International Journal of Rheumatic Diseases最新文献

{"title":"In memoriam: Professor Debashish Danda, MBBS, MD, DM, FRCP","authors":"Masayoshi Harigai, Nighat Ahmad, Alakendu Ghosh, Syed Atiqul Haq, Xinping Tian","doi":"10.1111/1756-185X.15380","DOIUrl":"10.1111/1756-185X.15380","url":null,"abstract":"<p>We are deeply saddened by the untimely passing away of Professor Debashish Danda, a towering figure in the field of rheumatology, who tragically lost his life in a road accident on 24 February 2024. His sudden departure has left an irreplaceable void in the hearts of his colleagues, students, and the global rheumatology community.</p><p>Professor Danda's illustrious career was marked by his unwavering dedication to advancing rheumatology in India and the Asia-Pacific region and across the globe. His journey began with his graduation from the Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, in 1985. He furthered his education with an MD in internal medicine from G.S.V.M. Medical College, Kanpur, in 1990 and a post-doctoral degree in clinical immunology from the Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, in 1995.</p><p>After advanced training in rheumatology in Adelaide, Australia, Professor Danda returned to India, where he joined the Christian Medical College (CMC), Vellore. There, he single-handedly established the Department of Clinical Immunology and Rheumatology, which has since grown to be one of the largest patient cohorts in the world. His vision led to the developing of a robust postgraduate education system at CMC, including the initiation of DM training in rheumatology and clinical immunology and a PhD program. His influence can be seen in the many faculty members at CMC who were his protégés.</p><p>Professor Danda's leadership extended beyond national borders. He served as President of the Indian Rheumatology Association (IRA) from 2017 to 2019. He held numerous roles within the Asia-Pacific League of Associations for Rheumatology (APLAR), including Editor-in-Chief of the International Journal of Rheumatic Diseases (IJRD), Treasurer, Vice President, and ultimately, President from 2021 to 2023. His dedication to rheumatology was recognized internationally, earning him numerous awards, including the Distinguished International Rheumatology Professional Award from the American College of Rheumatology (ACR) in 2023 (Figure 1-A).</p><p>A prolific author, Professor Danda published over 200 papers and delivered lectures at prestigious conferences worldwide. His research, particularly in the field of vasculitis, was not just significant, but truly groundbreaking. He led the APLAR Vasculitis Special Interest Group as Convener, advancing the diagnosis, education, and research of vasculitis, especially Takayasu arteritis, in the Asia-Pacific region (Figure 1-B). His establishment of the APLAR Academy and the Rheumatology Course for Physicians reflects his passion for education and his commitment to reducing disparities in rheumatology care.</p><p>Professor Danda was a brilliant scientist, visionary leader, and compassionate human being. He fought tirelessly against disparities in healthcare, ensuring that zonal and gender inequities were addressed within APLAR. His commitment to his pat","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The recent progress of γδ T cells and its targeted therapies in rheumatoid arthritis","authors":"Xue Feng,&nbsp;Yan Xu","doi":"10.1111/1756-185X.15381","DOIUrl":"10.1111/1756-185X.15381","url":null,"abstract":"<p>Rheumatoid arthritis (RA) is an autoimmune condition that mostly impacts the joints. During the advanced phases of the disorder, it may be accompanied by other problems. While the precise cause of RA is uncertain, various research has been conducted to gain a better understanding of the immunological processes involved in the development of RA. T cells are acknowledged as significant contributors to the progression of RA because of their roles in cytokine secretion, antigen presentation, and facilitating B cells in the manufacture of antibodies. γδ T cells are a small subset of T cells that have significant functions in the context of infection and diseases linked with tumors. γδ T cells have been the subject of investigation in autoimmune disorders in recent years. This review focused on the involvement of γδ T lymphocytes in the development of RA. In this article, we provide an analysis of the immunological capabilities of γδ T cells, intending to comprehend their significance in RA, which could be pivotal in the creation of innovative clinical treatments.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report on the coexistence of systemic lupus erythematosus, Sjogren syndrome, and thoracic collapse","authors":"Fanyu Meng,&nbsp;Qiyue Li,&nbsp;Yan Yang,&nbsp;Hanyu He,&nbsp;Jianmei Yin,&nbsp;Li Ling,&nbsp;Nian Liu,&nbsp;Rong Su,&nbsp;Jiangyun Peng,&nbsp;Weichao Liu","doi":"10.1111/1756-185X.15302","DOIUrl":"10.1111/1756-185X.15302","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise for improving bone health in patients with AIRDs: Understanding underlying biology and physiology","authors":"Ilke Coskun Benlidayi,&nbsp;Latika Gupta,&nbsp;Jasmine Parihar,&nbsp;Aviya Lanis Levy,&nbsp;Helene Alexanderson","doi":"10.1111/1756-185X.15402","DOIUrl":"10.1111/1756-185X.15402","url":null,"abstract":"<p>Exercise has numerous health benefits in patients with autoimmune inflammatory rheumatic diseases (AIRDs). Regular physical activity can help maintain/improve bone health. The aim of the present article was to review current knowledge on the effects of exercise on bone health in patients with AIRDs, particularly in those experiencing a high corticosteroid burden. The article also aimed to discuss potential mechanisms underlying the benefits of physical activity/exercise on bone tissue. Potential explanations regarding the role of exercise on bone health in AIRDs include anti-inflammatory effects, mechanical loading, improvement in muscle strength, hormonal changes, improvement in balance, and effects on telomere erosion, deoxyribonucleic acid methylation, and gene expression. Current evidence regarding the outcomes of exercise on bone health in patients with AIRDs is predominantly derived from studies focused on rheumatoid arthritis. Expanding research to include other rheumatic conditions would enhance the overall understanding of this topic.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Avacopan-induced severe liver injury with prolonged jaundice and lipoprotein X-induced dyslipidemia","authors":"Yoshiyuki Kioi,&nbsp;Eri Itotagawa,&nbsp;Yusuke Kawachi,&nbsp;Rumiko Ichikawa,&nbsp;Yoshinari Obata,&nbsp;Kohei Tsujimoto,&nbsp;Takahiro Kawasaki,&nbsp;Taro Akira,&nbsp;Kazuma Kosaka,&nbsp;Jeonghoon Park,&nbsp;Masashi Narazaki,&nbsp;Iichiro Shimomura,&nbsp;Atsushi Kumanogoh","doi":"10.1111/1756-185X.15400","DOIUrl":"10.1111/1756-185X.15400","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atlantoaxial arthritis is more common in polyarticular JIA as compared to systemic onset JIA—Retrospective study","authors":"Futaba Miyaoka,&nbsp;Maho Hatano,&nbsp;Yuko Hayashi,&nbsp;Shuya Kaneko,&nbsp;Asami Shimbo,&nbsp;Hitoshi Irabu,&nbsp;Yuko Akutsu,&nbsp;Yuko Segawa,&nbsp;Masaaki Mori,&nbsp;Masaki Shimizu","doi":"10.1111/1756-185X.15396","DOIUrl":"10.1111/1756-185X.15396","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: An unusual presentation of rapidly progressive fulminant microscopic polyangiitis","authors":"Atif Saleem Siddiqui","doi":"10.1111/1756-185X.15399","DOIUrl":"10.1111/1756-185X.15399","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of yoga and naturopathy interventions in the management of rheumatoid arthritis: A mechanistic review","authors":"Geetha B. Shetty,&nbsp;Prashanth Shetty,&nbsp;Balakrishna Shetty,&nbsp;A. Vijay,&nbsp;A. Mooventhan","doi":"10.1111/1756-185X.15389","DOIUrl":"10.1111/1756-185X.15389","url":null,"abstract":"&lt;p&gt;Rheumatoid arthritis (RA) is an autoimmune chronic systemic inflammatory disease characterized by polyarticular joint involvement associated with extra-articular manifestations. It affects 0.1%–2.0% of the population worldwide.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Despite advances in targeted biological and pharmacologic interventions, many patients with RA continue to have an inadequate response to therapies, or intolerable side effects, with the resultant progression of their disease. In complementary and alternative medicine, yoga, and naturopathy are commonly employed to treat various diseases including RA.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Examining the multi-modular, drugless approach of yoga and naturopathy to this autoimmune disease is equally important as it enables physicians to provide better care. Hence, the current review was undertaken to present an overview of the available scientific evidence on the mechanism of yoga and naturopathy (that are followed in India) therapeutic modalities in treating RA.&lt;/p&gt;&lt;p&gt;Online databases like PubMed/Medline, PubMed Central, Google Scholar, and IndMed were searched till December 2023. The list of keywords used was naturopathy, yoga therapy, hydrotherapy, balneotherapy, mud therapy, color therapy, acupuncture, diet therapy, and rheumatoid arthritis. Boolean operators such as queries (OR), (AND) were used appropriately. Randomized controlled trials, quasi-experimental studies, case reports, Case series, review articles published in English, and contain substantial mechanism of actions of effect of yoga and naturopathy in RA or the pathophysiology involved in RA were included in this review. The letter to the editor, comments, health news, studies with lack of sufficient information, and article published other than English were excluded from this review. The findings of studies included in the review are discussed based on their efficacy of each treatment with mechanism in the management of RA.&lt;/p&gt;&lt;p&gt;Yoga therapy, a philosophical approach involving asanas, pranayama, and meditation, can help reverse harmful epigenetic alterations, improve RA symptoms, and reduce the risk of relapse when combined with other healthy lifestyle behaviors.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Symptomatically RA is presented with morning stiffness, tenderness, symmetrical joint pains, swelling, and fatigue, affecting the quality of life of an individual. Endogenous opioids produced during sustained stretching of muscles in the practice of yoga help to relieve pain.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Auto-inflammation and autoimmunity in RA are linked to psychological stress and depression due to malfunctioning neuroendocrine systems, systemic inflammation, accelerated immunological aging, and abnormal Deoxyribonucleic acid (DNA) damage sensing and repair machinery.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; Yoga likely works through the psycho-neuro-immunological axis, balancing the sympathetic and parasympathetic branches of autonomic nervous system. This reduces the hypo","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Two cases of granulomatosis with polyangiitis in long-term drug-free remission with rituximab","authors":"Moe Watanabe,&nbsp;Daiki Nakagomi,&nbsp;Ryosuke Ito,&nbsp;Yoshiaki Kobayashi,&nbsp;Shunichiro Hanai,&nbsp;Shunsuke Furuta","doi":"10.1111/1756-185X.15395","DOIUrl":"10.1111/1756-185X.15395","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BPIFA1 alleviates allergic rhinitis by regulating the NF-κB signaling pathway and Treg/Th17 balance","authors":"Ying Yang,&nbsp;Shidong Li,&nbsp;Hongyan Xu","doi":"10.1111/1756-185X.15372","DOIUrl":"10.1111/1756-185X.15372","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Allergic rhinitis (AR) is an allergic condition characterized by inflammation of the nasal mucosa. Bacterial permeability-increasing family member A1 (BPIFA1) exhibits anti-inflammatory properties; however, its impact on AR remains unclear. Aim of this study is to investigate the expression and function of BPIFA1 in AR and its influence on inflammation and immune regulation in a mouse model of AR induced by ovalbumin (OVA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The expression of BPIFA1 was analyzed using quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC). Morphological assessments of nasal mucosal tissues were conducted. Levels of inflammatory mediators in nasal lavage fluid (NALF) and serum were quantified using enzyme-linked immunosorbent assay (ELISA) kits. Protein expressions of BPIFA1, phosphorylated and total p65 (p-p65/p65), and IκBα were evaluated through Western blot analysis. The total cell counts, including epithelial cells, eosinophils, and lymphocytes in NALF, were determined using a hemocytometer. A mouse model of AR was established by OVA management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BPIFA1 expression was found to be reduced in the nasal mucosa tissues of patients with AR, suggesting a potential role in the disease's progression. We successfully developed a mouse model of AR, where BPIFA1 was similarly downregulated, indicating its possible involvement in modulating the NF-κB signaling pathway. Overexpression of BPIFA1 in this model attenuated inflammation and allergic responses by inhibiting the NF-κB pathway. Additionally, overexpression of BPIFA1 promoted the differentiation of regulatory T cells (Treg) and inhibited the differentiation of T helper 17 cells (Th17) in the NALF of AR mice, further demonstrating its regulatory impact on immune responses. The study confirmed that BPIFA1 upregulation reduced the levels of inflammatory cytokines TNF-α and IL-6, decreased infiltration of inflammatory cells, and modulated antigen-specific immunoglobulin levels and histamine in serum.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>BPIFA1 mitigated both inflammatory and allergic responses in AR mice induced by OVA through the modulation of the NF-κB signaling pathway and the balance between regulatory T cells (Treg) and T helper 17 cells (Th17). These findings suggest that BPIFA1 could serve as a novel biomarker and therapeutic target for AR, offering potential for the development of targeted treatments to improve patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}