International Journal of Rheumatic Diseases最新文献

{"title":"CD244 Expression by Lymphocytes in Rheumatoid Arthritis With Concomitant Hepatitis C Infection","authors":"Fatma Hassan Abdelraouf,&nbsp;Iman Sami AbouBakr,&nbsp;Abla Ezz El-Arab,&nbsp;Hala Ahmed Raafat,&nbsp;Mariam Onsy F. Hanna,&nbsp;Shereen Mahmoud Shawky","doi":"10.1111/1756-185X.70218","DOIUrl":"https://doi.org/10.1111/1756-185X.70218","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We aimed to assess the populations of lymphocytes: NK cells, NKT cells and T cells, and the expression of the immunoregulatory receptor CD244 (2B4) by each population in rheumatoid arthritis (RA) patients with concomitant hepatitis C virus (HCV) infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Lymphocyte phenotyping for NK cells (CD3-CD56+), NKT cells (CD3 + CD56+), and T cells (CD3 + CD56-) was analyzed by flow cytometry in patients with HCV positive RA (<i>n</i> = 21), HCV negative RA (<i>n</i> = 20) and controls (<i>n</i> = 11). Surface expression of CD244 by each lymphocyte population was quantified as mean fluorescence intensity and frequency of CD244 expressing cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with and without concomitant HCV displayed comparable numbers of NK, NKT, and T cells to controls. We observed that the expression intensity of CD244 was downregulated by the lymphocyte populations in HCV positive and HCV negative RA compared to controls (NK CD244 <i>p</i> &lt; 0.001, NKT CD244 <i>p</i> = 0.047, T CD244 <i>p</i> &lt; 0.001). Yet, the downregulation was more profound in HCV positive RA, as CD244 expression by NK cells and T cells was decreased in HCV positive in relation to negative RA (<i>p</i> &lt; 0.001 and <i>p</i> = 0.003, respectively). In addition, the frequency of CD244-expressing NK and NKT cells in HCV positive RA was lower compared to HCV negative RA and controls (<i>p</i> &lt; 0.001 and <i>p</i> = 0.001, respectively). T cell CD244 expression was significant for discriminating clinically active from less active RA with and without HCV (<i>n</i> = 41), area under the curve = 0.717 (95% CI 0.560–0.873, <i>p</i> = 0.007).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings reveal a distinct expression pattern of CD244 by lymphocytes of RA with HCV infection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2024 Australian National Osteoporosis Guidelines in Postmenopausal Women and Men Aged Over 50 Years: A Comparative Perspective Within the Asia–Pacific Region","authors":"Alwin Lian,&nbsp;Manju Chandran,&nbsp;Peter K. K. Wong","doi":"10.1111/1756-185X.70220","DOIUrl":"https://doi.org/10.1111/1756-185X.70220","url":null,"abstract":"&lt;p&gt;Osteoporosis is a major public challenge in the Asia–Pacific region where it affects ≤ 30% of women aged ≥ 40 years and ≤ 10% of men in developed economies [&lt;span&gt;1&lt;/span&gt;]. Although many national guidelines within the Asia–Pacific region offer tailored strategies, differences in screening, risk assessment and treatment thresholds highlight the need for stronger, evidence-driven strategies to optimize patient outcomes and the importance of regional dialogue and knowledge exchange. This editorial explores Australia's recently released Osteoporosis Guidelines in the context of other Asia–Pacific recommendations, highlighting key similarities and differences in screening, risk assessment and treatment (Table 1).&lt;/p&gt;&lt;p&gt;The Royal Australian College of General Practitioners and Healthy Bones Australia published national guidelines for osteoporosis management in postmenopausal women and men aged ≥ 50 years in 2024 [&lt;span&gt;2, 3&lt;/span&gt;]. Representative Asia–Pacific guidelines published in English chosen were the 2024 Osteoporosis Society of Hong Kong (HK) Guideline for Clinical Management of Postmenopausal Osteoporosis [&lt;span&gt;5&lt;/span&gt;], the 2024 Guidelines for Osteoporosis—Korean Society of Menopause [&lt;span&gt;4&lt;/span&gt;], the 2021 Indian Society for Bone and Mineral Research Position Statement for the Diagnosis and Treatment of Osteoporosis in Adults [&lt;span&gt;6&lt;/span&gt;], the 2021 Clinical Standards for Fracture Liaison Services in New Zealand (NZ) [&lt;span&gt;9&lt;/span&gt;] with the 2017 Guidance on the Diagnosis and Management of Osteoporosis in NZ [&lt;span&gt;7&lt;/span&gt;], the 2018 Singaporean Appropriate Care Guide for Osteoporosis Identification and Management in Primary Care [&lt;span&gt;8&lt;/span&gt;], and the 2021 Summary of the Thai Osteoporosis Foundation Clinical Practice Guidelines on the Diagnosis and Management of Osteoporosis [&lt;span&gt;10&lt;/span&gt;]. (Of note, the Chinese guidelines were published in Mandarin and so not included in this Editorial [&lt;span&gt;11&lt;/span&gt;].) Like the Australian guideline, the Thai document targeted postmenopausal women and men aged ≥ 50 years [&lt;span&gt;10&lt;/span&gt;]. There was some variability in target population of the other guidelines, for example, the HK and Korean guidelines were directed as postmenopausal women [&lt;span&gt;4, 5&lt;/span&gt;] and the Singaporean guideline targeted postmenopausal women and men aged ≥ 65 years [&lt;span&gt;8&lt;/span&gt;]. Despite this, the principles discussed in the various guidelines were similar. It is not our intention to identify which guideline might be “better” as each document was written by local experts cognisant of the limitations and vagaries of their particular national healthcare system, funding envelope and at-risk population. There are obviously significant differences in national healthcare resources. This is particularly highlighted in the Indian guideline which was drafted specifically for a resource-constrained healthcare environment with a large at-risk population [&lt;span&gt;6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Although some countries have adopted ag","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Therapeutic Potential of Tocilizumab Monotherapy in Isolated Polymyalgia Rheumatica: A Systematic Review and Meta-Analysis","authors":"Abdullah,&nbsp;Muhammad Usama,&nbsp;Muhammad Umar Mansoor,&nbsp;Okasha Tahir,&nbsp;Barira Afzal,&nbsp;Noshaba Najeeb,&nbsp;Zain Ali,&nbsp;Faryal Razzaq","doi":"10.1111/1756-185X.70216","DOIUrl":"https://doi.org/10.1111/1756-185X.70216","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Ocular Manifestations Among Systemic Sclerosis Patients","authors":"Ariel Israel,&nbsp;Helana Jeries,&nbsp;Mahmud Omar,&nbsp;Eugene Merzon,&nbsp;Mohammad E. Naffaa","doi":"10.1111/1756-185X.70213","DOIUrl":"https://doi.org/10.1111/1756-185X.70213","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-Like Peptide-1 Receptor Agonists: Multifaceted Roles in Immune and Inflammatory Regulation, Glycemic Control, and Synergistic Therapeutic Applications","authors":"Chia-Chien Hsu,&nbsp;Chi-Jen Hsu,&nbsp;Xiangpei Fang,&nbsp;Fu-Shun Yen,&nbsp;Pui-Ying Leong","doi":"10.1111/1756-185X.70199","DOIUrl":"https://doi.org/10.1111/1756-185X.70199","url":null,"abstract":"&lt;p&gt;Glucagon-like peptide-1 (GLP-1) has gained considerable attention in recent years for its crucial role in glycemic and weight control, as well as its potential impact on inflammation and immune function. Secreted by enteroendocrine cells in response to nutrient intake, GLP-1 stimulates insulin secretion, reduces glucagon release, and slows gastric emptying [&lt;span&gt;1&lt;/span&gt;]. Beyond these effects, GLP-1 has multifaceted roles, including a complex interplay between inflammatory processes and immune regulation. The use of GLP-1 receptor agonists (GLP-1RAs) has been linked to significantly lower risks of all-cause mortality, cardiovascular events, and both cardiovascular and liver-related mortality [&lt;span&gt;2&lt;/span&gt;]. Recent studies have further explored the anti-inflammatory properties of oGLP-1 drugs and their effect on the immune system, unveiling additional mechanisms of action.&lt;/p&gt;&lt;p&gt;Originally developed as a diabetes treatment due to its ability to stimulate insulin secretion from beta cells, GLP-1's effects extend beyond glucose regulation to include significant roles in immune cell function. One of its notable impacts is on macrophage polarization. Research indicates that GLP-1 can modulate macrophage activity, highlighting its potential in controlling chronic inflammation. Activation of the GLP-1 receptor has been shown to shift macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. This transition is associated with a reduction in inflammatory mediators and an enhancement of tissue repair mechanisms [&lt;span&gt;3&lt;/span&gt;]. For instance, in a murine model of diet-induced non-alcoholic fatty liver disease (NAFLD), liraglutide demonstrated protective effects by promoting cAMP-PKA-STAT3-dependent polarization of Kupffer cells towards an M2 phenotype [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Moreover, GLP-1 receptor expression in T cells, particularly apoptotic and anergic cells, functions as a negative costimulatory molecule for T cells. This action has been shown to prolong allograft survival, mitigate alloimmunity, and even trigger antitumor immunity in a mouse model of colorectal cancer [&lt;span&gt;5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;A recent study uncovered a novel mechanism by which GLP-1 receptor agonists (GLP-1RAs) increase intestinal &lt;i&gt;Escherichia coli&lt;/i&gt; levels. This increase has been associated with sympathetic nervous system activation, resulting in the release of norepinephrine into the intestinal lumen. Elevated &lt;i&gt;E. coli&lt;/i&gt; levels may contribute to bacterial translocation by downregulating the expression of intestinal tight junction genes under stress. However, the implications of this rise in &lt;i&gt;E. coli&lt;/i&gt; levels require further investigation [&lt;span&gt;6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Activation of the GLP-1 receptor has also been shown to have significant anti-inflammatory effects. In a study by Chaudhuri et al., 24 obese individuals with type 2 diabetes mellitus (T2DM) were treated with the GLP-1 analog exenatide for 12 weeks. This treatment significantl","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NHIRD and TriNetX in Rheumatology: Opportunities and Challenges","authors":"Chao Chieh Cheng,&nbsp;Po-Cheng Shih,&nbsp;Su Boon Yong,&nbsp;Edward Chia-Cheng Lai","doi":"10.1111/1756-185X.70203","DOIUrl":"https://doi.org/10.1111/1756-185X.70203","url":null,"abstract":"&lt;p&gt;Rheumatic diseases are prevalent worldwide, with a considerable impact on patients' quality of life and a tendency to require long-term management. These conditions are complicated by common comorbidities, including cardiovascular disease, endocrine disorder, and mood disorder, further increasing both disease burden and treatment complexity. While biological therapies have revolutionized the management of various rheumatic diseases, high costs, potential adverse effects, and the heterogeneity of patient populations remain significant barriers to achieving optimal, personalized care.&lt;/p&gt;&lt;p&gt;In the history of the development of clinical research, randomized controlled trials (RCTs) have been the gold standard for evaluating efficacy and safety. However, their strict inclusion and exclusion criteria, limited sample sizes, and relatively short follow-up periods may fail to capture the full spectrum of disease heterogeneity and long-term real-world positive and negative outcomes. However, the use of real-world evidence (RWE) in research, as demonstrated in the original article published in the &lt;i&gt;International Journal of Rheumatic Diseases&lt;/i&gt; in early 2019 (Su-Boon Yong et al., 2019) [&lt;span&gt;1&lt;/span&gt;], has brought new hope for addressing such predicaments. Real-world evidence (RWE) derived from large-scale data sources, such as Taiwan's National Health Insurance Research Database (NHIRD) and the recent build global networks like TriNetX, offers the potential to overcome many of these limitations.&lt;/p&gt;&lt;p&gt;This editorial intends to explore the growing influence of RWE on rheumatologic research, discussing both its potential benefits and its limitations. We also highlight future directions for leveraging big data—particularly from Taiwan's NHIRD, TriNetX, and other global repositories, to optimize treatment strategies, refine risk prediction models, and guide real-world clinical decision-making in rheumatology.&lt;/p&gt;&lt;p&gt;The large heterogeneity of diseases leading to the challenge of research, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and idiopathic inflammatory myositis (IIM), each exhibiting considerable variability in clinical manifestations, progression, and therapeutic responses. Diagnostic accuracy is often compromised by nonspecific presentations and the limited reliability of current biomarkers, incomplete imaging data sets, and then elevating the risk of misdiagnosis. These limitations are especially magnified in rare rheumatic diseases, where small patient populations restrict the feasibility of clinical trials and inflate the costs of multinational studies.&lt;/p&gt;&lt;p&gt;With the advances of biological and targeted synthetic medications emerging, prolonged follow-up studies are frequently hampered by high financial demands and significant patient attrition. Insufficient resources, particularly in the realm of rare diseases and innovative drug development, further restrict progress [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;To overcome these chal","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.70203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Mitral Valve Chordae Tendineae Rupture and Splenic Infarction in Granulomatosis With Polyangiitis","authors":"Irem Sahinoğlu,&nbsp;Sadettin Uslu,&nbsp;Ulkü Güc,&nbsp;Fatma Can,&nbsp;Mustafa Ucar,&nbsp;Ayca Tan,&nbsp;Ozgül Soysal Gündüz","doi":"10.1111/1756-185X.70214","DOIUrl":"https://doi.org/10.1111/1756-185X.70214","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Atherosclerosis in Pediatric Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis","authors":"Pratap Kumar Patra,&nbsp;Aaqib Zaffar Banday,&nbsp;Adil Asghar,&nbsp;Rashmi Ranjan Das,&nbsp;Pakkiresh Reddy,&nbsp;Priyanka Priyanka,&nbsp;Pallavi Singh,&nbsp;Nutan Sharma,&nbsp;Shagufta Naaz,&nbsp;Rahila Nisar,&nbsp;Dharmagat Bhattarai,&nbsp;Abdus Sami Bhat,&nbsp;Anju Gupta","doi":"10.1111/1756-185X.70217","DOIUrl":"https://doi.org/10.1111/1756-185X.70217","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Adults with systemic lupus erythematosus (SLE) are at a higher risk of cardiovascular complications. Numerous meta-analyses in adults with SLE have consistently demonstrated altered surrogate parameters of atherosclerosis (subclinical atherosclerosis). However, meta-analyses assessing the impact of pediatric SLE (pSLE) on cardiovascular health are lacking. Herein, we perform a systematic review and meta-analysis of studies assessing subclinical atherosclerosis in pSLE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Embase, Web of Science, and PubMed databases were systematically searched for pertinent literature published between January 1965 and February 2024. Patients with SLE and healthy participants were included as cases and controls, respectively. Online PICO portal, Newcastle–Ottawa scale, Review Manager and R software, and GRADEpro GDT tool were used for study deduplication and data extraction, study quality evaluation, data synthesis/analysis (including meta-regression), and certainty of evidence assessment, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 9 studies (out of 126 citations), including 1021 participants (528 cases and 493 controls), were included in the analysis. Carotid intima–media thickness (CIMT) and pulse wave velocity (PWV) were significantly higher in cases as compared to controls [mean difference (MD) 0.04 (95% CI 0.01–0.08) mm, <i>p</i> = 0.007 and MD 0.48 (95% CI 0.02–0.94) m/s, <i>p</i> = 0.04, respectively]. The flow-mediated dilatation was similar in the two groups. Significant heterogeneity was observed for all the outcome measures. On meta-regression analysis, disease duration correlated significantly with both CIMT MD and PWV MD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A “low”-quality evidence suggests that pSLE may adversely impact vascular microanatomy and physiology. Longitudinal studies are needed to precisely quantify the cardiovascular risk in pSLE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Registration</h3>\u0000 \u0000 <p>PROSPERO (CRD42022323752).</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distal Renal Tubular Acidosis due to Sjogren's Syndrome Presenting as Quadriparesis in Pregnancy","authors":"Ilakyaa Rajakumar,&nbsp;Karthiga Prabhu Jayachandraprabhu,&nbsp;Vidhyalakshmi Ramadoss Kabilan,&nbsp;Udhaya Parivallal,&nbsp;Gerry George Mathew,&nbsp;Varadharajan Jayaprakash","doi":"10.1111/1756-185X.70208","DOIUrl":"https://doi.org/10.1111/1756-185X.70208","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Protective and Predisposing HLA-B Alleles and MICA Variants (MICA*049 and MICA*00901) in South Indian Behçet's Disease","authors":"Jiss John Francis,&nbsp;Spoorthi Raj D. R.,&nbsp;Ardra Das,&nbsp;Vivek Vinod,&nbsp;Mithun C B,&nbsp;Lalitha Biswas","doi":"10.1111/1756-185X.70221","DOIUrl":"https://doi.org/10.1111/1756-185X.70221","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}