International Journal of Rheumatic Diseases最新文献

{"title":"Confronting the Gout Crisis in the Pacific: A Neglected Public Health and Cultural Challenge.","authors":"Jose Paulo Lorenzo, James Cheng-Chung Wei","doi":"10.1111/1756-185x.70661","DOIUrl":"https://doi.org/10.1111/1756-185x.70661","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70661"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sjögren's Disease in Transition: Advances in Pathogenesis, Diagnosis, and Targeted Therapy.","authors":"Yan-Ru Xiao, Huai-An Yin, Susanne Rui Mosimann, Su-Boon Yong, Chao-Yi Wu","doi":"10.1111/1756-185x.70629","DOIUrl":"https://doi.org/10.1111/1756-185x.70629","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70629"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial Predictors of Self-Care Adherence in Patients With Systemic Lupus Erythematosus.","authors":"Icaro Moreira Costa, Cynthia de Freitas Melo, Maria Clara da Rocha Brito, Luis Eduardo Pontes Luna, Juliana Morais Gurjão, Nicole Campos Pontes","doi":"10.1111/1756-185x.70675","DOIUrl":"https://doi.org/10.1111/1756-185x.70675","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70675"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's Knees Are Not Gender-Neutral: A Global Scoping Review of Equity, Representation, and Context in Knee Osteoarthritis Research and Evidence.","authors":"Emmanuel Okon Enang, Ezra Onyedikachi Madu, Minha Awan","doi":"10.1111/1756-185x.70657","DOIUrl":"https://doi.org/10.1111/1756-185x.70657","url":null,"abstract":"<p><p>Women bear a disproportionate burden of knee osteoarthritis (KOA), yet global research systematically underrepresents sex-specific and context-sensitive analyses, limiting precision care and equitable interventions. We conducted a scoping review following PRISMA-ScR guidelines, systematically mapping studies on KOA in adults from 2000 to 2024 across PubMed, Embase, Scopus, Web of Science, and Cochrane Library. A predefined, version-controlled protocol was maintained with timestamped revisions and an independent audit to ensure methodological transparency. Dual independent screening, data extraction, and coding achieved high reliability (Cohen's κ = 0.87). A validated weighted gap scoring system assessed four equity domains: sex-disaggregated analysis, women's representation, contextual reporting, and geographic diversity. Integrated descriptive mapping and cross-tabulation quantified structural evidence gaps. Gray literature and non-English studies were excluded, acknowledging potential underrepresentation of low- and middle-income country (LMIC) data. Among 287 included studies, women were represented in 91%, yet only 22% were women-only cohorts, with high-income countries 2.4× more likely to conduct women-focused research than LMICs (χ² = 29.4, p < 0.001). Sex-disaggregated analyses were reported in 38% of mixed-sex studies, with profound neglect of psychosocial, preventive, and mechanistic outcomes. Intersectional analyses combining age, socioeconomic status, and context were extremely rare. Weighted gap scores highlighted very high deficiencies in SES, education, occupation, and LMIC representation, with minimal improvement over 24 years. KOA's evidence base does not merely underrepresent women; it systematically fails to generate clinically validated knowledge for them. As a result, interventions are routinely applied without clear evidence of the effectiveness across the population most affected, without mandatory sex-aggregated, mechanistic, and context-specific research.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70657"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting ARL15 Function in Rheumatoid Arthritis: Insights From Ex Vivo and in Vitro Synovial Fibroblast Models.","authors":"Sujit Kashyap, Anuj Kumar Pandey, Paritosh Kumar, Maumita Kanjilal, Uma Kumar, B K Thelma","doi":"10.1111/1756-185x.70668","DOIUrl":"https://doi.org/10.1111/1756-185x.70668","url":null,"abstract":"<p><strong>Objectives: </strong>ARL15, coding for a small GTPase, was identified as a non-HLA susceptibility gene in rheumatoid arthritis (RA) through a GWAS in a North Indian cohort, with serum adiponectin and ARL15 levels higher in RA patients with the associated genotype. This study aimed to delineate the functional role of ARL15 in RA pathobiology.</p><p><strong>Methods: </strong>Differential transcriptomics in both ex vivo RA synovial fibroblasts and in vitro MH7A cells using a gene knockdown (KD) approach and standard analyses pipeline were performed to obtain insights into ARL15's role.</p><p><strong>Results: </strong>In RASF, ARL15 KD led to downregulation of COMP-an extracellular matrix stabilizer linked to severe RA-alongside upregulation of adiponectin and IFN response genes like IFI6 and USP18. Furthermore, upregulation of NPTX1 and MX1, previously associated with disease modulation and treatment response, was observed. Downregulation of CTGF, CD248, and PTX3 suggested involvement of ARL15 in inflammation and RA-associated cardiovascular risk. Conversely, ARL15 KD in MH7A cells displayed distinct signatures with upregulated cytokines (IL1A, IL8, CXCLs) and downregulated inflammatory regulators (DOCK2, TLR4, TGFB2), reflecting an inflammatory bias distinct from patient-derived RASF.</p><p><strong>Conclusion: </strong>The dual-system approach, despite its divergent differential expression, underscores the multifaceted role of ARL15 in regulating connective tissue architecture, inflammation, and immune response. Limitations of immortalized cell models in capturing patient heterogeneity and disease complexity are apparent, but the key findings position ARL15 as a promising therapeutic target, warranting further investigation in RA animal models and genomic medicine. Taken together, this work provides a compelling rationale to pursue ARL15 targeted interventions in RA management.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70668"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Induced Subacute Cutaneous Lupus Erythematosus Under Adalimumab in a Child With Polyarticular Juvenile Idiopathic Arthritis: IFN-α and TNF-α-Skewed Cytokine Profile.","authors":"Yukari Aida, Mao Mizuta, Maho Hatano, Masaki Shimizu, Yasuo Nakagishi","doi":"10.1111/1756-185x.70663","DOIUrl":"https://doi.org/10.1111/1756-185x.70663","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70663"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catastrophic Antiphospholipid Syndrome as a Presenting Manifestation of Systemic Sclerosis-A Case Report.","authors":"Sankar J, Jithin Mathew, Chandra Bhushan Prasad, G S R S N K Naidu, Aman Sharma","doi":"10.1111/1756-185x.70680","DOIUrl":"https://doi.org/10.1111/1756-185x.70680","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70680"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum Matrix Metalloproteinase-3 Levels and Cognitive Function in Patients With Rheumatoid Arthritis.","authors":"Masahiro Tada, Yoshinari Matsumoto, Tomoyuki Nakamura, Hitoshi Goto, Masanori Matsuura","doi":"10.1111/1756-185x.70686","DOIUrl":"https://doi.org/10.1111/1756-185x.70686","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive impairment is increasingly recognized as a clinically relevant comorbidity in patients with rheumatoid arthritis (RA). Although chronic inflammation has been implicated in cognitive vulnerability, the relationship between RA-related inflammatory markers and cognitive function has not been fully elucidated.</p><p><strong>Methods: </strong>In this cross-sectional study, patients with RA underwent cognitive assessment using the Mini-Mental State Examination (MMSE). Serum matrix metalloproteinase-3 (MMP-3) and erythrocyte sedimentation rate (ESR) were evaluated as inflammatory markers. Multivariable linear regression analyses were performed to examine factors associated with MMSE score, adjusting for age, sex, educational level, and frailty. Sensitivity analyses included additional adjustments for ESR, renal function, and glucocorticoid use. Mild cognitive impairment (MCI), defined as an MMSE score ≤ 27, was examined using logistic regression models.</p><p><strong>Results: </strong>A total of 130 patients were included, of whom 34 were classified as having MCI. Higher serum MMP-3 levels were associated with lower MMSE scores after adjustment for demographic factors, educational level, and frailty. This association remained significant after additional adjustment for ESR, whereas ESR itself was not associated with MMSE score in fully adjusted models. Higher MMP-3 levels were also associated with increased odds of MCI, and this association remained significant in analyses restricted to female patients.</p><p><strong>Conclusions: </strong>Serum MMP-3 levels were associated with cognitive function in patients with RA, whereas ESR was not. These findings suggest that RA-related inflammatory activity reflected by MMP-3 may be relevant to cognitive vulnerability beyond nonspecific inflammation. Further longitudinal studies are warranted to clarify temporal relationships and clinical implications of these findings.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70686"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Acute Exacerbation of Rheumatoid Arthritis-Associated Interstitial Lung Disease Preceded by Cutaneous Vasculitis: Implications for a Shared Pathogenesis.","authors":"Koji Suzuki, Mitsuhiro Akiyama, Yuko Kaneko","doi":"10.1111/1756-185x.70673","DOIUrl":"https://doi.org/10.1111/1756-185x.70673","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70673"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Large Language Models in Rheumatology: A Transformative Paradigm for Academia.","authors":"Latika Gupta, Vincenzo Venerito, James Cheng-Chung Wei","doi":"10.1111/1756-185x.70679","DOIUrl":"https://doi.org/10.1111/1756-185x.70679","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70679"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}