International Journal of Rheumatic Diseases最新文献

{"title":"Metformin Suppress Th17 Differentiation and Function to Improve Glandular Function in Primary Sjögren's Syndrome.","authors":"Jian Wang, Mengli Liu, Zhou Fan, Zhuoyue Li, Longfei Wang, Lili Wang, Yongjun Mei, Zhirong Liu","doi":"10.1111/1756-185x.70669","DOIUrl":"https://doi.org/10.1111/1756-185x.70669","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the effects of metformin on T cell differentiation and the underlying mechanisms in NOD/Ltj mice, a model for primary Sjögren's syndrome (pSS). Specifically, we focus on metformin's role in modulating Th17 differentiation and its potential regulation through the mTOR/STAT3 signaling pathway.</p><p><strong>Methods: </strong>We established a metformin-treated pSS mouse model. Salivary flow rate, histological analysis, and flow cytometry were employed to assess inflammation and T cell subsets. Cytokine secretion was measured using qPCR, ELISA, and Western blot analysis. To investigate the molecular pathways involved, we examined mTOR/STAT3 signaling and administered mTOR and STAT3 agonists.</p><p><strong>Results: </strong>Metformin treatment significantly alleviated salivary gland inflammation and increased salivary flow in pSS mice. Flow cytometry showed that metformin reduced the proportions of Th1, Th2, and Th17 cells, while increasing Treg cells. The reduction in Th17 cells was the most prominent. Furthermore, metformin decreased the levels of pro-inflammatory cytokines (IL-21, IL-22, IFN-γ) and increased anti-inflammatory cytokines (IL-4, IL-10). Immunohistochemistry and Western blot analysis demonstrated that metformin inhibited IL-17 expression. Additionally, metformin treatment suppressed the mTOR/STAT3 signaling pathway, and mTOR/STAT3 agonists reversed the effects of metformin on Th17 differentiation.</p><p><strong>Conclusion: </strong>Metformin effectively modulates T cell differentiation and alleviates pSS symptoms, primarily by suppressing Th17 cell differentiation through the mTOR/STAT3 pathway. These findings provide insights into the therapeutic mechanisms of metformin in pSS and suggest its potential as a treatment strategy for immune-mediated diseases.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70669"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Biomarker Landscape in Still's Disease and Macrophage Activation Syndrome: Toward Precision Diagnosis and Management.","authors":"I-Chang Lai, Chen-Ching Wu, Pei-Fen Liao","doi":"10.1111/1756-185x.70672","DOIUrl":"https://doi.org/10.1111/1756-185x.70672","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70672"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: A Case of Refractory Polyarteritis Nodosa Treated With High-Dose Tofacitinib.","authors":"Roberto Pereira da Costa, Ana Rita Lopes, Pedro de Vasconcelos, Sofia Duarte, Nikita Khmelinskii","doi":"10.1111/1756-185x.70649","DOIUrl":"https://doi.org/10.1111/1756-185x.70649","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70649"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAR-T Therapies and Emerging Alternatives: Reassessing Cost-Effectiveness and Future Directions in Modern Immunotherapy.","authors":"Yen-Cheng Wang, Chia-Jung Li, Su-Boon Yong, Po-Cheng Shih","doi":"10.1111/1756-185x.70666","DOIUrl":"https://doi.org/10.1111/1756-185x.70666","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70666"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on \"Differential Impact of Concomitant Methotrexate and Glucocorticoid Dosages on Biologics and JAK Inhibitors: The ANSWER Cohort Study\".","authors":"Ching-Wei Wu, Renin Chang","doi":"10.1111/1756-185x.70677","DOIUrl":"https://doi.org/10.1111/1756-185x.70677","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70677"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Cardiovascular Mortality Associated With Systemic Connective Tissue Disorders in the United States: A 22-Year Population-Based National Analysis (1999-2020).","authors":"Chukwuemeka Christian Aghasili, Reuben Laryea Odai, Samuel A Mensah, Manfred Mate-Kole, Nathaniel Eyiah, Timothy Kopah, Albert Orhin, Isaac Adjei Opoku, Ikponmwosa Jude Ogieuhi, Gregory I Atafo, Martin E Matsumura","doi":"10.1111/1756-185x.70681","DOIUrl":"https://doi.org/10.1111/1756-185x.70681","url":null,"abstract":"<p><strong>Aim: </strong>To examine national trends and disparities in cardiovascular mortality associated with systemic connective tissue disorders (CTDs) in the United States from 1999 to 2020.</p><p><strong>Methods: </strong>We analyzed mortality data from the CDC WONDER database. Deaths were included where CTD (ICD-10: M05, M06, M30-M35) was the underlying cause and cardiovascular disease was a contributing cause. Age-adjusted mortality rates (AAMRs) per 1 000 000 were calculated using the 2000 US Standard Population. Joinpoint regression identified annual and average annual percentage changes. Analyses were stratified by sex, race/ethnicity, census region, and urbanization. Disease subgroup and state-level analyses were performed.</p><p><strong>Results: </strong>Between 1999 and 2020, 47 752 cardiovascular deaths occurred among individuals with systemic CTDs. The national AAMR declined from 14.4 to 8.2 per 1 000 000 (AAPC: -2.68%, 95% CI: -2.89 to -2.47, p < 0.001). Females had consistently higher mortality than males (average AAMR: 13.5 vs. 5.9 per 1 000 000; p < 0.001). Non-Hispanic Black individuals had the highest rates (average AAMR: 14.9 per 1 000 000), with widening disparities after 2008. Rural areas had higher mortality than urban areas (average AAMR: 11.4 vs. 9.9 per 1 000 000; p = 0.01). Subgroup analyses revealed heterogeneous trends across CTD subtypes, with SLE showing the slowest improvement (AAPC: -1.87%) and dermatomyositis the steepest decline (AAPC: -4.98%). State-level AAMRs ranged 2.2-fold, from 6.3 (District of Columbia) to 13.6 (Montana) per 1 000 000.</p><p><strong>Conclusions: </strong>Cardiovascular mortality associated with systemic CTDs has declined significantly over two decades; however, persistent racial disparities, urban-rural differences, heterogeneous disease-specific trends, and substantial geographic variation underscore the need for targeted, equitable interventions in this high-risk population.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70681"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Atypical Presentation of Nivolumab-Induced Immune-Related Vasculopathy Imitating Raynaud's Phenomenon in Lung Cancer.","authors":"Yasemin Bakkal Temi, Ayten Yazıcı","doi":"10.1111/1756-185x.70665","DOIUrl":"https://doi.org/10.1111/1756-185x.70665","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70665"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering 5th-Digit Sesamoiditis During Hand Ultrasound Examination.","authors":"Berkay Yalçınkaya, Hilmi Berkan Abacıoğlu, Ahmet Furkan Çolak, Adalet Elçin Yıldız, Levent Özçakar","doi":"10.1111/1756-185x.70671","DOIUrl":"https://doi.org/10.1111/1756-185x.70671","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70671"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations in Comparing Digital and in-Person Physical Therapy for Musculoskeletal Conditions.","authors":"Shih-Yu Chin, Wen-Bin Yeh, Renin Chang","doi":"10.1111/1756-185x.70678","DOIUrl":"https://doi.org/10.1111/1756-185x.70678","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70678"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Labyrinth of Rheumatic Disease: Finding the Optimal Path to Managing Cardiovascular Risk.","authors":"Jingying Wu, Qianyu Guo, Chongjuan Yin, James Cheng-Chung Wei, Li-Yun Zhang","doi":"10.1111/1756-185x.70654","DOIUrl":"https://doi.org/10.1111/1756-185x.70654","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 5","pages":"e70654"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}