International Journal of Rheumatic Diseases最新文献

{"title":"Nailfold Capillaroscopy as Predictor for Autoantibody Test Results","authors":"Mara Karcher, Anke Strölin, Sebastian Volc","doi":"10.1111/1756-185X.70146","DOIUrl":"https://doi.org/10.1111/1756-185X.70146","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Risk Prediction Model for the Development of Rheumatoid Arthritis, Sjögren's Syndrome, Systemic Sclerosis in Patients With Systemic Lupus Erythematosus: Multicenter Approaches","authors":"Rui-Cen Li,&nbsp;Wang-Dong Xu,&nbsp;Xiao-Yan Liu,&nbsp;Lu Fu,&nbsp;You-Yu Lan,&nbsp;Si-Yu Feng,&nbsp;An-Fang Huang","doi":"10.1111/1756-185X.70156","DOIUrl":"https://doi.org/10.1111/1756-185X.70156","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to construct a predictive model to evaluate the risk of overlapping syndrome (OS), including the combination of systemic sclerosis, rheumatoid arthritis, and Sjögren's syndrome in patients with systemic lupus erythematosus (SLE) from multicenters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included SLE patients in the development cohort (<i>n</i> = 4714) and the external validation cohort (<i>n</i> = 2271). SLE patients in the development cohort were randomly divided into the training cohort and the internal validation cohort at a 7:3 ratio. Laboratory variables were collected and compared by univariate logistic regression modeling. Multivariate logistic regression was further used to develop predictive models and plot a risk nomogram for OS. Receiver operating characteristic (ROC) and calibration curve analysis were used to assess model validity and accuracy. Decision curve analysis was used to assess net clinical benefit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Indexes including anti-SSA antibody, anti-SSB antibody, proteinuria, occult blood in urine, age, eosinophil ratio, hematocrit, platelet, direct bilirubin, indirect bilirubin, rheumatoid factor, immunoglobulin A, prothrombin time, and ferritin were included in the predictive model. The nomogram showed a wide range of predictive ability. The area under the curve (AUC) of the ROC curve for the training cohort was 0.874 (0.851–0.896), the AUC for the internal validation cohort was 0.877 (0.843–0.911), and the AUC for the external validation cohort was 0.760 (0.730–0.790).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The model has a good predictive performance and will be clinically valuable for the assessment of the risk of OS in SLE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evaluation of PNPLA2, ATGL, and G0S2 Levels in Serum and PBMCs of the Newly Diagnosed and the Chronic Patients With Rheumatoid Arthritis","authors":"Masoomeh Gholizadeh,&nbsp;Jahanbakhsh Asadi,&nbsp;Mehrdad Aghaei,&nbsp;Soroush Akbar,&nbsp;Romina Malakouti,&nbsp;Koushan Sineh Sepehr,&nbsp;Zahra Hesari","doi":"10.1111/1756-185X.70138","DOIUrl":"https://doi.org/10.1111/1756-185X.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Rheumatoid arthritis (RA) is an autoimmune disease that is marked by inflammatory response. <i>PNPLA2</i> (phospholipase patatin-like) which encodes ATGL (adipose triglyceride lipase) also been identified as playing in inflammation. <i>G0S2</i> (G0/G1) switch gene has been identified as one of the selective inhibitors of ATGL. <i>PNPLA2</i> and <i>G0S2</i> may be factors that can help predict the relationship between molecules affecting inflammation, as well as identify inflammatory pathways through genes involved in the metabolic pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In the present study, we analyzed the expression levels of <i>PNPLA2</i> and <i>G0S2</i> genes as well as their protein concentrations by real-time PCR and immunoassay, respectively on 60 peripheral blood mononuclear cells (PBMC) which are included into 3 different groups of new case patients with RA, chronic patients with RA, and the control individuals. Also, to obtain more accurate information and results, the synovial fluid, triglyceride, cholesterol, and ESR levels were also analyzed. Statistical analysis was then performed with the software SPSS-18.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>PNPLA2</i> gene expression level was significantly increased in the newly diagnosed patients and the chronic RA patients in compared to the control group. Also, the serum levels of ATGL in the newly diagnosed patients and the chronic RA patients were significantly reduced compared to the control group. The gene and protein levels of <i>G0S2</i> in the newly diagnosed patients elevated compared to other groups, but interestingly this increase in PBMCs was not significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This is predicted that <i>PNPLA2</i> gene expression in PBMCs is not only regulated by <i>G0S2</i> gene, but different regulatory factors can also affect the expression level of this gene in the immune cells.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Superior Cluneal Nerve Neuropathy Confused With Inflammatory Hip Pain","authors":"Alper Mengi,&nbsp;Melis Dilbil","doi":"10.1111/1756-185X.70152","DOIUrl":"https://doi.org/10.1111/1756-185X.70152","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Effective Treatment of Pyoderma Gangrenosum in a Patient Complicated With Diabetic Foot Ulcer Using Intravenous Immunoglobulin and Adalimumab","authors":"Dilek Menteşoğlu,&nbsp;Hakan Yıldırım,&nbsp;Ramazan Burak Sivri,&nbsp;Selda Pelin Kartal","doi":"10.1111/1756-185X.70154","DOIUrl":"https://doi.org/10.1111/1756-185X.70154","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Effective Treatments With Potential Threats: The Impact of Biologic Agent Use on Tuberculosis Development in Children With Chronic Inflammatory Disorders","authors":"Ayse Hitay Telefon,&nbsp;Merve Kilic Cil,&nbsp;Gulsum Sonmez,&nbsp;Elif Afat Turgut,&nbsp;Tugba Kandemir Gulmez,&nbsp;Didem Gulcu Taskin,&nbsp;Sevinc Garip,&nbsp;Rabia Miray Kisla Ekinci,&nbsp;Umit Celik","doi":"10.1111/1756-185X.70145","DOIUrl":"https://doi.org/10.1111/1756-185X.70145","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We aimed to investigate the frequency and clinical characteristics of tuberculosis in pediatric patients receiving both anti-TNF-alpha and other biological agents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The data of 270 patients who used biological agents due to rheumatologic diseases and inflammatory bowel disease (IBD) and were followed between January 2021 and October 2023 were retrospectively collected from their files.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the patients, 138(51.1%) were female, 132(48.9%) were male. The mean age at diagnosis was 107 months (min 8–max 215 months). Patients were most commonly followed for juvenile idiopathic arthritis (JIA) (191 patients, 70.7%), followed by other autoinflammatory diseases (49 patients) and IBD (26 patients, 9.6%). Treatments included adalimumab (97 patients, 35.9%), etanercept (85 patients, 31.5%), canakinumab (33 patients, 12.2%), tocilizumab (31 patients, 11.5%), infliximab (16 patients, 5.9%), anakinra (5 patients, 1.9%), tofacitinib (2 patients, 0.7%), and rituximab (1 patient, 0.4%). During follow-up, latent tuberculosis infection (LTBI) developed in 5 (1.9%) patients. Three of these patients had JIA (using adalimumab, etanercept and tocilizumab), one had Familial Mediterranean Fever (using canakinumab), and one had IBD (using adalimumab). The mean duration of biological agent treatment until LTBI development was 14.6 months (min 6–max 29 months). Tuberculosis disease was diagnosed in two patients. Both were patients followed up due to IBD. One of the patients was diagnosed with miliary tuberculosis after infliximab treatment, while the other was followed for tuberculosis lymphadenitis after adalimumab treatment. Quadruple anti-tuberculosis therapy was initiated for the patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The use of biological agents has revolutionized the course of chronic inflammatory diseases in childhood. However, in these patients, monitoring for tuberculosis risk is crucial.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B/ts DMARDs Utilization in the Management of Rheumatoid Arthritis: A Descriptive Study of a 12-Year Retrospective Cohort in Hong Kong","authors":"Kuan Peng,&nbsp;Elkie Chan Yu Kiu,&nbsp;Victoria Anna Yeo,&nbsp;Omar Wai Kiu Tsui,&nbsp;Franco W. T. Cheng,&nbsp;Eliza Y. T. Tam,&nbsp;Shirley C. W. Chan,&nbsp;Xue Li","doi":"10.1111/1756-185X.70140","DOIUrl":"https://doi.org/10.1111/1756-185X.70140","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Management of PASS Syndrome With Intravenous Immunoglobulin and Anti-Interleukin-1 Therapy: An Insightful Case Study","authors":"Ji-Won Kim,&nbsp;Hyoun-Ah Kim","doi":"10.1111/1756-185X.70148","DOIUrl":"https://doi.org/10.1111/1756-185X.70148","url":null,"abstract":"&lt;p&gt;PASS syndrome (PASS) is a rare and complex autoimmune disease that manifests as pyoderma gangrenosum (PG), acne vulgaris, hidradenitis suppurativa (HS), and ankylosing spondylitis (AS). Unlike other autoinflammatory syndromes such as PAPA and PASH, PASS does not have documented gene mutations, making diagnosis and treatment particularly challenging [&lt;span&gt;1&lt;/span&gt;]. Table 1 provides a comprehensive overview of various autoinflammatory diseases that share clinical features with PASS, including involvement of the skin, joints, and lymph nodes. This suggests a potential overlap in their underlying mechanisms. PAPA syndrome is characterized by sterile pyogenic arthritis, acne, and PG and is associated with a defect in the PSTPIP1 gene [&lt;span&gt;2&lt;/span&gt;]. PASH syndrome includes acne, PG, and HS, but unlike PASS, it does not involve the joints. A defect in the NCSTN gene is linked to PASH. PAPASH syndrome, which combines features of both PAPA and PASH, presents with pyogenic arthritis, acne, PG, and HS. In contrast to these syndromes associated with specific gene defects, PASS is characterized by the presence of seronegative spondyloarthritis alongside acne, PG, and HS [&lt;span&gt;3&lt;/span&gt;]. In addition to PASS, PAPASH, and the syndromes listed above, several other autoinflammatory disorders exist. These diseases exhibit a spectrum of clinical presentations, with unique combinations of skin and musculoskeletal manifestations. Examples include synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, and chronic recurrent multifocal osteomyelitis [&lt;span&gt;4&lt;/span&gt;]. Additionally, PsAPASH syndrome, also known as PAPASH-PsA, presents as a combination of psoriatic arthritis with PG, acne, and HS [&lt;span&gt;5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Research suggests that cytokines like interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and IL-18 play a key role in the development of PASS [&lt;span&gt;6, 7&lt;/span&gt;]. Elevated IL-1 levels are central to the inflammatory response, while TNF-α worsens tissue inflammation, particularly in HS and AS. IL-18 further amplifies this inflammatory cascade, contributing to the chronic and debilitating nature of the disease. The involvement of these cytokines highlights the importance of potential targeted therapies, making cytokine inhibitors a crucial part of treatment strategies [&lt;span&gt;7&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Traditional PASS treatment involves systemic corticosteroids and immunosuppressive drugs like methotrexate and cyclosporine to control inflammation and prevent flare-ups. Additionally, biological agents like TNF-α inhibitors may be used, though their effectiveness can vary among patients. A case study by Kırmızıer et al. [&lt;span&gt;8&lt;/span&gt;] presented a compelling example. A 25-year-old man with severe PASS, including ulcerated skin lesions, inflammatory nodules, joint swelling, and persistent back pain, showed no improvement despite treatment with corticosteroids and adalimumab. However, the introduction of intravenous immunoglobulin (IVIG) and methylpredni","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immature Granulocyte: A Novel Inflammatory Biomarker in Familial Mediterranean Fever","authors":"Zeynep Biyik,&nbsp;Yasemin Coskun Yavuz,&nbsp;Lutfullah Altintepe,&nbsp;Ahmet Cizmecioglu,&nbsp;Esra Yakşı,&nbsp;Muslu Kazım Korez,&nbsp;Sema Yılmaz","doi":"10.1111/1756-185X.70149","DOIUrl":"https://doi.org/10.1111/1756-185X.70149","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Our study aimed to evaluate the significance and clinical utility of immature granulocyte (IG) count (IGC) and IG percentage (IG%) in predicting attacks in patients with familial Mediterranean fever (FMF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 100 FMF patients and 50 healthy controls. Data from 24 patients during the attack period and 76 patients during the attack-free period in the FMF group were obtained from medical records. Complete blood count analyses were carried out with the Mindray BC-6200 automated hematology analyzer following standard laboratory protocols. Receiver operating characteristic (ROC) curve analysis was conducted to differentiate FMF patients in the attack period from those in the attack-free period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In FMF patients, levels of WBC (<i>p</i> = 0.032), neutrophils (<i>p</i> = 0.001), C-reactive protein (CRP) (<i>p</i> = 0.002), IG count (<i>p</i> &lt; 0.001), and IG percentage (<i>p</i> &lt; 0.001) were significantly higher compared to healthy controls. During the attack period, IG count and IG percentage levels were significantly elevated compared to the attack-free period (<i>p</i> &lt; 0.001 for both). Based on ROC analysis, IG count and IG percentage showed significant diagnostic potential in FMF patients, with AUC values of 0.841 and 0.766, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>IGC and IG% serve as indicators of inflammation in FMF patients and may facilitate the differential diagnosis of FMF attacks, with respective cut-off values of 0.04 × 10⁹/L and 0.4%. Given their accessibility and lack of additional cost, these parameters have the potential to enhance clinical practice by augmenting the diagnostic utility of conventional inflammatory biomarkers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Competency of Jeffrey Modell Foundation Warning Signs and Routine Laboratory Tests in Suspecting Primary Immunodeficiencies: A Cross-Sectional Multi-Centric Prospective Study From Eastern India” Ghosh, A, Samanta, M, Ghosh, P, Chatterjee, M, Mondal, R, Sabui, TK. Competency of Jeffrey Modell Foundation Warning Signs and Routine Laboratory Tests in Suspecting Primary Immunodeficiencies: A Cross-Sectional Multi-Centric Prospective Study From Eastern India. International Journal of Rheumatic Diseases 2024; 27:e15405. doi:https://doi.org/10.1111/1756-185X.15405","authors":"","doi":"10.1111/1756-185X.70046","DOIUrl":"https://doi.org/10.1111/1756-185X.70046","url":null,"abstract":"<p>In title page of the above article, the correspondence information was incorrect. It should be as follows:</p><p>Correspondence: Tapas Kumar Sabui, Department of Pediatrics, Shantiniketan Medical College, Bolpur, Birbhum, India. Email: <span>[email protected]</span></p><p>The online article has been amended.</p><p>We apologize for this error.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}