respectively (p = 0.003); the total CVI of 6 mm region centered on the fovea was 63.85% ± 1.16 and 64.87% ± 1.12, respectively (p < 0.001). There was no correlation between mRss score and Raynaud severity and CMT, CVI and CTs; however, there was a positive correlation between the mRss and the Raynaud severity (p = 0.0004, r = 0.507).</p><p><strong>Conclusion: </strong>This study found that choroidal thickness and CVI decreased in SSc patients. A decrease in CVI may be an indicator of damage, especially in luminal structures.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"181"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sterile keratolysis following pars plana vitrectomy for retinal detachment.","authors":"Anna Hillenmayer, Christian M Wertheimer, Efstathios Vounotrypidis, Armin Wolf, Melih Parlak","doi":"10.1007/s10792-025-03532-3","DOIUrl":"https://doi.org/10.1007/s10792-025-03532-3","url":null,"abstract":"<p><strong>Purpose: </strong>Pars plana vitrectomy (PPV) with various forms of tamponade and retinopexy is often the primary treatment for retinal detachment. However, a rare but serious complication is sterile keratolysis. We therefore aimed to evaluate the prevalence and potential risk factors for the development of corneal ulceration following vitreoretinal surgery for retinal detachment.</p><p><strong>Methods: </strong>This is a single-centre retrospective study including 14 cases of patients presenting to our department with sterile keratolysis involving the stroma after one or more PPVs for retinal detachment or vitreous hemorrhage. Time of primary procedure, time of onset of corneal complications, comorbidities, type of tamponade used, use of endophotocoagulation, cryoretinopexy and number of surgeries were recorded. Patients with additional comorbidities confounding a possible correlation were excluded from the case series.</p><p><strong>Results: </strong>A total of 14 patients were identified with corneal complications after pars plana vitrectomy for retinal detachment. Multiple vitrectomies were performed in 86% (12/14) of the cases. Surgical treatment consisted of six (43%) perforating keratoplasties and seven (50%) amniotic membrane keratoplasties in all but one patient. At an average of three months after the onset of corneal symptoms, the first corneal surgery was performed. Repeated corneal surgery was required in 4 patients (29%) and consisted of two penetrating keratoplasties and four amniotic membrane transplantation. Visual acuity at the first presentation of corneal complications was reduced (2.1 ± 0.6 logMAR), but was not statistically different from the visual acuity at baseline (1.6 ± 0.7 logMAR). At the last follow-up, visual acuity remained reduced at 1.8 ± 0.8 logMAR (p = 0.2).</p><p><strong>Conclusions: </strong>The risk of sterile keratolysis seems to increase with excessive laser or cryo-retinopexy, use of silicone oil and repeated procedures. The initial vitrectomy was a complex surgery in all cases and required a longer operating time. Ciliary nerve damage of neurotrophic origin may be the cause of sterile keratolysis, and controlled retinopexy sparing the long ciliary nerves and avoiding cryotherapy may reduce the risk. Controlled studies are needed to investigate the causality between vitreoretinal surgery and sterile keratolysis.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"179"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-proliferative diabetic retinopathy detection using Rosmarus Quagga optimized explainable generative meta learning based deep convolutional neural network model.","authors":"Ajita Arvind Mahapadi, Vishal Shirsath, Ajitkumar Pundge","doi":"10.1007/s10792-025-03528-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03528-z","url":null,"abstract":"<p><strong>Purpose: </strong>Non-Proliferative Diabetic Retinopathy (NPDR) is a complication of diabetes disease where there is damage of the blood vessels in retina but with no signs of formation of new vessels. It is present in the earlier stages and therefore the control of diabetes combined with constant check-up can address the challenge. Existing models face several challenges such as heterogeneity of the lesion with regard to size, shape, and distribution. Therefore, to reduce those existing challenges, in this research, a novel model Rosmarus Quagga optimized Explainable generative Meta learning based Deep Convolutional Neural Network (RQ-EGMCN) is proposed for Non-Proliferative Diabetic Retinopathy. The main purpose of the proposed research is to develop and validate the effective diagnosis of severe DR with lesion recognition using the retinal images.</p><p><strong>Methods: </strong>The presented approach develops the Rosmarus Quagga optimization, which exhibits the adaptive foraging behaviors are integrated along with the aspects of the leader-based feeding strategies to enhance the detection accuracy. Simultaneously, the proposed model employs explainable Convolutional Neural Networks to ensure interpretations which in turn provides a tradition of decision making by presenting the attention and saliency maps. The generative component allows to generate realistic retinal images for training purposes and meta-learning, when applied to new data, and accelerates learning while enhancing its' generalization potential.</p><p><strong>Main outcome measures: </strong>Moreover, the proposed model improves the NPDR diagnosis by minimizing the computational complexity, improving the accuracy and versatility of the model across different datasets.</p><p><strong>Results: </strong>Experimental analysis show that the RQ-EGMCN model obtained the maximum accuracy, precision, and recall of 95.47%, 95.34%, and 95.24% for the diabetic retinopathy detection dataset, respectively.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"178"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved functional and morphological outcomes with faricimab in nAMD eyes with poor response to prior intravitreal anti-VEGF therapy.","authors":"Nathalie Bleidißel, Matthias Weichenberger, Mathias Maier, Nina Spielberg, Nikolaus Feucht","doi":"10.1007/s10792-025-03525-2","DOIUrl":"https://doi.org/10.1007/s10792-025-03525-2","url":null,"abstract":"<p><strong>Introduction: </strong>Neovascular age-related macular degeneration (nAMD) is a major cause of vision loss in older adults. While anti-VEGF therapies have improved management by suppressing abnormal blood vessel growth, a substantial subset of patients show poor functional as well as morphological responses and require frequent injections. Faricimab (Vabysmo®), a bispecific inhibitor targeting VEGF-A and angiopoietin-2 (Ang-2), has shown promise in achieving more durable disease control.</p><p><strong>Methods: </strong>This retrospective study included 48 eyes from 47 nAMD patients previously treated with ranibizumab or aflibercept, who were switched to faricimab due to poor treatment response. Evaluations occurred at four time points, assessing best-corrected visual acuity (BCVA), intraretinal (IRF) and subretinal fluid (SRF), subretinal pigment epithelium fluid and fibrosis, central subfield thickness (CST), and central subfield volume (CSV) using spectral-domain OCT. Dosing intervals and patient-reported outcomes were also recorded.</p><p><strong>Results: </strong>BCVA improved consistently, with mean logMAR improving from 0.54 to 0.40, reflecting a gain of 1.4 Snellen lines. Dosing intervals extended from a median of 5 to 8 weeks, with over one-third of eyes reaching intervals of 10 weeks or more. Significant reductions in IRF, SRF, CST as well as CSV were observed (p < 0.05) with a quarter of eyes showing no intra- or subretinal fluid at the fourth faricimab injection. Three patients were switched back to their previous anti-VEGF treatment due to a decline in BCVA.</p><p><strong>Discussion: </strong>The findings suggest Faricimab as an effective option for nAMD patients who respond inadequately to prior anti-VEGF therapies, offering both functional and anatomical improvements. Extended intervals reduce treatment burden, indicating faricimab's potential to enhance disease control and patient quality of life in real-world settings.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"177"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the tear film and meibomian glands before and after cataract surgery by the ocular surface analyzer.","authors":"Osama Abd Allah El-Morsy, Hasnaa Hosam Eldin Ramadan, Ahmed Shebl Fayed","doi":"10.1007/s10792-025-03534-1","DOIUrl":"https://doi.org/10.1007/s10792-025-03534-1","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to assess the tear film and meibomian gland function before and after cataract surgery using the Lacrydiag ocular surface analyzer.</p><p><strong>Methods: </strong>This was an observational prospective study including 34 eyes that underwent phacoemulsification at the Ophthalmology Department of Menoufia University Hospital from October 2023 to January 2024. The patients were evaluated pre-operatively as well as 1 week, 1 month, and 3 months postoperatively. Dry eye symptoms were assessed using the Ocular Surface Disease Index (OSDI) questionnaire. Traditional tear break up time (TBUT) was performed as well as Schirmer I test. The Lacrydiag Ocular Surface Analyzer was used for assessment of the tear film and meibomian glands.</p><p><strong>Results: </strong>Ocular surface analyzer evaluations revealed statistically significant changes at 1 week, 1 month, and 3 months after surgery in comparison to the values before surgery. Significant reductions were observed in non-invasive tear break-up time (NITBUT) and tear meniscus height, as well as in Schirmer's test without anesthesia, and fluorescein break-up time at each postoperative interval. Some improvements were observed at 1 month and 3 months, however, measurements did not return to the initial preoperative levels. Ocular Surface Disease Index (OSDI) scores significantly increased after 1 week, 1 month, and 3 months post-surgery compared to preoperative levels. The proportion of meibomian gland area loss did not significantly increase after surgery (no structural alterations were noted).</p><p><strong>Conclusion: </strong>The study shows that phacoemulsification impacts both tear quantity and quality, affecting overall tear film stability and ocular surface health.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"180"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}