{"title":"Comparative outcome of patients with systemic autoimmune rheumatic disease affected by COVID-19 infection-An Asian perspective.","authors":"Kuo-Tung Tang","doi":"10.1111/1756-185X.15359","DOIUrl":"https://doi.org/10.1111/1756-185X.15359","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concurrent breast cancer and IgG4-related orbital pseudotumor in a man.","authors":"Tuba Yüce Inel, Sadettin Uslu, Meltem Soylev Bajin, Fatos Onen","doi":"10.1111/1756-185X.15362","DOIUrl":"https://doi.org/10.1111/1756-185X.15362","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Osteoporosis and inflammation: Cause to effect or comorbidity?","authors":"Majda I Khoury","doi":"10.1111/1756-185X.15357","DOIUrl":"https://doi.org/10.1111/1756-185X.15357","url":null,"abstract":"<p><p>Osteoporosis (OP) was long viewed as an inevitable process of aging, due to an imbalance between osteoclast bone resorbing and osteoblast bone formation function, leading to a negative balance in bone remodeling. This leads to low bone mass and increased bone fragility putting the patient at risk for fracture. While this view still holds, a better understanding disclosed that OP can occur at any age, as a comorbidity or a complication of many diseases and treatments. Differentiation, maturation, and function of osteoclasts and osteoblasts are affected by many factors from different morbidities: endocrine, metabolic, mechanical and inflammatory. Inflammatory diseases are often complicated by a generalized bone loss that subsequently leads to OP. Factors such as glucocorticoid treatment, immobilization, malnutrition, and insufficient intake of vitamin D play a role. However, the inflammatory process itself is involved and the resulting bone loss is termed immune-mediated bone loss. Experiments on animals and on humans, in addition to clinical studies, shed light on the role of inflammation in OP.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adamantiades-Behcet's disease: From the first known descriptions to the era of the biologic agents.","authors":"Ellie Stefanadi, Georgios Dimitrakakis, Inetzi-Angeliki Dimitrakaki, Nikolaos Sakellariou, Sangeeta Punjabi, Christodoulos Stefanadis","doi":"10.1111/1756-185X.15353","DOIUrl":"https://doi.org/10.1111/1756-185X.15353","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial: The role of Piezo 1 in osteoarthritis: Implications for pathogenesis and therapy.","authors":"Shangqi Guan, Yifang Mei","doi":"10.1111/1756-185X.15348","DOIUrl":"https://doi.org/10.1111/1756-185X.15348","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuan Feng, Jia Chen, Xichao Yang, Jie Liu, Xue Cao, Yan Zhang, Zhenbiao Wu
{"title":"Efficacy and safety of oral versus intravenous cyclophosphamide in treatment of connective tissue disease-related interstitial lung disease.","authors":"Yuan Feng, Jia Chen, Xichao Yang, Jie Liu, Xue Cao, Yan Zhang, Zhenbiao Wu","doi":"10.1111/1756-185X.15354","DOIUrl":"https://doi.org/10.1111/1756-185X.15354","url":null,"abstract":"<p><strong>Objective: </strong>Interstitial lung disease (ILD) resulting from connective tissue disease (CTD) greatly undermines people's health. Cyclophosphamide (CYC) is a widely used agent in treating CTD-ILD. We compared the efficacy and safety of oral and intravenous CYC in CTD-ILD treatment.</p><p><strong>Methods: </strong>The retrospectively enrolled CTD-ILD patients were divided into the oral and intravenous CYC groups. The chest high-resolution computed tomography examination, forced vital capacity (FVC), lung carbon monoxide diffusion capacity (Dlco) determinations, and 6 min walk test (6MWT) were performed pre-treatment and at the 3rd, 6th, and 12th months posttreatment. Radiographic ILD severity was assessed using the Warrick score. Krebs Von den Lungen-6, surfactant protein A (SP-A), SP-D, and erythrocyte sedimentation rate (ESR) before and at the 12th month post-treatment were determined. CYC cumulative dose and occurrence of adverse reactions during treatment were recorded.</p><p><strong>Results: </strong>CYC cumulative dose in the intravenous CYC group was reduced. Compared with oral CYC treatment, intravenous CYC caused decreased Warrick score and increased FVC and 6MWT at the 6th month, and elevated DLco at the 3rd and 6th months posttreatment. SP-A, SP-D and ESR levels in both groups were reduced 12 months posttreatment, with a more evident decrease in the intravenous CYC group. Intravenous CYC had lower total adverse reaction incidence.</p><p><strong>Conclusion: </strong>Compared with oral CYC, intravenous CYC decreases Warrick score and increases FVC and 6MWT at 6 months posttreatment, and reduces SP-A, SP-D, and ESR levels after 12 months of treatment, which shows low CYC cumulative dose and adverse reaction incidence in treating CTD-ILD.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic kidney disease in patients with lupus nephritis-Important but underrecognized.","authors":"Selene T Y Teoh, Desmond Y H Yap, Tak Mao Chan","doi":"10.1111/1756-185X.15361","DOIUrl":"https://doi.org/10.1111/1756-185X.15361","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is exercise therapy effective for the treatment of acute nonspecific low back pain? A Cochrane Review summary with commentary","authors":"Ayesha Afridi, Farooq Azam Rathore","doi":"10.1111/1756-185X.15352","DOIUrl":"https://doi.org/10.1111/1756-185X.15352","url":null,"abstract":"<p>The aim of this commentary is to discuss the Cochrane Review “Exercise therapy for treatment of acute non-specific low back pain”<span><sup>1</sup></span> by IJzelenberg et al., (This summary is based on a Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2023, Issue 8, Art. No.: CD009365. DOI:10.1002/14651858.CD009365.pub2. (see www.cochranelibrary.com for information). Cochrane Reviews are regularly updated as new evidence emerges and in response to feedback, and Cochrane Database of Systematic Reviews should be consulted for the most recent version of the review) published by Cochrane Back and Neck Group. This Cochrane Corner is produced in agreement with <i>International Journal of Rheumatic Diseases</i> by Cochrane Rehabilitation with views (The views expressed in the summary with commentary are those of the Cochrane Corner authors (different than the original Cochrane Review authors) and do not represent the Cochrane Library or Wiley) of the review summary authors in the “implications for practice” section.</p><p>Low back pain (LBP) is a common condition that affects a significant proportion of the population, leading to considerable pain and disability.<span><sup>2</sup></span> LBP refers to pain, muscle tension, or stiffness situated between the costal margin and the inferior gluteal folds, which may include referred leg pain (sciatica). Acute nonspecific LBP means LBP episodes lasting up to 6 weeks, which were not caused by known underlying conditions, such as infection, cancer, broken bones, or pregnancy.<span><sup>3</sup></span> Exercise therapy, a widely used conservative treatment, involves active interventions to enhance physical fitness, flexibility, stability, coordination, and muscle strength, but its efficacy in this context remains uncertain.<span><sup>4</sup></span> It may target specific muscles (e.g., transversus abdominus and multifidus) or broader muscle groups (trunk, abdomen, and back). Programs vary in intensity, frequency, duration, and setting. While commonly used, the efficacy of exercise therapy for acute nonspecific LBP remains uncertain.<span><sup>1</sup></span> Understanding its impact can guide clinical practice and improve patient outcomes.</p><p>Wilhelmina IJzelenberg, Teddy Oosterhuis, Jill A Hayden, Bart W Koes, Maurits W van Tulder, Sidney M Rubinstein, Annemarie de Zoete, 2023.</p><p>The implications of this Cochrane Review for rheumatology practice are nuanced due to very uncertain evidence about the effect of exercise therapy in reducing pain or improving functional status compared with placebo, no treatment, or other conservative approaches in people with acute, nonspecific LBP. Given this uncertainty and considering that acute LBP often improves spontaneously without any intervention, the necessity of exercise therapy for this population may be questioned. This contrasts with chronic LBP, where the natural progression differs, and exercise therapy may have a more cl","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young-Eun Kim, Jin-Myung Kim, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Sung Shin, Seokchan Hong
{"title":"Lupus flare and recurrent lupus nephritis following kidney transplantation in patients with lupus nephritis","authors":"Young-Eun Kim, Jin-Myung Kim, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Sung Shin, Seokchan Hong","doi":"10.1111/1756-185X.15349","DOIUrl":"https://doi.org/10.1111/1756-185X.15349","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Clinical manifestations and risk factors associated with systemic lupus erythematosus (SLE) flares, including recurrent lupus nephritis (LN), in patients with LN who undergo kidney transplantation have been unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Kidney transplant recipients with LN from January 1995 to December 2021 were included in this study. A disease flare was defined as either an increase in the non-renal SLE disease activity index score or the presence of biopsy-proven recurrent LN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among a total of 93 patients with LN who underwent kidney transplantation, 11 patients (11.8%) experienced SLE flares during a median follow-up period of 76.9 months (IQR, 43.0–122.4). The most common clinical manifestations of SLE flares were recurrent LN (4/11, 36.4%) and hematologic manifestations (4/11, 36.4%). Patients who had flares had significantly higher anti-double-stranded DNA (anti-dsDNA) antibody titers both before and after transplantation. Furthermore, an increased anti-dsDNA antibody level before transplantation was associated with a high risk of an SLE flare (HR, 1.030; <i>p</i> = .008). Conversely, preemptive transplantation was associated with a lower risk of a flare (HR, 0.617; <i>p</i> = .026). The rate of patient death-censored graft survival was found to be considerably lower in patients with recurrent LN than in those without LN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Approximately 10% of patients with LN experienced an SLE flare after transplantation, with recurrent LN being the most frequent manifestation. Anti-dsDNA antibody titers before transplantation were significantly related to the risk of an SLE flare. Notably, preemptive transplantation was associated with a reduced risk of flares following transplantation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}