International Journal of Rheumatic Diseases最新文献_第10页

Case Report: Surgery for the Patient With Systemic Lupus Erythematosus Complicated by Type A Aortic Dissection 病例报告：系统性红斑狼疮合并A型主动脉夹层的手术治疗

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-29 DOI: 10.1111/1756-185X.70245

Kaiyue Sun, Ruyuan Wei, Fushun Lin, Dexin Zhang, Kai Liu

引用次数: 0

Burden of Infection-Related Hospitalization and the Impact of Multidisciplinary Care in ANCA-Associated Vasculitis: A Retrospective Cohort anca相关性血管炎感染相关住院负担和多学科护理的影响：一项回顾性队列研究

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-26 DOI: 10.1111/1756-185X.70139

Emily K. Yeung, A. Richard Kitching, Michael Gingold, Kevan R. Polkinghorne, Jessica Ryan

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Patient-Reported Burden of Indolent Systemic Mastocytosis in a Managed Care Organization-Correspondence 在一个管理式医疗机构中，病人报告的惰性全身性肥大细胞增多症的负担-对应

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-26 DOI: 10.1111/1756-185X.70241

Ming-Hsiang Chu, Hui-Yi Hsu, Su-Boon Yong, Chin-Yuan Yii, Xiao-Ling Liu

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Beware of Missed Kawasaki Disease Presenting as Acute Coronary Syndrome in Adults: CT Coronary Angiography Findings in 4 Patients 警惕被遗漏的川崎病在成人中表现为急性冠状动脉综合征：4例患者的CT冠状动脉造影结果

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-25 DOI: 10.1111/1756-185X.70235

Rakesh Kumar Pilania, Abarna Thangaraj, Shayeri Roy Choudhury, Munish Arora, Rajesh Vijayvergiya, Parminder Singh Otaal, Arun Sharma, Surjit Singh, Manphool Singhal

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Targeted Therapies for Rheumatoid Arthritis in Super-Elderly Society: Insights From FIRST Registry, Japan 超老年社会类风湿关节炎的靶向治疗：来自日本FIRST Registry的见解

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-24 DOI: 10.1111/1756-185X.70232

Koshiro Sonomoto, Yoshiya Tanaka

{"title":"Targeted Therapies for Rheumatoid Arthritis in Super-Elderly Society: Insights From FIRST Registry, Japan","authors":"Koshiro Sonomoto, Yoshiya Tanaka","doi":"10.1111/1756-185X.70232","DOIUrl":"https://doi.org/10.1111/1756-185X.70232","url":null,"abstract":"<p>As the world's most rapidly aging society, Japan has faced significant challenges in the management of rheumatoid arthritis (RA) in elderly patients. Biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) have improved disease control, but concerns remain regarding the risk of infection and malignancy, especially in the elderly population. This review presents real-world data from FIRST registry, a prospective cohort following a total of 5500 patients over 20 years, and highlights strategies to balance efficacy and safety. Registry shows an increasing age of patients initiating b/tsDMARDs and an increase in comorbidities such as cardiovascular disease, chronic kidney disease, and malignancies. Infection control—including prophylaxis against pneumocystis pneumonia, screening for non-tuberculous mycobacteria, and vaccination—has been associated with a lower incidence of serious infections. Similarly, a proactive malignancy management strategy that includes computed tomography (CT) screening and multidisciplinary care has been correlated with improved detection of early-stage cancers and fewer treatment discontinuations due to malignancy. While these findings represent associations rather than direct causal effects, they reflect the evolving landscape of RA management over two decades. Meanwhile, the registry highlights unmet needs, particularly in patients with prior b/tsDMARD exposure, who often experience lower response rates. In addition, while clinical remission rates have improved, functional outcomes remain suboptimal, particularly in older patients. To address these challenges, personalized treatment selection is being explored. By sharing Japan's experience in managing RA in an aging society, this review provides insights into strategies that may be applicable to other aging populations worldwide.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Rheumatoid Arthritis Combined With Pigmented Villonodular Synovitis: A Report of Two Cases 病例报告：类风湿性关节炎合并色素绒毛结节性滑膜炎2例报告

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-24 DOI: 10.1111/1756-185X.70240

Yadan Zou, Ruohan Yu, Zhongxing Zhao, Qian Guo, Jing Xu, Shengguang Li

{"title":"Case Report: Rheumatoid Arthritis Combined With Pigmented Villonodular Synovitis: A Report of Two Cases","authors":"Yadan Zou, Ruohan Yu, Zhongxing Zhao, Qian Guo, Jing Xu, Shengguang Li","doi":"10.1111/1756-185X.70240","DOIUrl":"https://doi.org/10.1111/1756-185X.70240","url":null,"abstract":"<div>\u0000 \u0000 <p>This report presents two rare cases of rheumatoid arthritis (RA) complicated by pigmented villonodular synovitis (PVNS), highlighting the diagnostic and therapeutic challenges posed by their coexistence. RA is a chronic autoimmune disease characterized by joint inflammation and destruction, while PVNS is a rare proliferative synovial disorder that often presents with monoarticular joint involvement. The overlap in clinical and radiological features between RA and PVNS complicates diagnosis, necessitating advanced imaging techniques and histopathological evaluation for accurate differentiation. In the first case, an 85-year-old woman with a long-standing history of RA developed PVNS in the left knee, confirmed by MRI findings of hemosiderin deposition and nodular synovial hypertrophy. In the second case, a 72-year-old woman with seronegative RA and a prior history of PVNS in the elbows presented with PVNS in the left knee, confirmed by both imaging and pathology. Both patients underwent successful treatment involving a combination of systemic therapies, including disease-modifying antirheumatic drugs (DMARDs) and biologics, as well as localized interventions, such as synovectomy and corticosteroid injections. These cases underscore the importance of integrating imaging and histopathology in managing RA patients with persistent joint symptoms, as well as the necessity for a tailored therapeutic approach to address both systemic inflammation and localized pathology. A comprehensive literature review is provided to contextualize these findings, with a focus on the role of MRI and emerging therapies, such as colony-stimulating factor-1 receptor (CSF-1R) inhibitors, in the management of PVNS.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombotic Diathesis Combined With Connective Tissue Disease in a Chinese Teenage Male: A Case Report 中国青少年男性血栓性素质合并结缔组织疾病1例报告

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-23 DOI: 10.1111/1756-185X.70228

Xianglin Chen, Shuyi Song, Zhaojing Zhang, Jibo Wang

{"title":"Thrombotic Diathesis Combined With Connective Tissue Disease in a Chinese Teenage Male: A Case Report","authors":"Xianglin Chen, Shuyi Song, Zhaojing Zhang, Jibo Wang","doi":"10.1111/1756-185X.70228","DOIUrl":"https://doi.org/10.1111/1756-185X.70228","url":null,"abstract":"<div>\u0000 \u0000 <p>Thrombophilia is a pathological condition characterized by an increased propensity for blood clot formation and thromboembolism, resulting from various genetic or acquired factors. It can be classified as hereditary or acquired based on its etiology. Autoimmune diseases are common contributors to acquired thrombophilia. This article presents the clinical diagnosis and treatment of a patient with hereditary thrombophilia complicated by connective tissue disease, aiming to provide a reference for the clinical management of thrombophilia. A case of a 13-year-old male presenting with persistent pain and swelling in the left lower limb was investigated. Physical examination revealed there was swelling in the left lower limb with slightly elevated skin tension and warmth. Lower Limb Ultrasound: Thrombosis in the left calf muscle venous system. D-dimer was elevated and antinuclear antibodies (ANA) and titers were Positive. Family history revealed several kinsfolk had thromboembolic diseases. The patient underwent hydroxychloroquine sulfate, warfarin sodium, and aspirin for maintenance therapy. 10 months later, the patient presented with deep vein thrombosis in the left sole again. Thrombosis is a multifactorial process, and patients may have multiple thrombophilic risk factors simultaneously. Etiological screening for thrombophilia should not focus solely on a single risk factor. If autoimmune diseases cannot fully explain the severity of thrombophilia, other risk factors should be further investigated. It is essential to appropriately determine the indications for genetic screening in patients with VTE and autoimmune diseases.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pursuing Precision Medicine in Managing Rheumatoid Arthritis 类风湿关节炎的精准医学治疗

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-23 DOI: 10.1111/1756-185X.70239

Satoshi Kubo, Yoshiya Tanaka

{"title":"Pursuing Precision Medicine in Managing Rheumatoid Arthritis","authors":"Satoshi Kubo, Yoshiya Tanaka","doi":"10.1111/1756-185X.70239","DOIUrl":"https://doi.org/10.1111/1756-185X.70239","url":null,"abstract":"<p>Rheumatoid arthritis, characterized by immune dysregulation and joint destruction, is managed through a stepwise algorithm that combines methotrexate with biological and targeted synthetic disease-modifying antirheumatic drugs. Despite considerable advances, the lack of reliable biomarkers for selecting the most effective medication, especially in Phase II and beyond, remains a significant obstacle. As a result, achieving early clinical remission in all patients continues to be challenging. Rheumatoid arthritis demonstrates considerable clinical and molecular diversity, influenced by both genetic predispositions and environmental factors. Recent scientific and technological advances have shed light on the pathogenesis of rheumatoid arthritis, facilitating the stratification of patients into distinct phenotypic subgroups and potentially optimizing the choice of targeted therapies. However, persistent challenges include the high costs and logistical demands of these methodologies, as well as the complexities of conducting large-scale clinical trials. This review highlights the intricate pathogenesis of rheumatoid arthritis and underscores the need to address the disease's heterogeneity through precision medicine. Moving forward, a deeper investigation into rheumatoid arthritis pathogenesis, encompassing both genetic and environmental factors, is crucial. Pursuing precision medicine, grounded in accurate patient stratification, should be embraced as a “moonshot” objective in rheumatoid arthritis treatment, aiming to achieve transformative breakthroughs in management.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “LncRNA-HCP5 Regulates KLF5 by ceRNA and m6A Pathways to Inhibit the Progression of Osteoarthritis” 修正“LncRNA-HCP5通过ceRNA和m6A途径调控KLF5抑制骨关节炎进展”

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-23 DOI: 10.1111/1756-185X.70223

引用次数: 0

Case Series Report: The Dichotomy of Antiphospholipid Syndrome—Managing Bleeding in a Thrombotic Disorder 病例系列报告：抗磷脂综合征的二分法-管理血栓性疾病中的出血

IF 2.4 4区医学

International Journal of Rheumatic Diseases Pub Date : 2025-04-23 DOI: 10.1111/1756-185X.70209

Rohit Venugopal, Ishwarya Ramadoss, Merwin Samuel, Arul Rajamurugan

引用次数: 0