Ellipsoid zone reflectivity changes after idiopathic epiretinal membrane peeling: a pilot study.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2025-09-27 DOI:10.1007/s10792-025-03778-x

Alba Chiara Termite, Pasquale Viggiano, Giacomo Boscia, Lorenzo Accurso Tagano, Marta Zerbinati, Tommaso Festa, Giulia Fracchiolla, Antonio Fracchiolla, Ermete Giancipoli, Iaculli Cristiana, Francesco Pignatelli, Maria Grazia Pignataro, Federico Moscara, Pasquale Puzo, Nicola Recchimurzo, Giovanni Alessio, Francesco Boscia

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引用次数: 0

Abstract

Objective: This pilot study aimed to evaluate changes in ellipsoid zone (EZ) reflectivity and best-corrected visual acuity (BCVA) following epiretinal membrane (ERM) peeling surgery in patients with stage 2 and 3 ERM.

Methods: Thirty-five patients with stage 2 and 3 ERM underwent surgical intervention. Preoperative and three-month postoperative measurements of BCVA and EZ reflectivity were taken using spectral-domain optical coherence tomography (SD-OCT). The correlation between changes in BCVA and EZ reflectivity was analyzed.

Results: BCVA significantly improved from baseline (0.67 ± 0.23 LogMAR) to three months post-surgery (0.20 ± 0.20 LogMAR) (p < 0.0001). EZ reflectivity also showed a significant increase from baseline (0.62 ± 0.18) to the follow-up visit (0.99 ± 0.30) (p < 0.0001). A significant negative correlation was observed between BCVA (logMAR) and EZ reflectivity (r = - 0.758, p = 0.001).

Conclusions: This pilot study provides preliminary evidence that EZ reflectivity correlates with visual recovery after ERM peeling surgery and suggests potential utility as a biomarker for assessing photoreceptor health. Despite the small sample size, the significant correlation between improved BCVA and increased EZ reflectivity warrants further investigation in larger, longitudinal studies.

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特发性视网膜前膜剥离后椭球区反射率的变化：一项初步研究。

目的：本初步研究旨在评估2期和3期ERM患者视网膜前膜剥离手术后椭球区（EZ）反射率和最佳矫正视力（BCVA）的变化。方法：35例2、3期ERM患者行手术治疗。术前和术后3个月采用光谱域光学相干断层扫描（SD-OCT）测量BCVA和EZ反射率。分析BCVA与EZ反射率变化的相关性。结果：BCVA从基线（0.67±0.23 LogMAR）显著改善到术后3个月（0.20±0.20 LogMAR） (p)。结论：本初步研究提供了EZ反射率与ERM剥离手术后视力恢复相关的初步证据，并提示作为评估光感受器健康的生物标志物的潜在实用性。尽管样本量较小，但改善BCVA与增加EZ反射率之间的显著相关性值得在更大规模的纵向研究中进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.