{"title":"Honoring the Past, Empowering the Future-Reflections on the International Urogynecological Association at 50.","authors":"Maria A T Bortolini","doi":"10.1007/s00192-025-06273-0","DOIUrl":"10.1007/s00192-025-06273-0","url":null,"abstract":"","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1545-1546"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gamal Ghoniem, Felicia Lane, Bilal Farhan, Kelli Gilliam, S Abbas Shobeiri, Ahmed Salah
{"title":"Five-Year Follow-up Study on Safety and Efficacy of Macroplastique® in Female Patients with Stress Urinary Incontinence (the ROSE Study).","authors":"Gamal Ghoniem, Felicia Lane, Bilal Farhan, Kelli Gilliam, S Abbas Shobeiri, Ahmed Salah","doi":"10.1007/s00192-025-06163-5","DOIUrl":"10.1007/s00192-025-06163-5","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>This study presents the 5-year study close-out results from the Real-Time Observation of Safety and Effectiveness (ROSE) study, evaluating the safety and efficacy of the Macroplastique® (MPQ) urethral bulking agent for the treatment of stress urinary incontinence (SUI) in women with intrinsic sphincter deficiency (ISD).</p><p><strong>Methods: </strong>The ROSE study was an observational prospective study conducted at 22 US centers that enrolled 274 adult women with ISD-confirmed SUI. Participants underwent MPQ treatment with an option for repeat injections. Follow-up assessments were conducted at 3 months and then annually for 5 years, evaluating SUI severity (Stamey grade), Incontinence Quality of Life (I-QoL), and Patient Global Impression of Satisfaction. Safety outcomes included treatment-related adverse events (AEs) and serious adverse events (SAEs).</p><p><strong>Results: </strong>Of 274 enrolled participants, 147 (54%) completed the 5-year follow-up. At 5 years, 47.6% 19 (70/147) of women showed improvement in SUI severity as measured by Stamey grade from 20 baseline after their last injection. I-QoL scores improved significantly, from 45 ± 23.9 to 70.9 ± 21 24.5 (1.1, 100). One device-related SAE of urinary retention (0.4%) resolved within 4 months; no 22 late-onset SAEs were reported. The most common minor treatment-related adverse events were 23 urinary tract infections (30.8%) and transient urinary retentions (7.2%). No late-onset SAEs were 24 reported during the 5-year period.</p><p><strong>Conclusions: </strong>Macroplastique® demonstrated sustained long-term efficacy and safety in managing SUI owing to 27 ISD. These findings reinforce its role as a minimally invasive treatment option with 28 durable outcomes over 5 years.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1663-1670"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehr Jain, Jocelyn Stairs, Alana Sorgini, Aisling Clancy
{"title":"Readability of Online Patient-Directed Content About Cystoscopy and Urodynamic Testing.","authors":"Mehr Jain, Jocelyn Stairs, Alana Sorgini, Aisling Clancy","doi":"10.1007/s00192-025-06100-6","DOIUrl":"10.1007/s00192-025-06100-6","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>The objective was to assess the readability of commonly accessed patient-focused websites about cystoscopy or urodynamic studies (UDS).</p><p><strong>Methods: </strong>Keywords related to cystoscopy and UDS were searched in three commonly accessed search engines in 2024 and compared with a search from 2022. The top 25 search results from each search engine were assessed against the study inclusion/exclusion criteria. Readability scores (Flesch Reading Ease score [FRES], Flesch-Kincaid Grade Level [FKGL], Gunning Frequency of Gobbledygook [FOG], Simple Measure of Gobbledygook [SMOG]) were calculated for the websites included. Mean readability scores of websites were compared by procedure type and publisher using the Mann-Whitney test.</p><p><strong>Results: </strong>In 2024, a total of 75 patient-oriented websites were identified, 33 (44.0%) of which were about cystoscopy and 42 (56.0%) websites were about UDS. Cystoscopy websites were difficult to read (FRES median 56 [55-69]), requiring grade 8-11 reading level (Gunning FOG median 11.3 [10.3-12.3]; FKGL median 8 [7.11-8.84]) and 8 years of education to read (SMOG median 8.06 [7.41-8.71]). UDS websites were difficult to read (FRES median 56 [41-66]), requiring grade 9-11 reading level (Gunning FOG median 11.45 [9.5-13.7]; FKGL median 8.85 [6.93-10.88]) and 8 years of education to read (SMOG median 8.49 [7.11-9.98]). Websites in 2024 were significantly easier to read than websites in 2022 based on Gunning FOG (p value 0.0079), FKGL (p value 0.0001), and SMOG scores (p value 0.0001), but still did not meet the recommendation of grade 6 reading level.</p><p><strong>Conclusions: </strong>Patient-focused online information about cystoscopy and UDS was harder to read than the American Medical Association-recommended grade 6 reading level of patient information. Readability of cystoscopy and UDS online information has improved over 2 years.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1601-1606"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter to the Editor \"Joint Terminology Report: Terminology Standardization for Female Bladder Pain Syndrome\".","authors":"Rhonda Kotarinos, Sarah Collins","doi":"10.1007/s00192-025-06221-y","DOIUrl":"10.1007/s00192-025-06221-y","url":null,"abstract":"","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1713"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Music Intervention on Pain and Anxiety During Urodynamic Testing: A Randomized Controlled Trial.","authors":"Athiwat Songsiriphan, Purim Ruanphoo, Suvit Bunyavejchevin, Keerati Chiengthong","doi":"10.1007/s00192-025-06161-7","DOIUrl":"10.1007/s00192-025-06161-7","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>Urodynamic testing is used to evaluate urinary tract function and often causes patients to experience pain, anxiety, and embarrassment. Music intervention has been proposed as a strategy to alleviate these discomforts. This research was conducted to investigate the effects of music intervention on pain and anxiety levels in women during urodynamic testing compared to the standard protocol.</p><p><strong>Methods: </strong>During December 2021 to October 2022, 50 patients attending the Female Pelvic Medicine and Reconstructive Surgery clinic at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, that required urodynamic tests were randomized into the music intervention group and the control group (non-music). All participants were given questionnaires including demographic characteristics, pain score (Visual Analog Scale (VAS)), Thai-version State-Trait Anxiety Inventory Form (STAI) X-q by Spielberger, the embarrassment level and satisfaction score.</p><p><strong>Results: </strong>The median pain level with IQR (interquartile range) demonstrated no statistically significant differences between the two groups (2.50 (4.55) in the music group vs. 0.15 (2.18) in the non-music group, p = 0.064). There were no statistically significant differences in the mean total STAI score (41.07 ± 9.16 in the music group vs. 43.08 ± 7.96 in the non-music group, p = 0.415) and the median VAS of embarrassment score (4.05 (7.32) in the music group vs. 5.00 (6.20) in the non-music group, p = 0.646). There were no statistically significant differences in the satisfaction of both groups.</p><p><strong>Conclusion: </strong>There is no difference in the pain and anxiety in patients undergoing multichannel urodynamic testing with or without music intervention.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1655-1661"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John O L DeLancey, James A Ashton-Miller, Jennifer LaCross, Fernanda Pipitone, Payton Schmidt, Luyun Chen
{"title":"Urogenital Hiatus Closure: Facts, Fallacies, and Why a Unified Theory of Hiatal Failure is Needed.","authors":"John O L DeLancey, James A Ashton-Miller, Jennifer LaCross, Fernanda Pipitone, Payton Schmidt, Luyun Chen","doi":"10.1007/s00192-025-06153-7","DOIUrl":"10.1007/s00192-025-06153-7","url":null,"abstract":"<p><p>An enlarged urogenital hiatus is as important as apical support or fascial attachment failures in the development of prolapse and is strongly related to operative failure, yet we lack a conceptual model for factors responsible for hiatal failure. For a conceptual model to be valid, it cannot be proven false by empirical observation. We present six clinical observations with which future model development must be consistent. (1) Perineal body damage alone does not explain an enlarged urogenital hiatus. Three women have complete 4th degree lacerations but small hiatuses. (2) Levator damage is not a sole causal factor. One woman has bilateral levator avulsion but a normal hiatus, while another has intact muscles and an enlarged hiatus. (3) Hiatal assessment during straining is incomplete. Two women with similar straining urogenital hiatuses of 6-7 cm have respective 1.5 cm and 7 cm resting hiatuses. (4) Urogenital hiatus measurements during straining are confounded by Valsalva effort strength. Urogenital hiatus size increases by 30%, 51%, and 181% in one woman depending on straining strength. (5) Hiatal closure during pelvic muscle contraction differs widely. One woman can close her hiatus from 3.5 cm to 1.5 cm, while another shows no reduction despite evidence of contraction. (6) Prolapse/hiatus interactions occur with advancing age. One woman experiences progressive hiatal enlargement over 31 years. Our clinical observations reveal the complexity of the multiple factors involved in hiatal failure and support the need for a unified disease model consistent with these factors on which to base future research.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1581-1589"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vi Duong, Stephanie Schatzman-Bone, Joe Shi, Kaitlyn James, Milena M Weinstein
{"title":"Retrospective Cohort Study of Mesh-Related Complications of Minimally Invasive Sacrocervicopexy in 603 cases.","authors":"Vi Duong, Stephanie Schatzman-Bone, Joe Shi, Kaitlyn James, Milena M Weinstein","doi":"10.1007/s00192-025-06194-y","DOIUrl":"10.1007/s00192-025-06194-y","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>Minimally invasive sacrocolpopexy (SCP) with concurrent supracervical hysterectomy (SCH) has become the preferred treatment for uterovaginal prolapse over traditional open surgery. However, there is a lack of standardization in surgical materials and techniques, leading to variations in outcomes. This study aims to examine mesh-related complications in women undergoing SCP with concurrent SCH.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted within a large academic hospital system between May 2007 and December 2021. Participants who underwent SCP with concurrent SCH were included. Demographics, perioperative characteristics, and postoperative data were collected. Mesh complications were identified using CPT codes and confirmed by chart review. Parametric and nonparametric tests were used to assess differences in participant and surgical factors, with significance set at p ≤ 0.05.</p><p><strong>Results: </strong>A total of 603 participants were analyzed with a mean follow-up of 55 months. Most underwent laparoscopic SCP (87%), with 53% performed by minimally invasive gynecologic surgery (MIGS) and 47% performed by urogynecology and reconstructive pelvic surgery (URPS). Mesh exposure occurred in 1.2% of cases and was significantly associated with permanent multifilament braided suture use for vaginal mesh attachment (p < 0.001). All exposures occurred in surgeries performed by MIGS surgeons. No significant associations were found with smoking, menopausal status, estrogen use, primary energy instrumentation, or mesh weight. Notably, no mesh erosions were observed.</p><p><strong>Conclusion: </strong>Mesh-related complications following SCP with concurrent SCH are rare. Permanent multifilament braided suture was the only factor associated with mesh exposure. Further research is needed to evaluate surgical factors and optimize techniques.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1671-1677"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheymonti S Hoque, Susannah Ahern, Helen E O'Connell, Rasa Ruseckaite
{"title":"Patient and Clinician Feedback to Inform the Development of a New Pain-Specific Patient-Reported Outcome Measure for Pelvic Floor Surgery.","authors":"Sheymonti S Hoque, Susannah Ahern, Helen E O'Connell, Rasa Ruseckaite","doi":"10.1007/s00192-025-06248-1","DOIUrl":"https://doi.org/10.1007/s00192-025-06248-1","url":null,"abstract":"<p><strong>Introduction: </strong>Pelvic floor procedures may result in pain, negatively affecting women's health-related quality of life. Existing patient-reported outcome measures (PROMs) inadequately capture specific pain attributes and their relationship to pelvic floor disorders (PFDs). This study aimed to pretest items for a new pain-specific PROM post-pelvic floor surgery through focus groups/interviews.</p><p><strong>Methods: </strong>This qualitative study utilised six focus groups/interviews with 15 adult Australian and New Zealand women with PFDs experiencing post-surgical pain and mesh complications. Consolidation with the Australasian Pelvic Floor Procedure Registry Steering Committee, consisting of 11 clinicians, also occurred. Women and clinicians provided feedback regarding 35 potential items for the new pain-specific PROM. Data from the discussions were transcribed and then thematically analysed using NVivo.</p><p><strong>Results: </strong>Women and clinicians agreed the new PROM could effectively address PFDs and pelvic floor surgical pain. Their feedback guided decision-making to modify items and design the pain instrument. Women recommended removing 14 of the 35 items, and clinicians from the registry steering committee suggested removing a further five items. The preliminary PROM with 16 items has been developed under seven key pain-related domains: sensation, region, intensity and continuity, triggers, interference, comorbidities and complications, and pain relief and management.</p><p><strong>Conclusions: </strong>This qualitative study obtained direct input from women with PFDs and clinicians in formulating items for the new measure. A preliminary version of the PROM was produced from the feedback. Once fully developed and validated, the PROM could assist shared patient-clinician decision-making and track pain-related health outcomes important to women following pelvic floor surgery.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liam Christopher Martin, Alireza Hadizadeh, Henry H Chill, Durwash Badr, Steven D Abramowitch, Ghazaleh Rostaminia
{"title":"Differences in Pelvic Muscular Shape and Thickness in Women With and Without Significant Bladder Descent.","authors":"Liam Christopher Martin, Alireza Hadizadeh, Henry H Chill, Durwash Badr, Steven D Abramowitch, Ghazaleh Rostaminia","doi":"10.1007/s00192-025-06101-5","DOIUrl":"10.1007/s00192-025-06101-5","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>Pelvic organ prolapse (POP) is the descent of pelvic organs, causing patient discomfort. Despite its increasing prevalence, agreement in the field as to the cause is elusive. Weakness in pelvic floor muscles is implicated, but specific structural changes remain unclear. This study aimed to identify such differences in the levator ani, hypothesizing differences in pelvic muscle shape between greater and lesser bladder descent.</p><p><strong>Methods: </strong>We reviewed our patient database for cystocele diagnoses via MR defecography, including patients with static axial MRIs and dynamic midsagittal defecography. Patients were divided into two groups based on bladder descent relative to the genital hiatus (a measure our group had previously used). We used a statistical shape model of levator shapes to compare the groups. Additionally, we conducted MRI-based measurements (thickness of the obturator internus and anterior pelvic area) which have previously shown differences in similar groups.</p><p><strong>Results: </strong>Among 67 cystocele patients, 28 had greater bladder descent. The shape model identified significant variation in pelvic floor shape, specifically near the arcus tendineus levator ani (ATLA). The MRI-based measurements showed an increase in anterior pelvic area (53.8 ± 6.0 vs. 58.0 ± 5.3 cm<sup>2</sup>, p < 0.001) with increased prolapse severity and thinning of obturator's along the ATLA (16.2 ± 2.7 vs. 13.9 ± 2.2 mm, p < 0.001), specifically in the region around the insertion of the levators and obturators.</p><p><strong>Conclusions: </strong>Patients with greater bladder descent exhibited a larger anterior pelvic area, thinner obturators, and greater pelvic floor muscle descent, potentially due to muscle detachment at DeLancey's level II support.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1607-1615"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qi Wang, Xiaoxiang Jiang, Stefano Manodoro, Chaoqin Lin
{"title":"Outcomes of Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) for Uterosacral Ligament Suspension in Apical Compartment Prolapse: A Systematic Review.","authors":"Qi Wang, Xiaoxiang Jiang, Stefano Manodoro, Chaoqin Lin","doi":"10.1007/s00192-025-06195-x","DOIUrl":"10.1007/s00192-025-06195-x","url":null,"abstract":"<p><strong>Introduction and hypothesis: </strong>This systematic review is aimed at assessing the efficacy and safety of transvaginal natural orifice transluminal endoscopic surgery-uterosacral ligament suspension (vNOTES-USLS) based on current evidence.</p><p><strong>Methods: </strong>A comprehensive search of PubMed and Web of Science was conducted for studies published up to 31 December 2024. Original studies on vNOTES-USLS were included, whereas reviews, abstracts, and publications not in the English language were excluded. No restrictions were placed on sample size or publication date.</p><p><strong>Results: </strong>Nine studies with 336 patients met the criteria, including 1 randomized controlled trial, 3 prospective, and 5 retrospective studies. Operative time ranged from 17.4 ± 6.4 to 29.7 ± 8.2 minutes. Hemoglobin reduction varied between 1.12 ± 0.83 and 1.80 ± 1.57 g/dl. Hospital stays ranged from 1.0 ± 0.5 to 3.7 ± 1.1 days. Intraoperative complications occurred in 2.1% (7 out of 336), with bladder injury being the most common (3 cases). One patient required conversion to vaginal USLS, but no laparotomy conversions were reported. Ureteral kinking occurred in 1 case (0.3%) and was resolved intraoperatively. Postoperative complications were reported in 7.4% (25 out of 336), with urinary tract infection being the most frequent (10 cases). Over 1-37 months of follow-up, 1 patient required reoperation for anterior prolapse recurrence.</p><p><strong>Conclusion: </strong>vNOTES-USLS appears to be a promising option for apical prolapse, with favorable short-term outcomes. However, small sample sizes, short follow-ups, and study design variations limit current evidence. Larger prospective studies with longer follow-ups and direct comparisons with established procedures are needed to assess long-term safety and effectiveness.</p>","PeriodicalId":14355,"journal":{"name":"International Urogynecology Journal","volume":" ","pages":"1567-1580"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}