International Journal of Rheumatic Diseases最新文献

{"title":"Oxidative Phosphorylation Pathway in Ankylosing Spondylitis: Multi-Omics Analysis and Machine Learning","authors":"Yuling Chen,&nbsp;Yuan Xu,&nbsp;Shuangyan Cao,&nbsp;Qing Lv,&nbsp;Yuanchun Ye,&nbsp;Jieruo Gu","doi":"10.1111/1756-185X.70175","DOIUrl":"https://doi.org/10.1111/1756-185X.70175","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting the axial skeleton, characterized by immune microenvironment dysregulation and elevated cytokines like TNF-α and IL-17. Mitochondrial oxidative phosphorylation (OXPHOS), crucial for immune cell function and survival, is implicated in AS pathogenesis. This study explores OXPHOS-related mechanisms in AS, identifies key genes using machine learning, and highlights potential therapeutic targets for precision medicine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Peripheral blood mononuclear cells (PBMCs) bulk transcriptomic and single-cell RNA sequencing (scRNA-seq) data from AS patients were analyzed to investigate the role of the OXPHOS pathway in AS. Weighted gene co-expression network analysis (WGCNA) was performed to identify key gene modules associated with OXPHOS. Machine learning techniques, including support vector machine with recursive feature elimination (SVM-RFE), random forest, and least absolute shrinkage and selection operator (LASSO), were applied to identify significant AS-related genes. Real-time PCR (RT-PCR) was used to quantify gene expression, examine their patterns in specific cell subtypes, and explore their functional implications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pathway enrichment analysis identified OXPHOS as a significantly enriched pathway distinguishing AS patients from healthy controls, with high normalized enrichment scores and significant group separation in principal component analysis. ScRNA-seq revealed significantly higher OXPHOS scores in AS patients, especially in dendritic cells (DCs) and monocytes, highlighting cell type-specific dysregulation. WGCNA identified two key gene modules (MEyellow and MEtan) that are closely associated with OXPHOS. Three hub genes—<i>LAMTOR2</i>, <i>APBB1IP</i>, and <i>DGKQ</i>—were screened using machine learning methods and validated by RT-PCR and scRNA-seq. Among them, <i>LAMTOR2</i> was significantly more highly expressed in patients with AS, and functional analyses showed that it plays a role in promoting TH17 cell differentiation, which highlights its potential as a therapeutic target for ankylosing spondylitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This multi-omics study provides valuable insights into the complex interplay between OXPHOS and AS. The identified genes, particularly <i>LAMTOR2</i>, serve as potential therapeutic targets, contributing to our understanding of AS mechanisms and paving the way for precision medicine in AS treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Periprosthetic Joint Infection Rate Following Total Knee Arthroplasty in Rheumatoid Arthritis Patients: Insights From a Japanese Nationwide Medical Claims Database Study","authors":"Yu Mori,&nbsp;Kunio Tarasawa,&nbsp;Hidetatsu Tanaka,&nbsp;Ryuichi Kanabuchi,&nbsp;Hiroshi Hatakeyama,&nbsp;Naoko Mori,&nbsp;Kiyohide Fushimi,&nbsp;Toshimi Aizawa,&nbsp;Kenji Fujimori","doi":"10.1111/1756-185X.70249","DOIUrl":"https://doi.org/10.1111/1756-185X.70249","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Advances in pharmacological treatments have reduced joint deformities in rheumatoid arthritis (RA), leading to a decline in total knee arthroplasty (TKA) among RA patients. However, RA remains associated with higher risks of postoperative complications. This study compares postoperative complications during hospitalization in patients with RA and osteoarthritis (OA) undergoing TKA in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study utilized data from the Japanese Diagnosis Procedure Combination database from April 2016 to March 2023. Patients who underwent TKA were identified, and propensity score (PS) matching was performed to balance age, sex, body mass index, simultaneous surgeries, and comorbidities, resulting in 9048 matched pairs. Outcomes included periprosthetic joint infections (PJI), cognitive dysfunction, deep vein thrombosis (DVT), pulmonary embolism (PE), and periprosthetic fractures. Statistical analyses were conducted using multivariate logistic regression with a significance threshold of <i>p</i> &lt; 0.01.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>RA patients had higher risks of PJI (odds ratio [OR]: 1.473, 95% CI: 1.134–1.912, <i>p</i> = 0.004) and postoperative cognitive dysfunction (OR: 1.721, 95% CI: 1.190–2.488, <i>p</i> = 0.004) compared to OA patients. In contrast, no significant differences were observed in the incidence of DVT, PE, or periprosthetic fractures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RA patients undergoing TKA are at increased risk of PJI and cognitive dysfunction, highlighting the need for tailored perioperative management. These findings provide important insights into optimizing outcomes for RA patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Surgery for the Patient With Systemic Lupus Erythematosus Complicated by Type A Aortic Dissection","authors":"Kaiyue Sun,&nbsp;Ruyuan Wei,&nbsp;Fushun Lin,&nbsp;Dexin Zhang,&nbsp;Kai Liu","doi":"10.1111/1756-185X.70245","DOIUrl":"https://doi.org/10.1111/1756-185X.70245","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Infection-Related Hospitalization and the Impact of Multidisciplinary Care in ANCA-Associated Vasculitis: A Retrospective Cohort","authors":"Emily K. Yeung,&nbsp;A. Richard Kitching,&nbsp;Michael Gingold,&nbsp;Kevan R. Polkinghorne,&nbsp;Jessica Ryan","doi":"10.1111/1756-185X.70139","DOIUrl":"https://doi.org/10.1111/1756-185X.70139","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Burden of Indolent Systemic Mastocytosis in a Managed Care Organization-Correspondence","authors":"Ming-Hsiang Chu,&nbsp;Hui-Yi Hsu,&nbsp;Su-Boon Yong,&nbsp;Chin-Yuan Yii,&nbsp;Xiao-Ling Liu","doi":"10.1111/1756-185X.70241","DOIUrl":"https://doi.org/10.1111/1756-185X.70241","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beware of Missed Kawasaki Disease Presenting as Acute Coronary Syndrome in Adults: CT Coronary Angiography Findings in 4 Patients","authors":"Rakesh Kumar Pilania,&nbsp;Abarna Thangaraj,&nbsp;Shayeri Roy Choudhury,&nbsp;Munish Arora,&nbsp;Rajesh Vijayvergiya,&nbsp;Parminder Singh Otaal,&nbsp;Arun Sharma,&nbsp;Surjit Singh,&nbsp;Manphool Singhal","doi":"10.1111/1756-185X.70235","DOIUrl":"https://doi.org/10.1111/1756-185X.70235","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Therapies for Rheumatoid Arthritis in Super-Elderly Society: Insights From FIRST Registry, Japan","authors":"Koshiro Sonomoto,&nbsp;Yoshiya Tanaka","doi":"10.1111/1756-185X.70232","DOIUrl":"https://doi.org/10.1111/1756-185X.70232","url":null,"abstract":"<p>As the world's most rapidly aging society, Japan has faced significant challenges in the management of rheumatoid arthritis (RA) in elderly patients. Biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) have improved disease control, but concerns remain regarding the risk of infection and malignancy, especially in the elderly population. This review presents real-world data from FIRST registry, a prospective cohort following a total of 5500 patients over 20 years, and highlights strategies to balance efficacy and safety. Registry shows an increasing age of patients initiating b/tsDMARDs and an increase in comorbidities such as cardiovascular disease, chronic kidney disease, and malignancies. Infection control—including prophylaxis against pneumocystis pneumonia, screening for non-tuberculous mycobacteria, and vaccination—has been associated with a lower incidence of serious infections. Similarly, a proactive malignancy management strategy that includes computed tomography (CT) screening and multidisciplinary care has been correlated with improved detection of early-stage cancers and fewer treatment discontinuations due to malignancy. While these findings represent associations rather than direct causal effects, they reflect the evolving landscape of RA management over two decades. Meanwhile, the registry highlights unmet needs, particularly in patients with prior b/tsDMARD exposure, who often experience lower response rates. In addition, while clinical remission rates have improved, functional outcomes remain suboptimal, particularly in older patients. To address these challenges, personalized treatment selection is being explored. By sharing Japan's experience in managing RA in an aging society, this review provides insights into strategies that may be applicable to other aging populations worldwide.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Rheumatoid Arthritis Combined With Pigmented Villonodular Synovitis: A Report of Two Cases","authors":"Yadan Zou,&nbsp;Ruohan Yu,&nbsp;Zhongxing Zhao,&nbsp;Qian Guo,&nbsp;Jing Xu,&nbsp;Shengguang Li","doi":"10.1111/1756-185X.70240","DOIUrl":"https://doi.org/10.1111/1756-185X.70240","url":null,"abstract":"<div>\u0000 \u0000 <p>This report presents two rare cases of rheumatoid arthritis (RA) complicated by pigmented villonodular synovitis (PVNS), highlighting the diagnostic and therapeutic challenges posed by their coexistence. RA is a chronic autoimmune disease characterized by joint inflammation and destruction, while PVNS is a rare proliferative synovial disorder that often presents with monoarticular joint involvement. The overlap in clinical and radiological features between RA and PVNS complicates diagnosis, necessitating advanced imaging techniques and histopathological evaluation for accurate differentiation. In the first case, an 85-year-old woman with a long-standing history of RA developed PVNS in the left knee, confirmed by MRI findings of hemosiderin deposition and nodular synovial hypertrophy. In the second case, a 72-year-old woman with seronegative RA and a prior history of PVNS in the elbows presented with PVNS in the left knee, confirmed by both imaging and pathology. Both patients underwent successful treatment involving a combination of systemic therapies, including disease-modifying antirheumatic drugs (DMARDs) and biologics, as well as localized interventions, such as synovectomy and corticosteroid injections. These cases underscore the importance of integrating imaging and histopathology in managing RA patients with persistent joint symptoms, as well as the necessity for a tailored therapeutic approach to address both systemic inflammation and localized pathology. A comprehensive literature review is provided to contextualize these findings, with a focus on the role of MRI and emerging therapies, such as colony-stimulating factor-1 receptor (CSF-1R) inhibitors, in the management of PVNS.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombotic Diathesis Combined With Connective Tissue Disease in a Chinese Teenage Male: A Case Report","authors":"Xianglin Chen,&nbsp;Shuyi Song,&nbsp;Zhaojing Zhang,&nbsp;Jibo Wang","doi":"10.1111/1756-185X.70228","DOIUrl":"https://doi.org/10.1111/1756-185X.70228","url":null,"abstract":"<div>\u0000 \u0000 <p>Thrombophilia is a pathological condition characterized by an increased propensity for blood clot formation and thromboembolism, resulting from various genetic or acquired factors. It can be classified as hereditary or acquired based on its etiology. Autoimmune diseases are common contributors to acquired thrombophilia. This article presents the clinical diagnosis and treatment of a patient with hereditary thrombophilia complicated by connective tissue disease, aiming to provide a reference for the clinical management of thrombophilia. A case of a 13-year-old male presenting with persistent pain and swelling in the left lower limb was investigated. Physical examination revealed there was swelling in the left lower limb with slightly elevated skin tension and warmth. Lower Limb Ultrasound: Thrombosis in the left calf muscle venous system. D-dimer was elevated and antinuclear antibodies (ANA) and titers were Positive. Family history revealed several kinsfolk had thromboembolic diseases. The patient underwent hydroxychloroquine sulfate, warfarin sodium, and aspirin for maintenance therapy. 10 months later, the patient presented with deep vein thrombosis in the left sole again. Thrombosis is a multifactorial process, and patients may have multiple thrombophilic risk factors simultaneously. Etiological screening for thrombophilia should not focus solely on a single risk factor. If autoimmune diseases cannot fully explain the severity of thrombophilia, other risk factors should be further investigated. It is essential to appropriately determine the indications for genetic screening in patients with VTE and autoimmune diseases.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pursuing Precision Medicine in Managing Rheumatoid Arthritis","authors":"Satoshi Kubo,&nbsp;Yoshiya Tanaka","doi":"10.1111/1756-185X.70239","DOIUrl":"https://doi.org/10.1111/1756-185X.70239","url":null,"abstract":"<p>Rheumatoid arthritis, characterized by immune dysregulation and joint destruction, is managed through a stepwise algorithm that combines methotrexate with biological and targeted synthetic disease-modifying antirheumatic drugs. Despite considerable advances, the lack of reliable biomarkers for selecting the most effective medication, especially in Phase II and beyond, remains a significant obstacle. As a result, achieving early clinical remission in all patients continues to be challenging. Rheumatoid arthritis demonstrates considerable clinical and molecular diversity, influenced by both genetic predispositions and environmental factors. Recent scientific and technological advances have shed light on the pathogenesis of rheumatoid arthritis, facilitating the stratification of patients into distinct phenotypic subgroups and potentially optimizing the choice of targeted therapies. However, persistent challenges include the high costs and logistical demands of these methodologies, as well as the complexities of conducting large-scale clinical trials. This review highlights the intricate pathogenesis of rheumatoid arthritis and underscores the need to address the disease's heterogeneity through precision medicine. Moving forward, a deeper investigation into rheumatoid arthritis pathogenesis, encompassing both genetic and environmental factors, is crucial. Pursuing precision medicine, grounded in accurate patient stratification, should be embraced as a “moonshot” objective in rheumatoid arthritis treatment, aiming to achieve transformative breakthroughs in management.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}