International Journal of Rheumatic Diseases最新文献

{"title":"Association Between Traditional Chinese Medicine Use and Sepsis Risk and Glucocorticoid Exposure in Patients With Systemic Lupus Erythematosus: A Retrospective Cohort Study","authors":"Chiao-Hsuan Chu,&nbsp;Han-Hua Yu,&nbsp;Wei-Jen Cheng,&nbsp;Hsuan-Shu Shen,&nbsp;Po-Chuan Ko,&nbsp;Pei-Yi Cheng,&nbsp;Chen-Ying Wei","doi":"10.1111/1756-185x.70403","DOIUrl":"https://doi.org/10.1111/1756-185x.70403","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Sepsis greatly increases morbidity and mortality in patients with systemic lupus erythematosus (SLE). Conventional treatments, particularly glucocorticoids (GCs), raise infection risk. This retrospective cohort study aims to investigate the association of Traditional Chinese Medicine (TCM) use with sepsis incidence, mortality, and GC dependence in patients with SLE, based on data from the Chang Gung Research Database (CGRD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients in Taiwan with newly diagnosed SLE were enrolled from the CGRD between 2005 and 2020. They were stratified into groups based on TCM treatment post-diagnosis. Outcomes included sepsis incidence and the dose and duration of GC usage. Data were analyzed using Cox proportional hazard models and Kaplan–Meier analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 10 846 newly diagnosed patients with SLE, of whom 1801 received at least 28 days of TCM treatment, while 8302 did not. After propensity score matching, 5403 and 1801 individuals were included in the non-TCM and TCM groups, respectively, with no significant baseline differences in age, sex, biochemical profiles, and comorbidities between the groups. Integrative TCM usage was associated with a significantly lower risk of sepsis (adjusted hazard ratio [aHR]: 0.49; 95% confidence interval [CI]: 0.40–0.60, <i>p</i> &lt; 0.001) and mortality rate (aHR 0.52, 95% CI 0.44–0.60, <i>p</i> &lt; 0.001) over an 18-year period. Additionally, the TCM group had a significantly lower daily GC dose (1.74 vs. 2.47 units/day; <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TCM use was significantly associated with lower risks of sepsis and lower GC dosage in patients with SLE, suggesting its potential as an integrative therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Severe Legionnaires' Disease Complicated by Rhabdomyolysis and Acute Kidney Injury in a Patient With Rheumatoid Arthritis","authors":"Xiangni Wu,&nbsp;Amr Edrees","doi":"10.1111/1756-185x.70407","DOIUrl":"https://doi.org/10.1111/1756-185x.70407","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Traditional Chinese Medicine Rehabilitation Program on Knee Osteoarthritis in Aging Population: A Multicenter Randomized Controlled Trial","authors":"Weihong Zhong,&nbsp;Jiajia Ye,&nbsp;Daniel Kwasi Ahorsu,&nbsp;Xiaoqin Chen,&nbsp;Shanli Yang","doi":"10.1111/1756-185x.70398","DOIUrl":"https://doi.org/10.1111/1756-185x.70398","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Knee osteoarthritis (KOA) is a prevalent degenerative disease that causes pain and disability in older individuals. This study aimed to examine the effects of the traditional Chinese medicine (TCM) rehabilitation program for aging populations with KOA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 101 participants with KOA were randomly assigned to either a TCM rehabilitation group (<i>n</i> = 49) or a conventional physical therapy group (<i>n</i> = 52) with a 1:1 allocation ratio for this randomized controlled trial. Participants in the TCM group received acupuncture, massage, and South Shaolin exercise training for 4 weeks, with three sessions per week lasting 50 min per session. Participants in the control group received conventional physical therapies of equal duration and frequency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Outcomes were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), Knee Outcome Survey Activities of Daily Living Scale, the 6-min Walking test (6MWT), the Time Up and Go (TUG) Test, and the Stair-climbing Test. Significant improvements were observed in the WOMAC, VAS, 6MWT, TUG, and Stair-climbing test after a 4-week TCM rehabilitation intervention (<i>p</i> &lt; 0.05). The WOMAC and VAS were found to be decreased at the 4-week follow-up assessments compared to baseline scores (<i>p</i> &lt; 0.05). Only the TUG test showed significant changes in the control group compared with the TCM rehabilitation group (<i>p</i> = 0.043) after 4 weeks post-intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The TCM rehabilitation program improved knee function and reduced pain intensity in aging populations with knee osteoarthritis. Well-designed randomized controlled trials with long-term follow-up assessments are needed to draw more definitive conclusions. Trial registration Chinese Clinical Trial Register ChiCTR2000033351, date of registration: May 29, 2020.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Pediatric Generalized Pustular Psoriasis With Adalimumab: Case Report and Literature Review","authors":"Yandie Li,&nbsp;Yiping Xu,&nbsp;Qi Zheng,&nbsp;Jianqiang Wu,&nbsp;Lixia Zou,&nbsp;Meiping Lu","doi":"10.1111/1756-185x.70396","DOIUrl":"https://doi.org/10.1111/1756-185x.70396","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Facet Joint Ankylosis in Patients With Axial Spondyloarthritis Serves as a Surrogate Radiographic Indicator of Propensity for Bone Formation","authors":"In-Woon Baek,&nbsp;Seung Min Jung,&nbsp;Yun-Jung Park,&nbsp;Kyung-Su Park,&nbsp;Ki-Jo Kim","doi":"10.1111/1756-185x.70406","DOIUrl":"https://doi.org/10.1111/1756-185x.70406","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the involvement of facet joints and its clinical implications during the treatment course in patients with axial spondyloarthritis (axSpA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a retrospective observational study. Radiographs of the cervical and lumbar spine were evaluated for 799 patients with axSpA using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) and the de Vlam methods. Differences in radiographic progression indices and initiation of TNF inhibitors between patients with and without facet joint fusion were investigated using propensity score matching.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Facet joint involvement at the cervical spine was observed in a subset of patients with axSpA (20.6%). Patients with facet joint fusion (<i>n</i> = 71) had higher mSASSS and a higher number of syndesmophytes at both cervical and lumbar levels compared with the matched patients without facet joint fusion. Dagger signs and trolley-track signs were more commonly observed (<i>p</i> &lt; 0.001), and trolley-track signs developed more frequently in patients with facet joint fusion during follow-up (Δ9/49 vs. Δ1/68, <i>p</i> = 0.0038). Disease activity score and CRP level at baseline were also significantly higher in patients with facet joint fusion. The risk of initiation of TNF inhibitor was significantly higher in patients with facet joint fusion (hazard ratio [95% CI] 1.909 [1.187, 3.07], <i>p</i> = 0.007).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Facet joint involvement in the cervical spine was identified in a subset of patients with axSpA and was closely associated with advanced radiographic structural damage and the initiation of TNF inhibitors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinician Counseling for Weight Loss and Physical Activity Among US Adults With Arthritis, 2019 and 2023: A Cross-Sectional Study","authors":"Haowei Chen,&nbsp;Zhaohua Zhu,&nbsp;David J. Hunter,&nbsp;Changhai Ding","doi":"10.1111/1756-185x.70401","DOIUrl":"https://doi.org/10.1111/1756-185x.70401","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Update of Chinese Guidelines for Management of Hyperuricemia and Gout Part II: Recommendations for Patients With Common Comorbidities","authors":"Changgui Li,&nbsp;Mingshu Sun,&nbsp;Zhen Liu,&nbsp;Detian Li,&nbsp;Changqian Wang,&nbsp;Zibin Tian,&nbsp;Yuxiang Dai,&nbsp;Zhe Feng,&nbsp;Chengfu Xu,&nbsp;Dongbao Zhao,&nbsp;Feng Wei,&nbsp;Bo Ban,&nbsp;Chao Xie,&nbsp;Zhenmei An,&nbsp;Jia Liu,&nbsp;Zhuo Li,&nbsp;Yuwei He,&nbsp;Xinde Li,&nbsp;Fei Yan,&nbsp;Lin Han,&nbsp;Lidan Ma,&nbsp;Xiaoyu Cheng,&nbsp;Tian Liu,&nbsp;Xufei Luo,&nbsp;Lingling Cui,&nbsp;Ying Gong,&nbsp;Can Wang,&nbsp;Yaolong Chen,&nbsp;Zhaohui Lyu,&nbsp;Ronald M. L. Yip,&nbsp;Jiajun Zhao","doi":"10.1111/1756-185x.70402","DOIUrl":"https://doi.org/10.1111/1756-185x.70402","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this updated guideline is to provide comprehensive recommendations for the management of gout in patients with common comorbidities, such as chronic kidney disease (CKD), cardiovascular disease (CVD), diabetes, osteoarthritis (OA), and gastrointestinal disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This guideline was developed by a multidisciplinary expert panel consisting of specialists in endocrinology, rheumatology, nephrology, cardiology, gastroenterology, and methodology. The development process adhered to standard methodologies, including PICO (population, intervention, comparator, and outcomes) question deconstruction, systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) for evidence and recommendation evaluation, Delphi voting, and expert consensus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The guideline presents 26 evidence-based recommendations addressing seven clinical questions for patients with hyperuricemia and gout in the context of comorbidities. Key recommendations include the maintenance of strict serum urate targets, particularly for patients with CKD stage ≥ 3, chronic gouty arthritis, and OA, in order to prevent disease progression. In patients with CVD or diabetes, intra-articular triamcinolone is preferred over systemic glucocorticoids. Prioritized anti-inflammatory treatments for patients with CKD, gastrointestinal diseases, and OA are recommended. The guideline also introduces emerging therapies, such as interleukin-1 inhibitors and selective urate transport inhibitors, as potential treatment options for refractory cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The update offers a comprehensive, patient-centered approach to managing gout, particularly in individuals with associated comorbidities. Multidisciplinary collaboration and emerging new treatments and evidence ensure the optimization of the recommendations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Systemic Lupus Erythematosus in GATA2 Deficiency: Expanding the Spectrum of Rheumatological Features","authors":"Joydeep Samanta,&nbsp;Manish Kumar,&nbsp;Dibakar Sahu,&nbsp;Jhasaketan Meher,&nbsp;Vinay R. Pandit","doi":"10.1111/1756-185x.70404","DOIUrl":"https://doi.org/10.1111/1756-185x.70404","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatic Diseases and Sinusitis: Epidemiological Features, Immune Mechanisms, and Treatment Challenges","authors":"Ping-Ting Zhou,&nbsp;Zi-Hui Xie,&nbsp;Jian-Peng Wang,&nbsp;Yu-Chen Liu,&nbsp;Hai-Feng Pan","doi":"10.1111/1756-185x.70399","DOIUrl":"https://doi.org/10.1111/1756-185x.70399","url":null,"abstract":"&lt;p&gt;Rheumatic diseases are a diverse group of chronic disorders primarily affecting the joints, bones, muscles, and connective tissues, often involving internal organs, blood vessels, and the nervous system. They encompass systemic autoimmune diseases (e.g., systemic lupus erythematosus), inflammatory arthritides (e.g., rheumatoid arthritis), metabolic arthropathies (e.g., gout), degenerative conditions (e.g., osteoarthritis), and infection-related arthritis. In recent years, with the deepening understanding of immune-related diseases, researchers have gradually noticed a possible comorbid relationship between sinusitis and various rheumatic diseases. Sinusitis is considered a disease characterized by mucosal barrier dysfunction, chronic inflammation, and immune dysregulation. These features are also reflected in rheumatic diseases. Moreover, research has shown that patients with rheumatic diseases have a significantly increased risk of developing sinusitis [&lt;span&gt;1&lt;/span&gt;]. Based on this epidemiological characteristic, our study delves deeply into the association between RD and sinusitis regarding common immune pathways and molecular mechanisms cross-talk as well as drug treatment aspects, aiming to provide guiding insights for the future diagnosis and treatment of comorbidities between the two diseases, thereby improving the quality of life for patients.&lt;/p&gt;&lt;p&gt;Although the potential link between RD and sinusitis has garnered growing attention, relevant research still faces significant limitations. We reviewed research from PubMed, Web of Science, Embase, Cochrane, and Scope databases and summarized current findings (Figure S1; Table 1; Table S1). The results show new research advances in this field every year (Figure S2A). The published literature predominantly focuses on drug treatment (&lt;i&gt;n&lt;/i&gt; = 27), clinical correlation (&lt;i&gt;n&lt;/i&gt; = 22), molecular mechanisms (&lt;i&gt;n&lt;/i&gt; = 6), diagnostic management (&lt;i&gt;n&lt;/i&gt; = 4), physical therapy (&lt;i&gt;n&lt;/i&gt; = 2), and spa therapy (&lt;i&gt;n&lt;/i&gt; = 1) (Figure S2B). Research on drug treatment and clinical correlation is abundant, yet exploration of molecular mechanisms and drug development remains limited.&lt;/p&gt;&lt;p&gt;Further keyword clustering analysis of the literature in the Web of Science Core Collection (WOSCC) database (Figure S3) revealed that the research hotspots in this field focus on molecular mechanisms (blue cluster), drug treatment and pharmacological mechanisms (green, yellow, and red clusters), and clinical management (purple cluster). Research on molecular mechanisms has received considerable attention. Although some studies indicate that immune dysregulation and chronic inflammation may be common pathological features of RD and sinusitis [&lt;span&gt;2&lt;/span&gt;], the specific relationship between their onset and development remains unclear. Identification of specific immune pathways and key molecular markers remains limited.&lt;/p&gt;&lt;p&gt;Drug therapy is the primary focus of this field. Current research examines the effects ","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unequal Risk Relationship Between Sjögren's Syndrome and Autoimmune Thyroid Disease: A Mendelian Randomization Study","authors":"Jingyi Wu,&nbsp;Chenxi Yang,&nbsp;Yunfeng Yu,&nbsp;Gang Hu,&nbsp;Rong Yu,&nbsp;Chuanlong Zhou","doi":"10.1111/1756-185x.70358","DOIUrl":"https://doi.org/10.1111/1756-185x.70358","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"28 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}