Evaluation of optical coherence tomography angiography role in differentiating ischemic and non-ischemic central retinal vein occlusion.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2025-09-05 DOI:10.1007/s10792-025-03731-y

Iman Abdulhalim Muhammed Elhabiby, Sameh Saad Mandour, Sara Abdel Megeed Nage

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引用次数: 0

Abstract

Purpose: To evaluate the role of optical coherence tomography angiography (OCTA) in differentiating ischemic and non-ischemic central retinal vein occlusion (CRVO).

Methods: This prospective observational study included 72 eyes with CRVO (36 ischemic, 36 non-ischemic), all presenting with macular edema. Participants underwent clinical evaluation, fundus fluorescein angiography (FFA), and OCTA imaging. Key parameters analyzed included vessel density (VD) in the superficial and deep capillary plexuses (SCP and DCP), central retinal thickness (CRT), foveal avascular zone (FAZ) area, perimeter (PERIM), and flow density within 300 μm of the FAZ (FD-300).

Results: Ischemic CRVO eyes showed significantly lower superficial VD (45.13 ± 1.98 vs. 46.45 ± 3.42; p = 0.048), thinner CRT (390.53 ± 193.66 vs. 538.14 ± 139.63; p = 0.001), larger FAZ area (0.442 ± 0.239 vs. 0.245 ± 0.129; p = 0.001), and higher PERIM (2.82 ± 0.72 vs. 1.95 ± 0.56; p = 0.001) compared to non-ischemic eyes. FAZ (AUC = 0.769; sensitivity = 91.7%, specificity = 58.3%) and PERIM (AUC = 0.819; sensitivity = 88.9%, specificity = 66.7%) demonstrated strong diagnostic performance. Regression analysis identified age, intraocular pressure (IOP), CRT, FAZ, PERIM, and FD-300 as significant predictors of ischemia.

Conclusions: OCTA is a valuable, noninvasive tool for differentiating ischemic from non-ischemic CRVO based on quantitative microvascular parameters, with FAZ area and PERIM offering particularly strong diagnostic utility.

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光学相干断层血管造影在鉴别缺血性和非缺血性视网膜中央静脉阻塞中的作用评价。

目的：评价光学相干断层血管造影（OCTA）在鉴别缺血性和非缺血性视网膜中央静脉闭塞（CRVO）中的作用。方法：本前瞻性观察研究纳入72只CRVO眼（36只缺血性，36只非缺血性），均表现为黄斑水肿。参与者接受了临床评估、眼底荧光素血管造影（FFA）和OCTA成像。主要参数包括浅、深毛细血管丛血管密度（VD）（SCP和DCP）、视网膜中央厚度（CRT）、中央凹无血管区（FAZ）面积、周长（PERIM）和FAZ 300 μm范围内的血流密度（FD-300）。结果：缺血性CRVO眼与非缺血性CRVO眼相比，表浅VD（45.13±1.98∶46.45±3.42;p = 0.048）明显降低，CRT更薄（390.53±193.66∶538.14±139.63;p = 0.001）， FAZ面积更大（0.442±0.239∶0.245±0.129;p = 0.001）， PERIM更高（2.82±0.72∶1.95±0.56;p = 0.001）。FAZ （AUC = 0.769，灵敏度= 91.7%，特异性= 58.3%）和PERIM （AUC = 0.819，灵敏度= 88.9%，特异性= 66.7%）具有较强的诊断价值。回归分析发现，年龄、眼内压（IOP）、CRT、FAZ、PERIM和FD-300是缺血的重要预测因素。结论：基于定量微血管参数，OCTA是一种有价值的、无创的区分缺血性和非缺血性CRVO的工具，FAZ面积和PERIM具有特别强的诊断作用。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.