The effect of caffeine consumption on age-related macular degeneration: a systematic review and meta-analysis.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2025-05-03 DOI:10.1007/s10792-025-03531-4

Jennifer Electra, Elvina Theodoraliu, Gilbert Lazarus, Yeni Dwi Lestari, Ari Djatikusumo

{"title":"The effect of caffeine consumption on age-related macular degeneration: a systematic review and meta-analysis.","authors":"Jennifer Electra, Elvina Theodoraliu, Gilbert Lazarus, Yeni Dwi Lestari, Ari Djatikusumo","doi":"10.1007/s10792-025-03531-4","DOIUrl":null,"url":null,"abstract":"Purpose: To explore the state-of-the-art evidence on the effect of caffeine consumption on the development and progression of age-related macular degeneration (AMD), a significant cause of blindness worldwide.Methods: Eligible primary clinical studies published up to 15 June 2024 were included and appraised using the Joanna Briggs Institute critical appraisal tools for cohort and case-control studies. The available data were then analyzed using random-effects meta-analysis and effect direction-based vote-counting (PROSPERO CRD42023451237).Results: Five studies (9318 patients) were included in this systematic review, three of which investigated the effect of caffeine intake on the development of AMD and two on AMD progression. Caffeine intake from coffee or other beverages showed no significant association with the occurrence of early (adjusted odds ratio 1.11 [95% confidence interval 0.93-1.33], I2 = 0.0%) or late AMD. On the other hand, vote-counting analysis indicated that caffeine consumption, mainly tea, may prevent and hinder disease progression, potentially in a dose-dependent manner.Conclusion: The limited available evidence suggests that caffeine consumption may deter and impede the progression of AMD. In contrast, the protective effect of caffeine consumption on the development of AMD remains uncertain. Further prospective, large-scale studies exploring the effects and dose-response relationship of various caffeine beverages across a broader spectrum of AMD and populations are warranted to corroborate our findings.","PeriodicalId":14473,"journal":{"name":"International Ophthalmology","volume":"45 1","pages":"158"},"PeriodicalIF":1.4000,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10792-025-03531-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To explore the state-of-the-art evidence on the effect of caffeine consumption on the development and progression of age-related macular degeneration (AMD), a significant cause of blindness worldwide.

Methods: Eligible primary clinical studies published up to 15 June 2024 were included and appraised using the Joanna Briggs Institute critical appraisal tools for cohort and case-control studies. The available data were then analyzed using random-effects meta-analysis and effect direction-based vote-counting (PROSPERO CRD42023451237).

Results: Five studies (9318 patients) were included in this systematic review, three of which investigated the effect of caffeine intake on the development of AMD and two on AMD progression. Caffeine intake from coffee or other beverages showed no significant association with the occurrence of early (adjusted odds ratio 1.11 [95% confidence interval 0.93-1.33], I² = 0.0%) or late AMD. On the other hand, vote-counting analysis indicated that caffeine consumption, mainly tea, may prevent and hinder disease progression, potentially in a dose-dependent manner.

Conclusion: The limited available evidence suggests that caffeine consumption may deter and impede the progression of AMD. In contrast, the protective effect of caffeine consumption on the development of AMD remains uncertain. Further prospective, large-scale studies exploring the effects and dose-response relationship of various caffeine beverages across a broader spectrum of AMD and populations are warranted to corroborate our findings.

查看原文本刊更多论文

咖啡因摄入对年龄相关性黄斑变性的影响：一项系统综述和荟萃分析。

目的：探索咖啡因摄入对年龄相关性黄斑变性（AMD）的发展和进展的影响的最新证据，AMD是全球失明的一个重要原因。方法：纳入截至2024年6月15日发表的符合条件的初级临床研究，并使用乔安娜布里格斯研究所用于队列和病例对照研究的关键评估工具进行评估。然后使用随机效应荟萃分析和基于效应方向的投票计数（PROSPERO CRD42023451237）对可用数据进行分析。结果：本系统综述纳入了5项研究（9318例患者），其中3项研究调查了咖啡因摄入对AMD发生的影响，2项研究调查了AMD进展。从咖啡或其他饮料中摄入咖啡因与早期（校正优势比1.11[95%可信区间0.93-1.33],I2 = 0.0%）或晚期AMD的发生无显著关联。另一方面，投票计数分析表明，咖啡因的摄入，主要是茶，可能以剂量依赖的方式预防和阻碍疾病的进展。结论：有限的现有证据表明，咖啡因的摄入可能会阻止和阻碍AMD的进展。相比之下，咖啡因摄入对AMD发展的保护作用仍不确定。进一步的前瞻性、大规模研究探索各种咖啡因饮料在更广泛的AMD和人群中的作用和剂量-反应关系，有必要证实我们的发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.