International Journal of Rheumatic Diseases最新文献

{"title":"Uterine Abscess as the First Sign of Granulomatosis With Polyangiitis","authors":"Hanlin Yin, Yuan Li, Chunmei Wu, Chunyan Zhang, Sheng Chen, Xiaohua Qin, Shuang Ye, Liangjing Lu","doi":"10.1111/1756-185X.70072","DOIUrl":"10.1111/1756-185X.70072","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Chronic Obstructive Pulmonary Disease and Rheumatoid Arthritis: Findings of the Observational and Mendelian Randomization Study","authors":"Kang Wang,&nbsp;Zhujun Chen,&nbsp;Zhengxiao Wei,&nbsp;Lijun He,&nbsp;Liang Gong","doi":"10.1111/1756-185X.70052","DOIUrl":"10.1111/1756-185X.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Airway inflammation is considered one of the pathogenic factors in rheumatoid arthritis (RA), but the role of chronic obstructive pulmonary disease (COPD) in the development of RA remains unclear. We used cross-sectional studies and Mendelian randomization (MR) analysis to explore the link between COPD and RA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In National Health and Nutrition Examination Survey (NHANES) 2013–2018, the association between COPD and RA was investigated using weighted logistic regression models. We also used subgroup analysis and interaction tests to explore the relationship between COPD and RA in populations with different clinical characteristics. The inverse-variance weighted (IVW) method was the primary method of MR analysis for investigating the causal effect of exposure on outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After adjusting for smoking history and other variables, weighted logistic regression analysis of 14 768 participants indicated that COPD is associated with an increased odds of developing RA (OR = 1.899, <i>p</i> &lt; 0.001). Interaction tests showed that there is an interaction with this relationship concerning gender, age, body mass index (BMI), and hypercholesterolemia (<i>p</i> &lt; 0.05). MR analysis showed a causal relationship between COPD and increased odds of RA (OR = 1.072, <i>p</i> = 0.008). Multivariable MR analysis, adjusted for smoking, also yielded the same result (OR = 1.071, <i>p</i> = 0.024).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study suggests that COPD may have a potential causal role in the development of RA. Further research is needed to validate our findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of the Need for Anti-TNF Alpha Drugs in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis","authors":"Deniz Gezgin Yıldırım,&nbsp;Nuran Belder,&nbsp;Hüseyin Baran Özdemir,&nbsp;Sevcan A. Bakkaloğlu","doi":"10.1111/1756-185X.70056","DOIUrl":"10.1111/1756-185X.70056","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Relationships Between Staphylococcus aureus Colonization, Filaggrin Expression, and Pediatric Atopic Dermatitis—Correspondence","authors":"Yu-Hsi Lin,&nbsp;Yi-Chen Chen,&nbsp;Chin-Yuan Yii,&nbsp;Su-Boon Yong","doi":"10.1111/1756-185X.70071","DOIUrl":"10.1111/1756-185X.70071","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth Extraction as a Potential Risk Factor for Refractory Osteitis and Controversy of Using JAK Inhibitor to Alleviate Inflammation in SAPHO Syndrome","authors":"Alison Prosper,&nbsp;Rémi Esclassan,&nbsp;Thibault Canceill","doi":"10.1111/1756-185X.70051","DOIUrl":"10.1111/1756-185X.70051","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality and Survival Analysis in Patients With Cancer Occurrence After Sjögren's Syndrome: A Long-Term Cohort Study in China","authors":"Yezi Peng,&nbsp;Jiana Chen,&nbsp;Yafei Ren,&nbsp;Dan Yang,&nbsp;Ziyue Zhou,&nbsp;Xiangyi Shen,&nbsp;Junyan Qian,&nbsp;Xu Jiang,&nbsp;Lidan Zhao,&nbsp;Yunyun Fei,&nbsp;Hua Chen,&nbsp;Mengtao Li,&nbsp;Huaxia Yang,&nbsp;Fengchun Zhang","doi":"10.1111/1756-185X.70059","DOIUrl":"10.1111/1756-185X.70059","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to investigate the mortality, survival rates, and prognostic indicators of cancer occurrence after Sjögren's syndrome (SS-CA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The medical records of patients with SS-CA at the Peking Union Medical College Hospital (PUMCH) between January 2010 and August 2022 were retrieved. Clinical data and survival outcomes were compared to controls. The standard mortality ratio (SMR) versus the general population was calculated, and the survival and predictive markers of prognosis were analyzed using Kaplan–Meier curves and Cox regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 114 SS-CA patients were included, with a median follow-up time of 105.1 (57.3–168.0) months. Non-Hodgkin lymphoma (32, 28.1%) was the most common cancer in patients with SS-CA. The SMR of SS-CA patients was 2.61 (95% confidence interval [CI] 1.73–3.77). Patients with SS-CA exhibited significantly inferior outcomes compared to controls (<i>p</i> = 0.010), with 5- and 10-year overall survival rates of 91.2% and 83.2%, respectively. SS patients with a diagnostic interval between SS and cancer (SS-CA diagnostic interval) ≤ 3 years or with hematological malignancies had poorer survival compared to those with a diagnostic interval &gt; 3 years (<i>p</i> &lt; 0.001) or with solid tumors (<i>p</i> = 0.019). Multivariate Cox regression analysis identified the prognosis-associated factors of SS-CA as age at SS diagnosis &gt; 50 years (HR 3.129, 95% CI 1.224–7.998; <i>p</i> = 0.017), SS-CA diagnostic interval ≤ 3 years (HR 7.754, 95% CI 1.953–30.781; <i>p</i> = 0.004), and hematological malignancies (HR 2.648, 95% CI 1.201–5.838; <i>p</i> = 0.016).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Malignant comorbidities constituted a poor prognosis in patients with SS, wherein the SS-CA diagnostic interval and the types of cancer were associated with survival.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Risk Factors, and Quality of Life of Knee Osteoarthritis in Urban Community in Indonesia: A COPCORD Study","authors":"Pande Ketut Kurniari,&nbsp;Rudy Hidayat,&nbsp;Faisal Parlindungan,&nbsp;Mirza Zaka Pratama,&nbsp;Suryo Anggoro Kusumo Wibowo,&nbsp;Sumariyono Sarmidi,&nbsp;Cesarius Singgih Wahono,&nbsp;Bagus Putu Putra Suryana,&nbsp;Aditya Perdana Rahman,&nbsp;Radiyati Umi Partan,&nbsp;Muhammad Reagan,&nbsp;Surya Darma,&nbsp;Blondina Marpaung,&nbsp;Andi Raga Ginting,&nbsp;Rizqi Arini Siregar,&nbsp;Gede Kambayana,&nbsp;Dewa Ayu Kartika Tejawati,&nbsp;Dwijo Anargha Sindhughosa,&nbsp;Laniyati Hamijoyo,&nbsp;Andri Reza Rahmadi,&nbsp;Chevie Wirawan,&nbsp;Yulia Sofiatin,&nbsp;Nyoman Kertia,&nbsp;Lisa Kurnia Sari,&nbsp;Rakhma Yanti Hellmi,&nbsp;Ika Vemilia Warlisti,&nbsp;Fenda Adita,&nbsp;Yulyani Werdiningsih,&nbsp;Arief Nurudhin,&nbsp;Indrayana Sunarso,&nbsp;Mahriani Sylvawani,&nbsp;Rahmat Zuaidi,&nbsp;Dolly Jazmi,&nbsp;Najirman Najirman,&nbsp;Rikarni Rikarni,&nbsp;M. Agung Pratama Yudha,&nbsp;Nyoman Suarjana,&nbsp;Dimas Ariadie,&nbsp;Djallalluddin Djallalluddin,&nbsp;Cahyo Wibisono Nugroho,&nbsp;Lita Diah Rahmawati,&nbsp;Femi Syahriani,&nbsp;Paramitha Puspasari Harman,&nbsp;Sarafina Elwindy,&nbsp;Jeffrey Arthur Ongkowijaya,&nbsp;Pande Putu Januraga,&nbsp;Brigitta Dhyah Kunthi Wardhani,&nbsp;Putu Erma Pradnyani","doi":"10.1111/1756-185X.70014","DOIUrl":"10.1111/1756-185X.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study evaluates the prevalence, risk factors, and quality of life of patients with knee osteoarthritis (OA) in the Indonesian population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A cross-sectional study of 3597 adults (≥ 18 years old) was conducted in 2023 involving 15 different cities in Indonesia. Knee OA was classified according to the clinical ACR criteria. The COPCORD questionnaire was used for all subjects. The quality of life (QoL) was assessed using the WOMAC score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of knee OA was 15.0%. Banda Aceh has the highest prevalence of knee OA at 70.79%, whereas Bandung has the lowest (4.18%)—the odds of having knee OA increased with age. The adjusted odds ratio (aOR) were 5.01 (95% CI 2.47–10.15, <i>p</i> &lt; 0.001) for participants aged 40–49 years and 72.19 (95% CI 36.32–143.51, <i>p</i> &lt; 0.001) for participants aged 70 years or over, compared to participants under 40 years. Knee OA was higher among female participants (aOR = 1.91; 95% CI 1.53–2.39, <i>p</i> &lt; 0.001). Married and divorced participants had higher odds of having knee OA compared to those who never married (aORs 2.56 (95% CI 1.37–4.77, <i>p</i> = 0.003) and 2.40 (95% CI 1.23–4.68, <i>p</i> &lt; 0.010), respectively). Knee OA is less likely found among participants with elementary school education background (aOR 0.37; 95% CI 0.22–0.64, <i>p</i> &lt; 0.001) and those with senior high school (aOR 0.49; 95% CI 0.29–0.83, <i>p</i> = 0.007). The total WOMAC score was 25.9 ± 18.7 from all participants, indicating moderate impairment in QoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The prevalence of knee OA in several urban districts in Indonesia was 15.0%, with most patients having moderate impairment in QoL. Several sociodemographic factors were associated with the odds of having knee OA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Trends in Outcomes of Rehabilitation Among Patients With Systemic Connective Tissue Disorders in Germany: A Cross-Sectional Analysis of Routine Data","authors":"Patrick Brzoska","doi":"10.1111/1756-185X.70060","DOIUrl":"10.1111/1756-185X.70060","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Various demographic factors, including sex, socioeconomic status, and immigration status, have been linked to disparities in healthcare outcomes. Despite efforts by healthcare providers to address these inequities, interventions are not always effective. The present investigation provides empirical insights from Germany focusing on patients with systemic connective tissue disorders, highlighting the need for evaluated strategies to mitigate healthcare disparities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A 10% random sample of 2006–2016 routine data on patients with systemic connective tissue disorders (ICD-10 M30–M36) is used. The sample included information on 1819 patients. The primary outcome assessed was the persistence of impairment following rehabilitation treatment. Logistic regression models were employed to adjust for demographic confounders. Interaction analyses were conducted to explore variations in disparities across different time periods and diagnostic groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Non-German nationals were at 87% higher odds of impairment after treatment compared to German nationals (adjusted odds ratio [aOR] = 1.87; 95% confidence interval [CI] = 1.22–2.86). Furthermore, patients employed in semi-skilled or unskilled positions demonstrated a 40% greater chance of poor outcomes compared to those in skilled occupations (aOR = 1.40; 95% CI = 1.03–1.90). Disparities in outcomes did not significantly vary across different years in which services were utilized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study demonstrates disparities in healthcare outcomes associated with various diversity characteristics. These disparities are likely due to the different obstacles that some disadvantaged population groups encounter in the healthcare system. To address this heterogeneity, diversity-sensitive healthcare provision strategies need to be implemented.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Patient Experience in Rheumatology Outpatient Care","authors":"Madeleine J. Bryant,&nbsp;Rachel J. Black,&nbsp;Catherine L. Hill","doi":"10.1111/1756-185X.70044","DOIUrl":"10.1111/1756-185X.70044","url":null,"abstract":"&lt;p&gt;In the subspecialty of Rheumatology, we are increasingly compelled to pursue and practice comprehensive healthcare, reaching beyond the foundation blocks of excellent patient-clinician interactions and gold-standard therapeutics. Nearly 10 years have passed since the World Health Organization (WHO) signaled the need for a fundamental shift towards people-centered approaches to healthcare.&lt;/p&gt;&lt;p&gt;To this end, objectively evaluating outcomes through collection of Patient Reported Outcome Measure (PROM) data is now integral to appraising treatment response in clinical practice, clinical trial endpoints, and standard setting. Readers will be familiar with PROMs, which collect data on symptoms, disease activity, and functional status. Examples of PROM use in rheumatology include disease-specific instruments such as the Routine Assessment of Patient Index Data (RAPID) 2–5, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and generic instruments such as the Health Assessment Questionnaire (HAQ) and the 36-question Short Form Health Survey (SF-36).&lt;/p&gt;&lt;p&gt;Conceptually similar to PROMs, but distinct, are Patient Reported Experience Measures (PREMs), which collect information directly from patients on the experience of receiving healthcare. Specifically, PREMs address the process, content, and impact of care, in both functional and relational terms [&lt;span&gt;1-6&lt;/span&gt;]. Functional domains captured by PREMs include logistic appointment considerations, access to information about conditions and treatments, and access to inter-visit care. Relational domains captured by PREMs include individualization of care, respectful care delivery and patient empowerment. Using PREMs alongside PROMs can give comprehensive insights into how healthcare is delivered and can be improved. However, routine PREM capture in rheumatology is, to date, only sporadically described. Other contexts where PREMs are used in Australia include mental health, general practice, surgical specialties, renal medicine, and palliative care.&lt;/p&gt;&lt;p&gt;Endeavoring to bring a rheumatology-specific PREM to Australian patients has been the focus of a body of work over the past 3 years. Two key beliefs underpin the rationale for this work: the first is that experience-related data are essential to understanding whether healthcare services are truly patient-centered. The second is that patients are uniquely positioned to measure and evaluate the care they have received.&lt;/p&gt;&lt;p&gt;We conducted a systematic literature review in 2021 to ascertain the availability and frequency of use of rheumatology-specific PREMs worldwide. The review identified five validated PREMs for use with Rheumatology outpatients, with broad heterogeneity of study design and methodology and significant shortcomings in the rigor of content validity testing [&lt;span&gt;7&lt;/span&gt;]. Additionally, no clear consensus on bringing such instruments to routine clinical implementation was evident in published literature. This represents a kno","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Uric Acid Level With Bone Mineral Density and the Risk of Osteoporosis: A Dose–Response Meta-Analysis","authors":"Liusong Shen,&nbsp;Fanqiang Meng,&nbsp;Qiao Jiang,&nbsp;Junzhi Sheng,&nbsp;Haoran Feng,&nbsp;Yuqing Wang,&nbsp;Huizhong Long,&nbsp;Dongxing Xie,&nbsp;Tuo Yang,&nbsp;Xiang Ding,&nbsp;Yilin Xiong","doi":"10.1111/1756-185X.70013","DOIUrl":"10.1111/1756-185X.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Serum uric acid (SUA) may play positive roles in diseases associated with oxidative stress, such as osteoporosis (OP). Nevertheless, the specific impact of SUA levels on both bone mineral density (BMD) and the risk of OP remains uncertain. Considering such information crucial for clinicians when making decisions about urate-lowering therapy (ULT), we sought to fill this gap by conducting dose–response meta-analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, EMBASE, and Cochrane Library were searched for studies that met the inclusion criteria. Pooled standardized mean difference (SMD) for BMDs and the odds ratio (OR) for OP between the highest and lowest SUA categories as well as the nonlinear dose–response relationships were estimated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pooled SMDs indicate that participants in the highest category of SUA have greater BMDs at the lumbar spine (SMD = 0.37; 95% CI: 0.27, 0.46), femoral neck (SMD = 0.25; 95% CI: 0.21, 0.29), total hip (SMD = 0.34; 95% CI: 0.26, 0.42), and lower risk of OP (OR = 0.59, 95% CI: 0.52, 0.67) compared with the lowest. The nonlinear dose–response relationships were also observed. However, when the SUA level exceeded 6 mg/dL, the dose–response curve between SUA levels and the risk of OP tended to be flattened.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Nonlinear dose–response relationships were found that higher SUA levels are associated with greater BMDs and lower risk of OP. For patients receiving ULT, maintaining SUA level at around 6 mg/dL may be appropriate from the perspective of bone metabolism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}