International Urogynecology Journal最新文献

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Cadaveric Insights into Pudendal Nerve Variations for Sacrospinous Ligament Fixation: A Case Series 骶棘韧带固定术中牡肛神经变异的尸体观察:病例系列
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-10 DOI: 10.1007/s00192-024-05919-9
Ipek Betul Ozcivit Erkan, Eda Gorgun
{"title":"Cadaveric Insights into Pudendal Nerve Variations for Sacrospinous Ligament Fixation: A Case Series","authors":"Ipek Betul Ozcivit Erkan, Eda Gorgun","doi":"10.1007/s00192-024-05919-9","DOIUrl":"https://doi.org/10.1007/s00192-024-05919-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction and Hypothesis</h3><p>The proximity of the pudendal nerve to the sacrospinous ligaments (SSLs) can lead to serious complications during sacrospinous ligament fixation (SSLF). This case series is aimed at providing an overview of the anatomy of the pudendal nerve, including insights from cadaver dissections and discussions on rare variations observed during these dissections.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Dissections were conducted on five female cadavers using a posterior gluteal approach on both sides. The course, morphometric features and variations in the branches of the pudendal nerve were assessed at the level of the SSL and within the pudendal canal.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The number of pudendal trunks cranial to the SSL ranged from one to three, with double trunks being the most common (70%). In 2 out of 10 (20%) sides inferior rectal nerves (IRNs) pierced through the SSL. In Case 1, IRNs pierced the SSL bilaterally before entering the pudendal canal and exiting at distances of 23.81 mm and 41.18 mm from the ischial spine on the right and left sides respectively. In Case 2, nerves with a width of 2.12 mm and 2.49 mm pierced the SSL and joined the IRN, piercing the SSL at 13.38 mm and 12.55 medial to the ischial spine and 16.80 mm and 19.32 mm lateral to the sacrum, on the left and right sides respectively. In 60% of cases, the IRN entered the pudendal canal, exiting at a median distance of 21.25 mm from the ischial spine.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>We identified significant variations in the number of trunks and branching patterns of the pudendal nerve around the SSL and the course of the IRN caudal to the SSL. We documented IRNs or nerves joining the IRNs piercing the SSL. Identifying these variations is crucial for surgeons to minimize the risk of pudendal nerve injury during SSLF.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":"7 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pelvic Organ Prolapse Surgery: Postoperative Quality of Life in Ethiopian Women 盆腔器官脱垂手术:埃塞俄比亚妇女的术后生活质量
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-10 DOI: 10.1007/s00192-024-05910-4
Grace Pouch, Alemu Arja, Olivia Brookins, Courtney Jacks, Mulugeta Gebregziabher, Steven Swift, Nate Ross
{"title":"Pelvic Organ Prolapse Surgery: Postoperative Quality of Life in Ethiopian Women","authors":"Grace Pouch, Alemu Arja, Olivia Brookins, Courtney Jacks, Mulugeta Gebregziabher, Steven Swift, Nate Ross","doi":"10.1007/s00192-024-05910-4","DOIUrl":"https://doi.org/10.1007/s00192-024-05910-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction and Hypothesis</h3><p>Pelvic organ prolapse (POP) has a profound influence on a woman's quality of life (QoL). Assessment of QoL using patient-reported outcome (PRO) measures in pelvic organ prolapse surgery is common practice in developed countries, but despite the burden of POP in developing countries, such as Ethiopia, the use of PROs to record preoperative and postoperative QoL scores is limited. This study is aimed at assessing the QoL among Ethiopian women with POP before and after surgery using the validated Pelvic Organ Quality of Life (P-QoL) questionnaire. Additionally, we will compare postoperative QoL measurements of reconstructive procedures with those of obliterative procedures.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This is a prospective observational study conducted at a single hospital in Ethiopia on women who were scheduled for surgery for symptomatic POP. Patients' QoL was assessed preoperatively using the P-QoL questionnaire and at each subsequent follow-up visit for 1 year (3, 6, 9, and 12 months). Patients undergoing an obliterative procedure were evaluated and compared with those having reconstructive procedures.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The mean score for general health perceptions, prolapse impact, role limitations, physical limitations, social limitations, and emotions was 0 at 12 months postoperatively. Despite significant improvements from baseline, personal relationships, sleep or energy disturbance, and symptom severity measures continued to negatively impact QoL at 12 months postoperatively.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Quality of life among Ethiopian women with POP is poor across all domains. Native tissue repair employing either reconstructive or obliterative methods significantly improves QoL across all domains up to 12 months postoperatively. The use of validated tools to assess PROs is essential to provide evidence-based care that improves QoL in ways that are meaningful to patients.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":"58 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on "Effect of An Intrapartum Pelvic Dilator Device on Levator Ani Muscle Avulsion During Primiparous Vaginal Delivery: A Pilot Randomized Controlled Trial". 关于 "产前骨盆扩张器对初产妇阴道分娩时提肛肌撕脱的影响:随机对照试验 "的评论。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-01 Epub Date: 2024-08-27 DOI: 10.1007/s00192-024-05904-2
Zdenek Rusavy
{"title":"Commentary on \"Effect of An Intrapartum Pelvic Dilator Device on Levator Ani Muscle Avulsion During Primiparous Vaginal Delivery: A Pilot Randomized Controlled Trial\".","authors":"Zdenek Rusavy","doi":"10.1007/s00192-024-05904-2","DOIUrl":"10.1007/s00192-024-05904-2","url":null,"abstract":"","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1935-1936"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frailty and the Correlation Between Total Testosterone Levels and Urinary Incontinence Among Elderly Women. 老年妇女体弱与总睾酮水平和尿失禁之间的相关性。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-01 Epub Date: 2024-08-31 DOI: 10.1007/s00192-024-05906-0
Nobuo Okui, Machiko Okui
{"title":"Frailty and the Correlation Between Total Testosterone Levels and Urinary Incontinence Among Elderly Women.","authors":"Nobuo Okui, Machiko Okui","doi":"10.1007/s00192-024-05906-0","DOIUrl":"10.1007/s00192-024-05906-0","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>The objective was to explore the correlation between total testosterone levels and stress urinary incontinence (SUI) and urgency urinary incontinence (UUI) in older patients, emphasizing frailty.</p><p><strong>Methods: </strong>This prospective cross-sectional study included 1,328 women over 60 years of age at an incontinence specialty clinic. Participants were assessed for UI, frailty, using the Japanese Frailty Scale, and total testosterone levels. Analysis of a logistic regression model was employed for age, body mass index (BMI), and vaginal deliveries adjustment, with association and multivariate analyses to evaluate the associations with SUI and UUI.</p><p><strong>Results: </strong>The frailty and nonfrailty groups each consisted of 664 individuals. After age, BMI, and the number of vaginal deliveries adjustment, the analysis showed a negative association between total testosterone levels and both SUI (p < 0.001) and UUI (p < 0.001) in the frailty group. Multivariate analysis revealed that, in the nonfrailty group, factors such as low total testosterone levels (p = 0.0145), diabetes (p = 0.0052), and cerebral infarction (p = 0.0254) were related to SUI, whereas no significant factors were associated with UUI. In the frailty group, factors associated with SUI included low total testosterone levels (p < 0.0001), the number of vaginal deliveries (p < 0.0001), smoking (p = 0.0240), chronic lung disease (p < 0.0248), and hypertension (p < 0.0265). Factors associated with UUI were age (p < 0.0001), low total testosterone levels (p = 0.0025), diabetes (p < 0.0001), and the number of vaginal deliveries (p = 0.0152).</p><p><strong>Conclusions: </strong>The study highlights the significance of incorporating the assessment of frailty and testosterone levels in addressing UI among older women, particularly in the aged population, underscoring the need for tailored approaches in this demographic.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1909-1919"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Physical Activity and Pelvic Floor Disorders in Parous Ugandan Women. 乌干达雌雄同体妇女的体育锻炼与盆底障碍之间的关系
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-01 Epub Date: 2024-07-13 DOI: 10.1007/s00192-024-05859-4
Julia Diane Fleecs, Michael Derrick Ngobi, Flavia Matovu Kiweewa, Ramya Vemulapalli, JaNiese Elizabeth Jensen, Haley Alaine Steffen, Linder Hagstrom Wendt, Jay Brooks Jackson, Kimberly Ann Kenne
{"title":"Association Between Physical Activity and Pelvic Floor Disorders in Parous Ugandan Women.","authors":"Julia Diane Fleecs, Michael Derrick Ngobi, Flavia Matovu Kiweewa, Ramya Vemulapalli, JaNiese Elizabeth Jensen, Haley Alaine Steffen, Linder Hagstrom Wendt, Jay Brooks Jackson, Kimberly Ann Kenne","doi":"10.1007/s00192-024-05859-4","DOIUrl":"10.1007/s00192-024-05859-4","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>The aim was to assess the association between the degree of physical activity (PA) and the presence of pelvic floor disorders (PFDs) in a cohort of parous Ugandan women.</p><p><strong>Methods: </strong>In this cross-sectional study, PFDs were measured using symptom assessment, standardized questionnaires (Pelvic Floor Distress Inventory and Pelvic Floor Impact Questionnaire), and a standardized physical examination (POP-Q and cough stress test [CST]). Degree of PA was assessed using the International Physical Activity Questionnaire. Interquartile ranges were used to describe the age, parity, and body mass index (BMI) of participants. To examine the association between PA and PFDs, a log transformation was applied to the weekly minutes of PA variable and a logistic regression model was constructed with weekly minutes of moderate/vigorous PA, age, BMI, and parity as the predictors.</p><p><strong>Results: </strong>A total of 159 women were enrolled. Median age was 35 (IQR 32-37), median parity 4 (IQR 3-5), and median BMI 29.0 (IQR 24-33). The prevalence of PFD as determined by symptom assessment was 28% (n=44). The most frequent stage of prolapse identified by POP-Q was stage II (57%, n=91). Thirty-six percent of the women (n=58) reported vigorous PA. Ninety-nine percent of the cohort (n=158) reported moderate PA. When controlling for age, parity, and BMI there was a significant positive association between PFD (defined as a combination of stage II prolapse, positive CST, and urinary incontinence (UI)) and moderate PA (OR 2.20, 95% CI 1.08-5.14, p value 0.045).</p><p><strong>Conclusions: </strong>Pelvic floor disorders are common among parous Ugandan women and are associated with moderate PA when controlling for age, BMI, and parity. Understanding the risk factors associated with PFD in this population may better equip providers to screen and care for individuals.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1769-1775"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Self-Management in Pessary Therapy for Pelvic Organ Prolapse-A retrospective cohort study. 自我管理在盆腔器官脱垂的子宫环疗法中的作用--一项回顾性队列研究。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI: 10.1007/s00192-024-05864-7
Evy Paulussen, Renée Börger, Hugo van Eijndhoven, Marian Engberts, Pieternel Steures, Mirjam Weemhoff
{"title":"The Role of Self-Management in Pessary Therapy for Pelvic Organ Prolapse-A retrospective cohort study.","authors":"Evy Paulussen, Renée Börger, Hugo van Eijndhoven, Marian Engberts, Pieternel Steures, Mirjam Weemhoff","doi":"10.1007/s00192-024-05864-7","DOIUrl":"10.1007/s00192-024-05864-7","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>This study investigated pessary self-management (PSM). The primary outcome was how often PSM was taught to patients with pelvic organ prolapse (POP). Secondary outcomes were associations of PSM with treatment continuation, side effects, changing to surgery, and number of doctor consultations in the first year after treatment initiation compared with clinical management (CM).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted in 300 patients visiting three Dutch medical centres in 2019, and receiving a pessary for POP. The t test, Chi-squared test and logistic regression were performed to compare PSM with CM and to identify factors associated with treatment continuation.</p><p><strong>Results: </strong>A total of 35% of patients received PSM instructions, of which 92% were able to perform PSM successfully. Treatment was continued by 83% of patients practicing PSM and 75% of patients having CM (p = 0.16), side effects occurred in 26% and 39% respectively (p = 0.18). Pain or discomfort was associated with treatment discontinuation (p < 0.01). In a subgroup analysis of patients who had a pessary suitable for PSM, treatment continuation was significantly higher in the PSM group (97%) than in the CM group (74%; p < 0.01).</p><p><strong>Conclusions: </strong>Pessary self-management was only taught to 35% of patients who received a pessary, although the ability to perform PSM was high (92%). Treatment discontinuation was significantly lower in the PSM subgroup, when assessing the subgroup of patients using a pessary suitable for PSM. The large number of patients using a pessary suitable for PSM in the CM group implies that there is a lot to gain by promoting PSM.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1797-1805"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Outcomes of the Restoration of Uterovaginal Continuity and Vaginoplasty-Utero-Colo-Neovaginoplasty-in Cervicovaginal Agenesis Using the Sigmoid Colon. 利用乙状结肠恢复子宫阴道连续性和阴道成形术-子宫-结肠-新阴道成形术治疗宫颈阴道缺如的长期疗效。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1007/s00192-024-05878-1
Vijay Kumar, Sundeep Payyanur Thotan, Santosh P Prabhu, Pratap Kumar Narayan, Nitin G Pai, Ranjani Rammohan
{"title":"Long-Term Outcomes of the Restoration of Uterovaginal Continuity and Vaginoplasty-Utero-Colo-Neovaginoplasty-in Cervicovaginal Agenesis Using the Sigmoid Colon.","authors":"Vijay Kumar, Sundeep Payyanur Thotan, Santosh P Prabhu, Pratap Kumar Narayan, Nitin G Pai, Ranjani Rammohan","doi":"10.1007/s00192-024-05878-1","DOIUrl":"10.1007/s00192-024-05878-1","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>Congenital cervicovaginal agenesis in the presence of a functional endometrium is a rare Müllerian anomaly. The management ranges from hysterectomy historically to various reconstructive procedures more recently. We report our experience with utero-colo-vaginoplasty in the management of this anomaly and its long-term follow-up.</p><p><strong>Methods: </strong>The case records of all the patients with vaginal or cervicovaginal agenesis in our hospital from January 2002 to December 2019 were reviewed retrospectively. The patients were then called for an outpatient visit and examined in detail. The anatomical variations, surgical procedures and outcomes were recorded and analysed.</p><p><strong>Results: </strong>Sixteen patients aged 14 to 26 years were included during the study period. They presented with cyclical painful cryptomenorrhea. Magnetic resonance imaging (MRI) confirmed cervicovaginal or distal vaginal agenesis. All the patients underwent utero-colo-vaginoplasty. Intraoperative rectal injury led to post-operative faecal leak from the perineal wound in one patient in the post-operative period. Restoration of painless menstrual flow was possible in all 16 cases. Long-term complications were seen in 4 patients. These were stenosis of the perineal neovaginal orifice in 2 patients, obstruction at colo-uterine anastomosis in 1 patient and mucosal prolapse at the neovagina in 1 patient. Three of these patients needed secondary surgical procedures. Five were sexually active and reported consummation of penetrative intercourse. None of them had conceived.</p><p><strong>Conclusion: </strong>In our experience, utero-colo-vaginoplasty allows for regular painless menstruation and coitus with minimal long-term complications. The sole disadvantage is the failure to conceive.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1807-1816"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision in Practice: The Critical Role of Mesh and Procedure Type Specification in Urogynecological Surgeries and Research. 实践中的精确性:泌尿妇科手术和研究中网片和手术类型规范的关键作用。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-01 Epub Date: 2024-05-29 DOI: 10.1007/s00192-024-05820-5
Reut Rotem, Daniel Galvin, Yair Daykan, Sumaiya Al-Shukaili, Barry A O'Reilly, Orfhlaith E O'Sullivan
{"title":"Precision in Practice: The Critical Role of Mesh and Procedure Type Specification in Urogynecological Surgeries and Research.","authors":"Reut Rotem, Daniel Galvin, Yair Daykan, Sumaiya Al-Shukaili, Barry A O'Reilly, Orfhlaith E O'Sullivan","doi":"10.1007/s00192-024-05820-5","DOIUrl":"10.1007/s00192-024-05820-5","url":null,"abstract":"<p><p>Recently, the debate surrounding the use of mesh in urogynecological procedures has intensified, leading to FDA warnings and heightened safety concerns. This clinical opinion emphasizes the vital need to specify mesh types in these procedures, drawing attention to the risk profiles and clinical outcomes associated with various meshes and the procedures that utilize them. A significant issue identified in contemporary literature is the tendency to group diverse mesh types under the same umbrella, disregarding their unique characteristics and applications. We describe the range of mesh types, their application routes, and associated complications, highlighting the risks of this nonspecific approach to patient safety and informed decision making. We critically examine the generalization of mesh terminology in clinical and research dialogues. Concluding with specific recommendations for health care providers and researchers, the paper advocates for a more nuanced understanding and communication in the field, ultimately aiming to improve patient care and safety in urogynecological practice.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1763-1767"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Single-Dose Imipramine on Anal Sphincter Tone in Healthy Women: A Randomized, Placebo-Controlled Study Using Anal Acoustic Reflectometry. 单剂量丙咪嗪对健康女性肛门括约肌张力的影响:使用肛门声反射测量法进行的随机、安慰剂对照研究。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-01 Epub Date: 2024-08-21 DOI: 10.1007/s00192-024-05890-5
Thea Christoffersen, Jonatan Kornholt, Troels Riis, David P Sonne, Niels Klarskov
{"title":"Effect of Single-Dose Imipramine on Anal Sphincter Tone in Healthy Women: A Randomized, Placebo-Controlled Study Using Anal Acoustic Reflectometry.","authors":"Thea Christoffersen, Jonatan Kornholt, Troels Riis, David P Sonne, Niels Klarskov","doi":"10.1007/s00192-024-05890-5","DOIUrl":"10.1007/s00192-024-05890-5","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>Despite the high prevalence of fecal incontinence, existing treatment options may be inadequate. Drugs that enhance the tone of the anal sphincter complex could potentially be an effective pharmacological approach. This study investigated the effect of the tricyclic antidepressant imipramine on anal sphincter tone in healthy women, employing anal acoustic reflectometry as the evaluating method.</p><p><strong>Methods: </strong>In a double-blind, randomized, placebo-controlled crossover study, 16 healthy female volunteers were randomized to one of two treatment sequences. The participants attended two study visits separated by at least 7 days' washout. At each visit, they received a single dose of 50 mg imipramine or matching placebo, in alternating order. We assessed the anal opening pressure under the resting state and during voluntary squeezing of the pelvic floor. Measurements were performed pre-dose and 1 h after drug administration, corresponding to the estimated time of peak plasma concentration of imipramine.</p><p><strong>Results: </strong>All participants completed the study. In total, 44% of the participants reported at least one adverse effect, primarily anticholinergic. Compared with placebo, imipramine increased anal opening pressure by 15.2 cmH<sub>2</sub>O (95% confidence interval [CI] 2.0-28.2 cmH<sub>2</sub>O, p = 0.03) in the resting state and 15.1 (95% CI 4.2-26.0 cmH<sub>2</sub>O, p = 0.01) cmH<sub>2</sub>O during squeezing.</p><p><strong>Conclusions: </strong>The findings indicate that imipramine increases anal sphincter tone in healthy women. However, further research is required to evaluate its clinical impact on individuals with fecal incontinence. This research also demonstrates the effectiveness of using anal acoustic reflectometry for assessing pharmacological effects on anal sphincter function.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1873-1879"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levator Ani Muscle Avulsion After Vaginal Delivery Comparing Routine Versus Restrictive Episiotomy: A Pilot Study. 阴道分娩后的提肛肌撕裂:常规与限制性外阴切开术的比较:一项试点研究。
IF 1.8 3区 医学
International Urogynecology Journal Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1007/s00192-024-05883-4
Teerayut Temtanakitpaisan, Suvit Bunyavejchevin, Pranom Buppasiri, Chompilas Chongsomchai
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