International Journal of Rheumatic Diseases最新文献

{"title":"Myositis India: Early lessons from a patient support group in a resource-limited setting","authors":"Anushka Aggarwal, Narendra Kumar Bagri, Chengappa Kavadichanda, Sundeep Upadhyaya, Saloni Haldule, Parth Ladha, Neeraj Jain, Himanshu Pathak, Parthajit Das, Srijan Mittal, Rutvij Amol Tope, Aniket Ajay Nikale, Simran Nimal, Pankti Mehta, Kunal Chandwar, Rajkiran Dudam, Sourabh Malviya, Vijay K. R. Rao, Sunil Singh, Vanshaj Sharma, Namratha Edpuganti, Rishi Nalkande, Swaraj Salunke, Ujjwal Madan, Vanshita Batra, Rohit Aggarwal","doi":"10.1111/1756-185X.15351","DOIUrl":"https://doi.org/10.1111/1756-185X.15351","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of bone health in idiopathic inflammatory myopathies: A two-center audit in the United Kingdom and Hong Kong","authors":"Akanksha Thumbe,&nbsp;Aman Kumar,&nbsp;Adeola Ajibade,&nbsp;Hem Sapkota,&nbsp;Thomas P Sheeran,&nbsp;Srinivasan Venkatachalam,&nbsp;Ho So,&nbsp;Latika Gupta","doi":"10.1111/1756-185X.15268","DOIUrl":"https://doi.org/10.1111/1756-185X.15268","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with inflammatory idiopathic myopathies (IIM) face elevated risks of osteoporosis and fragility fracture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate current practice relating to bone health in adult patients with IIM in the United Kingdom and Hong Kong (HK).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients were identified from IIM patient lists. Demographics, osteoporosis risk factors, DXA scans, and bone protection treatment were recorded. Adherence to regional standards was evaluated for each center. Following this, in the United Kingdom, up-to-date DXA scans were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 136 patients identified, 51 met selection criteria (UK, <i>n</i> = 20, HK, <i>n</i> = 31). Mean age in the United Kingdom was 59 (IQR 54–66); in Hong Kong, 65 (IQR 52.5–70). Most were female (UK 70%; HK 77%), current or previous steroid treatment was common (UK 90%; HK 100%) and some had experienced fragility fracture (UK 15%; HK 9%). The mean daily dose of prednisolone that patients were prescribed during the study was 12.5 mg (UK) and 14.3 mg (HK). Some patients had had a DXA scan (UK 50%; HK 35%) though several were outdated. Among those with BMD measured (UK, <i>n</i> = 20; HK, <i>n</i> = 11), osteopenia prevalence was 35% (UK) and 36% (HK) while osteoporosis was 5% (UK) and 36% (HK). Notably, 25% (UK) and 64% (HK) exceeded treatment thresholds. Treatments included anti-osteoporotic agents (UK 55%; HK 15%), Vitamin D/calcium supplements (UK 95%; HK 52%), or no treatment (UK 5%, HK 15%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Poor compliance with guidelines exists in both centers, particularly around investigation and monitoring of bone health for IIM patients. Integrated care models and increased resource allocation to bone health are imperative to improve management of this aspect of IIM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appendicitis links to the afterward subsequent psoriatic disease occurrence in Taiwan national health insurance research database: A population-based cohort study","authors":"Chung-Yuan Hsu,&nbsp;Yu-Jih Su,&nbsp;Yung-Heng Lee,&nbsp;Hsian-Min Chen,&nbsp;Chih-Cheng Lu,&nbsp;Hsin-Hua Chen","doi":"10.1111/1756-185X.15289","DOIUrl":"https://doi.org/10.1111/1756-185X.15289","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To investigate the psoriatic disease risk among patients with previous appendicitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study was a nationwide population-based case–control study about the association between the psoriatic disease risk among patients with a history of appendicitis in Taiwan. The study population consisted of newly diagnosed psoriatic disease with at least two outpatient visits, and the control group included those patients without psoriatic disease at the same index date. Patients with a previous diagnosis of appendicitis or who underwent appendectomy surgery prior to their psoriatic disease diagnosis were recorded. The odds ratio of psoriatic disease diagnosis in the two groups with and without a history of appendicitis were analyzed and compared.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 48 894 individuals diagnosed with psoriatic disease were matched with 292 656 controls by age and gender. Notably, the proportion of patients with a history of appendicitis or primary appendectomy was significantly elevated among those with psoriatic disease compared with the control cohort (both &lt;i&gt;p&lt;/i&gt; &lt; .05). On average, the occurrence of appendicitis preceded the index date by 3.3 ± 2.3 years. Multivariate analysis revealed a heightened incidence rate of psoriatic disease in patients previously diagnosed with appendicitis, periodontal disease, Charlson comorbidity index score (CCIS) ≧1, and ill-defined intestinal infections. This association persisted after adjusting for confounding factors, such as periodontal disease, CCIS, &lt;i&gt;Salmonella&lt;/i&gt;, and ill-defined intestinal infections. The odds ratios for psoriatic disease in individuals with a history of appendicitis, periodontal disease, CCIS ≧1, and ill-defined intestinal infections were 1.16, 1.008, 1.69, and 1.23, respectively, with corresponding 95% confidence intervals of 1.03–1.31, 1.05–1.11, 1.65–1.74, and 1.20–1.26. These findings underscore the independent association between appendicitis and subsequent development of psoriatic disease, even after adjusting for relevant comorbidities and potential confounders.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our research illustrates that appendicitis is associated with an increased likelihood of developing a psoriatic disease, despite several limitations. These limitations encompass variables such as dietary and smoking habits, alongside other potential confounding factors that were not fully considered. Moreover, inherent biases in utilizing national health insurance data, such as the absence of laboratory information, as well as the constrain","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of combination maintenance therapy with mepolizumab and azathioprine for eosinophilic granulomatosis with polyangiitis","authors":"Yoshiyuki Abe,&nbsp;Masahiro Kogami,&nbsp;Taiki Ando,&nbsp;Ayako Makiyama,&nbsp;Yuko Asanuma,&nbsp;Ken Yamaji,&nbsp;Naoto Tamura","doi":"10.1111/1756-185X.15338","DOIUrl":"https://doi.org/10.1111/1756-185X.15338","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin-associated muscle symptoms: A comprehensive exploration of epidemiology, pathophysiology, diagnosis, and clinical management strategies","authors":"Meera Shah,&nbsp;Karun Shrestha,&nbsp;Chih-Wei Tseng,&nbsp;Aman Goyal,&nbsp;Teerin Liewluck,&nbsp;Latika Gupta","doi":"10.1111/1756-185X.15337","DOIUrl":"https://doi.org/10.1111/1756-185X.15337","url":null,"abstract":"<p>Statins are the first line of treatment for both primary and secondary prevention of atherosclerotic cardiovascular disease. Despite the positive effects of statins on cardiovascular events, not all patients can use them at an optimized dose. The reason for this is the skeletal muscle side effects, termed statin-associated muscle symptoms (SAMS). Despite extensive research, the precise pathophysiology of SAMS remains unclear and multiple mechanisms may contribute to this phenomenon. Various therapeutic options are available for the management of SAMS, ranging from rechallenging with the same or a different statin to utilizing non-statin therapeutic alternatives in patients intolerant to statins. However, the lack of consensus on the definition of SAMS, the absence of a definitive diagnostic test, and lack of a universally accepted management algorithm pose a great challenge in dealing with this entity. This review aims to explore the various pathophysiological mechanisms involved in SAMS and understand the difference between self-limited toxic myopathy and immune-mediated myopathy requiring immunomodulatory therapy. The conundrum of statin withdrawal, tapering, and rechallenge in SAMS will also be explored in detail along with the newer non-statin therapies that are available.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling organoids in the context of rheumatoid arthritis","authors":"Haiyang Wang,&nbsp;Shiyu Du,&nbsp;Xiaohu Tang","doi":"10.1111/1756-185X.15326","DOIUrl":"https://doi.org/10.1111/1756-185X.15326","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography coronary angiography for imaging in children with Kawasaki disease: An update","authors":"Rakesh Kumar Pilania,&nbsp;Suprit Basu,&nbsp;Surjit Singh,&nbsp;Tapas Sabui,&nbsp;Manphool Singhal","doi":"10.1111/1756-185X.15331","DOIUrl":"https://doi.org/10.1111/1756-185X.15331","url":null,"abstract":"&lt;p&gt;Kawasaki disease (KD) is an acute febrile illness that usually affects children below 5. KD has a predilection for involvement of medium-sized arteries and the development of coronary artery abnormalities (CAAs) is an important complication.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; If untreated or diagnosed late, CAAs can occur in up to 25% of KD patients, but with prompt treatment, this can be reduced to &lt;5%.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; CAAs of KD need long-term surveillance as these are prone to the development of complications such as thrombosis, coronary artery calcification, and steno-occlusive lesions. Two-dimensional echocardiography (2DE) has been the imaging modality of choice in patients with KD both in the acute phase and during long-term follow-up. However, there are several inherent limitations of 2DE. Other modalities for coronary artery assessment in KD include invasive catheter coronary angiography (CCA), CT coronary angiography (CTCA), and magnetic resonance coronary angiography (MRCA).&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Recently, CTCA has become a feasible imaging modality that is being increasingly used in clinical practice for comprehensive assessment of CAAs in patients with KD.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; In this review, we have discussed the evolution and role of CTCA in KD.&lt;/p&gt;&lt;p&gt;Coronary artery abnormalities require prompt and accurate diagnosis as timely intervention prevents progression and complications.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; CAAs in the acute phase of illness include coronary artery dilatation and aneurysms. These may either undergo remodeling or show resolution, especially if the size is small. Larger CAAs may persist and may develop thrombosis or stenoses.&lt;span&gt;&lt;sup&gt;2, 4, 5&lt;/sup&gt;&lt;/span&gt; Precise and accurate imaging is required to evaluate these complications.&lt;/p&gt;&lt;p&gt;Two-dimensional echocardiography is the current standard for KD care, offering the advantages of noninvasiveness, cost-effectiveness, and convenience.&lt;span&gt;&lt;sup&gt;2, 6&lt;/sup&gt;&lt;/span&gt; However, it has several limitations like operator dependency, inability to assess the left circumflex artery, and distal segments of coronary arteries. Additionally, poor acoustic windows in older children hinder coronary artery assessment. Several complications (e.g., coronary thrombosis, calcifications, and stenosis) are liable to be missed on 2DE.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Coronary artery abnormalitie is the gold standard for detecting CAAs in patients with KD. However, it is invasive, has high radiation exposure, and cannot be frequently repeated. Also, it fails to demonstrate mural abnormalities.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Cardiac MR is time-intensive, often needs general anesthesia (especially in infants and young children who cannot do breath holding), and demands special expertise. MRCA is especially useful for the evaluation of coronary thromboses.&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt; Considering the limitations of 2DE, CCA, and MRCA, there is a requirement for an imaging technique that can address ","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscular polyarteritis nodosa detected by FDG-PET/CT","authors":"Yoshinori Taniguchi,&nbsp;Hirotaka Yamamoto","doi":"10.1111/1756-185X.15342","DOIUrl":"https://doi.org/10.1111/1756-185X.15342","url":null,"abstract":"<p>A 56-year-old woman presented with high-grade fever and myalgia of the lower extremity. Physical examination showed muscle tenderness of the lower extremity. Laboratory examinations revealed an elevated CRP level of 8.5 mg/dL, an erythrocyte sedimentation rate of 126 mm/h, and white blood cells 18.4 × 10⁹/L, but normal a creatine phosphokinase level of 42 U/L. ANCA and ANA were all negative. Hepatic and renal functions were normal. Human leukocyte antigen typing demonstrated positive A2, A31, B46, and B61 antigens. 18F-FDG-PET demonstrated medium-sized vessels with increased FDG uptake (Figure 1A, arrowheads), and axial views of fusion PET/CT images with color coding showed medium-sized vascular inflammation with increased FDG uptake (SUVmax 2.8) in superficial femoral artery, lateral femoral circumflex artery (Figure 1B–D, arrowheads), peroneal artery, and posterior tibial artery (Figure 1E,F, arrowheads), indicating vasculitis in lower extremity. MRI (fat-suppressed T2-weighted image) revealed quadriceps femoris, adductor, and gastrocnemial muscular inflammation (Figure 1G, black in white arrow). Biopsy specimen that was percutaneously taken from gastrocnemial muscle demonstrated medium-sized necrotizing arteritis (Figure 1I, white arrow) and its inflammatory effect on the muscle (Figure 1I, black in white arrow). The patient was diagnosed as having muscular polyarteritis nodosa (PAN). Her symptoms and laboratory findings were completely improved by treatments with prednisolone and azathioprine. Furthermore, MRI findings of gastrocnemial muscle also improved (Figure 1H). Muscular connective tissue uptake on FDG-PET/CT could guide the diagnosis toward PAN.<span>¹</span> This case highlights the value of PET-CT in the diagnosis of muscular PAN.</p><p>Taniguchi Y and Yamamoto H equally contributed to this manuscript.</p><p>The authors received no funding for this study.</p><p>The authors declare no conflict of interest.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15342","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival analysis of patients with primary Sjögren's syndrome in China: A multicenter retrospective cohort study","authors":"Li Yueting,&nbsp;Qiao Lin,&nbsp;Xu Jian,&nbsp;Duan Xinwang,&nbsp;Wang Yongfu,&nbsp;Xiao Weiguo,&nbsp;Kong Xiaodan,&nbsp;Li Qin,&nbsp;Yin Songlou,&nbsp;Zhang Liyun,&nbsp;Wu Lijun,&nbsp;Wu Chanyuan,&nbsp;Zhao Jiuliang,&nbsp;Wang Yanhong,&nbsp;Chen Siyun,&nbsp;Xu Dong,&nbsp;Li Mengtao,&nbsp;Zeng Xiaofeng,&nbsp;Zhao Yan","doi":"10.1111/1756-185X.15284","DOIUrl":"https://doi.org/10.1111/1756-185X.15284","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to evaluate the long-term survival, causes of death, and prognostic factors in Chinese patients with primary Sjögren syndrome (pSS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included patients with pSS registered in the Chinese Rheumatism Data Centre between May 2016 and December 2021, and collected baseline clinical, laboratory, and treatment data. Survival and standard mortality rates were calculated using general population mortality data. Factors related to mortality were identified using Cox proportional hazards regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 8588 patients included, 274 died during a median follow-up of 4.0 years. The overall standardized mortality ratio was 1.61 (95% CI: 1.43–1.81). Overall survival rates were 98.2% at 5 years and 93.8% at 10 years. The predominant causes of death were comorbidities, including cardiovascular diseases, tumors, and infections, while the most frequent pSS-related causes of death were interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH). Male sex, older age, ILD, PAH, and high EULAR Sjögren's syndrome disease activity index (ESSDAI), thrombocytopenia, anemia, high immunoglobulin A (IgA) level, and glucocorticoid treatment independently increased the mortality risk, while using hydroxychloroquine was a protective factor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Mortality rates have significantly increased in Chinese patients with pSS. Comorbidities, rather than pSS-related organ damage, were the main causes of death. All-cause mortality was associated with male sex, older age, ILD, PAH, high ESSDAI, thrombocytopenia, anemia, high IgA level, and glucocorticoid treatment, whereas hydroxychloroquine use might improve the long-term survival.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142234026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-cell senescence was correlated with early atherosclerosis in patients with systemic lupus erythematosus","authors":"Mirza Zaka Pratama,&nbsp;Cesarius Singgih Wahono,&nbsp;Ahmad Bayhaqi Nasir Aslam,&nbsp;Syahrul Chilmi,&nbsp;Vidia Purnama Sari,&nbsp;Anugrah Abdurrohman,&nbsp;Ike Sulistiyowati,&nbsp;Aldo Aditya,&nbsp;Maxie Felix Johono,&nbsp; Robert","doi":"10.1111/1756-185X.15339","DOIUrl":"https://doi.org/10.1111/1756-185X.15339","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the correlation between T-cell senescence with the atherosclerosis markers in patients with systemic lupus erythematosus (SLE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study participants were 40 female SLE patients aged 18–45 years who met the 2019 EULAR/ACR criteria and 40 healthy individuals. The atherosclerosis markers were investigated using the Doppler ultrasonography examinations to measure the cIMT (carotid intima-media thickness) and flow-mediated dilation (FMD) and serological markers using soluble ICAM-1 and VCAM-1. Flow cytometry of CD4⁺CD57⁺, CD8⁺CD57⁺, CD4⁺CD28^null, and CD8⁺CD28^null T cells were used to assess the immunosenescence markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cIMT (<i>p</i> &lt; .001), sICAM-1 (<i>p</i> &lt; .001), and sVCAM-1 (<i>p</i> &lt; .001) were significantly higher in SLE patients compared with control, while FMD was significantly lower in SLE patients (<i>p</i> &lt; .001). The percentages of all T-cell senescence markers are also significantly higher in SLE patients than in healthy individuals. Positive correlations were shown between cIMT with the CD4⁺CD57⁺ (<i>R</i> = .301, <i>p</i> = .005), CD4⁺CD28^null (<i>R</i> = .448, <i>p</i> &lt; .001), and CD8⁺CD28^null (<i>R</i> = .422, <i>p</i> &lt; .001). Conversely, negative correlations were demonstrated between the FMD with CD4⁺CD57⁺ (<i>R</i> = −.236, <i>p</i> = .023), CD8⁺CD57⁺ (<i>R</i> = −.409, <i>p</i> &lt; .001), CD4⁺CD28^null (<i>R</i> = −.422, <i>p</i> &lt; .001), and CD8⁺CD28^null (<i>R</i> = −.318, <i>p</i> = .003). The soluble markers of sICAM-1 and sVCAM-1 were also positively correlated with the T-cell senescence markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Early sign of atherosclerosis was demonstrated in patients with SLE in this study. T-cell senescence markers had significant correlations with the atherosclerosis markers, including the cIMT, FMD, and soluble adhesion molecules levels. Understanding the link between immunosenescence and atherosclerosis might help to identify a new method for early detection and treatment of atherosclerosis in SLE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142234028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}