Two-year outcomes of accelerated contact lens-assisted corneal crosslinking versus accelerated corneal crosslinking: a comparative study.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2025-08-13 DOI:10.1007/s10792-025-03707-y

Fahri Onur Aydin, Elif Bağatur Vurgun, Gamze Özkan, Semra Akkaya Turhan, Ebru Toker

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引用次数: 0

Abstract

Purpose: To compare the 24-month outcomes of accelerated contact lens-assisted corneal crosslinking (A-CACXL) in thin corneas (< 400 microns) versus conventional accelerated CXL (A-CXL) in progressive keratoconus patients.

Methods: This study included progressive keratoconus patients who underwent A-CACXL (9 mW/cm² for 10 min) and A-CXL (9 mW/cm² for 10 min). A-CACXL was performed in cases with the thinnest corneal thickness of 400 μm or less. Preoperative and postoperative best spectacle-corrected visual acuity (BSCVA), keratometric, tomographic, aberrometric values, and Regularization Index (RI) were compared at a 2-year follow-up.

Results: The study enrolled 41 eyes; 20 eyes underwent A-CACXL and 21 eyes underwent A-CXL. Preoperative BSCVA, Kmax, K1, and K2 values were similar in both groups (p > 0.05). Preoperative thinnest corneal pachymetry measurements were significantly less in A-CACXL group (384.8 ± 25.2 vs. 450.4 ± 35.7; p < 0.001). ΔBSCVA, RI, and ΔKmax were similar in A-CACXL and A-CXL groups (- 0.14 ± 0.27 vs. - 0.17 ± 0.18; 5.9 D ± 4.9 D vs. 4.6 D ± 2.5 D; - 2.0 ± 3.5 D vs. - 2.0 ± 3.1 D; respectively). A-CACXL showed 95% of eyes halting progression, with 60% showing regression, similar to A-CXL (57.1% regression, 100% halting progression) (p = 0.521). In the A-CACXL group, curvature-based index (ARC) improved significantly (p = 0.002), pachymetric indices (ARTmax, RPIavg) worsened significantly (p = 0.002, 0.026), while no change was observed in aberrometric parameters (p > 0.05).

Conclusion: In eyes with thin corneas and progressive keratoconic condition, the safety and effectiveness of A-CACXL seemed comparable to that of A-CXL at the 2-year follow-up. Both techniques yielded similar visual, keratometric, tomographic, and aberrometric results.

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加速隐形眼镜辅助角膜交联与加速角膜交联的两年结果：比较研究。

目的：比较加速隐形眼镜辅助角膜交联（A-CACXL）在薄角膜中24个月的疗效(方法：本研究包括接受A-CACXL （9 mW/cm2，持续10分钟）和A-CXL （9 mW/cm2，持续10分钟）治疗的进展性圆锥角膜患者。最薄角膜厚度在400 μm以下的患者行A-CACXL。术前和术后最佳眼镜矫正视力（BSCVA）、角膜测量、层析成像、像差测量值和正则化指数（RI）在2年随访中进行比较。结果：该研究纳入了41只眼睛；20眼行A-CACXL， 21眼行A-CXL。两组术前BSCVA、Kmax、K1、K2值差异无统计学意义（p < 0.05）。A-CACXL组术前最薄角膜厚度测量值明显低于对照组（384.8±25.2比450.4±35.7）；p 0.05)。结论：在角膜薄、角膜渐近性病变的患者中，A-CACXL与A-CXL在2年随访中的安全性和有效性相当。两种技术产生了相似的视觉、角膜测量、层析成像和像差测量结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.