International Journal of Rheumatic Diseases最新文献

{"title":"Unveiling the Elevated Risk of Osteoporosis and Fractures in Idiopathic Inflammatory Myopathies: Emphasizing Awareness of Modifiable Risk Factors","authors":"Ilke Coskun Benlidayi, Helene Alexanderson, Latika Gupta","doi":"10.1111/1756-185X.15451","DOIUrl":"10.1111/1756-185X.15451","url":null,"abstract":"<p>Comorbid conditions such as cardiovascular diseases, mood disorders, and renal impairment can be observed in patients with autoimmune inflammatory rheumatic diseases. One of the most important comorbidities relates to bone health [<span>1</span>]. Osteoporosis and fragility fractures are more common in patients with idiopathic inflammatory myopathies (IIMs) compared to healthy population [<span>2, 3</span>]. Lee et al. reported increased osteoporosis risk in dermatomyositis or polymyositis independent of the treatments [<span>4</span>]. The current article aimed to (i) review the literature on bone health in IIMs and (ii) discuss the predictors of impaired bone health emphasizing awareness of modifiable risk factors.</p><p>The results of the previous studies revealed that 13%–32.7% of myositis population had osteoporosis [<span>5-9</span>] (Table 1). Fracture rate is also more common in patients with IIMs than in healthy subjects (17.9% vs. 5.1%) [<span>3</span>]. Patients with previous vertebral fractures accrue fractures at a rate of 26.2 per 100 patient years [<span>10</span>]. Moreover, almost half of the patients with inflammatory myositis have asymptomatic vertebral fractures [<span>8</span>]. The diversity in osteoporosis frequency may partly be related to the interpretation of dual energy X-ray absorptiometry (DXA) reports [<span>5-9</span>]. The Adult Official Positions of the International Society for Clinical Densitometry recommends BMD testing in all adults with a disease/condition causing low bone mass/bone loss or those taking medications related to low bone mass/bone loss. Measuring BMD at both the posteanterior spine and hip is recommended. Forearm BMD should be tested if hip and/or spine cannot be measured or interpreted, or if hyperparathyroidism exists, or the patient is above DXA weight limit [<span>11</span>]. According to the Adult Official Positions of the International Society for Clinical Densitometry, osteoporosis may be diagnosed in postmenopausal women and men aged ≥ 50 if the <i>T</i>-score of the lumbar spine, total hip, or femoral neck is ≤ −2.5. Other hip areas (e.g., Ward's area) should not be utilized to diagnose. In certain cases, the 33% radius may be used. On the other hand, in females prior to menopause and in males < 50 years of age, <i>Z</i>-scores are preferred instead of not <i>T</i>-scores. <i>Z</i>-scores ≤ −2.0 are defined as “below the expected range for age”. The diagnosis of osteoporosis cannot be made solely based upon BMD in men < 50 years of age. Women in the menopausal transition may be diagnosed using the World Health Organization criteria [<span>11</span>].</p><p>The risk factors of osteoporosis and fractures in IIMs can be categorized into three as (i) non-modifiable factors, (ii) potentially modifiable factors, and (iii) modifiable factors. Non-modifiable risk factors include advanced age [<span>2, 3, 8, 12</span>], female gender [<span>6</span>], disease duration [<span>13</span>],","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Erosions and Systemic Bone Loss on HR-pQCT in Men With Tophaceous Gout","authors":"Gabriela F. Rocha,&nbsp;Jeane B. Santos,&nbsp;Lucas P. Sales,&nbsp;André S. Franco,&nbsp;Valéria F. Caparbo,&nbsp;Liliam Takayama,&nbsp;Diogo S. Domiciano,&nbsp;Ricardo Fuller,&nbsp;Camille P. Figueiredo","doi":"10.1111/1756-185X.15434","DOIUrl":"https://doi.org/10.1111/1756-185X.15434","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Gout, a prevalent inflammatory arthropathy, predominantly affects males and arises from persistent hyperuricemia, resulting in monosodium urate crystal deposition. Hyperuricemia is associated with comorbidities, exacerbating patient morbidity. Conflicting literature exists regarding uric acid's impact on bone mineral density (BMD), with potential proinflammatory effects in gout patients. Localized bone destruction (erosions) is a hallmark of gout, necessitating early detection due to its predictive role in musculoskeletal disability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study included 26 tophaceous gout patients. Clinical and densitometric parameters were assessed, and high-resolution peripheral quantitative computed tomography (HR-pQCT) was used for bone microarchitecture evaluation, as well as bone erosions in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. A healthy control group of 52 age and BMI-matched individuals was included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Despite normal areal bone mineral density (BMD), tophaceous gout patients exhibited impaired HR-pQCT parameters, including lower cortical volumetric BMD (Ct.vBMD) and higher cortical porosity at the distal radius. Similar trends were observed at the tibia. Bone erosions were prevalent (96%), with distribution across MCP and PIP joints. Patients with ≥ 4 erosions displayed increased tophi prevalence and longer uricosuric use. Erosions correlated with compromised microarchitecture, emphasizing their association with disease activity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite normal BMD, tophaceous gout patients manifest systemic bone loss, with bone microarchitectural deterioration and localized bone erosions, underscoring the need for detailed clinical approaches to prevent musculoskeletal disabilities, including fragility fractures, in this population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Acute Additive Polyarthritis as a Presentation of Type 2 Lepromatous Reaction: The Role of Differential Diagnosis","authors":"Gloria Caterine Pérez Mingan,&nbsp;Bruny Carolina Llamas Castellanos,&nbsp;Esaú del Cristo Álvarez Lora,&nbsp;María Judith Palomino Vergara,&nbsp;Francisco Camacho Chaljub","doi":"10.1111/1756-185X.15437","DOIUrl":"https://doi.org/10.1111/1756-185X.15437","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Type 2 lepromatous reaction is a severe complication triggered by proinflammatory cytokines, it affects patients with lepromatous leprosy and border lepromatous leprosy. This reaction can occur before, during, or after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report</h3>\u0000 \u0000 <p>We report a case of acute polyarthritis as type 2 lepromatous reaction debut. A 30-year-old male with a history of Hansen's disease 5 years ago received a complete therapeutic regimen with cure criteria. Consulted due to a 3-day history of arthralgia predominantly affecting the hands, knees, and feet. On the fifth day of hospitalization, the patient developed intensely painful, nodular erythematous lesions. The pathological history, clinical presentation, and the presence of polymorphonuclear cells led to the diagnosis of type 2 lepromatous reaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Identifying individuals with risk factors or a history of leprosy, along with a high index of suspicion, positively impacts the early identification of leprosy reactions as an imitator of other causes of acute or chronic symmetrical polyarthritis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Complex Regional Pain Syndrome Treated Successfully With Pamidronate.","authors":"Chandra Bhushan Prasad","doi":"10.1111/1756-185X.70026","DOIUrl":"https://doi.org/10.1111/1756-185X.70026","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":"e70026"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alopecia Universalis in a Multiple Sclerosis Patient After Switching From Rituximab to Ocrelizumab: A Case Report.","authors":"Mahshid Mahyad, Mahdieh Baghaei, Ava Baghaei, Mohammadali Nahayati","doi":"10.1111/1756-185X.70028","DOIUrl":"https://doi.org/10.1111/1756-185X.70028","url":null,"abstract":"<p><p>Ocrelizumab is a humanized monoclonal antibody, which acts as an anti-CD20 antibody. It is used as a treatment of both relapsing-remitting multiple sclerosis (RRMS) and Progressive types. The aim of this study is to report the first patient with alopecia universalis after switching from rituximab to ocrelizumab. A 37-year-old woman with a history of SPMS, diagnosed 8 years ago, used to be treated with rituximab. Her drug was switched to ocrelizumab from 6 months ago. She presented with patchy scalp hair loss a day after receiving the second dose of ocrelizumab. Her hair loss rapidly progressed in 3-4 days to total body hair loss in a patchy pattern. Ocrelizumab may be responsible for autoimmune reactions such as alopecia universalis in immunocompromised patients.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":"e70028"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Fatal Stercoral Colitis: A Possible Complication in Polymyositis","authors":"Nattanicha Chaisrimaneepan,&nbsp;Jerapas Thongpiya,&nbsp;Pitchaporn Yingchoncharoen,&nbsp;Sakditad Saowapa","doi":"10.1111/1756-185X.15422","DOIUrl":"https://doi.org/10.1111/1756-185X.15422","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monoclonal gammopathy-related thrombocytopenia: Case report and literature review","authors":"Zhan Su,&nbsp;Xin Liu,&nbsp;Xiaoyun Yu","doi":"10.1111/1756-185X.15388","DOIUrl":"https://doi.org/10.1111/1756-185X.15388","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing the Indonesian Systemic Lupus Erythematosus Regional (ISLET) Registry: Aftermath of the Asia Pacific League of Associations for Rheumatology (APLAR) Center of Excellence Exchange Program.","authors":"Ayu Paramaiswari, Deddy Nur Wachid Achadiono, Nyoman Kertia, Dhite Bayu Nugroho, Min Jung Kim, Kichul Shin","doi":"10.1111/1756-185X.70020","DOIUrl":"https://doi.org/10.1111/1756-185X.70020","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":"e70020"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Vasculitic Neuropathy in Rheumatoid Arthritis.","authors":"Qian Wang, Hua Zhang, Sheng-Ming Dai","doi":"10.1111/1756-185X.70023","DOIUrl":"https://doi.org/10.1111/1756-185X.70023","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":"e70023"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “The Association Between Genetic Polymorphisms of Matrix Metalloproteinases and Knee Osteoarthritis: A Systematic Review and Meta-Analysis”","authors":"Rachana Mehta,&nbsp;Ashok Kumar Balaraman,&nbsp;Muhammed Shabil,&nbsp;Sanjit Sah","doi":"10.1111/1756-185X.15436","DOIUrl":"https://doi.org/10.1111/1756-185X.15436","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}