Bleed and Blister: A Case Report of a 40-Year-Old Woman With Hemorrhagic Bullous Henoch-Schonlein Purpura

Abstract

Henoch-Schonlein Purpura (HSP) is a rare immune vasculitis affecting small blood vessels. Hemorrhagic-bullous conversion of HSP is even rarer, especially in adults, and remains poorly characterized. We present a unique case of a 40-year-old female with hemorrhagic-bullous HSP. The patient presented with maculopapular and vesicular rashes, progressing to bullae predominantly on the bilateral legs. Past history included a similar episode at 17 years old. Laboratory findings showed elevated inflammatory markers, microscopic hematuria, and fecal occult blood. Skin biopsy confirmed leukocytoclastic vasculitis. Immunosuppression with hydrocortisone, colchicine, and azathioprine was initiated. Methylprednisolone pulse therapy was given; transitioning to prednisone. Concurrent urinary tract infection and nephrolithiasis were addressed. Lesions regressed, and the patient was discharged on a tapering prednisone regimen. HSP, particularly the hemorrhagic-bullous variant, is a diagnostic challenge; management remains varied. This case contributes to understanding this rare manifestation and emphasizes the importance of a multidisciplinary approach for optimal patient outcomes.