International Urogynecology Journal最新文献

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Dutch Translation, Cultural Adaption, and Validation of the German Pelvic Floor Questionnaire for Pregnant and Postpartum Women. 孕妇和产后妇女德国骨盆底问卷的荷兰语翻译、文化适应和验证。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-06-03 DOI: 10.1007/s00192-025-06173-3
Linde M L Titulaer, Viola C Sandfort, Lidwine B Mokkink, Annelies L Pool-Goudzwaard, Marco H Blanker, Gert-Jan van Baaren, Anna E Seijmonsbergen-Schermers, Jan-Paul W R Roovers, Corine J M Verhoeven
{"title":"Dutch Translation, Cultural Adaption, and Validation of the German Pelvic Floor Questionnaire for Pregnant and Postpartum Women.","authors":"Linde M L Titulaer, Viola C Sandfort, Lidwine B Mokkink, Annelies L Pool-Goudzwaard, Marco H Blanker, Gert-Jan van Baaren, Anna E Seijmonsbergen-Schermers, Jan-Paul W R Roovers, Corine J M Verhoeven","doi":"10.1007/s00192-025-06173-3","DOIUrl":"https://doi.org/10.1007/s00192-025-06173-3","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>Pregnancy and childbirth are important risk factors for developing pelvic floor dysfunction (PFD). A valid and reliable screening instrument is essential for timely identification and treatment of PFD. The German Pelvic Floor Questionnaire for Pregnant and Postpartum women (PFQ-PP) assesses symptoms, severity, and impact on quality of life for the bladder function, bowel function, prolapse, and sexual health domain. However, no similar questionnaire exists in Dutch. This study was aimed at translating, culturally adapting, and validating the German PFQ-PP for use in the Netherlands, resulting in the Dutch PFQ-PP.</p><p><strong>Methods: </strong>A forward-backward translation method was used to translate and cross-culturally adapt the German PFQ-PP. Content validity was assessed by an expert committee of seven health care professionals who reviewed the translated version, and by using semi-structured cognitive interviews with four pregnant and five postpartum women. For field testing, 202 pregnant and postpartum women completed the questionnaire twice, with a 1-week interval to assess test-retest reliability, measurement error, and known group validity.</p><p><strong>Results: </strong>The Dutch PFQ-PP demonstrated good content validity both in health care professionals and in pregnant and postpartum women. Intraclass correlation coefficients ranged from 0.82 to 0.92. Standard errors of measurement ranged from 0.38 to 0.60 for the four domains (all domain scores ranging from 0 to 10). The questionnaire discriminated as expected between women suffering from symptoms and those who do not.</p><p><strong>Conclusions: </strong>The Dutch PFQ-PP is valid and reliable in assessing bladder function, bowel function, prolapse, and sexual health in pregnant and postpartum women.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Prospective Study of the Impact of Persistent Nocturnal Enuresis on Female Sexual Function. 持续性夜间遗尿对女性性功能影响的前瞻性研究。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-31 DOI: 10.1007/s00192-025-06172-4
Kubilay Sarıkaya, Adem Sancı, Serkan Akpınar, Emre Hepşen, Metin Yığman
{"title":"A Prospective Study of the Impact of Persistent Nocturnal Enuresis on Female Sexual Function.","authors":"Kubilay Sarıkaya, Adem Sancı, Serkan Akpınar, Emre Hepşen, Metin Yığman","doi":"10.1007/s00192-025-06172-4","DOIUrl":"https://doi.org/10.1007/s00192-025-06172-4","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>The aim of this study is to examine the effects of persistent nocturnal enuresis on female sexual function.</p><p><strong>Methods: </strong>This prospective study included adult females with monosymptomatic nocturnal enuresis (group 1) and healthy controls (group 2), all of whom were sexually active and in a relationship, between March 2023 and April 2024. The comparative analysis of group 1 and group 2 was performed using individual items from the Female Sexual Function Index (FSFI), the total FSFI score, and the overall Rosenberg Self-Esteem Scale (SES) score. Additionally, the Incontinence Quality of Life Questionnaire (I-QOL) was employed to assess the patients' quality of life. The comparative statistical analyses were conducted using the Mann-Whitney U test and the independent samples t test. Statistical significance was considered to be p < 0.05.</p><p><strong>Results: </strong>A total of 60 patients were included, with 30 patients (age range 19-36) in group 1 and 30 healthy controls (age range 19-41) in group 2. Group 1 had a significantly higher I-QOL score (median 55, range 20-108) than group 2 (median 5, range 1-25; p < 0.001). FSFI score was significantly lower in group 1 across all domains: desire, arousal, lubrication, orgasm, satisfaction, and pain (p < 0.05 for all). The total FSFI score was also significantly lower in group 1 (16.21 ± 2.38) than in group 2 (24.50 ± 3.97; p < 0.001). Additionally, group 1 had a significantly lower median SES score (11, range 5-20) than group 2 (17, range 8-29; p < 0.001).</p><p><strong>Conclusions: </strong>Nocturnal enuresis negatively affects sexual function and self-esteem in adult females. These findings emphasize the importance of addressing these aspects in the management of enuresis.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Same Day Discharge with Vaginal Packing Following Pelvic Floor Reconstruction: An Analysis of Safety and Healthcare Utilization. 盆底重建术后阴道填塞当日出院:安全性和医疗保健利用分析
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-31 DOI: 10.1007/s00192-025-06186-y
Tyler Trump, Omer Anis, Howard B Goldman
{"title":"Same Day Discharge with Vaginal Packing Following Pelvic Floor Reconstruction: An Analysis of Safety and Healthcare Utilization.","authors":"Tyler Trump, Omer Anis, Howard B Goldman","doi":"10.1007/s00192-025-06186-y","DOIUrl":"https://doi.org/10.1007/s00192-025-06186-y","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>Vaginal packing is sometimes placed during pelvic floor reconstructive surgery to aid with hemostasis. Historically, these patients were admitted overnight. In the interest of moving patients safely and efficiently through the discharge process select patients are discharged home with vaginal packing. The objective of this study is to assess healthcare utilization and safety among patients discharged with packing.</p><p><strong>Methods: </strong>Retrospective review of patients undergoing pelvic organ prolapse (POP) surgery by a single surgeon between 2016 and 2023. Patients were identified before and after the 2020 COVID pandemic as this marked a transition point where same day discharge became heavily emphasized. The historic cohort (group 1) represents patients admitted overnight with vaginal packing compared to those discharged home same day to remove their own packing (group 2). Healthcare utilization and complications were recorded in the first 30 days postoperatively.</p><p><strong>Results: </strong>Thirty-eight patients were identified in group 1 and 39 in group 2. Age, BMI, and estimated blood loss was similar. There were 20 total unplanned encounters with 10 in each group (p = 0.95). Unplanned encounters in group 1 were seven phone calls/messages, one office visit, and two ED visits compared to three phone calls/messages, five office visits, and two ED visits in group 2. Overall complication rate was similar with six in group 1 and seven in group 2 (p = 0.80). There were zero cases of retained packing.</p><p><strong>Conclusion: </strong>Patients may safely be discharged home with vaginal packing in place with similar rate of complications and healthcare utilization when compared to hospital admission.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical Activity, Quality of Life, and Pelvic Floor Disorders Before and After Hysterectomy for Gynecological Cancer: A Prospective Cohort Study. 一项前瞻性队列研究:妇科癌症子宫切除术前后的身体活动、生活质量和盆底疾病
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-31 DOI: 10.1007/s00192-025-06157-3
Robyn Brennen, Kuan Yin Lin, Linda Denehy, Sze-Ee Soh, Thomas Jobling, Orla M McNally, Simon Hyde, Helena Frawley
{"title":"Physical Activity, Quality of Life, and Pelvic Floor Disorders Before and After Hysterectomy for Gynecological Cancer: A Prospective Cohort Study.","authors":"Robyn Brennen, Kuan Yin Lin, Linda Denehy, Sze-Ee Soh, Thomas Jobling, Orla M McNally, Simon Hyde, Helena Frawley","doi":"10.1007/s00192-025-06157-3","DOIUrl":"https://doi.org/10.1007/s00192-025-06157-3","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>This study investigated physical activity (PA) levels and health-related quality-of-life (HRQoL) before and after, and associations between pelvic floor disorders (PFD) and PA/HRQoL after, hysterectomy for gynecological cancer.</p><p><strong>Methods: </strong>Secondary analysis of a longitudinal cohort study, with assessments before, 6 weeks, and 3 months after hysterectomy for gynecological cancer. The International Physical Activity Questionnaire-short form was used to assess PA and European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire-C30 (QLQ-C30) to assess HRQoL. Changes over time were analyzed using generalized estimating equations or linear mixed models. Associations between PFD with PA and HRQoL were analyzed using logistic regressions and analyses of variance.</p><p><strong>Results: </strong>Of 126 participants, median age 63 years, most had endometrial (69%) and/or stage 1 cancer (72%) and underwent total hysterectomy (65%). Pre-surgery, 39% met PA guidelines, increasing to 53% 3 months post-surgery (+14%, 95% CI 2-25). Mean global health status/QoL domain scores from the QLQ-C30 did not change significantly (+4.4/100 points, 95% CI -0.8 to 9.6). Three months post-surgery, whether participants met PA guidelines was not associated with PFD. Participants with anal incontinence or double incontinence had lower global health status/QoL scores than participants without these symptoms (mean (SD) AI 61.4 (17.8) vs no AI 72.5 (18.7), p = 0.006; DI 61.5 (17.9) vs no DI 71.7 (18.8), p = 0.019).</p><p><strong>Conclusion: </strong>PA levels were low pre- and post-surgery but worse preoperatively. This presents an opportunity for prehabilitation interventions to optimize physical function. There was no association between meeting PA guidelines and PFD. Global health status/QoL was slightly below population norms pre- and post-surgery. Lower HRQoL was associated with some symptoms of PFD.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Female Urinary Incontinence in Africa: Prevalence Estimates from a Systematic Review and Meta-Analysis. 非洲女性尿失禁:来自系统回顾和荟萃分析的患病率估计。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-30 DOI: 10.1007/s00192-025-06146-6
Jeanne Bertuit, Andy-Muller Luzolo Nzinga, Véronique Feipel
{"title":"Female Urinary Incontinence in Africa: Prevalence Estimates from a Systematic Review and Meta-Analysis.","authors":"Jeanne Bertuit, Andy-Muller Luzolo Nzinga, Véronique Feipel","doi":"10.1007/s00192-025-06146-6","DOIUrl":"https://doi.org/10.1007/s00192-025-06146-6","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review and meta-analysis aimed to investigate the prevalence of urinary incontinence (UI) among women in African countries. Different types of UI, racial distributions, geographic locations, and methodological approaches were analyzed and compared.</p><p><strong>Methods: </strong>A systematic search was conducted using CINAHL, PubMed, Embase, and African Journals Online (AJOL). Studies published between 2000 and 2023 in French or English were included if they assessed the prevalence of UI among adult women (≥18 years) in Africa. A meta-analysis using a random-effects model was performed. The PRISMA checklist guided the reporting of this review.</p><p><strong>Results: </strong>A total of 22 studies were included. The pooled prevalence of UI was 24% (95% CI: 17-33%), with individual study estimates ranging from 2% to 80%. The pooled prevalence was 28% (95% CI: 19-38%) for urgency urinary incontinence (UUI), 35% (95% CI: 26-45%) for stress urinary incontinence (SUI), and 31% (95% CI: 18-45%) for mixed urinary incontinence (MUI). High heterogeneity was observed across studies (I² ranging from 72.6% to 99.8%; p 0.001 for Cochran's Q test in all UI subcategories).</p><p><strong>Conclusion: </strong>Urinary incontinence affects approximately one-quarter of adult women in Africa. However, the high heterogeneity in prevalence estimates-related to differences in methodology and UI definitions-limits the ability to draw firm conclusions.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and Safety of Same-Day Discharge After a Manchester Procedure. 曼彻斯特手术后当日出院的可行性和安全性。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-30 DOI: 10.1007/s00192-025-06177-z
Jozefien Hamilton, Joggem Veen, Anne Damoiseaux, Viviane Dietz, Jaklien Leemans, Sanne van Leijsen
{"title":"Feasibility and Safety of Same-Day Discharge After a Manchester Procedure.","authors":"Jozefien Hamilton, Joggem Veen, Anne Damoiseaux, Viviane Dietz, Jaklien Leemans, Sanne van Leijsen","doi":"10.1007/s00192-025-06177-z","DOIUrl":"https://doi.org/10.1007/s00192-025-06177-z","url":null,"abstract":"<p><strong>Introduction: </strong>With the implementation of the Enhanced Recovery After Surgery (ERAS) approach, the duration of hospital admission after vaginal prolapse surgery is reduced. In this study, we determined the safety and feasibility of same-day discharge in patients undergoing a Manchester procedure by comparing same-day discharge to overnight admission.</p><p><strong>Methods: </strong>This retrospective cohort study was performed in a teaching hospital in the Netherlands. During the period 2019-2023, all patients undergoing a Manchester procedure planned with overnight admission (group A) were compared to patients undergoing this surgery which was planned with same-day discharge (group B). The need for readmission and rate of prolonged hospitalization and complications were compared.</p><p><strong>Results: </strong>This study included 213 patients; 103 in group A and 110 in group B. Baseline characteristics were comparable between the two groups. The rate of readmission in both groups was similar (10.7% vs 15.5%; p = 0.183). No differences were found regarding complications such as discharge with prolonged catheterization due to urinary retention (15.5% vs 11.8%; p = 0.483).</p><p><strong>Conclusion: </strong>Performing the Manchester procedure with same-day discharge is safe and should be implemented as an important element of the ERAS approach. Same-day discharge further reduces length of hospital stay and could reduce costs, while promoting early patient mobilization.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Autophagy by the Cdk1/p53/p21 Feedback Loop in an Interstitial Cystitis/Bladder Pain Syndrome Cell Model: Implications for Inflammatory Response. 间质性膀胱炎/膀胱痛综合征细胞模型中Cdk1/p53/p21反馈回路对自噬的调节:对炎症反应的影响
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-30 DOI: 10.1007/s00192-025-06169-z
Kun Wang, Jian Shi, Zhen Chen, Yibo Zhuang, Dong Xue
{"title":"Regulation of Autophagy by the Cdk1/p53/p21 Feedback Loop in an Interstitial Cystitis/Bladder Pain Syndrome Cell Model: Implications for Inflammatory Response.","authors":"Kun Wang, Jian Shi, Zhen Chen, Yibo Zhuang, Dong Xue","doi":"10.1007/s00192-025-06169-z","DOIUrl":"https://doi.org/10.1007/s00192-025-06169-z","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>The Cdk1/p53/p21 feedback loop could play an important role in maintaining a consistently high urinary tract epithelial permeability. This study is aimed at elucidating whether this feedback loop is associated with the inadequate autophagic response and the heightened inflammatory response in interstitial cystitis/bladder pain syndrome (IC/BPS).</p><p><strong>Methods: </strong>To construct the IC/BPS cell model, HTB4 cells were first treated with 1% H<sub>2</sub>O<sub>2</sub> for 1 h, followed by a 24-h exposure to TNFα (10 ng/ml). The protein expression levels of LC3-I/II and Beclin 1 were assessed using Western blot analysis. Autophagosome formation was visualized using monodansylcadaverine (MDC) staining. The secretion levels of inflammatory cytokines, including IL-6, IL-8, and TNFα, were quantified using enzyme-linked immunosorbent assay. Additionally, malondialdehyde (MDA) levels and the activities of antioxidant enzymes (GSH and SOD2) were measured.</p><p><strong>Results: </strong>Compared with normal urothelial HTB4 cells, the number of autophagosomes and the levels of LC3-I/II and Beclin 1 are significantly increased in IC/BPS cells. These cells also exhibit markedly higher levels of inflammatory markers (TNFα, IL-6, IL-8) and MDA, alongside notably reduced levels of the antioxidants GSH and SOD2. Compared with IC/BPS cells or IC/BPS cells co-transfected with p21 siRNA and Cdk1 control, the IC/BPS cells co-transfected with p21 siRNA and Cdk1 inhibitor exhibit a significant increase in terms of autophagosome numbers and the LC3-I/II level. Additionally, the levels of inflammatory factors are significantly decreased in the IC/BPS cells co-transfected with p21 siRNA and Cdk1 inhibitor.</p><p><strong>Conclusion: </strong>In IC/BPS, the Cdk1/p53/p21 feedback loop could regulate the level of autophagy and inflammatory response. This discovery identifies promising new therapeutic targets for IC/BPS, which may pave the way for innovative clinical approaches to this complex disorder.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Mirabegron and Propiverine Combination in the Treatment of Refractory Overactive Bladder. Mirabegron联合丙丙碱治疗难治性膀胱过动症疗效观察。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-26 DOI: 10.1007/s00192-025-06178-y
Mehmet Gokhan Culha, Mehmet Ali Sezgin, Mustafa Erkoc, Eyyup Danis, Emre Can Polat, Alper Otunctemur
{"title":"Efficacy of Mirabegron and Propiverine Combination in the Treatment of Refractory Overactive Bladder.","authors":"Mehmet Gokhan Culha, Mehmet Ali Sezgin, Mustafa Erkoc, Eyyup Danis, Emre Can Polat, Alper Otunctemur","doi":"10.1007/s00192-025-06178-y","DOIUrl":"https://doi.org/10.1007/s00192-025-06178-y","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>The aim of this study is to evaluate the effectiveness and safety of mirabegron + propiverine combination in the treatment of overactive bladder (OAB) resistant to anticholinergic agent or beta-3 agonist treatment.</p><p><strong>Method: </strong>Patients who presented with OAB symptoms between March 2019 and August 2023 and did not respond to anticholinergic or beta-3 agonist treatment were included in the study. All patients were recommended to use mirabegron 50 mg (Betmiga, Astellas Pharma, Japan) and propiverine 30 mg (Mictonorm SR, 30 mg, Recordati Pharmaceuticals, Italy) once a day. Patients' symptoms were evaluated with OABSS and bladder diary 3 months after treatment. Side effects and satisfaction rates were recorded.</p><p><strong>Results: </strong>A total of 320 patients were included in the study. One-year data of a total of 264 patients were examined. After 1 year of treatment, the patients' OABSS score, mean daily micturition frequency according to the bladder diary, frequency of urge incontinence, nocturia, and number of pads decreased compared to before treatment (p < 0.001 for each). After 1 year, 62.1% (164/264) of patients benefited from the mirabegron + propiverine combination. The most common side effects were dry mouth in 43 patients (16.3%) and constipation in 59 patients (22.3%).</p><p><strong>Conclusion: </strong>Mirabegron + propiverine treatment is an effective and reliable treatment option in the treatment of OAB resistant to medical monotherapy. With this combination treatment to be used before botulinum toxin application in the treatment of resistant OAB, the number of patients who will receive Botox may decrease.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative Ultrasound Predictors of Treatment Failure after 24 Months of Transobturator Midurethral Sling. 经闭锁中尿道吊带术后24个月治疗失败的术前超声预测。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-23 DOI: 10.1007/s00192-025-06179-x
Enrique González-Díaz, Ana Victoria Martin Corral
{"title":"Preoperative Ultrasound Predictors of Treatment Failure after 24 Months of Transobturator Midurethral Sling.","authors":"Enrique González-Díaz, Ana Victoria Martin Corral","doi":"10.1007/s00192-025-06179-x","DOIUrl":"https://doi.org/10.1007/s00192-025-06179-x","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>To evaluate the role of pelvic floor ultrasound (PF-US) in predicting persistent urinary incontinence after tension-free vaginal obturator tape (TVT-O) placement surgery and to identify prognostic ultrasound parameters.</p><p><strong>Methods: </strong>We performed a retrospective analysis of 74 patients who underwent TVT-O placement for stress urinary incontinence (UI) or stress-predominant mixed UI. Preoperative assessment included clinical evaluation, urinary diary, validated questionnaires, and PF-US to measure bladder neck mobility and descent, presence of urethral funneling, urethral length, and bladder wall thickness (BWT). Surgical success was defined as resolution of incontinence at 24 months postoperatively.</p><p><strong>Results: </strong>At 24 months, 19% of patients presented with persistent incontinence. Preoperative factors associated with surgical failure were age, body mass index, BWT at dome, anterior wall and average BWT, urethral length and urethral funneling. In multivariate logistic regression analysis, only preoperative ultrasound findings were associated with UI persistence, including the presence of urethral funneling, a BWT greater than 7 mm at the dome of the bladder, and a urethral length longer than 45 mm.</p><p><strong>Conclusion: </strong>Preoperative ultrasound is a valuable tool to predict functional outcomes of TVT-O surgery. Preoperative assessment of urethral funneling, BWT at dome and urethral length may help identify patients at higher risk of surgical failure with persistent incontinence. Integration of ultrasound into routine evaluation could improve patient selection and surgical planning.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaginal Laser Treatment on Stress Urinary Incontinence: A Randomized Controlled Trial. 阴道激光治疗压力性尿失禁:随机对照试验。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2025-05-23 DOI: 10.1007/s00192-025-06160-8
Lok Wun Yim, Osanna Yee Ki Wan, Daniel Wong, Man Sum Tam, Yun Ting Lee, Kai Wan Lee, Kwong Wai Choy, Symphorosa Shing Chee Chan, Rachel Yau Kar Cheung
{"title":"Vaginal Laser Treatment on Stress Urinary Incontinence: A Randomized Controlled Trial.","authors":"Lok Wun Yim, Osanna Yee Ki Wan, Daniel Wong, Man Sum Tam, Yun Ting Lee, Kai Wan Lee, Kwong Wai Choy, Symphorosa Shing Chee Chan, Rachel Yau Kar Cheung","doi":"10.1007/s00192-025-06160-8","DOIUrl":"https://doi.org/10.1007/s00192-025-06160-8","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>This study evaluates the efficacy of vaginal Erbium:YAG laser treatment for stress urinary incontinence (SUI) compared with sham treatment over 12 months.</p><p><strong>Methods: </strong>This single-blinded, multicenter randomized controlled trial involved women diagnosed with urodynamic SUI at three urogynecology centers in Hong Kong. Participants were randomly assigned to receive either vaginal laser therapy (two sessions, 4 weeks apart) or sham treatment. The primary outcome was the reduction in Pelvic Floor Distress Inventory (PFDI) Urinary Distress Inventory (UDI) Stress subscale scores at 6 and 12 months. Secondary outcomes included urinary incontinence episodes, severity from bladder diaries, visual analog scale (VAS) scores, and scores from the Pelvic Floor Impact Questionnaire Urinary Impact Questionnaire and the International Consultation on Incontinence Questionnaire Urinary Incontinence Short Form.</p><p><strong>Results: </strong>Out of 114 screened women, 75 were randomized. Significant reductions in PFDI UDI stress subscale scores were shown in the treatment group at the 6-month and 12-month follow-up (p < 0.001 at 6 months; p < 0.001 at 12 months) but was not significant in the control group. Significant reductions were observed in the treatment group at the 6-month and 12-month follow-up in all secondary outcome parameters whereas the Pelvic Floor Impact Questionnaire UDI score and the VAS score of SUI severity at both 6 months and 12 months were not significantly reduced in the control group. There was no significant difference in both primary or secondary outcomes between groups.</p><p><strong>Conclusions: </strong>Vaginal Erbium: YAG laser improved SUI symptoms and shows potential as a minimally invasive option, but lacks significant differences from sham treatment, necessitating further research.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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