International Ophthalmology最新文献

{"title":"Delayed corneal haze after combined photorefractive keratectomy and corneal cross-linking in non-keratoconus patients.","authors":"Mehrnaz Atighehchian, Fateme Alipour, Hamidreza Ghanbari, Parya Abdolalizadeh, Hesam Hashemian","doi":"10.1007/s10792-025-03712-1","DOIUrl":"10.1007/s10792-025-03712-1","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the incidence rate of corneal haze after combined simultaneous photorefractive keratectomy (PRK) and accelerated (10-min, 9 mW/cm²) corneal cross-linking (CXL) for non-keratoconus.</p><p><strong>Methods: </strong>This is a retrospective cohort study on patients without keratoconus underwent simultaneous CXL-PRK. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), manifest refraction, corneal keratometry, and corneal haze were evaluated.</p><p><strong>Results: </strong>Included were 92 eyes of 55 subjects with mean age of 31.42 ± 4.62 years and mean follow-up time of 13.83 ± 11.24 months (range: 6 to 46 months). Mean UCVA improved significantly from 1.06 ± 0.36 to 0.14 ± 0.17 logMAR after procedure (P = 0.01), but the mean BCVA worsened significantly from 0.02 ± 0.05 to 0.08 ± 0.11 logMAR (P = 0.01). Significant corneal haze occurred in 18 eyes (19.6%). Among them 11 eyes (61.1%) developed corneal haze in first postoperative year. The BCVA deteriorated in 83.3% (15/18) of hazy eyes while 63.5% (47.74) of eyes without haze formation did not have any change of BCVA (P < 0.001). The UCVA improved in majority of eyes with (88.9%, 16/18) or without (97.3%, 72/74) haze formation (P = 0.18). Densitometry analysis showed that the densest layer of cornea in eyes with haze was anterior layer at 10-12 periphery zone followed by anterior layer at 2 mm central zone.</p><p><strong>Conclusion: </strong>Nearly one-fifth of eyes develops significant corneal haze after CXL-PRK procedure. Despite of UCVA improvement, the loss of BCVA in eyes with corneal haze, suggests that CXL-PRK procedure should be approached with caution.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"360"},"PeriodicalIF":1.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, demographic, and outcome differences between isolated and non-isolated lacrimal gland involvement in idiopathic orbital inflammation.","authors":"Elif Akbas Ulman, Melis Palamar, Berkay Anil Kupal, Banu Yaman, Taner Akalın, Naim Ceylan, Ozlem Barut Selver","doi":"10.1007/s10792-025-03737-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03737-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical data of idiopathic orbital inflammation with isolated and non-isolated lacrimal gland involvement.</p><p><strong>Methods: </strong>The medical records of patients who were diagnosed with idiopathic orbital inflammation between January 2016 and June 2022 were evaluated. The patients were divided into 2 groups: isolated and non-isolated lacrimal gland involvement, and were compared in terms of clinical characteristics, response to treatment and recurrence rates.</p><p><strong>Results: </strong>Thirty-three eyes of 32 patients (21 female, 11 male) were included in the study. The mean age of the patients was 47.4 ± 14.8 (range, 11-70). The mean follow-up period was 37.4 ± 21.5 (range, 6-76) months. Isolated lacrimal gland involvement was found in 18 eyes (54.5%), myositis and orbital adipose tissue involvement in addition to lacrimal gland involvement in 13 eyes (39.4%), and diffuse orbital inflammation in two eyes (6.1%). While a total of 24 patients (75.0%) were treated with systemic steroids alone, immunosuppressive drugs were used in addition to steroids in eight patients (25.0%). In patients with isolated lacrimal gland involvement, complete recovery with steroid treatment was significantly higher (p = 0.02), while the need for immunosuppressant medication (p = 0.02) and recurrence rates (p = 0.006) were found to be significantly lower.</p><p><strong>Conclusion: </strong>To the best of our knowledge, this is the first study to describe and compare the clinical features and treatment outcomes of lacrimal gland biopsy-proven idiopathic orbital inflammation according to the extent of involvement. Knowing whether lacrimal gland involvement is isolated or not may help predict steroid resistance and recurrence risk in patient management.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"362"},"PeriodicalIF":1.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative pain assessment using a digital force gauge during vitreoretinal surgery: a prospective feasibility study.","authors":"De-Zhi Zheng, Wei-Qi Chen, Zi-Jing Huang, Ding-Guo Huang, Pei-Min Lin","doi":"10.1007/s10792-025-03734-9","DOIUrl":"10.1007/s10792-025-03734-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the feasibility of real-time intraoperative pain assessment using a digital force gauge during vitreoretinal surgery under sub-Tenon's anesthesia.</p><p><strong>Methods: </strong>In this prospective observational study, 63 patients undergoing vitreoretinal surgery under sub-Tenon's anesthesia were enrolled between April and August 2023. The participants were asked to constantly compress a digital force gauge during the operation. The magnitude of the compressive force was directly proportional to the severity of pain they experienced. A Pain Index (PI) was derived from peak compressive force measurements to evaluate the intraoperative pain intensity. Immediately after the surgery, patients reported their intraoperative pain score and anxiety score using the Numerical Rating Scale (NRS). Concordance between PI and pain scores was analyzed using the intraclass correlation coefficient (ICC) and Kendall's tau-b analysis.</p><p><strong>Results: </strong>The PI was slightly higher than the patient-reported pain scores (1.37 ± 1.27 vs. 1.05 ± 1.28, P = 0.01). Complete consistency in values was observed in 33 cases (52.38%). Strong concordance emerged between PI and pain score (ICC = 0.75, 95% CI: 0.62-0.84; P < 0.01), along with a significant rank-order correlation (τ = 0.66, P < 0.01). Moreover, the PI showed a weaker correlation with anxiety score (τ = 0.32, P = 0.02) compared to pain score (τ = 0.51, P < 0.01).</p><p><strong>Conclusion: </strong>The PI demonstrated favorable consistency and correlation with the conventional NRS for pain evaluation.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"359"},"PeriodicalIF":1.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinical characteristics of Charles Bonnet syndrome in patients with glaucoma.","authors":"Ahan Banker, Divya Patel, Mahir Patel, Henil Patel, Urva Gupta, Purvi Bhagat, Jignesh Gosai","doi":"10.1007/s10792-025-03729-6","DOIUrl":"https://doi.org/10.1007/s10792-025-03729-6","url":null,"abstract":"<p><strong>Aims and background: </strong>Charles Bonnet Syndrome (CBS) is characterized by visual hallucinations in individuals with acquired vision loss. Despite its potential impact on the patient's quality of life, CBS remains underdiagnosed and is often misinterpreted as a psychiatric illness. This study aims to investigate the prevalence and clinical characteristics of CBS in patients with glaucoma, also highlighting its correlation with visual acuity and severity of glaucoma.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 200 patients diagnosed with glaucoma at a tertiary care center of western India. Patients were evaluated for CBS using a pre-designed questionnaire capturing demographic data, glaucoma profiles, and details about hallucinations. Statistical analysis was performed to ascertain the prevalence of CBS and its associations.</p><p><strong>Results: </strong>CBS was identified in 23 patients, resulting in a prevalence of 11.5%. Most affected individuals were aged 50-59 years, with a male-to-female ratio of 11:12. Most patients experienced simple visual phenomena, such as lines and light flickers. CBS was more prevalent in primary open-angle glaucoma (69.57%) compared to primary angle-closure glaucoma (30.43%). A significant proportion of patients reported that their hallucinations affected their emotional well-being and quality of life.</p><p><strong>Conclusion: </strong>This study underscores the prevalence of CBS in glaucoma patients, even among those with relatively good visual acuity. Recognizing CBS is crucial for appropriate management and support, as it significantly impacts the psychosocial health of patients. Increased awareness and education for both patients and clinicians are essential to ensure improved patient outcomes in overall glaucoma care.</p><p><strong>Clinical significance: </strong>Despite its potential impact on the patient's quality of life, CBS remains underdiagnosed and is often misinterpreted as a psychiatric illness. It can occur even among those with relatively good visual acuity and can significantly affect the emotional well-being and quality of life of patients. Timely detection and patient counselling may help to minimize the negative consequences of this condition.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"356"},"PeriodicalIF":1.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choriocapillaris perfusion assessed using optical coherence tomography angiography depends on eye color and projection artifact removal.","authors":"Dmitrii S Maltsev, Alexey N Kulikov, Anastasiya S Vasyukovich, Yana A Kalinicheva","doi":"10.1007/s10792-025-03735-8","DOIUrl":"https://doi.org/10.1007/s10792-025-03735-8","url":null,"abstract":"<p><strong>Aim: </strong>To study variation of choriocapillaris perfusion displayed with optical coherence tomography angiography (OCTA) in dependence of the eye pigmentation.</p><p><strong>Methods: </strong>Healthy individuals and patients with resolved central serous chorioretinopathy (CSCR) with blue or brown eyes were enrolled in this study. Analysis of choriocapillaris flow voids number was performed based on averaged 3 mm OCTA scans with and without projection artifact removal (PAR). The number and total area of flow voids taken every 1000 µm² between 1 and 5000 µm², was calculated and compared between blue and brown eyes.</p><p><strong>Results: </strong>Thirty-six healthy individuals and 28 CSCR patients were included. When PAR was active, brown eyes showed a statistically significant higher number (p < 0.05) and total area (p < 0.05) of large (1000 to 5000 µm²) choriocapillaris flow voids compared to blue eyes, in both healthy and CSCR eyes. No statistically significant difference was found in either number or total area of choriocapillaris flow voids (p > 0.05) between brown and blue eyes after inactivation of PAR. The number of large flow voids in CSCR eyes was statistically significantly higher than in healthy eyes, 316.4 ± 141.3 and 112.9 ± 60.1 (p < 0.001), respectively. Similarly, this difference was also statistically significant with inactivated PAR, 180.1 ± 96.9 and 54.9 ± 36.9, respectively (p < 0.001).</p><p><strong>Conclusion: </strong>OCTA displays more flow voids in the choriocapillaris in brown eyes than in blue. This difference results from the activity of PAR.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"357"},"PeriodicalIF":1.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pars plana vitrectomy with ILM peeling for macular edema of various etiologies: results from the SCRV macula surgery study.","authors":"Sylvain El-Khoury, Youssef Abdelmassih, Didier Ducournau, Andrei Drimbea, Alexandre Portmann","doi":"10.1007/s10792-025-03721-0","DOIUrl":"https://doi.org/10.1007/s10792-025-03721-0","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the outcome and complications associated with pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling in the treatment of macular edema of various etiologies.</p><p><strong>Methods: </strong>This observational, multicenter, longitudinal, retrospective study, initiated by the Société Française de Chirurgie Rétino-Vitréene in 2022, involved 27 surgeons from all over France. Data were collected preoperatively and at multiple postoperative time periods up to two years. The etiologies of macular edema included epiretinal membrane (ERM), vitreomacular traction syndrome (VMT), diabetic macular edema (DME), retinal vein occlusion (RVO), and postsurgical cystoid macular edema (PCME).</p><p><strong>Results: </strong>A total of 876 patients were included in the study. Best-corrected visual acuity (BCVA) significantly improved from 0.44 ± 0.26logMAR preoperatively to 0.22 ± 0.33logMAR at 1-2 years postoperatively (p < 0.001). Central macular thickness decreased from 422 ± 97 μm preoperatively to 337 ± 67 μm at 1-2 years. Intraoperative complications included retinal tear or retinal detachment in 6.3% of cases and intravitreal hemorrhage in 0.6% of cases. Postoperative retinal detachment occurred in 3.2% of patients. Intravitreal injection preoperatively was associated with poorer BCVA outcomes in the follow-up (p < 0.001). Patients who attained the best BCVA postoperatively demonstrated a macular thickness ranging from 320 to 400 μm.</p><p><strong>Conclusion: </strong>PPV with ILM peeling proved to be an effective treatment for macular edema across various etiologies. Interestingly, good visual acuity following ILM peeling appeared to be associated with a larger macular thickness compared to the normal population. Intravitreal injections of anti-VEGF or dexamethasone implant preoperatively seemed to limit visual recovery.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"352"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypoidal choroidal vasculopathy features among Filipino eyes with neovascular AMD: application of the Asia Pacific Ocular Smaging Society non-ICGA criteria.","authors":"Jonathan Paul B Lacanilao, Jose Carlo M Artiaga","doi":"10.1007/s10792-025-03715-y","DOIUrl":"10.1007/s10792-025-03715-y","url":null,"abstract":"<p><strong>Background/objectives: </strong>To determine the proportion of eyes with optical coherence tomography (OCT) features of polypoidal choroidal vasculopathy (PCV) among patients diagnosed as neovascular age-related macular degeneration (nAMD) based on Asia-Pacific Ocular Imaging Society (APOIS) Diagnostic Criteria.</p><p><strong>Methods: </strong>This study was a retrospective cross-sectional review of OCT images. Medical records of treatment-naïve nAMD patients between January 2018 and June 2023 were reviewed. Clinical and demographic profile at presentation was collected. OCT scans were reviewed for presence of APOIS Diagnostic Criteria. Eyes were classified as having PCV features (PCV) based on the presence of ≥ 2 major OCT APOIS diagnostic criteria and then compared with eyes not having these features (non-PCV).</p><p><strong>Results: </strong>OCT scans of 45 eyes of 38 patients diagnosed with nAMD were analyzed. Mean age was 69.4 years old (range 53-83), 71.1% of patients were female, and 81.6% had unilateral disease. There was no statistically significant difference among clinical and demographic characteristics between PCV and non-PCV groups. Twenty-four eyes (53.3%) had ≥ 2 major APOIS criteria for PCV. Among PCV eyes, sub-RPE ring-like lesion and double-layer sign were the most common major (87.5%) and minor OCT criteria (100%), respectively. Sharp-peaked PED (p < 0.001), sub-RPE ring-like lesion (p < 0.001), en face OCT complex RPE elevation (p = 0.005) and double-layer sign criteria (p = 0.007) were more frequent in the PCV than in the non-PCV group.</p><p><strong>Conclusion: </strong>More than half of Filipino eyes diagnosed with nAMD fulfill the OCT criteria for PCV. The APOIS PCV Workgroup Criteria helps identify patients who will benefit from additional confirmatory and treatment options.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"351"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical appraisal of \"efficacy and safety of botulinum toxin as a non-surgical option for upper eyelid retraction in active thyroid-associated ophthalmopathy\".","authors":"Ahmad Shabbir, Tahmina Sajjad, Fatima Shams","doi":"10.1007/s10792-025-03742-9","DOIUrl":"https://doi.org/10.1007/s10792-025-03742-9","url":null,"abstract":"","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"355"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing potential immune checkpoint inhibitor-associated optic neuritis: insights from the FDA adverse event reporting system.","authors":"Chang-Zhu He, Qin Qiu, Yu He","doi":"10.1007/s10792-025-03743-8","DOIUrl":"https://doi.org/10.1007/s10792-025-03743-8","url":null,"abstract":"","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"353"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic nutritional index in retinopathy of prematurity: a potential indicator of disease severity?","authors":"Ahmet Ozdemir, Abdulcemal Gurpinar, Zeynep Yuksel, Canan Seren, Ozlem Eski Yucel","doi":"10.1007/s10792-025-03726-9","DOIUrl":"https://doi.org/10.1007/s10792-025-03726-9","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the role of the Prognostic Nutritional Index (PNI) in predicting disease severity and the need for treatment of retinopathy of prematurity (ROP).</p><p><strong>Methods: </strong>This retrospective cohort study included 406 preterm infants. The cases were divided into three groups: without ROP (group 1), with spontaneously regressed ROP (group 2), and with ROP requiring treatment (group 3). Patients' clinical and demographic data, including gestational age (GA), birth weight (BW), serum albumin levels, and PNI values, were obtained from medical records. Logistic regression was performed to identify predictors of severe ROP, and receiver operating characteristic (ROC) analysis was conducted to determine the discriminative power of PNI for the treatment requirement of ROP.</p><p><strong>Results: </strong>GA and BW differed in all groups (p = 0.001). Serum albumin level, lymphocyte and platelet counts, and PNI values were lower in groups 2 and 3 than in group 1 (p = 0.001). In ordinal regression analysis, GA (OR = 0.750, p = 0.001) and PNI (OR = 0.787, p = 0.001) showed a significant and inverse association with severe ROP. ROC analysis showed that PNI (AUC = 0.822, p = 0.001) had the highest predictive power at the optimum cut-off value of 34.02 with 78.2% sensitivity and 75.5% specificity for predicting the treatment requirement of ROP.</p><p><strong>Conclusion: </strong>PNI is significantly associated with the severity of ROP and treatment requirements. This result supports the relationship between nutritional and immune status and ROP. Considering PNI with clinical parameters, such as GA and BW, will be very useful for the early determination of prognosis and treatment needs in ROP.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"354"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}