International Ophthalmology最新文献

{"title":"Relationship between type 2 diabetes mellitus and changes of the lid margin, meibomian gland and tear film in dry eye patients: a critical perspective.","authors":"Muhammad Owais, Muhammad Huzaifa Sabir, Muhammad Nouman Javed","doi":"10.1007/s10792-025-03739-4","DOIUrl":"https://doi.org/10.1007/s10792-025-03739-4","url":null,"abstract":"","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"347"},"PeriodicalIF":1.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of sleep quality in glaucoma and cataract patients: the need for developing appropriate treatment methods for chronodisruption.","authors":"Ioanna Mylona, Filaretos Glynatsis, Nikolaos Glynatsis, Stylianos Kandarakis","doi":"10.1007/s10792-025-03730-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03730-z","url":null,"abstract":"<p><strong>Purpose: </strong>Glaucoma and cataract are the most frequent causes of blindness worldwide with very distinct etiology and pathogenesis. Sleep disturbances have been reported in both conditions with their etiology attributed not only to the particular underlying eye condition but to other comorbid conditions such as chronic diseases and old age. This study compares sleep quality in fifty primary open-angle glaucoma patients and fifty cataract patients of similar vision loss in order to determine the comparative impact of those eye disorders in sleep quality.</p><p><strong>Methods: </strong>The glaucoma patients group was comprised of 50 patients with bilateral primary open-angle glaucoma, of moderate stage (38 men and 12 women, mean age = 62.94 years, SD = 4.99 years). The cataract patient group was comprised of 50 gender-matched cataract patients with either cortical sclerotic or posterior sclerotic types of cataracts (mean age = 62.38 years, SD = 4.62 years). All cataract patients were receiving a pre-surgery evaluation at the time of the study and had cataract involvement of both eyes that necessitated cataract surgery. All patients were administered the Pittsburgh Sleep Quality Index (PSQI), a self-administered questionnaire designed to subjectively evaluate sleep quality over the preceding month, and their findings were statistically compared.</p><p><strong>Results: </strong>Both groups had overall poor sleep quality but the glaucoma patients had worse PSQI total scores (p = .042), higher sleep latency (p = .005) and sleep disturbance (p = .002).</p><p><strong>Conclusion: </strong>Those findings suggest that among patients with comparable vision loss, glaucoma patients may be even more severely affected with disordered sleep than cataract patients. There is a need for the creation and testing of treatment modalities for chronodisruption in both patient groups.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"348"},"PeriodicalIF":1.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nesfatin-1 alleviates blue-light-emitting diodes induced retinal damage in Sprague-Dawley rats.","authors":"Saeid Chekani Azar, Nilüfer Sabuncuoğlu","doi":"10.1007/s10792-025-03710-3","DOIUrl":"https://doi.org/10.1007/s10792-025-03710-3","url":null,"abstract":"<p><strong>Purpose: </strong>Light-emitting diodes (LEDs) are extensively used across various devices and applications. However, the effects of prolonged or excessive exposure to white and blue LED light on the retina remain inadequately understood.</p><p><strong>Methods: </strong>This study investigated the impact of such exposure over 14 weeks on retinal structural and morphological changes and the potential protective effect of nesfatin-1 (N1) administered subcutaneously (0.5 mg/kg body weight) during the final two weeks. Three-week-old Sprague Dawley rats (n = 40) were assigned to six groups: two control groups (C = standard fluorescent lighting; CS = C + sesame oil) and four experimental groups (blue LED, white LED, blue LED + N1, and white LED + N1). Blood and eye samples were collected for biochemical and histopathological analysis at the end of the study.</p><p><strong>Results: </strong>The blue LED exposure group exhibited significantly elevated serum nesfatin-1 levels (p < 0.001) and reduced concentrations of melatonin and adrenocorticotropic hormone (ACTH; p < 0.05). The retina displayed normal, well-defined structural and morphological features in both control groups, including distinct boundaries and orderly nuclear layer cells between the inner and outer segments. However, slight disorganization of the nuclear layers and a few irregular nuclei were observed in the CS group. Cell loss and damage were more prominent in the LED-exposed groups in both the inner and outer retinal segments and nuclear layers, accompanied by other notable histopathological changes. The inner and outer retinal structures in both white LED groups showed mild disorganization, characterized by irregular nuclei and a noticeable reduction in nuclear layer cells. Retinal damage in both blue LED groups was more pronounced, with marked rod cell loss, disrupted arrangement of the inner and outer plexiform and nuclear layers, and irregular nuclei. Prolonged exposure to blue LED light induced edema in the photoreceptor layers; however, nesfatin-1 administration significantly reduced this inflammation and mitigated other pathological alterations.</p><p><strong>Conclusion: </strong>Biochemical and histological findings indicated that blue LED exposure may disrupt physiological systems by lowering melatonin and ACTH levels, potentially triggering compensatory nesfatin-1 secretion through a rapid feedback mechanism. These results underscore the need for further investigation into the effects of long-term exposure to short-wavelength light on retinal integrity and highlight the possible utility of nesfatin-1 as a biomarker in stress response regulation.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"349"},"PeriodicalIF":1.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postsurgical lateral canthal web correction using vertical Z-plasty combined with 5-fluorouracil (5-FU) injections.","authors":"Ayşe Dolar Bilge, Bülent Yazıcı","doi":"10.1007/s10792-025-03723-y","DOIUrl":"https://doi.org/10.1007/s10792-025-03723-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the surgical outcomes of lateral canthus reconstruction using vertical Z-plasty combined with canthoplasty and 5-fluorouracil (5-FU) injections in patients with post-surgical lateral canthal webbing.</p><p><strong>Methods: </strong>A retrospective review was conducted on 11 patients (17 eyelids) who underwent lateral canthal reconstruction between 2021 and 2024 due to post-surgical lateral canthal webbing. The technique involved vertical Z-plasty combined with canthopexy or canthoplasty, along with 5-FU injections in all cases.</p><p><strong>Results: </strong>No intraoperative complications were reported. During the follow-up period (mean 14 months; range 5-23 months), all cases showed significant improvement in lateral canthal webbing with no recurrence observed.</p><p><strong>Conclusion: </strong>The Z-plasty technique effectively corrected lateral canthal webbing without significant scarring. This method is particularly beneficial in patients with prior multiple surgeries, significant scarring, and vertical skin contraction. In cases with concurrent horizontal eyelid shortening, the technique was successfully combined with a periosteal flap to restore lower eyelid length.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"350"},"PeriodicalIF":1.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latest research hot spots of glaucoma management using selective laser trabeculoplasty: a bibliometric analysis and visualized review.","authors":"Abdulrahman Hameed Alsubhi, Mohammed Abdulqader Salawi, Jawza Ali Almutairi, Amnah Ali Alkhawajah, Fajr Saad Alkhalifa, Wejdan Abdullah Al Mustafa, Alwaleed Abdulhadi Alqahtani, Abdullah Alqahtani","doi":"10.1007/s10792-025-03699-9","DOIUrl":"https://doi.org/10.1007/s10792-025-03699-9","url":null,"abstract":"<p><strong>Background: </strong>Selective Laser Trabeculoplasty (SLT) has been shown to be a safe and effective method for lowering intraocular pressure in open-angle glaucoma. This study aims to analyze research trends in glaucoma management using SLT through a bibliometric analysis.</p><p><strong>Methods: </strong>The data for the study were gathered from the Web of Science Core Collection. We employed VOSviewer (version 1.6.18) to analyze and visualize information concerning countries, institutions, journals, and co-cited journals, journal co-citations, funding agencies, and keywords.</p><p><strong>Results: </strong>As of November 2024, a total of 386 original and review articles were included. The USA had the highest number of relevant publications, totaling 129. The University of Hong Kong was the leading institution with 15 publications. The Journal of Glaucoma (IF = 2.0) ranked first with 58 articles published and being the most cited journal. The United States Department of Health and Human Services was the top funding institution. The most frequently used keywords, in descending order, were \"selective laser trabeculoplasty,\" \"glaucoma,\" \"intraocular pressure,\" \"ocular hypertension,\" and \"open-angle glaucoma.\"</p><p><strong>Conclusion: </strong>The research demonstrates SLT efficacy in reducing intraocular pressure and controlling open-angle glaucoma as a non-invasive therapeutic alternative to eye drops. This thorough overview provides important insights and highlights existing research trends.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"346"},"PeriodicalIF":1.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in optical coherence tomography (OCT) parameters in follow-up of acute posterior multifocal placoid pigment epitheliopathy (APMPPE).","authors":"Burcu Kemer Atik, Ibrahim Uzar, Cigdem Altan, Berru Yargi Ozkocak, Berna Basarir","doi":"10.1007/s10792-025-03718-9","DOIUrl":"https://doi.org/10.1007/s10792-025-03718-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate retinal and choroidal optical coherence tomography (OCT) parameters in eyes with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and their changes during the follow-up.</p><p><strong>Methods: </strong>Best corrected visual acuity (BCVA- Snellen), central macular thickness (CMT), central choroidal thickness (CCT), total choroidal area (TCA), and choroidal vascularity index (CVI) and the other clinical findings were recorded at baseline and month 1, month 3, and year 1.</p><p><strong>Results: </strong>Twenty-two eyes of 11 patients were included in this study. The mean follow-up period was 18.3 ± 11.9 months. While the mean BCVA value was 0.54 at the initial visit; it improved statistically significantly to 0.74 at the 3rd-month visit (p = 0.025). The highest levels of CMT, CCT, TCA and CVI were at baseline. Statistically significant decreases were observed in CMT at month 3 and in choroidal parameters at month 1 (p < 0.05, for each). Baseline and 1-year CMT values were positively correlated with 1-year BCVA (p = 0.001, r = 0.80 and p = 0.013, r = 0.67; respectively).</p><p><strong>Conclusion: </strong>The acute phase of APMPPE disease is associated with increased retinal thickness and choroidal thickness, area, and vascularity. These parameters, which can be obtained non-invasively, can be valuable in the follow-up period.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"344"},"PeriodicalIF":1.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A twin-paired study on the independent effect of birth weight on retinopathy of prematurity.","authors":"Aslihan Uzun, Asena Keles Sahin","doi":"10.1007/s10792-025-03720-1","DOIUrl":"https://doi.org/10.1007/s10792-025-03720-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of discrepancy between birth weight (BW) of twin preterm babies on retinopathy of prematurity (ROP) development.</p><p><strong>Methods: </strong>Medical records of twins who were followed up for ROP between 2014 and 2023 were reviewed retrospectively. A total number of 254 twin babies with a gestational age (GA) of ≤ 34 weeks were included in the study. All patients were divided into 2 groups according to BW; the pairs with lower BW in Group 1 and their co-twins with higher BW in Group 2. Then, the discrepancy of ROP between groups was compared by within-pair analysis.</p><p><strong>Results: </strong>The mean GA and BW was 32.08 ± 1.95 weeks and 1806.63 ± 441.52 g, respectively. Any stage ROP was detected in 109 (21.5%) twin pairs and ROP requiring treatment was found in 30 (5.9%) babies. There were no significant differences in ROP development, ROP stages and type of treatment between larger and smaller infants, in twin-paired analysis (p = 0.331, p = 0.511 and p = 0.655, respectively). Binary logistic regression analysis showed that the smaller GA and lower BW were associated with the risk of any stage ROP in both groups. However, there was no significant relationship between perinatal risk factors (GA and BW) and ROP stages or need for treatment in babies with ROP in both groups (p > 0.05).</p><p><strong>Conclusion: </strong>Lower BW and smaller GA have a risk for any stage ROP in twin pairs. However, being the smaller baby is not the only predictor of ROP development in twin babies with the same GA but different BW.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"345"},"PeriodicalIF":1.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the management of uveitic cataract: current strategies and emerging perspectives.","authors":"Dimitrios Kalogeropoulos, Imran Akram, Nolan Remedios Cota, Nikolaos Krassas, Ahmed Ibraheem, Sofia Androudi, Chris Kalogeropoulos","doi":"10.1007/s10792-025-03695-z","DOIUrl":"https://doi.org/10.1007/s10792-025-03695-z","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to summarize the current knowledge concerning the management of cataract in patients with uveitis.</p><p><strong>Methods: </strong>A meticulous literature search was performed in the PubMed database. A supplementary search was made in Google Scholar to complete the collected items. Studies published up to the end of 2024 were included based on their relevance. To ensure a comprehensive review process, we carried out a critical appraisal evaluating study design, methodology, sample size, and potential bias. Studies that did not provide apposite information or lacked methodological rigor were excluded.</p><p><strong>Results: </strong>Cataract is one of the most frequent complications in patients with uveitis and requires a detailed management to achieve good anatomical and functional outcomes. Comprehensive assessment, patient selection, and preoperative counselling are mandatory, while inflammation must be in remission for at least 3 months before surgery. Since even mild chronic inflammatory activity can contribute to the cumulative damage associated with uveitis, perioperative anti-inflammatory treatment is crucial. Surgery for uveitic patients is made more difficult by a number of factors (such as poorly dilating pupils), but better results can be achieved with advanced surgical methods, careful postoperative monitoring, and timely management of complications. Moreover, the implication of steroid-sparing agents is also very useful in the optimal long-term control of the inflammation.</p><p><strong>Conclusions: </strong>Cataract surgery in patients with uveitis can be highly challenging. The ophthalmic surgeon must conduct a thorough preoperative assessment, develop a strategic plan for potential intraoperative challenges, and be prepared to manage possible postoperative complications. Recent advances including artificial intelligence, robotic surgery, next-generation intraocular lenses and novel drugs are expected to enhance the management of cataract in uveitic eyes.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"343"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year outcomes of faricimab for neovascular age related macular degeneration with OCT angiography: focus on resistant and refractory cases.","authors":"Alessandra Scampoli, Matteo Mario Carlà, Giulia Grieco, Lorenzo Governatori, Roberta Catalani, Stanislao Rizzo, Tomaso Caporossi","doi":"10.1007/s10792-025-03717-w","DOIUrl":"10.1007/s10792-025-03717-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the 12-month effectiveness and safety of intravitreal faricimab (IVF) in patients with neovascular age-related macular degeneration (nAMD) resistant to previous anti-VEGF treatment.</p><p><strong>Methods: </strong>Prospective, monocentric study including consecutive patients with resistant/refractory nAMD switched to IVF between July 2023 and November 2024. Primary endpoints were safety, best corrected visual acuity (BCVA), central subfield thickness (CST), and subfoveal choroidal thickness. Secondary endpoints included changes in optical coherence tomography (OCT) and OCT angiography biomarkers: fluid prevalence, pigment epithelial detachment (PED) height, and vascular densities. All patients received four monthly loading doses of faricimab, with subsequent treat-and-extend regimen.</p><p><strong>Results: </strong>The study included 30 eyes of 30 patients. Mean follow-up was 14.2 ± 1.9 months and no adverse events were reported. BCVA significantly improved from 0.77 to 0.62 LogMAR at the end of the study period (p = 0.009), with 67% of eyes showing stable vision. CST significantly decreased from baseline (-57 μm on average, p < 0.001), along with PED height which showed its main decrease during the loading phase. Forty-seven percent of eyes achieved complete macular dryness at week 16, with significant reduction in terms of subretinal fluid (SRF) and intraretinal fluid (IRF) prevalence. At the end of the study, 90% of patients achieved treatment intervals of at least q8w, with 27% of eyes being on q12w. Finally, no changes in superficial/deep vessel densities were observed.</p><p><strong>Conclusion: </strong>Faricimab demonstrated efficacy and safety in refractory/resistant nAMD, with significant improvements in structural outcomes and stable/improved visual acuity. Extended treatment intervals suggest a potential reduction in treatment burden.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"342"},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bayesian analysis of enucleation versus pre-enucleation in choroidal melanoma mortality.","authors":"Lucas M Barbosa, Vinícius Martins Rodrigues Oliveira, Lara Guedes, Marcelo Ramos","doi":"10.1007/s10792-025-03719-8","DOIUrl":"10.1007/s10792-025-03719-8","url":null,"abstract":"","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"337"},"PeriodicalIF":1.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}