中心性浆液性脉络膜视网膜病变患者的新型高分辨率原型与标准光谱光学相干断层扫描对比。

IF 1.9 Q2 OPHTHALMOLOGY
Lorenzo Ferro Desideri, Luc Hennebert, Yousif Subhi, Martin Zinkernagel, Rodrigo Anguita
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引用次数: 0

摘要

目的:与标准OCT相比,评估高分辨率OCT在检测与中心性浆液性脉络膜视网膜病变(CSC)相关的生物标记物方面的准确性:我们进行了一项横断面研究,CSC 患者在同一次就诊中接受了高分辨率 OCT 和标准 OCT 检查。我们使用 SPECTRALIS 高分辨率 OCT 设备(德国海德堡海德堡工程公司)获取黄斑 B 扫描图像,并与使用 SPECTRALIS HRA + OCT 设备(德国海德堡海德堡工程公司)获取的图像进行比较。进行了定性评估,并对两种 OCT 模式的性能进行了统计分析比较:共纳入 31 名确诊为 CSC 的患者,平均年龄为 56.3 岁(± 10.2)岁。其中,29%(9 人)被归类为急性 CSC(aCSC),71%(22 人)为慢性 CSC(cCSC)。高分辨率 OCT 在检测视网膜外层的微结构变化方面优于标准 OCT,包括更高的连接区(IZ)破坏率(29% 对 6%,P = 0.003)和视网膜色素上皮(RPE)破坏率(12% 对 2%,P = 0.0024)。研究者之间的一致性很高(Cohen's Kappa = 0.85):结论:高分辨率 OCT 有望识别与 CSC 相关的关键生物标志物,尤其是 IZ 和 RPE 的破坏。结论:高分辨率 OCT 有望识别与 CSC 相关的关键生物标志物,尤其是 IZ 和 RPE 的破坏,需要在更大的队列中进行进一步验证,以确认它们对 CSC 患者的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New high-resolution prototype versus standard spectralis optical coherence tomography in patients with central serous chorioretinopathy.

Purpose: To assess the accuracy of High-Resolution OCT in detecting biomarkers associated with central serous chorioretinopathy (CSC) compared to standard OCT.

Methods: We conducted a cross-sectional study involving CSC patients who underwent High-Resolution and standard OCT during the same visit. Using the SPECTRALIS High-Res OCT device (Heidelberg Engineering, Heidelberg, Germany), macular B-scans were obtained and compared with those acquired using a SPECTRALIS HRA + OCT device (Heidelberg Engineering, Heidelberg, Germany). Qualitative assessments were performed, and statistical analyses compared the performance of both OCT modalities.

Results: Thirty-one patients diagnosed with CSC were included with a mean age of 56.3 years (± 10.2). Among them, 29% (n = 9) were classified as acute CSC (aCSC), while 71% (n = 22) had chronic CSC (cCSC). High-Resolution OCT outperformed standard OCT in detecting microstructural changes in the outer retinal layers, including a higher prevalence of disrupted interdigitation zone (IZ) (29% vs. 6%, p = 0.003) and retinal pigment epithelium (RPE) disruption (12% vs. 2%, p = 0.0024). Intergrader agreement was high (Cohen's Kappa = 0.85).

Conclusion: High-Resolution OCT demonstrates promise in identifying critical biomarkers associated with CSC, particularly disruptions in the IZ and RPE. Further validation in larger cohorts is required to confirm their clinical relevance in patients with CSC.

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来源期刊
CiteScore
3.50
自引率
4.30%
发文量
81
审稿时长
19 weeks
期刊介绍: International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities
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