International Ophthalmology最新文献

{"title":"Chronological age was not an independent predictor of visual recovery following cataract surgery in adults aged ≥ 75 years: a retrospective tertiary referral centre audit.","authors":"Hidayah Embong, Iqbal Tajunisah","doi":"10.1007/s10792-026-04276-4","DOIUrl":"10.1007/s10792-026-04276-4","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether chronological age independently influences surgical success, intraoperative challenges, complications and visual outcomes following cataract surgery in patients aged ≥ 75 years.</p><p><strong>Methods: </strong>This retrospective clinical audit included 189 eyes from 183 consecutive patients aged ≥ 75 years who underwent cataract surgery at a tertiary referral centre. Demographic data, ocular and systemic comorbidities, intraoperative challenges, complications and postoperative visual outcomes were analysed. The primary outcome was best-corrected visual acuity (BCVA) ≥ 6/12 at six weeks. Multivariable logistic regression identified independent predictors of visual success.</p><p><strong>Results: </strong>The mean patient age was 80.98 ± 4.28 years. Systemic multimorbidity was present in 97.8% of patients and ocular comorbidities were identified in 49.2% of eyes. Phacoemulsification was performed in 92.6% of eyes, while 7.4% underwent planned or conversion to extracapsular cataract extraction (ECCE). Intraoperative challenges included small pupils (52.9%), hazy corneas (20.6%), floppy iris syndrome (14.7%) and patient restlessness (11.8%). Intraoperative complications occurred in 18.5% of eyes. At six weeks, 76.7% achieved BCVA ≥ 6/12 and 89.9% showed visual improvement. Independent predictors of failure to achieve BCVA ≥ 6/12 were severe preoperative visual impairment ( adjusted odds ratio [aOR] 0.13, p < 0.001), ocular comorbidities (aOR = 0.35, p = 0.015) and intraoperative complications (aOR = 0.31, p = 0.012). Chronological age was not independently associated with visual outcome.</p><p><strong>Conclusion: </strong>Patients aged ≥ 75 years can achieve favourable visual outcomes after cataract surgery despite having multiple comorbidities and increased surgical complexity. Postoperative visual recovery is primarily determined by ocular status and intraoperative complications rather than age factor alone. Advanced age should not be a deterrent for cataract surgery if required.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum myelin basic protein in POAG patients at a tertiary institution in Lagos, Nigeria.","authors":"Judith Ogechi Anikwenwa, Adetunji Olusesan Adenekan, Adegboyega Sunday Alabi, Oluwatobi Olalekan Idowu, Ademola Ayoda Sule, Olufisayo Temitayo Aribaba, Solomon Oladapo Rotimi, Adeola Olukorede Onakoya","doi":"10.1007/s10792-026-04275-5","DOIUrl":"10.1007/s10792-026-04275-5","url":null,"abstract":"<p><strong>Purpose: </strong>Glaucoma, a neurodegenerative disorder, causes retinal ganglion cell damage and loss of neurons in the visual system up to the visual cortex. The loss of myelin sheath leads to the release of myelin sheath components, including the myelin basic protein (MBP), into the bloodstream. While MBP has shown promise as a biomarker for glaucoma in some Asian populations, data among individuals of African descent remain limited. This study evaluated the serum levels of MBP in primary open-angle glaucoma (POAG) patients compared to non-glaucoma controls, with the aim of reporting its usefulness as a biomarker for glaucoma detection in an African population.</p><p><strong>Methods: </strong>This cross-sectional study compared serum MBP levels in treatment-naive primary open-angle glaucoma (POAG) patients and non-glaucoma controls. Blood samples were collected from 83 treatment-naive POAG participants and 83 age and sex matched non-glaucoma participants and analyzed using enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>The mean age of POAG participants was 50.78 ± 17.3 years, with a male predilection. The mean intraocular pressure (IOP) was significantly higher in POAG patients (18.22 ± 6.8 mmHg) than in controls (13.89 ± 2.5 mmHg). Serum MBP levels were significantly elevated in POAG patients (1128.75 ng/L) compared to controls (963.75 ng/L; p < 0.001). There was no significant correlation between MBP levels and disease severity. MBP levels were higher in high-tension glaucoma and females; however, the difference was not statistically significant.</p><p><strong>Conclusion: </strong>Findings supported the neurodegenerative state of POAG and the use of serum MBP levels as a potential biomarker for early POAG detection.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune inflammatory targets and anti-inflammatory therapy in dry eye disease.","authors":"Zongcan Zhu, Wenjing Zhang, Qibing Mei","doi":"10.1007/s10792-026-04278-2","DOIUrl":"10.1007/s10792-026-04278-2","url":null,"abstract":"<p><strong>Background: </strong>Dry eye disease (DED) is a common category of ocular surface disease caused by insufficient tear secretion or reduced tear film quality, which leads to damage to ocular surface epithelial cells and initiates an inflammatory response, ultimately forming a vicious cycle dominated by chronic inflammation. The signaling pathways involved in DED are complex and need to be further explored.</p><p><strong>Methods: </strong>A literature search of PubMed was conducted to identify studies on DED published between 2013 and 2026.The search strategy adopted a combination of keywords as follows: \"dry eye disease\", \"neuroimmune and inflammation\", \"inflammatory signaling pathway\", \"ocular surface microenvironment. Inclusion Criteria\": 1.Original human clinical trials, in vitro cellular experiments, and animal model studies related to DED;2. Systematic reviews focusing on immunity and inflammation in DED.</p><p><strong>Exclusion criteria: </strong>1. Studies solely addressing other ocular surface diseases such as conjunctivitis, keratitis, and uveitis; 2. Studies lacking experimental data supporting anti-inflammatory therapeutic effects.</p><p><strong>Results: </strong>Previous studies have shown that anti-inflammatory therapies hold great promise for the treatment of moderate to severe DED. Inhibiting T cell activation or the release of inflammatory cytokines can help break the vicious cycle of inflammation. The NF-κB pathway plays a central role in the pathogenesis of DED.</p><p><strong>Conclusions: </strong>Chronic inflammation can continuously damage epithelial cells, exacerbating the severity of DED and significantly impacting the patient's quality of life. Therefore, understanding the underlying inflammatory mechanisms is crucial for the development of effective therapeutic strategies for DED.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-traumatic ınfectious keratitis: clinical, microbiological, and visual outcomes.","authors":"Emine Doğan, Alik Salamatov, Burçin Çakır, Sibel Alişan Alimoğlu, Gürsoy Alagöz","doi":"10.1007/s10792-026-04280-8","DOIUrl":"10.1007/s10792-026-04280-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the demographic, etiological, clinical and microbiological characteristics of patients diagnosed with post-traumatic infectious keratitis and to assess treatment outcomes.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 30 patients diagnosed with post-traumatic infectious keratitis between 2016 and 2024 at a tertiary ophthalmology clinic. Data on demographics, mechanisms of injury, timing of presentation, clinical findings, microbiological results, treatment modalities and visual outcomes were reviewed.</p><p><strong>Results: </strong>The mean age was 54.45 ± 18.06 years, with a distinct seasonal peak during the harvest period (July-September). Agricultural injuries (plant material, soil, and metal) were the primary causes. Corneal scraping cultures were positive in 8 patients (26.7%). Despite the relatively low culture positivity rate, likely due to prior antimicrobial therapy (33.3%), favorable visual outcomes (final visual acuity ≥ 0.5) were achieved in 66.7% of patients following prompt empirical antimicrobial therapy, with a mean final visual acuity of 0.71 ± 0.24.</p><p><strong>Conclusion: </strong>Post-traumatic infectious keratitis is a significant occupational hazard, particularly during harvest seasons. Our study suggests that even when microbiological yield is low, prompt initiation of empirical fortified antibiotic therapy may result in favorable visual outcomes.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of overlooked Fuchs' Endothelial Corneal Dystrophy: postoperative results following intraocular interventions.","authors":"Gozde Sahin Vural, Ferhat Avci","doi":"10.1007/s10792-026-04277-3","DOIUrl":"10.1007/s10792-026-04277-3","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate postoperative outcomes in patients with previously unrecognized Fuchs endothelial corneal dystrophy (FECD) following intraocular surgery and to identify clinical, endothelial, and tomographic features associated with delayed diagnosis and corneal decompensation.</p><p><strong>Methods: </strong>This retrospective observational study included patients who underwent intraocular surgery without a preoperative diagnosis of FECD and were subsequently referred for persistent postoperative corneal edema. Demographic data, surgical history, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) were recorded. Endothelial cell parameters were assessed using non-contact specular microscopy, and corneal morphology was evaluated with Scheimpflug-based tomography, including pachymetric distribution, posterior corneal elevation, and higher-order aberrations.</p><p><strong>Results: </strong>Forty-five eyes of 39 patients (mean age 69.8 ± 10.5 years; 86% female) were analyzed. Phacoemulsification was the most common prior procedure (91.1%), and the mean interval between surgery and FECD diagnosis was 33.4 ± 24.1 months. Mean BCVA showed a numerical but statistically non-significant increase from 0.18 ± 0.07 at presentation/FECD diagnosis to 0.36 ± 0.19 at the last follow-up visit (p = 0.090). Mean IOP was 16.0 ± 4.3 mmHg at presentation/FECD diagnosis and 14.8 ± 4.4 mmHg at the last follow-up visit, with no statistically significant change (p = 0.087). Specular microscopy demonstrated reduced endothelial cell density (1146.7 ± 467.7 cells/mm²), increased polymegathism (CV: 33.8 ± 14.9%), and decreased hexagonality (17.5 ± 29.9%). Mean central corneal thickness was 588.0 ± 83.6 µm by specular microscopy and 636.0 ± 105.5 µm by tomography. Tomography revealed loss of regular isopach contours (90%), posterior corneal elevation (66.7%), and thinnest point displacement (46.7%). Posterior corneal higher-order aberrations were increased (3.93 ± 4.01 µm RMS). Endothelial keratoplasty was indicated in 38 eyes (84.4%).</p><p><strong>Conclusions: </strong>Previously unrecognized FECD may predispose patients to postoperative corneal decompensation after intraocular surgery, and comprehensive endothelial and tomographic assessment may facilitate earlier diagnosis, improved risk stratification, and reduced postoperative corneal morbidity.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular surface dryness and disease activity in rheumatoid arthritis patients attending rheumatology clinic at Alexandria Main University Hospital.","authors":"Mohamed Sobhy Hassan, Btoul Khaldon Bitmani, Nermen Magdy Abdelmegeid, Tamer Hamdy Massoud","doi":"10.1007/s10792-026-04247-9","DOIUrl":"10.1007/s10792-026-04247-9","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate ocular surface dryness in patients with rheumatoid arthritis and to investigate its association with disease activity parameters.</p><p><strong>Methods: </strong>This cross-sectional study included adult RA patients attending the Rheumatology Outpatient Clinic at Alexandria Main University Hospital. All participants underwent rheumatologic evaluation including Disease Activity Score-28, laboratory assessment of rheumatoid factor, anti-cyclic citrullinated peptide antibodies, and C-reactive protein, as well as comprehensive ophthalmologic examination. Dry eye assessment included the validated Arabic Ocular Surface Disease Index, Schirmer tear test I with and without anesthesia, and fluorescein staining graded using the Oxford scale.</p><p><strong>Results: </strong>Thirty-one female RA patients were included, with a mean age of 45.32 ± 10.26 years. Most patients exhibited moderate disease activity (64.5%), followed by high (19.4%) and low activity (16.1%). Severe dry eye symptoms were reported by 87.1% of participants based on OSDI scores. Objective testing revealed reduced tear production in a substantial proportion of eyes, with severe aqueous deficiency detected in 11.3% without anesthesia and 21.0% after anesthesia. Fluorescein staining demonstrated predominantly minimal to mild epithelial changes. Correlation analysis showed no statistically significant associations between disease activity, inflammatory markers, serological status (RF and anti-CCP), disease duration, and any subjective or objective dry eye parameters.</p><p><strong>Conclusion: </strong>Ocular surface dryness is highly prevalent among patients with rheumatoid arthritis, with severe symptoms frequently observed despite generally mild to moderate objective findings. The absence of significant correlations with disease activity, inflammatory markers, or disease duration suggests that dry eye in RA may occur independently of systemic disease status. Routine ophthalmologic screening should therefore be considered for all RA patients regardless of disease activity.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude, patterns, and determinant factors of diabetic macular edema among people with diabetes at Debre Markos Referral Hospital, Northwest Ethiopia, 2025: a hospital-based cross-sectional study.","authors":"Melkamu Tilahun, Nibret Abebaw Yeneneh, Megbar Dessalegn, Adane Adugna, Mohammed Jemal, Haile Amha, Yeshimareg Shita Mekete","doi":"10.1007/s10792-026-04282-6","DOIUrl":"10.1007/s10792-026-04282-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetic macular edema (DME) is the most common cause of vision loss in people with diabetes. Although the global prevalence of DME is increasing and several studies have been conducted worldwide, research on the burden and risk factors of diabetic macular edema in Ethiopia remains limited. This research aimed to investigate the magnitude, patterns, and determinants of DME among people with diabetes at Debre Markos Referral Hospital.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;A hospital-based prospective cross-sectional study was conducted among 426 type 1 and type 2 people with diabetes from April 1 to May 30, 2025. Participants were selected via systematic random sampling using the patient registry as a sampling frame. Data were collected using three approaches: medical record review, participant interviews, and direct clinical assessment. Blood pressure, body weight, height, blood glucose, and serum lipid profiles were measured directly for all participants. Fundus evaluation was performed using slit-lamp biomicroscopy and optical coherence tomography, and diabetic macular edema was defined according to the Early Treatment Diabetic Retinopathy Study criteria. Data were entered into EpiData 3.1 and exported to SPSS version 25. Descriptive statistics and logistic regression analyses were conducted. Variables with a p &lt; 0.25 in the bivariate analysis were included in the multivariable model, with statistical significance set at p &lt; 0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Diabetic macular edema was identified in 112 of 426 participants (26.29%; 95% CI 22.29-30.71%), of whom 28/112 (25.00%) had clinically significant diabetic macular edema. Among the 112 participants with diabetic macular edema, diffuse DME was the most common morphological pattern (49/112, 43.75%), followed by cystoid (27/112, 24.10%), tractional (21/112, 18.75%), combined (11/112, 9.82%), and serous (4/112, 3.57%). Diabetic retinopathy was present in 148/426 (34.74%) participants. Among participants with NPDR, 68/106 (64.15%) had DME, whereas 36/42 (85.71%) of those with PDR had DME. Visual acuity impairment was observed in 99/112 (88.39%) participants with DME and in 178/426 (41.78%) of the total study population. Multivariable logistic regression showed that age 41-65 years (AOR=3.02, 95% CI 1.53-5.98), age &gt; 65 years (AOR=5.73, 95% CI 2.04-16.12), poor glycemic control (AOR=3.15, 95% CI: 1.81-5.45), elevated total cholesterol (AOR = 1.97, 95% CI 1.07-3.62), hypertension (AOR = 3.10, 95% CI 1.7-5.44), BMI ≥25 kg/m&lt;sup&gt;2&lt;/sup&gt; (AOR = 2.39, 95% CI 1.35-4.22), and diabetes duration &gt;10 years (AOR = 4.10, 95% CI 2.41-6.98) were independently associated with DME.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion and recommendation: &lt;/strong&gt;Diabetic macular edema is a significant complication among people with diabetes. Age, glycaemic control level, hypertension, BMI, total cholesterol, and diabetic duration were associated with DME. Therefore, we recommend strengthening routine DME screen","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of topical insulin in the treatment of isotretinoin-associated dry eye disease in patients with acne vulgaris.","authors":"Mehmet Komur, Hasan Altinkaynak, Caner Kutlugun, Osman Sayin","doi":"10.1007/s10792-026-04279-1","DOIUrl":"10.1007/s10792-026-04279-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of topical insulin (TI) for isotretinoin-associated dry eye disease.</p><p><strong>Materials and methods: </strong>In this retrospective study, 48 patients with isotretinoin-associated dry eye disease received either topical insulin (study group) or artificial tears (control group). Ocular surface disease index (OSDI), Tear break-up time (TBUT), and Schirmer I test (ST) values were assessed at baseline and after 4 weeks.</p><p><strong>Results: </strong>OSDI and ST values improved significantly in the study group, whereas OSDI worsened and ST values remained unchanged in controls. TBUT was stable in the study group but decreased significantly in controls. No adverse effects were observed.</p><p><strong>Conclusions: </strong>TI may represent a potentially useful therapeutic option for isotretinoin-associated dry eye disease.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in visual outcomes in diabetic macular edema through the reduction of macular thickness fluctuations using the 0, 19 mg fluocinolone acetonide implant.","authors":"Susana Penas, Bernardete Pessoa, Carla Teixeira, Miguel Ruão, João Paulo Castro Sousa, Ângela Carneiro, Rufino Silva, Angelina Meireles","doi":"10.1007/s10792-026-04262-w","DOIUrl":"10.1007/s10792-026-04262-w","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the effectiveness of 0.19-mg fluocinolone acetonide intravitreal (FAc) implant to control retinal thickness fluctuations (RTF) in diabetic macular edema (DME) and its effect on best-corrected visual acuity (BCVA).</p><p><strong>Methods: </strong>The RIVER study was a multicenter, retrospective, non-interventional study analyzing data of the Retina.pt portuguese national registry in DME. Retinal thickness was assessed using the spectral domain optical coherence tomography (SD-OCT). The primary endpoint was the assessment of RTF along the follow-up, through the combined measurement of retinal thickness amplitude (RTA), retinal thickness standard deviation (RTSD), and central subfield thickness area under the curve (CST-AUC). Eyes were stratified into quartiles (Q) and median-split according to these variables.</p><p><strong>Results: </strong>The mean follow-up time after the FAc implantation was 82 ± 26, 96 months. From baseline to last follow-up visit after the implant, mean RTA decreased from 187.6±150.4 to 151.6±126.4 µm (p=0.1204), mean RTSD significantly reduced from 96.3±78.1 to 60.8±57.3 µm (p=0.0032) and mean CST-AUC significantly reduced from 446 to 349 µm (p<0.0001). BCVA significantly improved in eyes with RTA Q1, Q2, Q3 (p<0.05); eyes with RTSD Q1, Q2, and Q3 (p<0.05); and eyes with CST-AUC Q1, Q2, and Q3 (p<0.05). According to the median split, eyes with RTA and RTSD < to median showed greater BCVA improvement.</p><p><strong>Conclusions: </strong>Retinal thickness fluctuation was significantly reduced after the Fc implant. Moreover, a lower retinal thickness variability tended to be associated with better visual outcomes.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotational stability and visual outcomes of toric implantable collamer lenses in eyes with horizontal and non-horizontal implanting orientation: an observational study.","authors":"Xiaoe Fan, Teruko Fukuyama, Lingling Niu, Xiaohong Zheng, Zhe Zhang, Jing Zhao, Xingtao Zhou","doi":"10.1007/s10792-026-04225-1","DOIUrl":"10.1007/s10792-026-04225-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the short-term rotational stability and visual outcomes of the toric intraocular collamer lens (TICL) with horizontal and non-horizontal implantation orientation based on the Callisto eye system.</p><p><strong>Methods: </strong>This observational study analyzed 77 eyes from 51 patients with horizontal (n = 41) and non-horizontal (n = 36) TICL implantation. Examinations were performed preoperatively and at 1 week, 1 month, and 3 months. Outcomes included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction, and TICL axis position; rotational stability was quantified from dilated slit-lamp photographs. The primary endpoint was mean absolute rotation at 3 months.</p><p><strong>Results: </strong>At 3 months, absolute rotation was 3.71 ± 2.72° (horizontal) and 3.15 ± 2.85° (non-horizontal), with no between-group difference (P = 0.385). Rotation ≤ 5° occurred in 73.17% (horizontal) and 88.89% (non-horizontal); ≤ 10° in 100% and 97.22%, respectively. Visual outcomes were excellent and comparable: at 3 months, UDVA 20/20 or better in 100% of eyes in both groups; efficacy index 1.19 ± 0.21 (horizontal) vs 1.17 ± 0.15 (non-horizontal); safety index 1.25 ± 0.21 vs 1.22 ± 0.19. Achieved refraction closely matched target (attempted-vs-achieved slope y = 1.02x + 0.01). Residual cylinder at 3 months was -0.42 ± 0.28 dioptres (D) (horizontal; within ±0.50 D in 87.8%, within ±1.00 D in 97.56%) and -0.33 ± 0.32 D (non-horizontal; within ±0.50 D in 94.44%, within ±1.00 D in 100%); difference non-significant (P = 0.156).</p><p><strong>Conclusion: </strong>Non-horizontal EVO-TICL implantation yields rotational stability, safety and efficacy comparable to horizontal placement over 3 months, with small mean rotations and tight refractive predictability. These findings support non-horizontal orientation as a viable alternative when anatomy or vault optimization warrants it.</p>","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13597637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}