Vitamin D Status in Paraguayan Children With Autoimmune Diseases

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2025-09-04 DOI:10.1111/1756-185x.70408

Zoilo Morel, Lourdes Paredes, Irene Benítez, Hassel Jimmy Jiménez, María Leticia Ramírez Pastore

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引用次数: 0

Abstract

Introduction

Vitamin D plays a crucial role in modulating the immune system. Numerous studies have elucidated the association between low serum levels of vitamin D and autoimmune diseases. Vitamin D deficiency has been implicated in systemic lupus erythematosus, rheumatoid arthritis (RA), Hashimoto's thyroiditis, juvenile dermatomyositis, inflammatory bowel disease, among others.

Objective

This study aims to assess the vitamin D levels in a cohort of pediatric patients diagnosed with autoimmune diseases.

Methodology

This descriptive study, complemented with an analytical cross-sectional component, enrolled individuals under the age of 18 diagnosed with autoimmune disorders who underwent vitamin D assessment. The study spanned from January 2016 to December 2020 and was conducted across three specialized clinics.

Results

Among the 81 pediatric patients with autoimmune pathologies enrolled during the study period, 60 (74.04%) were female. The mean age of the participants at the time of the study was 9 years, ranging from 2 to 17 years old. Of the total cohort, 78 individuals (96.3%) were Latin-American. The most prevalent diagnosis was Juvenile Idiopathic Arthritis (JIA) in 53 patients (65.43%), followed by autoimmune thyroiditis in 9 patients (11.11%), systemic lupus erythematosus (SLE) in 8 patients (9.88%), and other conditions in 11 patients (11.11%), including dermatomyositis and celiac disease. Regarding vitamin D levels, the mean concentration was 24.69 ng/mL. Specifically, 19 patients (23.46%) had sufficient levels (≥ 30 ng/mL), 41 patients (50.62%) had insufficiency, 20 patients (24.69%) had deficiency, and 1 patient (1.23%) had severe deficiency. No statistically significant differences were observed between vitamin D levels and sex (p = 0.82), age (p = 0.88), disease remission (p = 0.97), antinuclear antibody (ANA) value (p = 0.78), or season of the year.

Conclusion

Our findings suggest that the currently referenced levels of vitamin D do not exhibit a significant correlation with disease activity in pediatric patients with autoimmune diseases.

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巴拉圭自身免疫性疾病儿童维生素D水平

维生素D在调节免疫系统中起着至关重要的作用。许多研究已经阐明了低血清维生素D水平与自身免疫性疾病之间的联系。维生素D缺乏与系统性红斑狼疮、类风湿性关节炎（RA）、桥本甲状腺炎、青少年皮肌炎、炎症性肠病等疾病有关。目的本研究旨在评估诊断为自身免疫性疾病的儿科患者队列中的维生素D水平。这项描述性研究，辅以分析性横断面成分，招募了18岁以下被诊断患有自身免疫性疾病并接受维生素D评估的个体。这项研究从2016年1月持续到2020年12月，在三个专业诊所进行。结果81例有自身免疫性疾病的儿童患者中，60例（74.04%）为女性。参与者在研究时的平均年龄为9岁，从2岁到17岁不等。在整个队列中，78人（96.3%）是拉丁美洲人。诊断最多的是幼年特发性关节炎（JIA） 53例（65.43%），其次是自身免疫性甲状腺炎9例（11.11%），系统性红斑狼疮（SLE） 8例（9.88%），皮肌炎、乳糜泻等其他疾病11例（11.11%）。关于维生素D水平，平均浓度为24.69 ng/mL。其中，充足（≥30 ng/mL） 19例（23.46%），不足41例（50.62%），缺乏20例（24.69%），严重缺乏1例（1.23%）。维生素D水平与性别（p = 0.82）、年龄（p = 0.88）、疾病缓解程度（p = 0.97）、抗核抗体（ANA）值（p = 0.78）和季节之间无统计学差异。结论：我们的研究结果表明，目前维生素D的参考水平与患有自身免疫性疾病的儿科患者的疾病活动没有显着相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.