International Journal of Rheumatic Diseases最新文献

{"title":"Exploring the Interaction Between HLA-B27 and Other Risk Factors of Valvular Heart Disease in Axial Spondyloarthritis","authors":"Yupeng Lai,&nbsp;Yanpeng Zhang,&nbsp;Shuo Cheng,&nbsp;Shaozhen Mo,&nbsp;Yihong Huang,&nbsp;Jiaming Huang,&nbsp;Suo Zhang,&nbsp;Zhongfeng Lou,&nbsp;Haoliang Li,&nbsp;Jing Li,&nbsp;Xingjiao Liu,&nbsp;Meiying Wang","doi":"10.1111/1756-185X.70157","DOIUrl":"https://doi.org/10.1111/1756-185X.70157","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>HLA-B27 plays a critical role in axial spondyloarthritis (axSpA). Valvular heart disease (VHD) is a life-threatening extra-articular manifestation of axSpA. The evidence for the association between HLA-B27 and VHD in axSpA is still scarce and controversial. In this study, we aim to mainly explore the association of HLA-B27 and VHD in axSpA, and the interaction between HLA-B27 and other risk factors of VHD in axSpA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyze cross-sectional data of axSpA patients from 2016 to 2022 in Shenzhen Second People's Hospital. Multivariable logistic regression models were fitted to evaluate the association between HLA-B27 and VHD in axSpA patients. When discovering the interaction between HLA-B27 and sex and disease duration, we made stratified analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Included were 444 axSpA patients with echocardiography during inpatient admission. Males were 299, and females were 145. In the adjusted model of multivariable logistic analysis, only age increased the risk of VHD (OR 1.054; 95% CI 1.021–1.087). To detect interactions between HLA-B27 and other variables that affected the outcome of VHD, sex and categorical disease duration were found to interact with HLA-B27 after being adjusted by age (<i>p</i> &lt; 0.05). In sex-stratified analysis, male patients with HLA-B27 increased the risk of VHD (OR 11.2; 95% CI 1.40–89.36) after being adjusted by age. In stratified analysis of disease duration, over 24 months of duration increased the risk of VHD (OR 5.86; 95% CI 1.27–27.07).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study provided evidence that age was the only independent risk factor for VHD in axSpA. HLA-B27 interacted with sex and disease duration to increase the risk of VHD in axSpA patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Evaluation of the Anterior Cruciate Ligament in Patients With Advanced Gonarthrosis","authors":"Elif Polat,&nbsp;Burak Gunaydin,&nbsp;Sevil Karabağ,&nbsp;Nurettin Heybeli","doi":"10.1111/1756-185X.70160","DOIUrl":"https://doi.org/10.1111/1756-185X.70160","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Knee osteoarthritis is a degenerative disease of the knee joint that leads to progressive loss of articular cartilage. There is only limited information in the literature on the degeneration of the anterior cruciate ligament (ACL) in patients with gonarthrosis. In this study, ACL samples excised during the surgery of patients undergoing total knee replacement (TKR) in 2019–2020 were evaluated histopathologically. The present study aims to investigate the relationship between the degeneration of the ACL and the stage of gonarthrosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Direct X-rays of 47 patients undergoing knee arthroplasty were evaluated and stratified into two groups: Stage 3 (Group 1) and Stage 4 (Group 2). ACL samples were examined histopathologically. Staining was performed with hematoxylin–eosin (H&amp;E), Alcian blue, and Masson's trichrome. The degree of degeneration was determined according to the Movin score and Bonar score. Based on these scores, the statistical significance of the relationship between the stage of gonarthrosis and histopathological examination results was evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>When Group 1 patients were graded according to total Movin scores, the result was mild degeneration in 72.7% of the patients, while the corresponding rates were 76% in Group 2. None of the patients had a score reflecting severe degeneration. The total Bonar scores showed mild degeneration in 68.2% of Group 1 patients. In Group 2, the scores showed mild degeneration in 52% of the patients. No statistically significant difference was found between the groups in either scoring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>It was determined that comparable degeneration occurred in the ACL with the progression of the stage of gonarthrosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canakinumab Treatment in Familial Mediterranean Fever Patients: With/Without Colchicine","authors":"Tahir Saygın Öğüt,&nbsp;Veli Yazisiz,&nbsp;Melis Dilbil,&nbsp;Mine Nokay,&nbsp;Mustafa Ender Terzioğlu,&nbsp;Funda Erbasan","doi":"10.1111/1756-185X.70159","DOIUrl":"https://doi.org/10.1111/1756-185X.70159","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare the differences in attack characteristics, acute-phase reactants, and renal outcomes in patients using canakinumab with or without colchicine treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>FMF patients treated with canakinumab for ≥ 3 months were retrospectively reviewed. Patients unable to continue colchicine for various reasons were identified and grouped as those receiving the canakinumab + colchicine combination (CAN + CLC) and canakinumab monotherapy (CANmono). Attack frequency, C-reactive protein (CRP), urine protein–creatinine ratio (UPCR), and kidney function tests were recorded before and after canakinumab treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-five patients receiving canakinumab treatment were included in the study. Thirty-one patients (56.4%) used CAN + CLC and 24 (43.6%) CANmono. With both CAN + CLC and CANmono treatment, there was no significant change in UPCR of patient groups with GFR &gt; 60 and &lt; 60 mL/min/1.73 m². Amyloid A (AA) amyloidosis was present in 21 (38.2%) patients. In patients with AA amyloidosis receiving CAN + CLC, there was a nonsignificant decrease in UPCR and increased creatinine levels after treatment (<i>p</i> = 0.214 and <i>p</i> = 0.051, respectively). Median GFR decreased significantly from 69 (IQR, mg/dl, 45–95) to 44 (IQR, mg/dl, 28–75) with CAN + CLC treatment (<i>p</i> = 0.021). In the CANmono group, compared to baseline values, there was no significant change in posttreatment UPCR, serum creatinine, and GFR values.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>It is difficult to make a recommendation regarding the discontinuation or continuation of colchicine treatment in all FMF patients who initiated anti-IL-1 treatment. Canakinumab can be continued as monotherapy in patients who cannot continue colchicine treatment due to side effects and patient noncompliance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fourteen-Year Retrospective Cohort Study on the Impact of Climatic Factors on Chronic Musculoskeletal Pain: A Spanish Primary Care Analysis","authors":"Juan Nicolás Cuenca-Zaldívar,&nbsp;Carmen del Corral-Villar,&nbsp;Silvia García-Torres,&nbsp;Rafael Araujo-Zamora,&nbsp;Paula Gragera-Peña,&nbsp;Pedro Martínez-Lozano,&nbsp;Eleuterio A. Sánchez-Romero","doi":"10.1111/1756-185X.70125","DOIUrl":"https://doi.org/10.1111/1756-185X.70125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Chronic musculoskeletal pain, often affected by environmental factors such as temperature, humidity, and atmospheric pressure, can influence pain perception and increase the number of healthcare visits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study examined the link between climate variables and referral rates for chronic musculoskeletal pain in Spanish primary care over 14 years and evaluated the impact of climatic factors on rehabilitation referrals based on variations in pain type, age, and sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective cohort of 44 212 adults diagnosed with chronic musculoskeletal pain (2010–2023) across three primary care centers was analyzed. The inclusion criteria were CIAP2 (International Classification of Primary Care, second edition) diagnostic codes, with ethical clearance from the Puerta de Hierro Majadahonda Hospital (PI 70/24). This study adhered to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for observational reporting. Climatic data, including temperature, precipitation, wind speed, hours of sunlight, and barometric pressure, were obtained from (Agencia Estatal de Meteorología). Statistical analyses used ARIMAX (AutoRegressive Integrated Moving Average with eXternal regressors) and ETSX (Exponential Smoothing State Space Model with eXternal regressors) models, optimizing model fit through root mean squared error (RMSE), mean absolute percentage error (MAPE), and mean absolute scaled error (MASE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant associations were found between climate factors and referral rates. Higher minimum temperatures reduced shoulder/arm pain referrals by −0.019 (95% CI: −0.036, −0.002; <i>p</i> &lt; 0.05). Male patients were more likely to consult, with age being inversely linked to thoracic/lumbar pain (−0.044; 95% CI: −0.071, −0.018; <i>p</i> &lt; 0.05) and positively associated with shoulder/arm pain (0.038; 95% CI: 0.024, 0.052; <i>p</i> &lt; 0.05). ARIMAX was optimal for most pain types, except for cervical pain, for which ETSX was better.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Climatic factors, such as temperature and pressure, affect referral patterns, highlighting the need for climate-sensitive healthcare planning to aid resource management and patient guidance on pain in varying weather conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid Arthritis and Tuberculosis","authors":"Qianshi Zhang,&nbsp;Xu Dong,&nbsp;Pengqi Zhang,&nbsp;Dongyan Wang,&nbsp;Yifang Mei","doi":"10.1111/1756-185X.70090","DOIUrl":"https://doi.org/10.1111/1756-185X.70090","url":null,"abstract":"&lt;p&gt;Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects joints, leading to progressive deterioration and potentially permanent joint damage [&lt;span&gt;1&lt;/span&gt;]. Compared with the general population, the risk of disability and mortality is greater in the affected population [&lt;span&gt;2&lt;/span&gt;]. Based on global epidemiological studies, the incidence of RA is expected to increase by approximately 80.2% between 2020 and 2050 [&lt;span&gt;3&lt;/span&gt;]. Mycobacterial infections are strongly associated with the occurrence of RA, and complications of pulmonary infections are a major cause of death in patients with rheumatic disease [&lt;span&gt;4&lt;/span&gt;]. Tuberculosis (TB) infections are the main cause of lung infections and the treatment process is complicated to cure them completely. TB is particularly dangerous for people with a weakened immune system, such as those receiving immunosuppressive therapy for RA [&lt;span&gt;5, 6&lt;/span&gt;]. A cross-sectional study indicated that 29.5% of RA patients had latent tuberculosis infection (LTBI) and 3.4% developed active TB during treatment, underscoring the heightened risk of TB infection in RA patients due to their disease and its treatment [&lt;span&gt;7&lt;/span&gt;]. The connection between RA and TB has been the subject of considerable research; however, the evidence base remains insufficient to demonstrate a causal relationship. The reliability of findings from observational studies is affected by a lack of consideration and control of potential confounding factors and biases, and there is a risk of reverse causality [&lt;span&gt;8&lt;/span&gt;]. Therefore, the correlations found do not provide definitive evidence of a causal relationship between RA and TB.&lt;/p&gt;&lt;p&gt;This study utilized a two-sample bidirectional Mendelian Randomization analysis with Genome-Wide Association Study data to explore the potential causality between RA and TB. The primary method was the inverse variance weighted approach, supported by MR-Egger regression and the weighted median method for a thorough analysis. We also conducted reverse MR analysis to investigate any potential reverse causal effects. Our research involved 19 and 10 independent single nucleotide polymorphisms in studying the effect of RA on tuberculosis and the effect of tuberculosis on RA. There was a significant association between genetically predicted RA and TB risk in IVW (odds ratio (OR) = 1.132, 95% confidence interval (CI):1.080–1.188, &lt;i&gt;p&lt;/i&gt; = 3.732e-07) and there was no significant correlation between genetic TB and RA (OR = 1.011, 95% CI: 0.966–1.058, &lt;i&gt;p&lt;/i&gt; = 0.635) as shown in Table 1. No significant heterogeneity or horizontal pleiotropy was found for the instrumental variables, suggesting that these results were reliable and robust (see Table 1). The results indicate that RA is a risk factor for the development of TB, while TB does not appear to influence the onset of RA.&lt;/p&gt;&lt;p&gt;The World Health Organization's Global TB Report 2023 indicates that individuals with rheumatic","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Diagnostic Challenges of Pancreatic Cancer in a Patient With Stevens–Johnson Syndrome","authors":"Po-Chien Wu,&nbsp;Yi-Teng Hung,&nbsp;Jennifer Wu","doi":"10.1111/1756-185X.70155","DOIUrl":"https://doi.org/10.1111/1756-185X.70155","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in Hand Joint Flexibility Following Upadacitinib Treatment of Palmoplantar Pustulosis in Adolescents","authors":"Qinchen Gu,&nbsp;Chen Zhang,&nbsp;Wei Song,&nbsp;Zhimin Lin,&nbsp;Chen Li,&nbsp;Zhenhua Ying","doi":"10.1111/1756-185X.70132","DOIUrl":"https://doi.org/10.1111/1756-185X.70132","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nailfold Capillaroscopy as Predictor for Autoantibody Test Results","authors":"Mara Karcher,&nbsp;Anke Strölin,&nbsp;Sebastian Volc","doi":"10.1111/1756-185X.70146","DOIUrl":"https://doi.org/10.1111/1756-185X.70146","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Risk Prediction Model for the Development of Rheumatoid Arthritis, Sjögren's Syndrome, Systemic Sclerosis in Patients With Systemic Lupus Erythematosus: Multicenter Approaches","authors":"Rui-Cen Li,&nbsp;Wang-Dong Xu,&nbsp;Xiao-Yan Liu,&nbsp;Lu Fu,&nbsp;You-Yu Lan,&nbsp;Si-Yu Feng,&nbsp;An-Fang Huang","doi":"10.1111/1756-185X.70156","DOIUrl":"https://doi.org/10.1111/1756-185X.70156","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to construct a predictive model to evaluate the risk of overlapping syndrome (OS), including the combination of systemic sclerosis, rheumatoid arthritis, and Sjögren's syndrome in patients with systemic lupus erythematosus (SLE) from multicenters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included SLE patients in the development cohort (<i>n</i> = 4714) and the external validation cohort (<i>n</i> = 2271). SLE patients in the development cohort were randomly divided into the training cohort and the internal validation cohort at a 7:3 ratio. Laboratory variables were collected and compared by univariate logistic regression modeling. Multivariate logistic regression was further used to develop predictive models and plot a risk nomogram for OS. Receiver operating characteristic (ROC) and calibration curve analysis were used to assess model validity and accuracy. Decision curve analysis was used to assess net clinical benefit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Indexes including anti-SSA antibody, anti-SSB antibody, proteinuria, occult blood in urine, age, eosinophil ratio, hematocrit, platelet, direct bilirubin, indirect bilirubin, rheumatoid factor, immunoglobulin A, prothrombin time, and ferritin were included in the predictive model. The nomogram showed a wide range of predictive ability. The area under the curve (AUC) of the ROC curve for the training cohort was 0.874 (0.851–0.896), the AUC for the internal validation cohort was 0.877 (0.843–0.911), and the AUC for the external validation cohort was 0.760 (0.730–0.790).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The model has a good predictive performance and will be clinically valuable for the assessment of the risk of OS in SLE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evaluation of PNPLA2, ATGL, and G0S2 Levels in Serum and PBMCs of the Newly Diagnosed and the Chronic Patients With Rheumatoid Arthritis","authors":"Masoomeh Gholizadeh,&nbsp;Jahanbakhsh Asadi,&nbsp;Mehrdad Aghaei,&nbsp;Soroush Akbar,&nbsp;Romina Malakouti,&nbsp;Koushan Sineh Sepehr,&nbsp;Zahra Hesari","doi":"10.1111/1756-185X.70138","DOIUrl":"https://doi.org/10.1111/1756-185X.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Rheumatoid arthritis (RA) is an autoimmune disease that is marked by inflammatory response. <i>PNPLA2</i> (phospholipase patatin-like) which encodes ATGL (adipose triglyceride lipase) also been identified as playing in inflammation. <i>G0S2</i> (G0/G1) switch gene has been identified as one of the selective inhibitors of ATGL. <i>PNPLA2</i> and <i>G0S2</i> may be factors that can help predict the relationship between molecules affecting inflammation, as well as identify inflammatory pathways through genes involved in the metabolic pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In the present study, we analyzed the expression levels of <i>PNPLA2</i> and <i>G0S2</i> genes as well as their protein concentrations by real-time PCR and immunoassay, respectively on 60 peripheral blood mononuclear cells (PBMC) which are included into 3 different groups of new case patients with RA, chronic patients with RA, and the control individuals. Also, to obtain more accurate information and results, the synovial fluid, triglyceride, cholesterol, and ESR levels were also analyzed. Statistical analysis was then performed with the software SPSS-18.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>PNPLA2</i> gene expression level was significantly increased in the newly diagnosed patients and the chronic RA patients in compared to the control group. Also, the serum levels of ATGL in the newly diagnosed patients and the chronic RA patients were significantly reduced compared to the control group. The gene and protein levels of <i>G0S2</i> in the newly diagnosed patients elevated compared to other groups, but interestingly this increase in PBMCs was not significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This is predicted that <i>PNPLA2</i> gene expression in PBMCs is not only regulated by <i>G0S2</i> gene, but different regulatory factors can also affect the expression level of this gene in the immune cells.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}