A Scoping Review of Respiratory Dysfunction in Inclusion Body Myositis

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2025-09-05 DOI:10.1111/1756-185x.70409

Kevin Renz Ambrocio, Bianca R. Ragusa, Rohit Aggarwal, David Lacomis, Gail Kouame, Kendrea L. Garand, Focht

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引用次数: 0

Abstract

Objectives

Inclusion body myositis (IBM) can result in deadly respiratory consequences. Yet, the mechanism driving this issue remains equivocal. We mapped the literature to identify physiological respiratory characteristics in IBM and the types of respiratory assessments used.

Methods

We performed a scoping review using seven databases and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines.

Results

Our search yielded 381 studies, of which 17 studies were reviewed. Case studies/series predominated (53%). Studies mainly used pulmonary function testing (76%), suggesting restrictive respiratory abnormalities. However, insufficient reporting of race/ethnicity (82%), disease duration (59%) and severity (77%), and assessment operations (82%) and interpretation (59%) protocols were problematic. Half of the studies relied on standalone assessments, and 75% of studies that reported interpretation protocols applied interpretation cutoff thresholds.

Conclusion

Low-level evidence guides our understanding of IBM-induced respiratory dysfunction. Future studies should ensure detailed and transparent reporting and follow current best practices for respiratory assessment to define IBM-induced respiratory dysfunction.

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包涵体肌炎呼吸功能障碍的综述

目的包涵体肌炎（IBM）可导致致命的呼吸后果。然而，推动这一问题的机制仍然模棱两可。我们对文献进行了映射，以确定IBM的生理呼吸特征和所使用的呼吸评估类型。方法：我们使用7个数据库和系统评价首选报告项目和meta分析扩展范围评价（PRISMA-ScR）指南进行范围评价。结果我们检索到381项研究，其中17项研究被回顾。案例研究/系列占主导地位（53%）。研究主要使用肺功能检查（76%），提示限制性呼吸异常。然而，种族/民族（82%）、疾病持续时间（59%）和严重程度（77%）以及评估操作（82%）和解释（59%）方案的报告不足存在问题。一半的研究依赖于独立评估，75%报告解释方案的研究应用了解释截止阈值。结论低水平的证据指导我们对ibm引起的呼吸功能障碍的认识。未来的研究应确保详细和透明的报告，并遵循当前呼吸评估的最佳实践，以定义ibm引起的呼吸功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.