International Journal of Rheumatic Diseases最新文献

{"title":"Correction to “LncRNA-HCP5 Regulates KLF5 by ceRNA and m6A Pathways to Inhibit the Progression of Osteoarthritis”","authors":"","doi":"10.1111/1756-185X.70223","DOIUrl":"https://doi.org/10.1111/1756-185X.70223","url":null,"abstract":"<p>P. Jiang, Y. Song, P. Li, Y. Yang and J. Zhang, “LncRNA-HCP5 Regulates KLF5 by ceRNA and m6A Pathways to Inhibit the Progression of Osteoarthritis,” <i>International Journal of Rheumatology</i> 28, no. 1 (2025): e70035, https://doi.org/10.1111/1756-185X.70035.</p><p>There are errors in the article title. The correct article title is “LncRNA-HCP5 Regulates KLF5 by ceRNA and m6A Pathways to Inhibit the Progression of Osteoarthritis”.</p><p>There are errors in the affiliations. The correct affiliations should be “1 Department of Orthopedics, Shaanxi Rehabilitation Hospital, Xi'an, Shaanxi, China; 2 Department of Occupational Therapy, Shaanxi Rehabilitation Hospital, Xi'an, Shaanxi, China”.</p><p>The description of Figure 4D is missing from the end of Section 3.4. The description should be “Further research revealed that ov-HCP5 significantly increased the expression of the methyltransferase METTL3, while DZNeP inhibited the expression of METTL3 (Figure 4D).”</p><p>The online article has been corrected.</p><p>We apologize for the errors.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Series Report: The Dichotomy of Antiphospholipid Syndrome—Managing Bleeding in a Thrombotic Disorder","authors":"Rohit Venugopal,&nbsp;Ishwarya Ramadoss,&nbsp;Merwin Samuel,&nbsp;Arul Rajamurugan","doi":"10.1111/1756-185X.70209","DOIUrl":"https://doi.org/10.1111/1756-185X.70209","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Acupuncture Therapy Based on the Principles of Primary Point Selection, Local Point Selection, and Syndrome Differentiation in Rheumatoid Arthritis","authors":"Jun Zhao,&nbsp;Qiongxiao Wang,&nbsp;Shiyao Zhang,&nbsp;Longming Lei,&nbsp;Dahong Fang,&nbsp;Xiangqian Zhang,&nbsp;Xuebin Lu","doi":"10.1111/1756-185X.70226","DOIUrl":"https://doi.org/10.1111/1756-185X.70226","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the clinical efficacy of acupuncture treatment based on the principles of primary point selection, local point selection, and syndrome differentiation in patients with rheumatoid arthritis (RA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>RA patients recruited from the rheumatology department of our hospital between January 2022 and January 2024 were randomly assigned to either the sham acupuncture group or the acupuncture group. The sham group received medication combined with sham acupuncture, while the acupuncture group received medication combined with acupuncture based on the principles above. Comparisons were made on Traditional Chinese Medicine (TCM) syndrome scores, quality of life, clinical symptoms, and inflammatory status after 4 weeks of treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 65 patients in the acupuncture group and 66 in the sham group were analyzed. The acupuncture group showed a substantially higher total effective rate than the sham group, underscoring a significant advantage in treatment efficacy (81.56% vs. 60.61%). After treatment, the reduction in TCM syndrome scores in the acupuncture group was greater by 1.16 compared to the sham group (95% CI: 0.21–2.12). Following treatment, both groups showed notable improvements, as shown by notable decreases in their Disease Activity Score for 28 joints and Health Assessment Questionnaire ratings. The acupuncture group reported significantly lower scores than the sham group (all <i>p</i> &lt; 0.05). Additionally, rheumatoid factor, high-sensitivity C-reactive protein, and erythrocyte sedimentation rate levels were decreased in both groups. All of the results were statistically significant (all <i>p</i> &lt; 0.05). However, the acupuncture group had significantly lower levels of these markers than the sham group. This suggests that acupuncture has a stronger therapeutic impact when treating illness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Acupuncture treatment based on primary point selection, local point selection, and syndrome differentiation significantly alleviates clinical symptoms and inflammatory states in patients with RA, thereby improving quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impact of PA and Sedentary Behavior on Gout Risk in Hyperuricemia: Insights From Machine Learning and SHAP Analysis","authors":"Yanliang Jiao,&nbsp;Ziliang Cheng,&nbsp;Zhongjiang Lan,&nbsp;Shihu Kan,&nbsp;Yibin Du","doi":"10.1111/1756-185X.70238","DOIUrl":"https://doi.org/10.1111/1756-185X.70238","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with hyperuricemia (HUA) are widely recognized as being at increased risk for gout. This study aimed to investigate how physical activity (PA) duration and sedentary duration impact gout risk in individuals with HUA and to develop predictive models to assess their risk of developing gout.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively collected clinical characteristics of 8057 individuals with HUA from the National Health and Nutrition Examination Survey (NHANES) consortium for the period 2007–2018. By developing and comparing four classic machine learning algorithms, the best-performing Random Forest (RF) model was selected and combined with the SHAP interpreting algorithm to analyze the dose–response relationship between PA duration, sedentary time, and gout risk. Additionally, the RF model was used to identify the most critical factors influencing gout risk and to develop a free online tool for predicting gout risk in HUA individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The RF model outperformed others, achieving a Receiver Operating Characteristic (ROC) of 0.957 in the training cohort and 0.799 in the testing cohort. In the test cohort, it demonstrated an accuracy of 0.778, a Kappa of 0.247, a sensitivity of 0.701, a specificity of 0.785, a positive predictive value of 0.224, a negative predictive value of 0.967, and an F1 score of 0.340. SHAP analysis revealed the following insights: (1) hypertension, serum uric acid, age, gender, and BMI were identified as the top five factors for gout risk; (2) factors such as higher serum uric acid levels, age, BMI, creatinine, sedentary duration, lower PA, hypertension, male sex, and diabetes were associated with an elevated risk of gout; and (3) a PA duration of 1–7 h per week was linked to a lower risk of gout, while sedentary time exceeding 6 h per day increased gout risk, regardless of age, sex, or comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We encourage individuals with HUA to engage in 1–7 h of PA per week and limit daily sedentary time to less than 6 h to reduce gout risk. The developed prediction model is freely available as a web-based app at: https://sasuki.shinyapps.io/GoutRisk/.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Reimagined: CRISPR and Multiomics Transform Systemic Lupus Erythematosus Diagnosis and Therapy","authors":"Zhuo Chen,&nbsp;Elaheh Pilehvar,&nbsp;Hadi Sadeghi,&nbsp;Younes Pilehvar","doi":"10.1111/1756-185X.70189","DOIUrl":"https://doi.org/10.1111/1756-185X.70189","url":null,"abstract":"<div>\u0000 \u0000 <p>Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with diverse clinical manifestations and unpredictable progression, posing significant challenges to accurate diagnosis and effective treatment. Traditional biomarkers and treatments often fail to address the disease's molecular and clinical heterogeneity. Recent advancements in CRISPR gene-editing technology and multiomics approaches offer transformative opportunities for personalized SLE care by unraveling its underlying molecular complexity and enabling precise therapeutic interventions. CRISPR technology allows targeted editing of SLE-associated genetic mutations, addressing disease drivers directly, while multiomics—including genomics, transcriptomics, and proteomics—provides insights into dysregulated immune networks, identifying biomarkers and therapeutic targets. Integrating these approaches can refine patient stratification and enhance the precision of treatments. Artificial intelligence (AI) complements these technologies by synthesizing high-dimensional data, enabling personalized treatment plans, predicting disease trajectories, and optimizing therapeutic strategies. However, the integration of CRISPR and multiomics in clinical settings raises challenges, including technical limitations, ethical concerns, and economic barriers. Emerging clinical trials and case studies demonstrate the potential of these innovations to personalize care and improve outcomes. Nonetheless, the transition from experimental research to routine clinical application requires robust regulatory frameworks and strategies to address these challenges. This review aims to explore the potential of CRISPR and multiomics technologies to revolutionize SLE diagnosis and therapy, emphasizing their integration with AI to advance personalized care. By addressing existing barriers, the review envisions a future where precision medicine transforms SLE management, paving the way for individualized, patient-centered autoimmune therapy.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key Points in the Association of Rheumatoid Arthritis With Major Adverse Cardiovascular Events and Malignancies","authors":"Seher Sener,&nbsp;Yusuf Ziya Sener","doi":"10.1111/1756-185X.70236","DOIUrl":"https://doi.org/10.1111/1756-185X.70236","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Analysis of Intersecting Neutrophil Signatures in Behçet's Disease and Inflammatory Bowel Disease","authors":"Pengchong Li,&nbsp;Yuxiao Ji,&nbsp;Dan Shen,&nbsp;Yuqi Liu,&nbsp;Yuanzhen Hao,&nbsp;Deyi Yang,&nbsp;Yuhui Fan,&nbsp;Wenkun Li,&nbsp;Shengtao Zhu,&nbsp;Wei Sun,&nbsp;Peng Li,&nbsp;Shutian Zhang","doi":"10.1111/1756-185X.70229","DOIUrl":"https://doi.org/10.1111/1756-185X.70229","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Behçet's disease (BD) and inflammatory bowel disease (IBD) are chronic inflammatory diseases characterized by immune system dysregulation. The critical role of neutrophils in these conditions is increasingly recognized. This study aimed to identify a shared set of neutrophils differentially expressed genes (NDEGs) to aid in the differential diagnosis of the two diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Bioinformatics analysis of GEO data combined with WGCNA identified 65 key NDEGs. Functional enrichment and immune infiltration analyses were conducted. RT-qPCR validated six hub NDEGs in neutrophils from IBD and BD patients. Serum CD226 levels were measured by ELISA, and a ROC curve assessed its diagnostic value. Additionally, neutrophils were stimulated with patient serum, followed by Western blot analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Immune infiltration analysis showed higher blood neutrophil levels in BD than in IBD. Neutrophil sequencing identified NDEGs upregulated in BD but downregulated in IBD, linked to T-cell receptor pathways. RT-PCR confirmed elevated FYN, CD99, SKAP1, and CD226 in BD neutrophils, while KLRG1 and MATK were higher in IBD. ELISA showed increased serum CD226 in BD. Western blot revealed higher Elastase and PAD4 in BD-stimulated neutrophils, while CXCL11 was elevated in IBD-stimulated neutrophils.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that BD and IBD neutrophils may have distinct functional states, potentially linked to differential T-cell interactions. These insights highlight neutrophils' diverse roles in immune dysregulation and their potential as diagnostic markers and therapeutic targets.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Blau Syndrome With Thrombocytopenia","authors":"Di Pan,&nbsp;Xiaoling Dai,&nbsp;Pan Li,&nbsp;Hongwei Fu,&nbsp;Qianghua Wei","doi":"10.1111/1756-185X.70230","DOIUrl":"https://doi.org/10.1111/1756-185X.70230","url":null,"abstract":"<div>\u0000 \u0000 <p>We report a case of Blau syndrome in a 22-year-old Chinese female. The patient initially presented with joint swelling and pain at the age of one, subsequently developing a generalized rash and uveitis. Initially diagnosed with juvenile idiopathic arthritis, she was treated based on this diagnosis. However, genetic testing conducted in 2020 revealed a heterozygous mutation, C. 1538(exon 4)T &gt; C, in the NOD2 gene (NM_022162), resulting in the substitution of methionine with threonine at position 513 of the encoded protein (p. M513T). This finding led to the re-diagnosis of Blau syndrome. The patient exhibited intermittent hemorrhagic lesions on the skin of both lower extremities on three occasions—in 2011, 2022, and 2024—and was subsequently diagnosed with severe thrombocytopenia upon hospitalization. Analyzing and summarizing this case can provide valuable insights into the clinical characteristics of Blau syndrome, thereby contributing a deeper understanding of this rare condition.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tofacitinib Treatment for Primary Sjögren's Disease Complicated by Immune Thrombocytopenia: A Case Report","authors":"Jing Ning,&nbsp;Qinghong Liu,&nbsp;Linger Guan,&nbsp;Jing He","doi":"10.1111/1756-185X.70225","DOIUrl":"https://doi.org/10.1111/1756-185X.70225","url":null,"abstract":"<div>\u0000 \u0000 <p>Primary Sjögren's disease (SjD) is a systemic autoimmune disorder that primarily affects the salivary and lacrimal glands. It has been associated with immune thrombocytopenia (ITP) in about 12% of cases. Current research into new treatment strategies for patients with SjD with ITP is limited. In this report, we present the case of a 38-year-old woman who has suffered from SjD and ITP for over 20 years. Despite undergoing treatment with prednisone, mycophenolate mofetil, rituximab, tacrolimus, and cyclosporine A, she has been unable to achieve a normalization of her platelet count. Eventually, tofacitinib was introduced into her treatment plan, which led to stable platelet counts and allowed for the complete discontinuation of prednisone. She has maintained this stability for more than 2 years so far. This case underscores the potential role of tofacitinib in managing SjD-ITP, particularly for patients who do not respond adequately or are intolerant to conventional immunosuppressive therapies.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Successful Remission With Upadacitinib in Behçet's Syndrome Following a History of PFAPA Syndrome","authors":"Hideki Oka,&nbsp;Shuji Sumitomo,&nbsp;Daisuke Yamashita,&nbsp;Koichiro Ohmura","doi":"10.1111/1756-185X.70231","DOIUrl":"https://doi.org/10.1111/1756-185X.70231","url":null,"abstract":"<div>\u0000 \u0000 <p>Recent studies have revealed a shared genetic background and pathogenesis between Behçet's syndrome (BS) and periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. This study suggests genetic similarities between recurrent aphthous stomatitis, PFAPA syndrome, and BS and proposes the concept of Behçet's spectrum disorders. An 18-year-old female with a history of PFAPA syndrome who had experienced repeated attacks until puberty visited our hospital complaining of oral ulcers, arthralgia, rash, and abdominal pain that had persisted for 2 weeks. Colonoscopy revealed a deep ulcer in the ileocecal region. Pathological findings showed no evidence suggestive of viral infection, malignancy, or vasculitis, and only nonspecific inflammatory cell infiltration. After ruling out various autoinflammatory diseases through genetic testing, the patient was diagnosed with Behçet's spectrum disorder. The patient was refractory to adalimumab and achieved remission after upadacitinib therapy. Genetic similarities have been reported between PFAPA syndrome and BS, involving genes such as IL-10 and IL-12A. Since the IL-10, IL-12, and IL-23 pathways can be blocked by JAK inhibitors, JAK inhibition therapy may be a potentially effective treatment option for Behçet's syndrome in a patient with a history of PFAPA syndrome.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}