Exploring the Relationship Between Alcohol Consumption and Gout: A Narrative Review

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2025-09-19 DOI:10.1111/1756-185x.70421

María Cristina Martínez-Ávila, Paul Alejandro Mendez-Patarroyo, Alieth Lucía Acosta Cardozo, Gerardo Quintana-López, Wilson Bautista-Molano

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引用次数: 0

Abstract

Gout, a chronic inflammatory condition, is intricately linked to lifestyle factors such as diet and alcohol consumption. Alcohol significantly influences gout development and flares through mechanisms including hyperuricemia, oxidative stress, and purine metabolism. The impact of alcohol varies by type and quantity, with beer and spirits posing a higher risk due to their purine and ethanol content, while moderate wine consumption may confer potential anti-inflammatory benefits. Recent advances underscore the multifactorial nature of gout, revealing how host genetics and epigenetic modifications modulate alcohol's effects. Variants in genes regulating urate transport (SLC2A9, ABCG2) and alcohol metabolism (ADH1B, ALDH2) influence individual susceptibility, highlighting the need for personalized management strategies. This narrative review synthesizes evidence from genetics, lifestyle, and public health perspectives, emphasizing the importance of moderation, pharmacogenomics, and tailored interventions in improving gout outcomes.

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探索酒精消费与痛风之间的关系：一个叙述性的回顾。

痛风是一种慢性炎症，与饮食和饮酒等生活方式因素有着复杂的联系。酒精通过高尿酸血症、氧化应激和嘌呤代谢等机制显著影响痛风的发展和发作。酒精的影响因种类和数量而异，啤酒和烈酒因其嘌呤和乙醇含量而风险更高，而适量饮用葡萄酒可能具有潜在的抗炎作用。最近的进展强调痛风的多因素性质，揭示了宿主遗传和表观遗传修饰如何调节酒精的作用。调节尿酸转运（SLC2A9, ABCG2）和酒精代谢（ADH1B, ALDH2）的基因变异影响个体易感性，强调个性化管理策略的必要性。这篇叙述性综述综合了遗传学、生活方式和公共卫生方面的证据，强调了适度、药物基因组学和量身定制的干预措施对改善痛风结局的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.