International Journal of Rheumatic Diseases最新文献

{"title":"Discordance in Patient and Physician's Perception of Disease Activity Among Idiopathic Inflammatory Myopathy Patients: Insights From the COVAD Study","authors":"Rudra P. Goswami, Parikshit Sen, Zoha Zahid Fazal, Jasmine Parihar, Yogesh Preet Singh, R. Naveen, James B. Lilleker, Mrudula Joshi, Vishwesh Agarwal, Arvind Nune, Mrinalini Dey, Jessica Day, Ashima Makol, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Elena Nikiphorou, Tulika Chatterjee, Sinan Kardes, Ai Lyn Tan, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Lorenzo Cavagna, Oliver Distler, Manali Sarkar, Vikas Agarwal, Latika Gupta, COVAD study group","doi":"10.1111/1756-185X.70428","DOIUrl":"10.1111/1756-185X.70428","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Pilates Exercise on Health-Related Outcomes in Patients With Knee Osteoarthritis: A Systematic Review and Meta-Analysis","authors":"Túlio Medina Dutra de Oliveira, Diogo Carvalho Felício, José Elias Filho, Rayane Quintão Castro, Fernando Junior da Silva Gomides, Luis Felipe Petronilho Pires, Diogo Simões Fonseca, Carla Malaguti","doi":"10.1111/1756-185x.70434","DOIUrl":"10.1111/1756-185x.70434","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Knee osteoarthritis (KOA) is a chronic, progressive condition characterized by cartilage degeneration, synovial inflammation, and bone changes leading to pain and functional impairment. Despite the availability of various treatment options, including multidisciplinary approaches and muscle strengthening exercises, there remains uncertainty regarding the efficacy of Pilates as a therapeutic intervention for KOA. This highlights the need for a systematic review to synthesize current evidence on the effects of Pilates on health-related outcomes in this population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review aimed to analyze the effects of Pilates compared to no exercise or conventional exercises on pain in individuals with knee osteoarthritis, as well as on secondary outcomes including function, quality of life, range of motion, balance, and adverse events. A secondary aim is to characterize the key components and implementation characteristics of the Pilates interventions applied in the included studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The review protocol has been registered in PROSPERO under the number CRD42024532727. Searches were conducted in PubMed/MEDLINE, Embase, CINAHL, CENTRAL, Scopus, Web of Science, and SPORTDiscus. Eligible studies included randomized controlled trials (RCTs) that investigated the impact of Pilates exercises in patients aged ≥ 18 years, diagnosed with KOA according to the Kellgren and Lawrence criteria or the American College of Rheumatology. Studies including participants with systemic arthritis, knee joint surgery within the past 12 months, lower extremity arthroplasty, intra-articular steroid injections within the past 6 months, or any neurological conditions were excluded. The risk of bias was assessed using the RoB 2 tool, and the quality of evidence was evaluated using the GRADE approach. Meta-analyses used random-effects models, with standardized mean differences (SMDs) and heterogeneity analyzed using <i>I</i><sup>2</sup> statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eleven studies involving 476 participants were included, of which seven contributed to the quantitative synthesis. Based on this analysis, Pilates exercises reduced pain compared to no intervention (SMD −1.09; 95% CI −2.04 to −0.14; <i>I</i><sup>2</sup> = 66%; <i>p</i> = 0.02; 3 studies; <i>n</i> = 66; low-quality evidence), but did not demonstrate superiority over conventional exercises (SMD −0.28; 95% CI −1.06 to 0.50; <i>I</i><sup>2</sup> = 86%; <i>p</i> =","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Prognostic and Hemodynamic Outcomes of Intensive Immunosuppressive Therapy in Patients With Pulmonary Arterial Hypertension Associated With Connective Tissue Disease","authors":"Kaito Yamada,&nbsp;Nobuhiro Yaoita,&nbsp;Taijyu Satoh,&nbsp;Saori Yamamoto,&nbsp;Yusuke Yamada,&nbsp;Naoki Chiba,&nbsp;Kohei Komaru,&nbsp;Haruka Sato,&nbsp;Nobuhiro Kikuchi,&nbsp;Hideaki Suzuki,&nbsp;Kotaro Nochioka,&nbsp;Shunsuke Tatebe,&nbsp;Satoshi Miyata,&nbsp;Tomonori Ishii,&nbsp;Satoshi Yasuda","doi":"10.1111/1756-185X.70431","DOIUrl":"10.1111/1756-185X.70431","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intensive immunosuppressive therapy (IIT) is recommended for PAH associated with connective tissue disease (CTD-PAH). However, the long-term effects of IIT on pulmonary hemodynamics in this population remain unexplored. Additionally, its effectiveness in patients with systemic sclerosis (SSc)-associated PAH (SSc-PAH) is poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>This retrospective analysis included 69 consecutive patients with CTD-PAH treated at our institution (men/women: 9/60, mean age 55.3 ± 14.0 years). Patients were divided into two groups, wherein 41 patients received IIT (IIT group) and 28 did not (non-IIT group). Both groups received conventional vasodilator therapy. The prognosis and pulmonary hemodynamics were evaluated in all patients. The IIT group exhibited significantly lower rates of PAH-related mortality (<i>p</i> &lt; 0.001) compared with the non-IIT group. The mean PAP (mPAP) improved significantly in the IIT group during the follow-up (baseline: 38.7 ± 12.2 mmHg; 1 year: 27.0 ± 8.2 mmHg; 5 years: 26.8 ± 7.3 mmHg, <i>p</i> &lt; 0.05), while it remained unchanged in the non-IIT group. None of the patients with CTD-PAH required IIT retreatment. Among the 27 patients with SSc-PAH, the IIT group (<i>n</i> = 9) showed a significantly greater improvement in mPAP compared with the non-IIT group (<i>n</i> = 18) (ΔmPAP at 1 year: −13.4 ± 6.5 mmHg in IIT group vs. −3.0 ± 6.2 mmHg in non-IIT group, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study's findings suggest that IIT may lead to sustained improvements in pulmonary hemodynamics and better long-term outcomes in patients with CTD-PAH, including potential benefits in those with SSc-PAH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization in Autoimmune Disease Research","authors":"Yunuo Wang,&nbsp;Hanjing Huang,&nbsp;Mengjiao Gu,&nbsp;Yuanhao Wu,&nbsp;Chen Li","doi":"10.1111/1756-185x.70435","DOIUrl":"10.1111/1756-185x.70435","url":null,"abstract":"&lt;p&gt;Autoimmune diseases (ADs) constitute a diverse array of disorders marked by the disruption of immune tolerance and the aberrant activation of the immune system. Recent research has revealed a progressive annual increase in both the prevalence and incidence of ADs, impacting 5%–10% of the global population [&lt;span&gt;1&lt;/span&gt;]. Drawing on Mendelian inheritance laws and instrumental variable estimation techniques, Mendelian Randomization (MR) harnesses genetic variations linked to particular exposures to investigate the causal impacts of modifiable exposures—such as potential risk factors—on health, society, and economy. MR has been widely used in the medical field for a multitude of applications. For example, it can not only confirm and reveal the causal relationships between clinically relevant risk factors, behavioral traits, and environmental elements with associated diseases, but also be employed to simulate drug targets and investigate genetic susceptibilities [&lt;span&gt;2&lt;/span&gt;]. As current research struggles to pinpoint the causal risks of ADs, the emerging technique of MR aids in hypothesizing risk factors, pathogenesis, potential drug targets, and the potential causal relationships with other diseases, offering a fresh perspective on understanding these conditions.&lt;/p&gt;&lt;p&gt;Epidemiological research indicated that environmental influences are critical risk factors contributing to the breakdown of immune tolerance [&lt;span&gt;3&lt;/span&gt;]. Wen et al. [&lt;span&gt;4&lt;/span&gt;] conducted a MR study that identified a causal link between air pollutants and an increased risk of developing hypothyroidism, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and ulcerative colitis (UC). Conversely, they found a decreased risk of coeliac disease associated with air pollution. Additionally, another MR study [&lt;span&gt;5&lt;/span&gt;] supported the role of environmental pollution in AD, which revealed a causal association between PM2.5 and psoriasis in European populations. Research has established a correlation between Body Mass Index (BMI) and the risk of developing various ADs, with obesity increasing the risk of AD onset [&lt;span&gt;6&lt;/span&gt;]. When exploring the relationship between diet and disease, existing observational studies on the association between folate and vitamin B12 with ADs present conflicting findings [&lt;span&gt;6&lt;/span&gt;]. In a MR analysis conducted by Yang et al. [&lt;span&gt;7&lt;/span&gt;] discovered that genetically elevated circulating folate levels are linked to a lower risk of vitiligo, suggesting that folate supplementation might serve as a preventative strategy against this condition. Moreover, Zhao et al. [&lt;span&gt;8&lt;/span&gt;] reported similar findings, which showed that higher levels of 25-hydroxyvitamin are causally associated with a reduced risk of psoriasis and SLE. Additionally, attention must also be paid to the relationship between individual factors (such as mental health, education) and ADs. Emotional instability was considered a modifiable risk factor for hypo","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PROMIS-29 and SF-36 Quality of Life Scales Are Not Interchangeable in Systemic Sclerosis","authors":"Murray Baron,&nbsp;Charmaine van Eeden,&nbsp;Mohamed Osman,&nbsp;Mianbo Wang,&nbsp;the Canadian Scleroderma Research Group","doi":"10.1111/1756-185x.70413","DOIUrl":"10.1111/1756-185x.70413","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the Spontaneous Resolution Nature of Gout: Molecular Crosstalk Between Immune Cells, Neutrophil Extracellular Traps, Non-Coding RNAs, and Inflammatory Factors","authors":"Jing Ma,&nbsp;Xinru Liu,&nbsp;Yuewang Li,&nbsp;Jing Zhao,&nbsp;Chunlei Li,&nbsp;Dafu Man,&nbsp;Huilin Li,&nbsp;Gula Da,&nbsp;Yan Chen,&nbsp;Yu Yang,&nbsp;Hongbin Li,&nbsp;Cheng Wang,&nbsp;Yong Wang","doi":"10.1111/1756-185x.70427","DOIUrl":"10.1111/1756-185x.70427","url":null,"abstract":"<div>\u0000 \u0000 <p>Gout, a prevalent rheumatic disorder, arises from purine metabolic dysfunction characterized by elevated uric acid levels, which culminates in hyperuricemia, crystallization of sodium urate, and subsequent deposition of these crystals in joints, synovium, and other tissues or organs. Spontaneous resolution of gout is defined as the self-resolution of acute gouty arthritis observed in some patients within 7–10 days without pharmacological intervention, with no residual sequelae. The mechanistic basis underlying this spontaneous resolution remains incompletely understood, involving a spectrum of biological entities including immune cells, RNA, neutrophil extracellular traps, inflammatory mediators, and pattern recognition receptors. This review synthesizes current research progress on the spontaneous resolution of gout, with the objective of delineating directions for future investigations.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Galectins and Risk of Dermatopolymyositis: A Mendelian Randomization Study","authors":"Ke Xue,&nbsp;Ruilian Lin,&nbsp;Lili Ma,&nbsp;Lirui Qiao,&nbsp;Jiaping Qi,&nbsp;Jia Chen","doi":"10.1111/1756-185x.70433","DOIUrl":"10.1111/1756-185x.70433","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Self-reported Sleep Disturbance and Unhealthy Sleep Duration Among US Adults with Arthritis, 2005–2018","authors":"Yuxin Lai,&nbsp;Huiting Liang,&nbsp;Haowei Chen,&nbsp;Changhai Ding,&nbsp;Zhaohua Zhu","doi":"10.1111/1756-185X.70430","DOIUrl":"10.1111/1756-185X.70430","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric Sacroiliitis as the Presenting Manifestation of Axial Gout","authors":"Lekshmi Minikumari Rahulan,&nbsp;Swapnil Suresh Jagtap,&nbsp;Kunal Chandwar,&nbsp;Able Lawrence,&nbsp;Amita Aggarwal","doi":"10.1111/1756-185X.70429","DOIUrl":"10.1111/1756-185X.70429","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Cryptococcal Meningitis During Tofacitinib Therapy in Ulcerative Colitis: A Rare Opportunistic Infection","authors":"Chien-Ming Chen,&nbsp;Hsu-Heng Yen,&nbsp;Yang-Yuan Chen","doi":"10.1111/1756-185x.70419","DOIUrl":"10.1111/1756-185x.70419","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}