Evaluation of retinal vascular structure via optic coherence tomography angiography in obstructive sleep apnea.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2025-09-01 DOI:10.1007/s10792-025-03724-x

Zeynep Akgun, Cumali Degirmenci, Mehmet Sezai Tasbakan, Ozen K Basoglu, Melis Palamar

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引用次数: 0

Abstract

Objectives: Evaluation of the retinal vascular structure with optic coherence tomography angiography (OCT-A) in patients with obstructive sleep apnea (OSA).

Materials and methods: A total of 47 severe (Group 1), 30 moderate (Group 2), and 25 mild (Group 3) OSA patients and 51 healthy volunteers (Group 4) were included. Total, parafoveal, perifoveal superficial (SCP), and deep capillary plexus (DCP) vascular densities, foveal avascular zone (FAZ) and blood flow of choriocapillaris and outer retina were evaluated. Results were examined comparatively, and their correlation with hypoxia parameters (minSpO₂, meanSpO₂, T90%) in polysomnography was investigated.

Results: There was no difference in terms of age and gender (p = 0.155, p = 0.313, respectively). No difference was detected between the groups in terms of SCP and DCP (p > 0.005 for all parameters). FAZ were 0.28 ± 0.28, 0.26 ± 0.08, 0.25 ± 0.09, and 0.28 ± 0.98 mm² for Group 1-4, respectively (p = 0.880). For Group 1-4; blood flow areas of outer retinal layer were 8.38 ± 4.5 (4.5-17.1), 8.18 ± 1.9 (5-16.8), 8.62 ± 2.1 (5.5-17.2), 8.44 ± 3.2 (5.1-17.5) mm² and blood flow areas of choriocapillaris were 19.96 ± 1.4 (17.6-31.2), 19.98 ± 0.8 (18.5-21.6), 19.98 ± 1.1 (17.7-22.2), 19.97 ± 1.1 (18.1-23.2) mm², respectively (p = 0.622, 0.558, respectively). Total, parafoveal and perifoveal DCP densities were correlated with meanSpO₂ (ρ = 0.269, 261, and 0.277, respectively); total and perifoveal DCP densities were correlated with meanSpO₂ (r = 0.028, 0.042, respectively). No correlation was detected between T90% and any OCT-A parameters.

Conclusion: After considering confounding factors, no significant difference was observed in the retinochoroidal circulation between the study group and healthy volunteers, or across different stages of OSA. The weak to moderate correlation between hypoxia parameters and DCP density may suggest that the microvascular structure could be impacted in the early stages.

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阻塞性睡眠呼吸暂停患者视网膜血管结构的光学相干断层扫描评价。

目的：应用光学相干断层扫描血管造影（OCT-A）评价阻塞性睡眠呼吸暂停（OSA）患者的视网膜血管结构。材料与方法：重度OSA患者47例（第一组），中度OSA患者30例（第二组），轻度OSA患者25例（第三组），健康志愿者51例（第四组）。评估总血管密度、中央窝旁血管密度、中央窝周围血管密度、深毛细血管丛血管密度、中央窝无血管带密度和绒毛膜毛细血管及外视网膜血流。结果比较，并探讨其与多导睡眠图缺氧参数（minSpO2、meanSpO2、T90%）的相关性。结果：年龄、性别差异无统计学意义（p = 0.155、p = 0.313）。各组间在SCP和DCP方面无差异（所有参数p > 0.005）。《法兰克福汇报》分别为0.28±0.28,0.26±0.08,0.25±0.09,0.28±0.98平方毫米集团1 - 4分别(p = 0.880)。1-4组；视网膜外层血流面积分别为8.38±4.5（4.5-17.1）、8.18±1.9（5-16.8）、8.62±2.1（5.5-17.2）、8.44±3.2 (5.1-17.5)mm2，绒毛膜血流面积分别为19.96±1.4（17.6-31.2）、19.98±0.8（18.5-21.6）、19.98±1.1（17.7-22.2）、19.97±1.1 (18.1-23.2)mm2 （p分别为0.622、0.558）。总、中央凹旁和中央凹周围DCP密度与平均spo2相关（ρ分别为0.269、261和0.277）；总DCP密度与平均spo2呈正相关（r分别为0.028、0.042）。T90%与OCT-A参数无相关性。结论：在考虑混杂因素后，实验组与健康志愿者的视网膜脉络膜循环无显著差异，OSA的不同阶段也无显著差异。低氧参数与DCP密度之间的弱至中度相关性可能提示微血管结构在早期受到影响。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.