International Journal of Rheumatic Diseases最新文献

{"title":"Vasculitic Myopathy as an Early Manifestation of ANCA-Associated Vasculitis: The Necessity of Its Differentiation From Polymyalgia Rheumatica","authors":"Naoki Tanomogi, Yasuhiro Shimojima, Takanori Ichikawa, Dai Kishida, Yoshiki Sekijima","doi":"10.1111/1756-185X.70019","DOIUrl":"10.1111/1756-185X.70019","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive Gastrointestinal Bleeding in Patient With Immunoglobulin (Ig) A Vasculitis Patient due to Widespread Arterial Microaneurysms Treated With Intravenous Immunoglobulin (IVIG)","authors":"Reşit Yıldırım, Döndü Üsküdar Cansu, Burcu Ceren Uludoğan, Gökhan Çoban, Berat Acu, Cengiz Korkmaz","doi":"10.1111/1756-185X.70018","DOIUrl":"10.1111/1756-185X.70018","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TabNet Model for Diagnosing Axial Spondyloarthritis Using MRI Imaging Findings and Clinical Risk Factors","authors":"Zhaojuan Zhang,&nbsp;Yiling Pan,&nbsp;Yanjie Lu,&nbsp;Lusi Ye,&nbsp;Mo Zheng,&nbsp;Guodao Zhang,&nbsp;Dan Chen","doi":"10.1111/1756-185X.70004","DOIUrl":"10.1111/1756-185X.70004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study is to develop and validate a model for predicting axial spondyloarthritis (axSpA) based on sacroiliac joint (SIJ)-MRI imaging findings and clinical risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study is implemented on the data of 942 patients which contains of 707 patients with axSpA and 235 patients with non-axSpA. To begin with, the patients were split into training (<i>n</i> = 753) and validation (<i>n</i> = 189) cohorts. Secondly, multiple assessors manually extract the features of active inflammation (bone marrow edema) and structural lesions (erosions, sclerosis, ankylosis, joint space changes, and fat lesions). Meanwhile, we utilize 11 machine learning models and TabNet to develop imaging models, which contain six clinical risk factors for clinical models and combined clinical-imaging models. Finally, the diagnostic performance of the aforementioned models was evaluated in the validation cohort including accuracy, area under the receiver operating characteristic curve (AUC), sensitivity, specificity, F1-score, and Matthew's correlation coefficient (MCC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Six features were extracted from the imaging findings. The combined clinical-imaging models outperform the clinical and imaging models. In contrast, the combined clinical-imaging model via TabNet (CCMRT) achieved the optimal AUC of 0.93(95% CI: 0.89, 0.97). Furthermore, it is observed that the bilateral joint space changes and right-sided erosions, HLA-B27 positivity, and CRP values significantly affected axSpA diagnostic prediction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The prediction model based on clinical risk factors and SIJ-MRI imaging features can distinguish axSpA and non-axSpA effectively. In addition, the TabNet demonstrates superior diagnostic efficacy compared with machine learning models.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroconversion of Rheumatoid Factor Prior to the Onset of Rheumatoid Arthritis in Patients With Interstitial Lung Disease: A Single-Center Retrospective Case Series","authors":"Naoshi Nishina,&nbsp;Takahisa Gono,&nbsp;Yohei Isomura,&nbsp;Shinji Watanabe,&nbsp;Yuichiro Shirai,&nbsp;Mitsuhiro Takeno,&nbsp;Masataka Kuwana","doi":"10.1111/1756-185X.70017","DOIUrl":"10.1111/1756-185X.70017","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utility of Thermography in Detecting Subclinical Joint Inflammation at the Elbows in Patients With Rheumatoid Arthritis","authors":"York Kiat Tan,&nbsp;Rehena Sultana","doi":"10.1111/1756-185X.70015","DOIUrl":"10.1111/1756-185X.70015","url":null,"abstract":"&lt;p&gt;Thermography, an emerging imaging modality, assesses joint inflammation by measuring joint surface temperatures objectively [&lt;span&gt;1&lt;/span&gt;]. It has recently gained interest among researchers in the field of degenerative and inflammatory arthritides as evidenced by the increased publication trend in the past decade [&lt;span&gt;2&lt;/span&gt;]. In comparison, ultrasound is an established tool for joint inflammation assessment, with its use in rheumatoid arthritis (RA) supported by a substantial amount of data that have amassed especially over the past two decades [&lt;span&gt;3, 4&lt;/span&gt;]. According to the European Alliance of Associations for Rheumatology (EULAR) recommendations [&lt;span&gt;4&lt;/span&gt;] and the American College of Rheumatology (ACR) guidance report [&lt;span&gt;5&lt;/span&gt;], ultrasound may respectively be used to assess for persistent inflammation in patients with RA (as it can detect inflammation that predicts subsequent joint damage, even in clinical remission) [&lt;span&gt;4&lt;/span&gt;] and can be reasonably used to evaluate for subclinical inflammatory arthritis in patients with mono- or oligoarthralgia without definitive diagnosis on clinical examination at certain specified asymptomatic joints or regions [&lt;span&gt;5&lt;/span&gt;]. Although ultrasound can be a valuable tool for subclinical joint inflammation assessment in RA, its use is not without limitations [&lt;span&gt;3&lt;/span&gt;]. For example, it can take considerable amount of training for sonographers to gain competency in musculoskeletal ultrasonography and scanning multiple different joint sites can be time-consuming. Hence, there is a need to explore other low-cost imaging modalities with high feasibility for use in the routine clinical practice for joint inflammation assessment. Thermography is safe, non-invasive, with modern thermal cameras being compact, portable, and straightforward to use; hence thermography is well-suited for use as an adjunctive tool in the busy rheumatology outpatient setting [&lt;span&gt;1&lt;/span&gt;]. The elbow joint, important for daily activity, is chosen in our study as it is commonly affected in RA, with a 15-year endpoint study revealing Larsen grade 2 radiographic erosion(s) in about two-thirds of its RA study cohort [&lt;span&gt;6&lt;/span&gt;]. In this single-site cross-sectional study conducted at a local tertiary hospital, we aim to compare thermography with ultrasound-detected power Doppler (PD) and grey-scale (GS) joint inflammation at clinically quiescent (non-swollen; non-tender) elbows of patients with RA fulfilling the 2010 EULAR/ACR RA classification criteria [&lt;span&gt;7&lt;/span&gt;]. Our study conforms to the relevant research ethical guidelines and received approval by our local institutional review board. All patients provided informed consent before joining the study.&lt;/p&gt;&lt;p&gt;Clinical and imaging assessment at each patient's elbow occurred during the same study visit. Elbow joint swelling and tenderness were elicited by independent joint assessors (trained rheumatology nurses blinded to the imaging finding","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic Evaluation of Urate Crystal Deposition in Tendons With Gout Patients","authors":"Si-Hui Deng,&nbsp;Jie Wang,&nbsp;Jing Hu,&nbsp;Bin Tu,&nbsp;Wan-Tai Dang,&nbsp;Jian Liu","doi":"10.1111/1756-185X.70006","DOIUrl":"10.1111/1756-185X.70006","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To use ultrasound technology to assess the deposition of urate crystals in the common lower limb tendons of patients with gout, providing additional imaging information for the management of these patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>High-frequency ultrasound was retrospectively used to evaluate urate crystal deposition in common lower limb tendons—quadriceps, patellar, and Achilles—in patients with gouty arthritis. Comparative statistical analysis was conducted among asymptomatic hyperuricemia patients and healthy individuals during the same period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Aggregates were detected in the tendons of all three groups, whereas tophi were found exclusively in tendons of asymptomatic hyperuricemia and gout groups. The prevalence of intratendinous aggregates and tophi in gout was significantly higher than the other groups (<i>p</i> &lt; 0.05). The Achilles tendon showed the highest involvement, followed by the quadriceps and patellar tendons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Tendons are common sites of urate deposition in patients with gout and asymptomatic hyperuricemia. Aggregates and tophi are frequently observed in and around large tendons such as the quadriceps, patellar, and Achilles tendons in gout patients. Ultrasonography proves useful in highly sensitive and specific evaluation of urate deposition within and around tendons.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Characterization of SLC2A3 in Rheumatoid Arthritis: Unraveling Its Role in Ferroptosis and Inflammatory Pathways","authors":"Zhiping Lin,&nbsp;Peng Li,&nbsp;Chaojun Wang,&nbsp;Hongchang Tan","doi":"10.1111/1756-185X.70009","DOIUrl":"10.1111/1756-185X.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hence, we investigated that the function and effects of SLC2A3 in rheumatoid arthritis (RA) and the underlying mechanism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>C57BL/6 mice were immunized with bovine type II collagen to induce mice model of RA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The expression of serum SLC2A3 was down-regulated, and was negative correlation with CRP, RF or anti-CCP in patients with RA. In mice model of RA, SLC2A3 mRNA and protein expression in joint tissue were reduced. Sh-SLC2A3 promoted RA and inflammation in mice model. SLC2A3 promoted cell growth and osteogenic differentiation of MC3T3-E1 cells in vitro model of RA. SLC2A3 reduced ferroptosis in vitro model or mice model of RA. SLC2A3 induced Tiam1 protein expression, and SLC2A3 protein linked with Tiam1 protein in model of RA. Tiam1 reduced the effects of sh-SLC2A3 on RA and inflammation in mice model. Tiam1 inhibitor the effects of SLC2A3 on osteogenic differentiation and ferroptosis in vitro model of RA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Collectively, SLC2A3 reduced inflammation levels and ferroptosis through the inactivation of mitochondrial damage by Tiam1 in model of RA, could serve as a potent therapeutic agent for alleviating RA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the Genetic Association Between Sjogren's Syndrome and Autoimmune Thyroid Disease: A Bidirectional Two-Sample Mendelian Randomization Study","authors":"Mingming Zhao,&nbsp;Yuanyuan Zhang,&nbsp;Guoxun Sun","doi":"10.1111/1756-185X.70008","DOIUrl":"10.1111/1756-185X.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although observational studies have suggested a correlation between Sjogren's syndrome (SS) and autoimmune thyroid disease (AITD), a conclusive evidence supporting a causal relationship is still lacking. This study aims to explore the potential causal relationship between SS and AITD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using genome-wide association studies, we performed a bidirectional two-sample Mendelian randomization (MR) analysis. In our analysis, the random-effects inverse variance weighted (IVW) method was predominantly employed, followed by several sensitivity analyses, which include heterogeneity, horizontal pleiotropy, outliers, and “leave-one-out” analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the study of the effect of SS on AITD, SS was associated with an increased risk of Hashimoto's thyroiditis (OR = 1.09, 95%CI 1.02–1.16, <i>p</i> = 0.01). The causal associations were supported by sensitivity analyses. In reverse MR analyses, Hashimoto's thyroiditis (OR = 1.24, 95% CI 1.08–1.42, <i>p</i> &lt; 0.01) and Graves' disease (OR = 1.11, 95% CI 1.03–1.21, <i>p</i> &lt; 0.01) were found to be risk factors for SS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results support a bidirectional causal relationship between SS and Hashimoto's thyroiditis and a positive correlation of genetically predicted Graves' disease on the risk of SS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Causal Relationship Between Genetically Determined Plasma Metabolites and Rheumatoid Arthritis","authors":"Kunpeng Song,&nbsp;Julei Ma,&nbsp;Bing Wang","doi":"10.1111/1756-185X.15447","DOIUrl":"10.1111/1756-185X.15447","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Presently, research examining the impact of plasma metabolites on rheumatoid arthritis (RA) is scarce. We utilized a bidirectional two-sample Mendelian randomization (MR) analysis to explore the potential causal link between 1400 plasma metabolites and RA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a two-sample MR analysis to assess the causal association between 1400 plasma metabolites and RA. The primary method of two-sample MR Analysis was the Inverse Variance Weighted (IVW) model, and the secondary methods were the Weighted Median (WM) and MR Egger methods. We conducted sensitivity analyses using Cochran's <i>Q</i> test, MR-Egger intercept test, MR-PRESSO, and Leave-One-Out analyses. Steiger test was used for validation of the metabolites. The main results were validated in the UK Biobank.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the discovery dataset, 60 metabolites were identified as significantly associated with the onset of RA. A notable finding was the strong correlation between Valve levels and RA risk, showing the highest positive correlation (OR [95% CI]: 1.361 (1.112, 1.667), <i>p</i> = 0.0028). Subsequent analysis of the validation dataset revealed 46 metabolites linked to RA, with X-22771 levels displaying the strongest positive association (OR [95% CI]: 1.002 (1.00, 1.004), <i>p</i> = 0.037). Notably, Glycohydrocolate levels exhibited a protective effect on RA in both datasets. Specifically, the effect size in the initial dataset was (OR [95% CI]:0.867 (0.753, 1.000), <i>p</i> = 0.050), whereas in the validation dataset, the effect was weaker (OR [95% CI]: 0.999 (0.997, 1.000), <i>p</i> = 0.048). These findings were further validated through a series of sensitivity analyses, affirming their robustness and reliability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights a strong correlation between elevated Valine levels and an increased risk of RA, as well as potential protective effects of Glycohydrohorate in independent datasets.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paravertebral Soft Tissue Shadows on a Chest Radiograph","authors":"Koki Nakamura,&nbsp;Ken Nagahata,&nbsp;Hiroyuki Nakamura,&nbsp;Hiroki Takahashi","doi":"10.1111/1756-185X.70005","DOIUrl":"10.1111/1756-185X.70005","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}