International Journal of Retina and Vitreous最新文献

{"title":"Deep learning assisted analysis of biomarker changes in refractory neovascular AMD after switch to faricimab.","authors":"Michael Hafner, Franziska Eckardt, Jakob Siedlecki, Benedikt Schworm, Tina R Herold, Ben Asani, Siegfried G Priglinger, Johannes B Schiefelbein","doi":"10.1186/s40942-025-00669-2","DOIUrl":"https://doi.org/10.1186/s40942-025-00669-2","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI)-driven biomarker segmentation offers an objective and reproducible approach for quantifying key anatomical features in neovascular age-related macular degeneration (nAMD) using optical coherence tomography (OCT). Currently, Faricimab, a novel bispecific inhibitor of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2), offers new potential in the management of nAMD, particularly in treatment-resistant cases. This study utilizes an advanced deep learning-based segmentation algorithm to analyze OCT biomarkers and evaluate the efficacy and durability of Faricimab over nine months in patients with therapy-refractory nAMD.</p><p><strong>Methods: </strong>This retrospective real-world study analyzed patients with treatment-resistant nAMD who switched to Faricimab following inadequate responses to ranibizumab or aflibercept. Automated segmentation of key OCT biomarkers - including fibrovascular pigment epithelium detachment (fvPED), intraretinal fluid (IRF), subretinal fluid (SRF), subretinal hyperreflective material (SHRM), choroidal volume, and central retinal thickness (CRT) - was conducted using a deep learning algorithm based on a convolutional neural network.</p><p><strong>Results: </strong>A total of 46 eyes from 41 patients completed the nine-month follow-up. Significant reductions in SRF, fvPED, and choroidal volume were observed from baseline (mo0) to three months (mo3) and sustained at nine months (mo9). CRT decreased significantly from 342.7 (interquartile range (iqr): 117.1) µm at mo0 to 296.6 (iqr: 84.3) µm at mo3 and 310.2 (iqr: 93.6) µm at mo9. The deep learning model provided precise quantification of biomarkers, enabling reliable tracking of disease progression. The median injection interval extended from 35 (iqr: 15) days at mo0 to 56 (iqr: 20) days at mo9, representing a 60% increase. Visual acuity remained stable throughout the study. Correlation analysis revealed that higher baseline CRT and fvPED volumes were associated with greater best-corrected visual acuity (BCVA) improvements and longer treatment intervals.</p><p><strong>Conclusions: </strong>This study highlights the potential of AI-driven biomarker segmentation as a precise and scalable tool for monitoring disease progression in treatment-resistant nAMD. By enabling objective and reproducible analysis of OCT biomarkers, deep learning algorithms provide critical insights into treatment response. Faricimab demonstrated significant and sustained anatomical improvements, allowing for extended treatment intervals while maintaining disease stability. Future research should focus on refining AI models to improve predictive accuracy and assessing long-term outcomes to further optimize disease management.</p><p><strong>Trial registration: </strong>Ethics approval was obtained from the Institutional Review Board of LMU Munich (study ID: 20-0382). This study was conducted in accordance with the Declaration of","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"44"},"PeriodicalIF":1.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SmartPlus: a computer-based image analysis method to predict continuous-valued vascular abnormality index in Retinopathy of Prematurity.","authors":"Sayed Mehran Sharafi, Nazanin Ebrahimiadib, Ramak Roohipourmoallai, Afsar Dastjani Farahani, Marjan Imani Fooladi, Golnaz Gharehbaghi, Elias Khalili Pour","doi":"10.1186/s40942-025-00668-3","DOIUrl":"https://doi.org/10.1186/s40942-025-00668-3","url":null,"abstract":"<p><p>Plus disease is characterized by abnormal changes in retinal vasculature of premature infants. Presence of Plus disease is an important criterion for identifying treatment-requiring cases in Retinopathy of Prematurity (ROP). However, diagnosis of Plus disease has been shown to be subjective and there is wide variability in the classification of Plus disease by ROP experts, which is mainly because experts have different cut-points for distinguishing the levels of vascular abnormality. This suggests that a continuous Plus disease severity score may reflect more accurately the behavior of expert clinicians and may better standardize the classification. The effect of using quantitative methods and computer-based image analysis to improve the objectivity of Plus disease diagnosis have been well established. Nevertheless, the current methods are based on categorical classifications of the disease severity and lack the compatibility with the continuous nature of the abnormal changes in retinal vasculatures. In this study, we developed a computer-based method that performs a quantitative analysis of vascular characteristics associated with Plus disease and utilizes them to build a regression model that outputs a continuous spectrum of Plus severity. We evaluated the proposed method against the consensus diagnosis made by four ROP experts on 76 posterior ROP images. The findings of our study indicate that our approach demonstrated a relatively acceptable level of accuracy in evaluating the severity of Plus disease, which is comparable to the diagnostic abilities of experts.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"43"},"PeriodicalIF":1.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early real-world outcomes of intravitreal aflibercept 8 mg in treatment-Naïve neovascular AMD: AI-assisted fluid volume analysis.","authors":"Jennifer Cattaneo, Eva C De Oliveira Figueiredo, Andrea Montesel, Sandra Vermeirsch, Chiara M Eandi","doi":"10.1186/s40942-025-00665-6","DOIUrl":"10.1186/s40942-025-00665-6","url":null,"abstract":"<p><strong>Background: </strong>This study was conducted as a retrospective, exploratory analysis to assess early anatomical and functional effects of intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (nAMD) in a small cohort of patients.</p><p><strong>Methods: </strong>This retrospective study was conducted at the Jules Gonin Eye Hospital in Lausanne, Switzerland, and included treatment-naïve patients with nAMD. Patients received a minimum of two intravitreal injections (IVT) of aflibercept 8 mg over a 3-month period. Key outcomes assessed were changes in best-corrected visual acuity (BCVA), central subfield thickness (CST), mean retinal thickness (RT), total fluid (TF) volume which was calculated as the sum of intraretinal fluid (IRF), subretinal fluid (SRF) and pigment epithelial detachment (PED) volumes. These parameters were evaluated at baseline, month 1, and month 3 using the RetinAI Discovery^® platform, an artificial intelligence-based analysis system.</p><p><strong>Results: </strong>10 eyes of 10 patients were enrolled. Mean age was 77.7 ± 12.5 years. Comparative analysis between baseline, month 1, and month 3 revealed statistically significant reduction in CST, RT and TF volume, indicating a positive early response to treatment. One adverse event of intraocular inflammation (IOI) occurred in one patient (10%) after the second IVT injection. Treatment was subsequently interrupted, and IOI resolved with topical corticosteroids therapy.</p><p><strong>Conclusion: </strong>Intravitreal aflibercept 8 mg demonstrated early anatomical and functional improvements in nAMD treatment-naïve patients after the first 3-months. The use of the AI-based analysis allowed for detailed and automated assessment of retinal changes, providing valuable insights into early treatment effects. Given the retrospective design and small cohort, further studies are warranted to assess long-term outcomes and the potential predictive value of early changes on long-term visual prognosis and safety.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"42"},"PeriodicalIF":1.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence, data sharing, and privacy for retinal imaging under Brazilian Data Protection Law.","authors":"Luis Filipe Nakayama, Lucas Zago Ribeiro, Fernando Korn Malerbi, Caio Saito Regatieri","doi":"10.1186/s40942-024-00596-8","DOIUrl":"10.1186/s40942-024-00596-8","url":null,"abstract":"<p><p>The integration of artificial intelligence (AI) in healthcare has revolutionized various medical domains, including radiology, intensive care, and ophthalmology. However, the increasing reliance on AI-driven systems raises concerns about bias, particularly when models are trained on non-representative data, leading to skewed outcomes that disproportionately affect minority groups. Addressing bias is essential for ensuring equitable healthcare, necessitating the development and validation of AI models within specific populations. This viewpoint paper explores the critical role of data in AI development, emphasizing the importance of creating representative datasets to mitigate disparities. It discusses the challenges of data bias, the need for local validation of AI algorithms, and the misconceptions surrounding retinal imaging in ophthalmology. Additionally, highlights the significance of publicly available datasets in research and education, particularly the underrepresentation of low- and middle-income countries in such datasets. The Brazilian General Data Protection Law is also examined, focusing on its implications for research and data sharing, including the legal and ethical measures required to safeguard data integrity and privacy. Finally, the manuscript underscores the importance of adhering to the FAIR principles (Findability, Accessibility, Interoperability, and Reusability) to enhance data usability and support responsible AI development in healthcare.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"41"},"PeriodicalIF":1.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interferon alpha-2b addition to intravitreal bevacizumab for diabetic macular edema: a randomized controlled trial.","authors":"Saeed Karimi, Mehdi Nouri, Amir Reza Mansouri, Golnar Hassanzadeh, Hosein Nouri, Saber Mohsen Rikani, Seyed-Hossein Abtahi","doi":"10.1186/s40942-025-00663-8","DOIUrl":"10.1186/s40942-025-00663-8","url":null,"abstract":"<p><strong>Background: </strong>Intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents are the standard of care in DME, a sight-threatening complication of diabetic retinopathy. However, many patients show suboptimal response to anti-VEGF agents alone. This study aimed to investigate the effect of adding interferon alpha 2b eye drops to intravitreal bevacizumab (IVB) in treating patients with DME.</p><p><strong>Methods: </strong>In this double-blind, placebo-controlled, parallel clinical trial, eligible eyes of DME patients were randomized into two treatment arms: (1) three monthly doses of intravitreal bevacizumab (IVB) (2) three monthly doses of IVB plus interferon alpha 2b eye drops (IVB + IFN). Outcome measures were changes in central macular thickness (CMT) and best corrected visual acuity (BCVA) over four months. Intraocular pressure (IOP) and possible adverse events were also documented.</p><p><strong>Results: </strong>A total of 87 eyes of 87 patients with DME were included (mean age: 64.1, female-to-male ratio ~ 1:1). Anatomical and visual improvements were significant in both groups (p-value < 0.001). CMT reduction and BCVA improvement were greater in the IVB + IFN compared to the IVB group (-117 μm vs. -54 μm, 0.2 vs. 0.1 LogMAR, p-values = 0.004 and < 0.001, respectively). Final IOP was lower in the IVB + IFN group (p value = 0.02), but within groups changes were not significant in either arm (p-value > 0.05). No serious side effects associated with IFN alpha 2b were observed.</p><p><strong>Conclusions: </strong>Adjunction of topical IFN alpha 2b to standard IVB therapy may result in superior functional and structural improvements in eyes with DME in short-term follow-up.</p><p><strong>Trial registration: </strong>Iranian Registry of Clinical Trials (irct.behdasht.gov.ir), IRCT20230103057035N1, March 18th, 2023.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"40"},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing axial length estimation for intraocular lens power calculation in phacovitrectomy for macula-off retinal detachment.","authors":"Sukhum Silpa-Archa, Chitchanok Samanwongthai, Variya Nganthavee, Korawin Charoensuk","doi":"10.1186/s40942-025-00666-5","DOIUrl":"10.1186/s40942-025-00666-5","url":null,"abstract":"<p><strong>Background: </strong>To evaluate methods of preoperative axial length (AL) estimation for intraocular lens (IOL) power calculation in patients with macula-off rhegmatogenous retinal detachment (RRD). These methods included optical biometry, A-scan biometry, and novel decision algorithms.</p><p><strong>Methods: </strong>A retrospective analysis of prospectively collected data was conducted at a tertiary hospital from January 2018 to December 2023. Preoperative and postoperative AL measurements were obtained using optical biometry (IOL Master 700, Zeiss, Germany) and A-scan biometry (VuMAX, Sonomed, USA). The primary outcome was the mean absolute prediction error (MAE) between postoperative AL and preoperative estimates generated by five methods, including two novel algorithms.</p><p><strong>Results: </strong>The study included 56 patients (56 eyes). The lowest MAE was achieved using the simple algorithm (0.31 ± 0.55 mm), followed by the AL of the fellow eye measured via IOL Master (0.34 ± 0.60 mm), and the advanced algorithm (0.36 ± 0.62 mm). A Kruskal-Wallis H test found no statistically significant difference in MAE across the five methods (P = 0.118). Bland-Altman analysis demonstrated good agreement between preoperative and postoperative AL measurements obtained with the IOL Master.</p><p><strong>Conclusion: </strong>For patients undergoing phacovitrectomy for macula-off RRD, the simple algorithm provides accurate AL estimation for IOL power calculation. In cases where AL measurement of the affected eye is not feasible using the IOL Master, the fellow eye's AL is a reliable alternative.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"39"},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of age and gender on retinal and choroidal thickness and vascular densities: a comprehensive analysis.","authors":"Fariba Ghassemi, Morteza Karimi, Farhad Salari, Kia Bayat","doi":"10.1186/s40942-024-00619-4","DOIUrl":"10.1186/s40942-024-00619-4","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the significance of age and gender on macular retinal and choroidal thicknesses (RT and CT) and related vascular density (VD) using optical coherence tomography angiography (OCTA) in a wide spectrum of normal participants.</p><p><strong>Methods: </strong>This was a cross-sectional study of 435 eyes of 234 normal healthy children and adults aged 5-97 years old who performed macular 3 × 3 mm scans using Optovue RTVue OCTA.</p><p><strong>Results: </strong>A statistically meaningful relationship was detected between age and macular layered VD and RT parameters. The middle retinal thickness (MRT) experiences minimal alterations throughout the lifespan. The mean foveal superficial capillary plexus density (SVD), deep capillary plexus density (DVD), and parafoveal SVD had the most density between the 20-40 years and tended to decrease to lowest point by the seventies. Foveal choriocapillaris vascular density (CVD), parafoveal CVD and parafoveal DVD had a decreasing course during the life course. There was no significant difference in choroidal vascular index between age groups. FAZ revealed relatively insignificant minor changes across age groups. The male participants had higher VD than the female participants in all measured parameters, except for parafoveal DVD.</p><p><strong>Conclusion: </strong>RT of different layers as well as the whole retina is known to be influenced by age while the MRT experiences minimal alterations throughout the lifespan. The VD of male participants exceeded that of female participants across all measured parameters, except parafoveal DVD. Differential retinal and choroidal vascular plexuses have different course during a man's life.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"38"},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between inferior posterior staphyloma on choroidal vessels running patterns in healthy eyes.","authors":"Hiroto Terasaki, Ryoh Funatsu, Koki Okamura, Naohisa Mihara, Hideki Shiihara, Takehiro Yamashita, Shozo Sonoda, Taiji Sakamoto","doi":"10.1186/s40942-025-00661-w","DOIUrl":"10.1186/s40942-025-00661-w","url":null,"abstract":"<p><strong>Background: </strong>Effects of macular shape changes on the retina have been studied in pathologic myopia. However, whether there are individual differences in macular shape in non-pathologic myopia and the influence of macular shape on retinochoroidal disease in these eyes is not well known. A recently developed ultra-wide-field optical coherence tomography (UWF-OCT) has a wider imaging range and can be used to evaluate inferior posterior staphyloma (IPS). We aimed to investigate the effect of IPS on Haller vessel running patterns (HVRPs) in healthy eyes using UWF-OCT.</p><p><strong>Methods: </strong>This single-center retrospective study included healthy subjects. UWF-OCT images of normal subjects were stretched vertically to enhance the macula's shape and classified into IPS (n = 16) and non-IPS (n = 113) groups with or without propensity score matching (PSM) for age, sex, and ocular axis length. The HVRPs were subjectively classified into symmetry, superior dominant, and inferior dominant. Differences in the proportions of the patterns between the two groups were compared using Fisher's exact test.</p><p><strong>Results: </strong>In the non-IPS group, 65 (57.5%) individuals had a symmetric pattern of Haller's vessels, 32 (28.3%) had an upper-dominant pattern, and 16 (14.1%) had a lower-dominant pattern. In the IPS group, 14 eyes (87.5%) presented an upper dominant pattern, and 2 (12.5%) presented a symmetric pattern. There was a significant difference in vascular running patterns between the two groups (P < 0.001). After the PSM, a similar trend was confirmed.</p><p><strong>Conclusions: </strong>The eyes with IPS are likely to have superior dominant HVRPs compared to the non-IPS group in healthy eyes. Macular shape may play a role in HVRPs, which are involved in the pathogenesis of retinochoroidal diseases.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"37"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of different topical anesthetic methods for intravitreal injections: a randomized crossover study.","authors":"Jeffrey Man Yeung Lo, Veronica Yui Yan Li, Rachel Ka Ying Cheung, Shing Chuen Chow, Kendrick Co Shih, Nicholas Siu Kay Fung, Wai-Ching Lam","doi":"10.1186/s40942-025-00649-6","DOIUrl":"10.1186/s40942-025-00649-6","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the potential adjunctive effect of pledget anesthetic to topical proparacaine applied in a droplet form in patients undergoing intravitreal injections (IVI).</p><p><strong>Method: </strong>This is a single-centre, prospective, randomized, double-blinded crossover study. 60 patients were included. Patients receiving IVI were given topical 0.5% proparacaine drops then randomized in a 1:1 ratio to receive 0.5% proparacaine soaked pledget or normal saline soaked pledget as placebo. The patients would later be crossed over to receive the alternative intervention. Pain was assessed with a visual analog scale (VAS) and questionnaire immediately afterwards, 10-minutes and 20-minutes after injection.</p><p><strong>Result: </strong>Pain intensity as assessed on the visual analogue scale was lower for the placebo group compared to the pledget group immediately (2.51 cm vs. 2.8 cm), 10-minutes (1.81 cm vs. 2.13 cm) and 20-minutes (1.23 cm vs. 1.65 cm) after injection, however this was not statistically significant (p = 0.48, p = 0.43, p = 0.24 respectively). However, in a subgroup of treatment naïve patients, the addition of pledget anesthesia may lower pain and make IVI more tolerable.</p><p><strong>Conclusion: </strong>Additional pledget soaked with proparacaine does not enhance anesthesia compared to solely using topical proparacaine for IVI, except in a subset of treatment naïve patients.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"36"},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluorocarbon liquid as a short-term tamponade for managing severe open globe injuries.","authors":"Liang Li, Xinghong Sun, Mengru Su, Xiaofang Wang, Feng Jiang","doi":"10.1186/s40942-025-00659-4","DOIUrl":"10.1186/s40942-025-00659-4","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the use of perfluorocarbon liquids (PFCLs) as a short-term tamponade in a staged vitrectomy approach for managing severe open globe injuries (OGIs).</p><p><strong>Methods: </strong>This retrospective, interventional case series included patients undergoing 23-gauge pars plana vitrectomy with PFCL tamponade for 7-14 days (mean 11.2 ± 3.36 days), followed by secondary vitrectomy and silicone oil exchange. Key outcome measures included retinal and choroidal reattachment rates, best-corrected visual acuity (BCVA), intraocular pressure (IOP), and postoperative complications. Statistical analyses were performed using McNemar's test and Student's t-test.</p><p><strong>Results: </strong>Five eyes from five patients (mean age 55.6 ± 10.12 years; male to female ratio 4:1) were included, with a mean follow-up of 8.4 ± 4.9 months. All patients sustained zone II and III globe ruptures secondary to blunt trauma, with baseline visual acuity ranging from light perception (LP) to no light perception (NLP). Intraoperative findings included total hyphema, funnel retinal detachment, traumatic choroidal rupture (TCR), suprachoroidal hemorrhage (SCH) and extensive intraocular hemorrhage (EIH). Following PFCL removal, SCH exhibited full or partial resolution, and the posterior retina remained attached in all cases. All eyes were salvaged, and visual acuity improved to hand motion (HM) on postoperative day 1, maintaining stability throughout follow-up (P = 0.03682). No significant IOP changes were observed postoperatively (preoperative: 9.66 ± 2.38 mmHg; postoperative: 9.48 ± 3.31 mmHg, P = 0.9063). Retinal and choroidal attachment were maintained during follow-up, with no cases of phthisis bulbi, endophthalmitis, recurrent hyphema, or ocular hypertension. One patient developed corneal degeneration three months postoperatively.</p><p><strong>Conclusions: </strong>Short-term PFCL tamponade in a staged vitrectomy may facilitates retinal and choroidal stabilization while minimizing complications, offering a viable alternative for managing severe OGIs.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"35"},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}