International Journal of Rheumatic Diseases最新文献

{"title":"Seasonal Variation in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Onset Before and During the Coronavirus Disease 2019 (COVID-19) Pandemic: Findings From the Multicenter J-CANVAS Registry.","authors":"Naoya Oka, Yusuke Yoshida, Genki Kidoguchi, Makoto Fujii, Hiroki Kobayashi, Yohei Hosokawa, Michinori Ishitoku, Tomohiro Sugimoto, Takashi Kida, Nobuyuki Yajima, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Makoto Wada, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Hirosuke Takagi, Koji Endo, Naoto Azuma, Tohru Takeuchi, Shoichi Fukui, Kazuro Kamada, Ryo Yanai, Yusuke Matsuo, Yasuhiro Shimojima, Ryo Nishioka, Ryota Okazaki, Tomoaki Takata, Mayuko Moriyama, Ayuko Takatani, Yoshia Miyawaki, Tsuyoshi Shirai, Hiroaki Dobashi, Takafumi Ito, Isao Matsumoto, Toshihiko Takada, Toshiko Ito-Ihara, Takashi Kawaguchi, Yutaka Kawahito, Shintaro Hirata","doi":"10.1111/1756-185x.70878","DOIUrl":"10.1111/1756-185x.70878","url":null,"abstract":"<p><strong>Aim: </strong>To investigate seasonal patterns in new-onset antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during the coronavirus disease 2019 (COVID-19) pandemic in Japan.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using data from the nationwide multicenter registry of patients with AAV. Patients newly diagnosed with AAV between 2017 and 2022 were included, comprising microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA). We compared the seasonal distribution of AAV onset between the pre-COVID-19 (2017-2019) and COVID-19 (2020-2022) periods.</p><p><strong>Results: </strong>A total of 871 patients were included (499 before and 372 during the COVID-19 period). Poisson regression analysis revealed a seasonal variation in AAV onset in the pre-COVID-19 period (p < 0.001), with lower onset in autumn [incidence rate ratio (IRR) 0.64, p < 0.001] and higher onset in spring and summer (IRR 1.16, p = 0.048 and IRR 1.23, p = 0.005) compared to winter. Importantly, a significant interaction between season and period (p for interaction = 0.032) indicated that the seasonal pattern differed between periods, with a relative increase in spring (IRR 1.16, p = 0.010). In the subanalyses, seasonal variation was consistently observed in MPA, but not in GPA and EGPA. The interaction between season and period was not statistically significant in each disease group.</p><p><strong>Conclusion: </strong>AAV exhibited a clear seasonal pattern, which differed during the COVID-19 period. However, these differences were not consistently observed across individual disease subtypes, and the factors underlying them remain unclear.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70878"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DN4-Positive Neuropathic Pain Features in End-Stage Knee Osteoarthritis Awaiting Arthroplasty: Prevalence and Relationship With Function and Quality-of-Life.","authors":"Alan P Mozella, Ana Carolina Leal, Rafael Erthal de Paula, Aline Cordeiro Fernandes Ladeira, Sandra Minamoto, Matheus Carvalho, Jordanna Franco Sucupira, Ricardo Kobayashi, Thiago Lemos","doi":"10.1111/1756-185x.70882","DOIUrl":"10.1111/1756-185x.70882","url":null,"abstract":"<p><strong>Objectives: </strong>This cross-sectional study investigated the occurrence of neuropathic pain features (NP) in individuals with end-stage knee osteoarthritis (KOA) referred to total knee arthroplasty (TKA) and explored its association with functional and quality-of-life outcomes.</p><p><strong>Methods: </strong>In 902 patients, NP was screened using the Douleur Neuropathique 4 (scores ≥ 4). Distribution of NP features (positive/negative) regarding sex were assessed with z-test for proportions. The influence of NP features on the outcomes (visual analog scale for pain, WOMAC, SF-36) were tested with the Mann-Whitney U, followed by a multivariate logistic regression model to identify independent predictors of NP features, using 5% as statistical threshold.</p><p><strong>Results: </strong>The cohort was 72.6% female, with a mean ± SD age of 70 ± 8 years. NP-positive features prevalence was 28.6% (95% CI of 25.7%-31.6%), which was significantly higher in females (31.5%) than males (21.1%; p < 0.001). Patients with NP-positive features reported worse scores across all measured domains: higher pain intensity (VAS; p < 0.001), worse knee-related symptoms/function (WOMAC pain, function, and total scores; all p < 0.001), and lower quality-of-life in specific SF-36 domains (general health, vitality, role-emotional, mental health; all p < 0.01). The multivariate model confirmed that higher WOMAC total score and specific SF-36 scores were independently associated with NP-positive features.</p><p><strong>Conclusions: </strong>NP features are prevalent in approximately one-third of the patients with end-stage KOA awaiting arthroplasty, particularly among females. Its presence is independently associated with poorer joint-related function and reduced quality-of-life, suggesting the potential value of NP features assessment and management into pre- and postsurgical care.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70882"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy Outcomes for Indigenous Females With Rheumatoid Arthritis in Western Australia.","authors":"M Venables, C A Inderjeeth, J C Nossent","doi":"10.1111/1756-185x.70859","DOIUrl":"10.1111/1756-185x.70859","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70859"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atlantoaxial Dislocation: Myths, Evidence, and a Practical Clinical Framework.","authors":"Rajat Kumar Sahu, Abhishek Gollarahali Patel, Monalisha Sahoo, Urmila Dhakad, Puneet Kumar","doi":"10.1111/1756-185x.70861","DOIUrl":"10.1111/1756-185x.70861","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70861"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Non-Bacterial Osteitis Initially Attributed to Knee Osteoarthritis in an Older Adult: Bone Scintigraphy and MRI Findings","authors":"Cen Chang,&nbsp;Zhimin Lin,&nbsp;Jingchen Yang,&nbsp;Naigang Chen,&nbsp;Cheng Xu,&nbsp;Fanzhang Meng,&nbsp;Chen Li,&nbsp;Dongyi He","doi":"10.1111/1756-185x.70788","DOIUrl":"10.1111/1756-185x.70788","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Upadacitinib Induces Rapid Healing of Refractory Punched-Out Cutaneous Ulcers in Anti-MDA5-Positive Dermatomyositis.","authors":"Xiaoxiao Zuo, Mengzhu Zhu, Ruicai Ge","doi":"10.1111/1756-185x.70777","DOIUrl":"https://doi.org/10.1111/1756-185x.70777","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70777"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migratory Swellings and Fever: A Rheumatologic Riddle.","authors":"Joban Preet Singh Deol, G S R S N K Naidu, Praveen Sharma, Rajender Kumar, Aman Sharma","doi":"10.1111/1756-185x.70744","DOIUrl":"https://doi.org/10.1111/1756-185x.70744","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70744"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgA Nephropathy at a Therapeutic Inflection: From Supportive Care to Pathway-Specific Therapy.","authors":"Ming-Yuan Victor Chao, Yao-Min Hung","doi":"10.1111/1756-185x.70815","DOIUrl":"https://doi.org/10.1111/1756-185x.70815","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70815"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Tofacitinib Versus Placebo in Patients With Early-Grade Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Rini Fasni, Sujit Kumar Tripathy, Archana Mishra, Shahnawaz Khan, Rachita Meher, Jagat Panda, Debasish Hota, Anand Srinivasan","doi":"10.1111/1756-185x.70877","DOIUrl":"10.1111/1756-185x.70877","url":null,"abstract":"<p><strong>Aim: </strong>Knee osteoarthritis causes major pain and disability, yet disease-modifying drugs remain limited. Tofacitinib, an oral Janus kinase (JAK) inhibitor, suppresses pro-inflammatory cytokine signaling implicated in osteoarthritis but is unexplored in the knee; we evaluated it versus placebo in early-grade disease.</p><p><strong>Methods: </strong>In this single-center, randomized, double-blind, placebo-controlled trial, 100 patients with Kellgren-Lawrence Grades 1 and 2 knee osteoarthritis were randomized to tofacitinib 11 mg extended-release once daily (n = 49) or placebo (n = 51) for 12 weeks. The primary outcome was change in VAS pain to Week 12; secondary outcomes were WOMAC, Oxford Knee Score, EQ-5D-5L, and analgesic use, assessed to Week 12 and a Month-6 follow-up, and analyzed by intention-to-treat with a mixed model for repeated measures.</p><p><strong>Results: </strong>Baseline characteristics were balanced. Both groups improved within-group during treatment (p < 0.001), but between-group differences were not significant; the Week-12 VAS effect (tofacitinib minus placebo) was +0.02 (95% CI -0.84 to 0.89), with WOMAC, Oxford Knee Score, and EQ-5D-5L likewise excluding their minimal clinically important differences. Improvements rebounded toward baseline by Month 6. Drug-related adverse events were more frequent with tofacitinib (14.3% vs. 0%, p = 0.005) but were gastrointestinal and self-limiting.</p><p><strong>Conclusion: </strong>Tofacitinib was not superior to placebo in early-grade knee osteoarthritis, and the large within-group improvement rebounded toward baseline by 6 months, consistent with a predominantly non-specific (contextual) response. Because participants were selected radiographically without inflammatory phenotyping, these findings do not support tofacitinib in unselected early-grade disease but cannot exclude benefit in an inflammatory phenotype; future trials should stratify accordingly, with longer follow-up and structural outcomes.</p><p><strong>Trial registration: </strong>Clinical Trials Registry of India: CTRI/2025/07/090567.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70877"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Clinicopathological Study Investigating Immunohistochemical Markers (CD61 and Fibrin) for Detecting Platelet Aggregates and Fibrin Deposition in Lupus Nephritis.","authors":"Eda Otman Akat, Irfan Ocal, Fulya Cakalagaoglu, Spyridon Katechis, Zeki Soypacacı, Dilek Solmaz, Servet Akar","doi":"10.1111/1756-185x.70879","DOIUrl":"https://doi.org/10.1111/1756-185x.70879","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate platelet aggregates and fibrin deposition in kidney biopsies of patients with lupus nephritis (LN) and to identify associated clinicopathological factors.</p><p><strong>Methods: </strong>Initial kidney biopsies of LN, classified according to the 2003 ISN/RPS criteria, were retrospectively analyzed. Specimens were immunostained with CD61 for platelet aggregates and fibrin antibodies for fibrin deposition. Associations with clinical, laboratory, and histopathological parameters were examined.</p><p><strong>Results: </strong>A total of 44 patients with biopsy-proven LN were included, of whom 37 (84%) were female. The mean age was 41.5 ± 14.1 years, and the median follow-up duration was 32 months (IQR, 9-73.5). CD61 and fibrin positivity were observed in 56.8% and 45.5% of cases, respectively, predominantly in glomeruli. CD61 positivity was associated with low complement 4 levels at kidney biopsy (OR: 4.50, 95% CI: 1.10-18.27; p = 0.035). The mean cellular crescent score was higher in the CD61-positive group than in the CD61-negative group (0.33 ± 0.56 vs. 0.05 ± 0.22, p = 0.047). Additionally, the fibrin-positive group showed a higher mean chronicity index compared to the fibrin-negative group (2.90 ± 1.16 vs. 2.30 ± 1.25). Fibrin positivity was associated with alopecia, antiphospholipid antibody positivity (including lupus anticoagulant or anticardiolipin IgG and/or IgM) in univariable analysis.</p><p><strong>Conclusions: </strong>CD61-positive platelet aggregates and fibrin deposits were commonly seen in LN biopsies and were linked to specific clinical and pathological features. Nevertheless, these should not be considered equivalent to true microthrombi and might indicate a combination of inflammatory and thrombotic processes causing microvascular injury. Further validation is warranted.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 9","pages":"e70879"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}