International Journal of Rheumatic Diseases最新文献

{"title":"Labyrinth of Rheumatic Disease: Finding the Optimal Path to Managing Cardiovascular Risk.","authors":"Jingying Wu, Qianyu Guo, Chongjuan Yin, James Cheng-Chung Wei, Li-Yun Zhang","doi":"10.1111/1756-185x.70654","DOIUrl":"https://doi.org/10.1111/1756-185x.70654","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70654"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating AI-Based Chatbots for Exercise and Rehabilitation Strategies in Patients With Rheumatoid Arthritis: Quality, Reliability Accuracy and Readability Analysis.","authors":"Yasemin Mirza, Fulden Sari","doi":"10.1111/1756-185x.70676","DOIUrl":"https://doi.org/10.1111/1756-185x.70676","url":null,"abstract":"<p><strong>Background: </strong>Although artificial intelligence (AI) is increasingly recognized for enhancing efficiency in healthcare services, its role in exercise and rehabilitation strategies remains unclear.</p><p><strong>Objectives: </strong>To assess the quality, reliability, accuracy, and readability of three large language models (LLMs), ChatGPT-5, DeepSeek-R1, and Gemini 2.5, in response to questions commonly asked by patients with rheumatoid arthritis (RA) regarding exercise and rehabilitation strategies.</p><p><strong>Methods: </strong>Using a cross-sectional comparative design, a structured assessment framework was developed that included exercise- and rehabilitation-related questions grouped into five thematic domains between 22 and 29 September 2025: exercise and physical activity (S1), hand function (S2), joint protection techniques (S3), breathing and pulmonary health (S4), and general topics (S5). Information quality was evaluated with the modified DISCERN tool, while content reliability was evaluated with the Reliability Score, and accuracy was measured using a five-point likert Accuracy Scale. Readability was determined through the Flesch Reading Ease scale.</p><p><strong>Results: </strong>DeepSeek-R1 and ChatGPT-5 achieved significantly higher scores for quality, reliability, accuracy, and readability compared with Gemini 2.5. In the S1 and S2 subgroups, both models consistently outperformed Gemini 2.5 across all evaluation metrics. Mean readability scores were 50.20 for DeepSeek-R1, 46.66 for ChatGPT-5, and 37.33 for Gemini 2.5, indicating that all responses were classified as difficult to read.</p><p><strong>Conclusions: </strong>This study highlighted that DeepSeek-R1 and ChatGPT-5 generated more accurate and reliable RA-related responses than Gemini 2.5; however, the complex language used by all models may limit accessibility for patients with low health literacy, underscoring the need for professional supervision in RA exercise planning.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70676"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Steroid-Responsive Ureteric Pseudotumour Causing Hydronephrosis in Sjögren Disease.","authors":"Reyhan Kose Cobanoglu, Utku Sentosun, Erhan Ates, Gokhan Sargin","doi":"10.1111/1756-185x.70684","DOIUrl":"https://doi.org/10.1111/1756-185x.70684","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70684"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application, Advantages, and Limitations of Mendelian Randomization Analysis in Ankylosing Spondylitis.","authors":"Morong Wu, Manli Wang, Xinyi Wu, Yuehan Yu, Yingying Mao","doi":"10.1111/1756-185x.70656","DOIUrl":"https://doi.org/10.1111/1756-185x.70656","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70656"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV Vaccination in Rheumatology: An Overlooked Opportunity for Infection Prevention and Beyond.","authors":"Yan-Yu Liu, Hao-Yun Chen, Yi-Hsuan Tu, Su-Boon Yong, Chin-Yuan Yii","doi":"10.1111/1756-185x.70664","DOIUrl":"https://doi.org/10.1111/1756-185x.70664","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70664"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aseptic Abscess Syndrome Associated With Relapsing Polychondritis-A Rarely Reported Association.","authors":"Bhargavi Pridhivi, Manish Soneja, Rakesh Kumar, Naveet Wig, Siddharth Jain","doi":"10.1111/1756-185x.70670","DOIUrl":"https://doi.org/10.1111/1756-185x.70670","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70670"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperuricemia Among College Students: Dietary Prevention May Be an Effective Measure.","authors":"Wenlong Ma, Mengdie Xu, Zhengyi Sun, Ruixia Gu, Xiaohong Wang","doi":"10.1111/1756-185x.70645","DOIUrl":"https://doi.org/10.1111/1756-185x.70645","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70645"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Big Data Research: A Bridge From Basic Research to Clinical Trial Emulation.","authors":"Renin Chang, Yao-Min Hung, James Cheng-Chung Wei","doi":"10.1111/1756-185x.70660","DOIUrl":"https://doi.org/10.1111/1756-185x.70660","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70660"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Correlation Between Genotypes of Drug-Metabolizing Enzymes and the Therapeutic Efficacy and Adverse Reactions of Cyclophosphamide in Childhood-Onset Lupus Nephritis: A Chinese Cohort Study","authors":"Wei Qijiao,&nbsp;Jian Shan,&nbsp;Wang Changyan,&nbsp;Ma Mingsheng,&nbsp;Zhong Linqing,&nbsp;Dong Yanqing,&nbsp;Wang Wei,&nbsp;Song Hongmei","doi":"10.1111/1756-185x.70561","DOIUrl":"10.1111/1756-185x.70561","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the association between genetic polymorphisms (CYP2B6, CYP2C19, GSTP1) and haplotypes of cyclophosphamide (CTX)-metabolizing enzymes with therapeutic efficacy and adverse drug reactions (ADRs) in pediatric patients with lupus nephritis (LN).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective cohort study was conducted on 46 childhood-onset LN patients treated with CTX pulse therapy at Peking Union Medical College Hospital. Genetic polymorphisms of CYP2B6, CYP2C19, and GSTP1 were analyzed using blood samples. Patients were stratified into effective (<i>n</i> = 38) versus ineffective (<i>n</i> = 8) groups based on 3-month clinical outcomes, and adverse reaction (<i>n</i> = 13) versus control (<i>n</i> = 33) groups. Genotype/allele frequencies and haplotype distributions were compared using <i>χ</i>² tests, Hardy–Weinberg equilibrium, and PHASE 2.1 software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mutations in CYP2C19 (rs4244285) and GSTP1 (rs1695) were associated with reduced therapeutic efficacy (<i>p</i> &lt; 0.05). No significant differences in genotype/allele frequencies were observed between adverse reaction and control groups (<i>p</i> &gt; 0.05). Haplotype distribution frequencies showed no association with ADRs and efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CYP2C19 × 2 and GSTP1 polymorphisms may reduce CTX efficacy in pediatric LN patients. Genetic variations showed no correlation with ADRs. These findings highlight the potential of pharmacogenetic testing to guide CTX therapy, though larger prospective studies are needed for validation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Trial Number</h3>\u0000 \u0000 <p>Not applicable.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Radiographic Axial Spondyloarthritis","authors":"Alexander Alexandrov,&nbsp;Chen Chao,&nbsp;Anand Kumthekar","doi":"10.1111/1756-185x.70637","DOIUrl":"10.1111/1756-185x.70637","url":null,"abstract":"&lt;p&gt;Non-radiographic axial spondyloarthritis (nr-axSpA) is a distinct clinical entity characterized by the absence of sacroiliitis on plain radiographs, despite evidence of active sacroiliac inflammation on magnetic resonance imaging (MRI). Khan and colleagues first described this condition in 1985, referring to it as “spondylitic disease without radiologic evidence of sacroiliitis” [&lt;span&gt;1&lt;/span&gt;]. Although the concept of nr-axSpA had been recognized prior to this description, the 2009 Assessment of Spondyloarthritis International Society (ASAS) classification criteria brought the entity to the forefront of clinical practice and research. According to these criteria, individuals younger than 45 years with chronic low back pain lasting more than 3 months may be classified as having axial spondyloarthritis if they fulfill either the clinical arm, requiring at least two spondyloarthritis (SpA) features, or the imaging arm, requiring at least one SpA feature in conjunction with imaging evidence of sacroiliitis [&lt;span&gt;2&lt;/span&gt;]. The prevalence of nr-axSpA in the United States is estimated to be approximately 0.35%, compared with a combined axial SpA prevalence of 0.9%–1.4% [&lt;span&gt;3, 4&lt;/span&gt;]. In contrast, a survey-based study from Japan estimated the prevalence of radiographic axSpA (r-axSpA) to be 0.0026%, with an even lower prevalence of nr-axSpA at 0.0006% [&lt;span&gt;5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Historically, axial SpA has been regarded as a predominantly male disease; however, more recent data suggest that the male-to-female ratio has narrowed, with several studies reporting near equivalence, particularly within nr-axSpA cohorts [&lt;span&gt;6&lt;/span&gt;]. Sex-based differences in clinical presentation have also been observed, with women more likely to report widespread pain, including cervical and upper thoracic symptoms that may not meet traditional definitions of inflammatory back pain [&lt;span&gt;7&lt;/span&gt;]. Women additionally tend to exhibit less radiographic damage, a factor that may contribute to the longer diagnostic delays consistently reported among female patients compared with males [&lt;span&gt;7&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Findings from large observational cohorts have further clarified the clinical characteristics of nr-axSpA. In the German Spondyloarthritis Inception Cohort (GESPIC), patients with early nr-axSpA demonstrated active inflammatory disease, with radiographic progression associated with HLA-B27 positivity, elevated C-reactive protein (CRP), and the presence of baseline MRI osteitis [&lt;span&gt;8&lt;/span&gt;]. The French Devenir des Spondylarthropathies Indifférenciées Récentes (DESIR) cohort showed that most patients with early inflammatory back pain remain non-radiographic over long-term follow-up, with women exhibiting greater pain burden and lower inflammatory markers than men [&lt;span&gt;9&lt;/span&gt;]. Data from the Corrona registry in the United States similarly demonstrated sex- and inflammation-related differences, identifying a higher proportion of women, lower CRP levels, and l","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}