International Journal of Rheumatic Diseases最新文献

{"title":"A Study on the Diagnostic Value of Dual-Energy CT (DECT) Imaging in Patients With Gouty Arthritis","authors":"YiXin Luan, XingShuai Gao","doi":"10.1111/1756-185X.15431","DOIUrl":"https://doi.org/10.1111/1756-185X.15431","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To explore the diagnostic value of dual-energy computed tomography (DECT) in patients with gouty arthritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 160 patients with gouty arthritis who were treated in our hospital from January 2023 to October 2023 were selected as the research subjects. The participants were randomly divided into two groups: an observation group and a control group. Each group had 80 cases. Observation group performed DECT examination and control group performed X-ray examination. The researchers recorded the general information of the participants in both groups and conducted single-factor analysis. They compared the detection of positive diseased joints between the two groups, as well as compared the distribution of positive diseased joints. In addition, the number of joint lesions was compared in the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were not any statistically great differences between the two groups in gender, age, BMI, disease duration, blood uric acid, and erythrocyte sedimentation rate (<i>p</i> > 0.05). During the DECT examination, a total of 82 positive diseased joints were identified in the observation group. The observation group also had a positive rate of 85.42% (82/96) in the DECT examination. While the control group had a total of 55 positive diseased joints during the X-ray examination with a positive rate of 59.78% (55/92). The difference between the two groups of patients in the positive rate of two kinds of examination was statistically significant (<i>χ</i><sup>2</sup> = 15.616, <i>p</i> < 0.001). No statistical significance was found in the distribution of the number of positive diseased joints between two groups (<i>χ</i><sup>2</sup> = 1.986, <i>p</i> = 0.851). Both DECT and X-ray examinations of patients in the two groups revealed that the lesions were primarily located in the soft tissues or ligaments surrounding the distal small joints of the limbs, such as metatarsophalangeal joints, ankle joints, and proximal interphalangeal joints. Compared with the X-ray examination of the patients, the DECT examination of the patients showed a great increase in the number of bone destruction, gout nodules, and soft tissue swelling (<i>χ</i><sup>2</sup> = 7.712, 10.441, 5.389, <i>p</i> = 0.005, 0.001, 0.020). Moreover, the DECT examination of patients showed the presence of urate crystals and joint effusion, while the X-ray examination of patients in the control group did not show any.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 ","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transparent and Reproducible Research Practices in Rheumatology: Protocol for A 20-Year Longitudinal Analysis","authors":"Chak Kwan Cheung, Hugo W. F. Mak, Julio Lau, Shirley C. W. Chan, Philip H. Li","doi":"10.1111/1756-185X.15429","DOIUrl":"https://doi.org/10.1111/1756-185X.15429","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Extended Vascular Screening Be Performed in All Asymptomatic Behçet's Disease Patients With Previously Diagnosed Vascular Involvement or Unexplained Inflammatory Response?","authors":"Haner Direskeneli, Kerem Yiğit Abacar, Fatma Alibaz-Oner","doi":"10.1111/1756-185X.15435","DOIUrl":"https://doi.org/10.1111/1756-185X.15435","url":null,"abstract":"<p>Behçet's disease (BD) usually start with mucocutaneous symptoms such as orogenital ulcers and later on develop ocular, vascular, gastrointestinal, and neurological manifestations [<span>1</span>]. Oral ulcers are the first manifestation in up to two thirds, whereas ocular manifestations (~50%) are usually observed in the first few years and vascular disease in 5–10 years of follow-up [<span>2, 3</span>]. However, as major organ manifestations can be the first manifestation without orogenital ulcers, the hallmark of the disease, diagnosis can be delayed [<span>4</span>]. Recently, efforts to increase diagnostic tools in BD has shown “femoral vein wall assessment” with Doppler US as a useful diagnostic test for BD [<span>5</span>].</p><p>Disease monitoring in early Behçet's disease is usually limited to multi-systemic assessment of symptoms or signs with laboratory tests to detect systemic inflammation (with routinely available acute-phase reactant biomarkers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)) or necessary for drug monitorization. As most patients with early disease has mainly mucocutaneous manifestations, this approach is usually sufficient. However, in centers experienced in severe BD and working with ethnicities with a high-risk of major organ involvement, all patients are seen by ophthalmologists for early asymptomatic disease. In a recent study, Uçar et al. observed that BD patients without uveitis but with cellular debris in the anterior vitreous have a higher risk of clinically significant ocular disease (22% vs. 1%) during follow-up [<span>6</span>]. Therefore, subclinical ocular findings might have prognostic implications in patients with BD screened for ocular involvement.</p><p>Vascular disease in BD is reported to be 15%–50% in different series with the highest prevalence around the Mediterranean basin [<span>2, 3, 7</span>]. In addition to genetic factors, follow-up of patients in different specialties such as dermatology or ophthalmology can also explain different prevalences, as guidelines for systemic disease monitoring is not established.</p><p>Vascular disease in BD has characteristics of a variable-vessel vasculitis involving both venous and arterial systems [<span>2, 8</span>]. Patients are usually young males in the third/fourth decades and present most frequently (up to 70%) with superficial thrombophlebitis or deep vein thrombosis of the lower extremities (DVT) [<span>9, 10</span>]. Any male, physically active young patient presenting with DVT without traditional risk factors (immobility, surgery, etc.) should lead an experienced clinician to a search for the diagnosis of BD, at least in regions with a high prevalence of vascular-BD. About 10% of the cases with a further diagnosis of BD can have a vascular event as the first manifestation without mucocutaneous features [<span>10</span>]. In patients without immune-suppressive treatment after the first attack, relapses are observed in up to 5","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Modern Epidemic of Autoimmunity","authors":"Jie-Fu Zheng,&nbsp;Yung-Heng Lee,&nbsp;Pui-Ying Leong","doi":"10.1111/1756-185X.15426","DOIUrl":"https://doi.org/10.1111/1756-185X.15426","url":null,"abstract":"<p>Autoimmunity occurs when the immune system mistakenly attacks the body, but the presence of autoantibodies, such as antinuclear antibodies (ANAs), does not always lead to autoimmune diseases. Globally, autoimmunity is on the rise, influenced by socioeconomic factors, environmental exposure, diet, and stress. Climate change and pollution further exacerbate risks. The COVID-19 pandemic has worsened the issue, with unvaccinated individuals showing higher rates of autoimmune conditions postinfection. Preventive strategies, including healthy diets, stress management, and vaccination, are crucial in combating this growing epidemic. Collaboration between individuals, healthcare providers, and policymakers is critical to mitigate the rise in autoimmune disorders and enhance public health.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185X.15426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anasarca and Systemic Capillary Leak Syndrome as an Unusual Presentation of Juvenile Dermatomyositis: Report of Three Cases and Case-Based Review","authors":"Srinivasavaradan Govindarajan,&nbsp;Aswani Rajan,&nbsp;Puttashankariah Likhitha,&nbsp;Shivaprasad Pannasamudra Mohankumar,&nbsp;Pragati Jain,&nbsp;Manisha Jana,&nbsp;Narendra Kumar Bagri,&nbsp;Pankaj Hari,&nbsp;Rakesh Lodha","doi":"10.1111/1756-185X.15425","DOIUrl":"https://doi.org/10.1111/1756-185X.15425","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic Cushing's Syndrome With Lipid Deposition in Spinal Canal","authors":"Yong Chen,&nbsp;Cai-Lin Li,&nbsp;Yan-Juan Chen,&nbsp;Juan Chen","doi":"10.1111/1756-185X.15424","DOIUrl":"https://doi.org/10.1111/1756-185X.15424","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Health-Related Quality of Life in Brazilian Patients With Idiopathic Inflammatory Myopathies","authors":"Letícia Queiroga de Figueiredo,&nbsp;Rafael Alves Cordeiro,&nbsp;Samuel Katsuyuki Shinjo","doi":"10.1111/1756-185X.15423","DOIUrl":"https://doi.org/10.1111/1756-185X.15423","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scavenger receptor-A is a sensitive disease activity biomarker in ESR and CRP normal rheumatoid arthritis","authors":"Shixiong Cao,&nbsp;Xu Liu,&nbsp;Yang Xie,&nbsp;Fanlei Hu,&nbsp;Zhanguo Li,&nbsp;Yin Su,&nbsp;Li Luo,&nbsp;Xiaolin Sun","doi":"10.1111/1756-185X.15404","DOIUrl":"10.1111/1756-185X.15404","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Identification of rheumatoid arthritis (RA) patients in active disease with normal ESR and CRP is a challenge in disease activity assessment. The objective of this study was to evaluate the performance and clinical significance of Scavenger receptor-A (SRA) as a disease activity biomarker in RA, especially in ESR and CRP normal patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred and sixty-two RA (40 discovery cohort; 122 validation cohort), 20 osteoarthritis (OA), and 36 healthy controls (HCs) were recruited. Ten disease activity markers were evaluated by Bio-Plex Pro Human Cytokine Assay in the discovery cohort. SRA levels were measured by enzyme-linked immunosorbent assay (ELISA) in the validation cohort. The association between SRA and clinical phenotypes was also analyzed. ROC analysis was performed for disease activity prediction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SRA was found to be correlated with disease activity in the discovery cohort. The serum SRA level was verified by ELISA in the validation cohort, and was found to be correlated with disease activity index in RA patients, including DAS28-ESR (<i>r</i> = .477, <i>p</i> &lt; .001), swollen joint counts, and tender joint counts; as well as inflammation markers, including ESR and CRP. In ESR and CRP normal RA, there was a strong correlation between SRA and DAS28-ESR (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msup>\u0000 <mi>χ</mi>\u0000 <mn>2</mn>\u0000 </msup>\u0000 </mrow>\u0000 <annotation>$$ {chi}^2 $$</annotation>\u0000 </semantics></math> = 4.564, <i>p</i> = .003). In addition, area under the ROC of SRA was higher than AUC_ESR and AUC_CRP in ESR and CRP normal RA patients, suggesting that serum SRA could be more sensitive than ESR and CRP for disease activity assessment in this group of patients. In the low DAS28-ESR (≤3.2) group, the AUC of SRA for disease activity measurement was higher than that of ESR and CRP, indicating that SRA was also more sensitive than ESR and CRP in low-disease activity RA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SRA was correlated with RA disease activity and may be a sensitive serum biomarker for disease activity evaluation, especially in ESR and CRP normal patients, as well as in the low-disease activity group. SRA could be a promising marker for disease activity assessment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: ISG15 Deficiency and a Glimpse Into Autoimmunity","authors":"Lujayn Akbar,&nbsp;Bashayer Alawam,&nbsp;Meshal Alhassan,&nbsp;Sarah Yousef Faisal,&nbsp;Mohammed Ahmed Al-Omari,&nbsp;Sulaiman Mohammed Al-Mayouf","doi":"10.1111/1756-185X.15420","DOIUrl":"https://doi.org/10.1111/1756-185X.15420","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of an Osteoporosis Refracture Prevention Program—A Comparison of Two Australian Rural Centers Using Population Database Linkage","authors":"Peter K. K. Wong,&nbsp;Aedan Roberts,&nbsp;Tracey Ho,&nbsp;Sandy Fraser,&nbsp;Julia Thompson,&nbsp;Jennifer Williamson,&nbsp;Elizabeth Hay","doi":"10.1111/1756-185X.15421","DOIUrl":"https://doi.org/10.1111/1756-185X.15421","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}