International Journal of Retina and Vitreous最新文献

{"title":"Outcomes of pars plana vitrectomy for visually significant floaters in Northern Alberta.","authors":"Malshi Karunatilake, Brendon Fijardo, Eugene Michael, Rizwan Somani","doi":"10.1186/s40942-025-00676-3","DOIUrl":"https://doi.org/10.1186/s40942-025-00676-3","url":null,"abstract":"<p><strong>Background: </strong>Vision degrading mydesposiae (VDM) can have a significant impact on a patient's quality of life. Pars plana vitrectomy (PPV) is a surgical modality used to treat a variety of vitreoretinal diseases and is an accessible treatment option for relief of VDM. This article analyzes outcomes and postoperative complications in a large, local sample of patients who have undergone PPV for symptomatic floaters from a northern Alberta perspective.</p><p><strong>Methods: </strong>A retrospective chart review was conducted at Alberta Retina Consultants in Edmonton, Alberta. Patients who underwent PPV for VDM between 2017 and 2023 were identified. Only cases with floaters due to PVD and asteroid hyalosis were included; cases of prior vitrectomies, scleral buckle surgeries as well as cases of secondary myodesopsiae (i.e. uveitis) were excluded.</p><p><strong>Results: </strong>A total 452 eyes were identified and following application of exclusion criteria, 410 eyes of 308 patients were included. There were 157 male and 151 female patients with the average age of participants being 68 years (standard deviation (SD) ± 9). Vitrectomy was performed due to symptomatic PVD in 400 eyes (98%) with 10 eyes (2%) being symptomatic due to asteroid hyalosis. There were 181 phakic eyes (44%) and 229 eyes and pseudophakic eyes (56%). There were 26 patients (25.2%) who elected to undergo floaterectomy in the contralateral eye. There was no significant difference in visual acuity noted between preoperative and postoperative periods.</p><p><strong>Conclusions: </strong>The current study supports PPV as an effective treatment option for symptomatic floaters. There was no statistically significant difference between preoperative and postoperative visual acuity. However, 29.9% of eyes underwent floaterectomy in the contralateral eye, which is in support of patient satisfaction. The observed complication rate was 7.3%, with retinal detachment being the most common complication. Of the 410 eyes, 30 eyes (7.3%) had postoperative complications which included adverse events that were recorded to have occurred between the immediate postoperative period and three years after vitrectomy. Complications include retinal detachment (2.4%), elevated IOP (1.5%), clinically significant cataract requiring surgery (1.5%), vitreous hemorrhage (0.73%), cystoid macular edema (0.98%), dislocated IOL (0.24%), endophthalmitis (0.24%) and epiretinal membrane (0.24). There was a statistically significant difference in visual acuity between preoperative and postoperative periods for eyes with complications.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"54"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of intraoperative melphalan to prevent recurrent PVR: the IOMPVR study.","authors":"Carlos A Moreira-Neto, Jose S Pulido, Luca Bongiovanni de Miranda Gonçalves, Gabriel Nunes Cavalcanti, Acacio Souza Lima, José de Paula Barbosa Neto, Daniel Lavinsky, Talita Virginia Fernandes de Oliveira, Fernando Ejii Ogata, Lucas Zago Ribeiro, Luiz Fernando Teixeira, Flavia Borelli Gomes do Nascimento, Luiz H Lima, Octaviano Jr Magalhães, Michel Eid Farah, Maurício Maia","doi":"10.1186/s40942-025-00675-4","DOIUrl":"https://doi.org/10.1186/s40942-025-00675-4","url":null,"abstract":"<p><strong>Background: </strong>Proliferative vitreoretinopathy (PVR) is a major cause of failure in cases of retinal detachment (RD) repair. Intravitreal melphalan, a known inhibitor of cellular proliferation, offers a novel therapeutic approach to reduce PVR recurrence and improve outcomes. We evaluated the safety and efficacy of 5 µg/0.1 ml intravitreal melphalan at the end of pars plana vitrectomy (PPV) before silicone oil (SO) injection in eyes with primary PVR related to rhegmatogenous retinal detachments (RRDs) with a minimal 90-day follow-up period.</p><p><strong>Methods: </strong>This prospective, cross-sectional, interventional pilot study was conducted at the Department of Ophthalmology of the Federal University of São Paulo in patients with primary RRD and PVR. Patients were included who were aged 18 to 85 years with PVR grade CP2 or worse secondary to RRDs in eyes without having undergone a previous RRD surgery. They underwent PPV + scleral buckle + fluid air exchange followed by intravitreal injection of 5 µg/0.1 ml melphalan (270 mOsm) and SO injection.</p><p><strong>Results: </strong>Six eyes of six patients were enrolled. Ocular examination and imaging showed no retinal toxicity. The logarithm of the minimum angle of resolution best-corrected visual acuity improved from the mean ± standard deviation preoperatively of 2.11 ± 0.22 to 0.89 ± 0.37 at 30 and to 0.84 ± 0.42 at 90 days postoperative (P < 0.001). Optical coherence tomography identified intraretinal cysts in five of six eyes and outer retinal layer loss in all study eyes. Only one of six eyes developed a recurrent localized RD on day 90 unrelated to recurrent PVR. PVR recurrence was not observed during the study follow-up.</p><p><strong>Conclusions: </strong>In this pilot study, the preliminary data showed that PPV followed by intravitreal injection of 5 µg/0.1 ml melphalan was not related to ocular toxicity. The absence of PVR recurrence at 3 months follow-up in these complex PVR eyes is an interesting finding that justifies further investigation.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"53"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hypertensive disorders of pregnancy and gestational diabetes mellitus with developing severe retinopathy of prematurity.","authors":"Narges Khoshtinat, Maryam Moayeri, Hanieh Fakhredin, Afsar Dastjani Farahani, Fariba Ghassemi, Alireza Mahmoudi, Fatemeh Bazvand, Amin Nabavi","doi":"10.1186/s40942-025-00635-y","DOIUrl":"https://doi.org/10.1186/s40942-025-00635-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), and their combined presence (GDM-HDP) as perinatal risk factors for severe retinopathy of prematurity (ROP).</p><p><strong>Methods: </strong>The hospital records of all premature infants referred to a tertiary center between 2020 and 2022 were retrospectively reviewed. Infants born to mothers with GDM, HDP, or both were selected for analysis. Demographic variables, perinatal risk factors, as well as clinical and treatment characteristics of the infants were collected and analyzed.</p><p><strong>Results: </strong>A total of 1161 infants and 2322 eyes, including HDP group (1110 eyes from 555 infants), GDM group (944 eyes from 472 infants), and GDM-HDP group (268 eyes from 134 infants), were enrolled. The mean gestational age (GA) and birth weight (BW) for all infants were 31.6 ± 2.5 weeks and 1572 ± 427 g, respectively. A higher percentage of eyes (76.5%) in the GDM group were classified as ROP or incomplete vascularization compared to the HDP group (71.6%), with the prevalence of severe ROP also higher in the GDM group (13.5%) than in the HDP group (9.9%; P < 0.05 for both comparisons). The rates of ROP and severe ROP were similar between the GDM and GDM-HDP groups. When considering only infants with BW < 1500, the GDM group still exhibited a higher rate of ROP and severe ROP compared to the HDP group. Treatment was required in 17.5% of eyes in the GDM group, 16.8% in the GDM-HDP group, and 13.9% in the HDP group (P = 0.071).</p><p><strong>Conclusion: </strong>GDM is a higher risk factor for ROP and developing severe ROP than HDP. However, the data indicate that careful monitoring and management of both GDM and HDP during pregnancy may be crucial in mitigating the risk of severe ROP.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"52"},"PeriodicalIF":1.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective and dichotomous study of biomarkers with swept-source OCT and OCT-angiography in naive patients with diabetic macular edema.","authors":"Marcussi Palata Rezende, Fernanda Atoui Faria, Daniel Prado Beraldo, Julia Polido, Rubens Belfort, Thiago Cabral","doi":"10.1186/s40942-025-00672-7","DOIUrl":"https://doi.org/10.1186/s40942-025-00672-7","url":null,"abstract":"<p><strong>Background: </strong>We used state-of-the-art high-resolution retinal imaging to explore the treatment (loading dose of aflibercept) of diabetic macular edema (DME) among treatment-naive patients. Swept-source (SS) OCT and OCT-Angiography (SS-OCTA) were performed, and a dichotomous analysis was conducted to compare responders and treatment-resistant patients (responsive and resistant). Furthermore, treatment responses were evaluated based on the subdivision of choroidal thickness.</p><p><strong>Materials and methods: </strong>This prospective, noncomparative, interventional case series study examined the following biomarkers: best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), avascular area of the superficial plexus (AASP), avascular area of the deep plexus (AADP), and vessel density (VD). Data from the baseline and 4-month examinations were compared.</p><p><strong>Results: </strong>Twenty-eight eyes from 25 patients were included. Significant improvements were observed in BCVA (0.7250 ± 0.23 to 0.3957 ± 0.21; p < 0.000), CMT µm (339.04 ± 66.19 to 265.21 ± 55.75; p < 0.000), CCT µm (221.71 ± 69.69 to 209.07 ± 70.92; p < 0.000), VD (17.90 ± 7.82 to 15.35 ± 5.80; p < 0.038), AASP µm² (235,374 ± 91,299 to 157,326 ± 77,815; p < 0.000) and AADP µm² (996,335 ± 1,000,047 to 362,161 ± 277,225; p < 0.000). Dichotomous analysis revealed that 15 patients were responsive (53.57%), and 13 resistant (46.43%). There were no significant differences between any of the pretreatment biomarkers. In the subdivision of choroidal thickness, which ranged from 211 to 270 µm (group 3), we found greater reductions in the CCT, AADP and CD. The choroidal thickness ranged from 181 to 210 µm (group 2): BCVA and AASP exhibited the greatest reductions.</p><p><strong>Conclusion: </strong>BCVA, CMT, CCT, AASP, AADP and VD were improved after treatment. The pretreatment biomarkers did not predict treatment response between the responsive and resistant. Regarding choroidal stratification, values within the normal range of CCT showed the greatest reductions, indicating that these values may be more responsive to treatment. Notably, this is the first study to analyze biomarkers provided by SS OCT and OCTA, stratify the choroid, and perform a dichotomous analysis.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"51"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacillary layer detachment in acute Vogt-Koyanagi-Harada disease: an early predictor of long-term complications in a Brazilian cohort.","authors":"Ruy Felippe Brito Gonçalves Missaka, Mauro Goldbaum, Cleide Guimarães Machado, Emmett T Cunningham, Fernanda Maria Silveira Souto, Marcelo Mendes Lavezzo, Priscilla Figueiredo Campos da Nóbrega, Camillo Carneiro Gusmão, Viviane Mayumi Sakata, Maria Kiyoko Oyamada, Carlos Eduardo Hirata, Joyce Hisae Yamamoto","doi":"10.1186/s40942-025-00673-6","DOIUrl":"https://doi.org/10.1186/s40942-025-00673-6","url":null,"abstract":"<p><strong>Background: </strong>Long-term complications occur in some patients with Vogt-Koyanagi-Harada disease (VKHD).This study aimed to evaluate the presence of bacillary layer detachment (BALAD) at presentation as an early predictor of long-term structural and functional outcomes in a Brazilian cohort of patients with VKHD.</p><p><strong>Methods: </strong>Retrospective, clinic-based cohort study in Sao Paulo, Brazil, including 33 patients (66 eyes) with acute VKHD systematically followed for 12 months, since presentation. Clinical and multimodal data collected on spectral domain optical coherence tomography (SD-OCT) were analyzed at baseline and months (M) 1, 3, 6, 9 and 12. Correlations between OCT-based structural findings and the occurrence of subretinal fibrosis (SRFib), sunset glow fundus (SGF), and nummular chorioretinal lesions (NCL) at month 12 were studied. Outcomes were presence of retinal changes on SD-OCT during the study period; risk factors for SRFib, SGF and NCL at month 12. Univariate, bivariate, and multivariate analyses were employed.</p><p><strong>Results: </strong>At baseline, serous retinal detachments (SRD) were observed in 96.4% and BALAD in 48.2% of 56 eyes; at M1, SRD were observed in 42.4% and BALAD in 6.1% of 66 eyes. Subretinal fluid (SRFld) was still present in 9.1% at M3, in 4.5% at M6 and in 3.0% of eyes at M9. Using bivariate analysis, the early presence of BALAD was associated with a larger SRD area (p = 0.036) at presentation, and with the presence of both SRFib (p < 0.001) and SGF (p = 0.008) at M12. Using multivariate regression analysis, both early BALAD (OR, 12.04; p = 0.011) and a longer interval to treatment start (32 vs. 17 days; OR, 1.17; p = 0.004) were each independently associated with the formation of SRFib at M12, whereas both early BALAD (OR, 14.78; p = 0.002) and anterior uveitis recurrences (OR, 30.94; p = 0.022) were each associated with the development of SGF. The late occurrence of NCL was not associated with the presence of BALAD at presentation.</p><p><strong>Conclusions: </strong>In acute VKHD, the presence of BALAD at presentation was associated with a markedly increased long-term risk of developing both SRFib and SGF.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"50"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of artificial intelligence in diabetic retinopathy screening: a systematic review and meta-analysis.","authors":"Abdullah S Alqahtani, Wasan M Alshareef, Hanan T Aljadani, Wesal O Hawsawi, Marya H Shaheen","doi":"10.1186/s40942-025-00670-9","DOIUrl":"https://doi.org/10.1186/s40942-025-00670-9","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the efficacy of artificial intelligence (AI) in screening for diabetic retinopathy (DR) using fundus images and optical coherence tomography (OCT) in comparison to traditional screening methods.</p><p><strong>Methods: </strong>This systematic review was registered with PROSPERO (ID: CRD42024560750). Systematic searches were conducted in PubMed Medline, Cochrane Central, ScienceDirect, and Web of Science using keywords such as \"diabetic retinopathy,\" \"screening,\" and \"artificial intelligence.\" Only studies published in English from 2019 to July 22, 2024, were considered. We also manually reviewed the reference lists of relevant reviews. Two independent reviewers assessed the risk of bias using the QUADAS-2 tool, resolving disagreements through discussion with the principal investigator. Meta-analysis was performed using MetaDiSc software (version 1.4). To calculate combined sensitivity, specificity, summary receiver operating characteristic (SROC) plots, forest plots, and subgroup analyses were performed according to clinician type (ophthalmologists vs. retina specialists) and imaging modality (fundus images vs. fundus images + OCT).</p><p><strong>Results: </strong>18 studies were included. Meta-analysis showed that AI systems demonstrated superior diagnostic performance compared to doctors, with the pooled sensitivity, specificity, diagnostic odds ratio, and Cochrane Q index of the AI being 0.877, 0.906, 0.94, and 153.79 accordingly. The Fagan nomogram analysis further confirmed the strong diagnostic value of AI. Subgroup analyses revealed that factors like imaging modality, and doctor expertise can influence diagnostic performance.</p><p><strong>Conclusion: </strong>AI systems have demonstrated strong diagnostic performance in detecting diabetic retinopathy, with sensitivity and specificity comparable to or exceeding traditional clinicians.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"48"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of vitrectomy for chorioretinitis sclopetaria following blast-related ocular trauma.","authors":"Nadiia Ulianova, Oksana Sidak-Petretska, Nataliia Bondar","doi":"10.1186/s40942-025-00674-5","DOIUrl":"https://doi.org/10.1186/s40942-025-00674-5","url":null,"abstract":"<p><strong>Background: </strong>To analyse the anatomical and functional results of pars plana vitrectomy in patients with Chorioretinitis Sclopetaria caused by severe combat-related ocular trauma.</p><p><strong>Methods: </strong>This retrospective, observational study involved 24 cases of pars plana vitrectomy in patients with Chorioretinitis Scleropetaria following combat-related ocular trauma. Best-corrected visual acuity and retinal reattachment were studied. The data were analysed via quantitative and categorical correlation analyses, as well as logistic regression models.</p><p><strong>Results: </strong>Postoperative best-corrected visual acuity improved in 18 patients (75%) but remained unchanged in 5 patients (20.8%). In 1 patient (4.2%), best-corrected visual acuity deteriorated due to the development of traumatic optic neuropathy. Retinal detachment was noted in 13 patients, whereas a macular hole was present in 5 patients. In 2 patients, both retinal detachment and macular holes were diagnosed simultaneously. After pars plana vitrectomy, retinal reattachment was achieved in 23 patients (95.8%). In one case, reattachment was unsuccessful. The localization of Chorioretinitis Sclopetaria was significantly associated with the final best-corrected visual acuity, with the best surgical outcome observed in patients with Chorioretinitis Sclopetaria located in the inferior sector of the fundus (p < 0.05). The outcome of pars plana vitrectomy for Chorioretinitis Sclopetaria with concomitant retinal detachment is significantly better when the procedure is performed earlier following blast injury.</p><p><strong>Conclusions: </strong>Chorioretinitis Sclopetaria following blast ocular trauma is characterized by a significant, persistent, best-corrected visual acuity decreasing, a high frequency of vitreous haemorrhages, macular holes, and retinal detachment. Pars plana vitrectomy in Chorioretinitis Sclopetaria has shown considerable effectiveness in improving visual function, retinal reattachment, and macular hole closure in patients with blast-related ocular trauma.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"49"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OCT macular changes in type 1 ROP following Ranibizumab injections.","authors":"Rawan Hosny, Jylan Gouda, Tamer A Macky, Ayman Khattab, Hany Mekkawy, Abdussalam M Abdullatif","doi":"10.1186/s40942-025-00664-7","DOIUrl":"https://doi.org/10.1186/s40942-025-00664-7","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the OCT macular changes in type 1 ROP one month following Ranibizumab injections.</p><p><strong>Methods: </strong>Preterm infants with type 1 ROP indicated for Ranibizumab injections were included in this study. Handheld OCT imaging was performed at baseline, 1 week, and 1 month post injection. Central full thickness (CFT), inner retinal layer (IRL), and outer retinal layer (ORL) thickness measurements were taken from foveal center and parafoveal region.</p><p><strong>Results: </strong>24 eyes of 12 infants were included in this study. There were no significant changes in the mean CFT and IRL thickness at 1 month (p = 0.5 and 0.1 respectively). However, there was significant increase in the mean ORL thickness at 1 month (69.9 ± 16, 96.1 ± 25 at baseline and one month respectively, p < 0.001), with differentiation (appearance of IS/OS junction ± ELM) in 55.6% of eyes. Macular edema (ME) was observed in 12 eyes (50%) and was associated with smaller birth weight (p = 0.0290). There was no significant decrease in mean CFT in eyes with ME at 1 month (p = 0.13), with complete resolution in only 6 eyes (50%) during the study period. Regression of plus was associated with lower CFT (1 week and 1 month; p = 0.02 and 0.03, respectively).</p><p><strong>Conclusion: </strong>Ranibizumab treated eyes in type 1 show ORL thickening and differentiation but with inadequate resolution of ME.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"47"},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ocular hypothermia: potential perspectives in vitreoretinal surgery.","authors":"Emanuele Crincoli, Matteo Mario Carlà, Alfonso Savastano, Mariacristina Savastano, Raphael Kilian, Clara Rizzo, Tomaso Caporossi, Stanislao Rizzo","doi":"10.1186/s40942-025-00667-4","DOIUrl":"https://doi.org/10.1186/s40942-025-00667-4","url":null,"abstract":"<p><strong>Purpose: </strong>To summarize knowledge about the effects of experimental and iatrogenic hypothermia on ocular structures, with a specific focus on retinal consequences and therapeutical perspectives in vitreoretinal surgery.</p><p><strong>Materials and methods: </strong>This review of the literature includes a section on the effects of low temperature on different ocular structures (sclera, choroid, retina, vitreous and ciliary body), a focus on the effect on retinal pigment epithelium (RPE), retinal neurons and inflammation and a section about results of vitreoretinal surgery performed at low temperature. In vitro, animal and human studies were included.</p><p><strong>Results: </strong>Temperature changes induce several regulatory responses within the eye, including modifications of intraocular pressure (IOP), local blood flow, cytokine secretion and cellular metabolism. Cooling of retinal structures has been demonstrated to induce beneficial effects including increased survival of RPE and retinal neurons. Vitreoretinal surgery performed at lower intraocular temperatures has shown positive effect on postoperative inflammation, even though the rebound effect of a sudden postoperative temperature increase seems to be detrimental.</p><p><strong>Conclusions: </strong>Despite being a promising approach, vitreoretinal surgery performed under lower intraocular temperature conditions deserves refinement in its methodologies. Hopefully, new randomized clinical trials will provide indications on how to apply this technique in the safest and most effective way.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"46"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance, safety and efficiency comparison between a 25G 20,000 and a 10,000 cuts per minute vitrectomy: a prospective randomized control study.","authors":"Shing Chuen Chow, Jeffrey Man Yeung Lo, Mehnaz Quddus, Qing Li, Wai Ching Lam, Nicholas Siu Kay Fung","doi":"10.1186/s40942-024-00613-w","DOIUrl":"https://doi.org/10.1186/s40942-024-00613-w","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to compare the safety and efficacy of 20,000 cuts per minute (cpm) with 10,000 cpm in vitreous cutters.</p><p><strong>Methods: </strong>This was a prospective, parallel, single masked randomized control trial comparing the 25 gauge 20,000 cpm HYPERVIT Dual Blade from Alcon Laboratories, Fort Worth, TX, USA and 10,000 cpm ULTRAVIT vitrectomy cutter from Alcon Laboratories, Inc, Fort Worth, TX. Standard T-test by SPSS version 27 was used to compare efficiency and safety between two groups.</p><p><strong>Results: </strong>In total 72 patients were recruited for the study and among them 71 patients completed the study. This study did not show any significant difference between 20,000 cpm probe and 10,000 cpm probe (p value = 0.347) for the core vitrectomy duration in all included eyes. The mean of core vitrectomy time was 269.28 s in the 25 gauge 20,000 cpm group and 289.44 s in the 25 gauge 10,000 cpm group. However, by comparing the two systems operated on epiretinal membrane eyes, 20,000 cpm probe had a significantly shorter mean core vitrectomy time than 10,000 cpm group (P = 0.03). The majority of all the patients had no intraoperative retinal tear (98.6.8%) and post-operative retinal tear (95.8%). There were no intraoperative iatrogenic breaks, and 3 postoperative retinal tears with rhegmatogenous retinal detachment (RRD) were documented. All the retinal tears belongs to the 20,000 cpm group but no significant difference was found between the two groups in terms of retinal tear and complications.</p><p><strong>Conclusions: </strong>25-gauge 20,000 cpm Hypervit dual blade showed a faster trend in vitrectomy time although this was not statistically significant in all included eyes. By comparing vitrectomy time operated on epiretinal membrane eyes, a significant shorter time was found in 25-gauge 20,000 cpm. With more efficient and faster vitrectomy systems, the effect of surgeon factor likely plays a larger role. Our study suggest that the two devices may have a similar efficacy and safety. However, further studies may be needed to compare the core vitrectomy time between them after excluding the surgeon factor influence.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"11 1","pages":"45"},"PeriodicalIF":1.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}