International Journal of Retina and Vitreous最新文献

{"title":"Primary vitreoretinal lymphoma: diagnostic and therapeutic insights from a Slovenian population-based study.","authors":"Nika Vrabič, Lučka Boltežar, Matej Panjan, Veronika Kloboves Prevodnik, Polona Jaki Mekjavič, Marija Skoblar Vidmar, Pia Klobučar, Mojca Globočnik Petrovič, Nataša Vidovič Valentinčič","doi":"10.1186/s40942-026-00830-5","DOIUrl":"10.1186/s40942-026-00830-5","url":null,"abstract":"<p><p>BACKGROUND: This study aimed to determine the national incidence, characterize clinical features, and evaluate the treatment outcomes of primary vitreoretinal lymphoma (PVRL) in Slovenia. METHODS: We conducted a population-based, retrospective case series of all patients diagnosed with PVRL at the Eye Hospital, University Medical Center Ljubljana, between January 2013 and May 2024. The diagnosis was histopathologically confirmed, and primary central nervous system involvement was excluded. Clinical presentation, diagnostic delay, treatment modality, and adverse events were analyzed. Progression-free survival (PFS), overall survival (OS), and lymphoma-specific survival (LSS) were calculated. RESULTS: Twelve patients were diagnosed with PVRL (four men, eight women; median age of 76 years). The average annual incidence was 0.52 cases per million. The median time from symptom onset to diagnosis was 238 days. The two most common symptoms were decreased visual acuity (75%) and floaters (58%). Vitreous cellular infiltration was the predominant clinical sign and was observed in 92% of patients. Five patients presented with unilateral disease, seven with bilateral disease, and three with unilateral disease that progressed to bilateral involvement. The median follow-up was 31.5 months. Eleven patients received one or more treatment modalities: intravitreal rituximab and/or methotrexate, local radiotherapy, and/or systemic chemotherapy. Local remission was achieved in all treated eyes. Two cases of granulomatous uveitis occurred during intravitreal rituximab therapy. The median PFS was 12 months; the two- and three-year PFS rates were 37.5% and 18.8%, respectively. The median OS was not reached; the two- and three-year OS rates were 70% and 56%, respectively. The LSS was 80% at two years and 64% at three years. CONCLUSIONS: This Slovenian population-based study provides real-world insights into PVRL management. In elderly and medically fragile patients, local treatment modalities provided effective ocular disease control with acceptable toxicity. </p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study.","authors":"Paula Basso Dias, Iara Messias-Reason, Germano Ramos Boff, Kenzo Hokazono, Renato Nisihara","doi":"10.1186/s40942-026-00821-6","DOIUrl":"10.1186/s40942-026-00821-6","url":null,"abstract":"<p><p>BACKGROUND: Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as C3a and C5a, have been identified in both vitreous and plasma samples from individuals with DR. This study aimed to evaluate plasma concentrations of C3a and C5a in relation to DR onset and severity. METHODS: A total of 150 patients with diabetes mellitus (DM) underwent ophthalmic examination and were categorized into groups: without DR (control group), mild/moderate/severe non-proliferative DR (NPDR) and proliferative DR (PDR). Plasma C3a and C5a levels were measured using sandwich enzyme-linked immunosorbent assays (ELISA). RESULTS: Significant elevations in C3a levels were found in severe NPDR (p = 0.02) and PDR (p < 0.05) groups compared to controls. Furthermore, severe/proliferative DR exhibited higher C3a levels than mild/moderate NPDR (p = 0.015). No significant differences in C5a concentrations were observed among the groups. CONCLUSION: These findings suggest the involvement of complement in the pathogenesis of DR, and the association of C3a with DR severity highlights its potential as a prognostic biomarker and therapeutic target. </p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guiding syringe selection for intravitreal injections: injectability and stability analysis of compounded pegcetacoplan (SYFOVRE) and the broader implications for high-viscosity ophthalmic therapies.","authors":"Tina Felfeli, Natalie M Lane, Efrem D Mandelcorn","doi":"10.1186/s40942-026-00832-3","DOIUrl":"10.1186/s40942-026-00832-3","url":null,"abstract":"<p><p>PURPOSE: SYFOVRE, the brand name of pegcetacoplan and the first FDA-approved treatment for geographic atrophy arising from dry age-related macular degeneration, is currently available only in vial format. Consequently, it is often compounded and transferred into syringes. This study aims to identify the optimal syringe type for both storage and intravitreal injection (IVI) of medium- and high-viscosity formulations such as SYFOVRE. METHODS: SYFOVRE was prepared in four syringe types and stored under refrigeration in amber bags for up to 110 days. Samples were evaluated for potency, aggregation, protein integrity, binding activity, pH, appearance, sterility, and container closure integrity. Syringe particulate contribution was examined using light obscuration. Injectability of each syringe was assessed through administration of 15 cP and 120 cP viscosity mimics into the vitreous of human cadaver eyes, and injection force was recorded over time. RESULTS: Pegcetacoplan remained stable across all syringe types for 110 days. The ClearJect (0.5 mL) syringe exceeded particulate safety limits as defined by USP <789>. Ophthalmic-specific syringes (Zero Residual [0.2 mL] and StaClear [0.25 mL]) required significantly lower injection forces than the BD (1 mL) and ClearJect (0.5 mL) (p < 0.0001). CONCLUSION: While all syringes preserved stability of SYFOVRE, injection force increased with higher viscosity. The borosilicate syringe (ClearJect) failed particulate testing, disqualifying it as a viable IVI option. Low-volume ophthalmic-specific syringes (Zero Residual and StaClear) demonstrated superior performance, suggesting they should be used for the safer delivery of intravitreal therapies. Notably, Zero Residual is the only IVI-indicated syringe that eliminates silicone oil–associated risks. </p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplified suprachoroidal buckling: sclerotomy-free viscoelastic injection with a novel device in porcine eyes.","authors":"Yariv Keshet, Assaf Ben-Arzi, Orly Gal-Or, Roee Arnon, Assaf Dotan","doi":"10.1186/s40942-026-00831-4","DOIUrl":"10.1186/s40942-026-00831-4","url":null,"abstract":"<p><p>PURPOSE: To evaluate the technical feasibility of a standardized, sclerotomy-free method for injecting viscoelastic material into the suprachoroidal space using a novel mechanical injector, and to evaluate an upgraded injector version in an ex vivo porcine model. METHODS: This laboratory investigation was conducted at a central medical research center using thirteen freshly enucleated pig eyes obtained from a local farm. All eyes underwent a 360-degree peritomy and were fixed to a Styrofoam platform. In cohort 1 (n = 5), a custom mechanical injector (Supra SEG) with a 30-gauge needle and selectable penetration depths (0.7 mm and 0.9 mm) was used to inject saline or viscoelastic materials (Biolon Prime, Healon 5 Pro, and Healon EndoCoat) into the suprachoroidal space (SCS). In cohort 2 (n = 8), an upgraded injector (27-gauge needle and larger-diameter tubing) was evaluated using the 0.9 mm depth. Ultrasound biomicroscopy (UBM) was performed before and after each injection to confirm SCS localization. The primary outcome was successful UBM-verified delivery into the SCS. RESULTS: In cohort 1, injections at 0.7 mm were unsuccessful in all attempts, whereas 0.9 mm enabled correct SCS delivery in all eyes. In cohort 2, successful UBM-confirmed suprachoroidal delivery was achieved in all eight eyes across multiple viscoelastic materials, including sequential and repeat injections that produced a larger, merged suprachoroidal bleb. UBM demonstrated characteristic echogenic appearances for each material. Injection resistance in cohort 2 was consistently mild to moderate. CONCLUSION: A sclerotomy-free, image-guided, tangential suprachoroidal injection technique using a purpose-built injector is technically feasible in ex vivo porcine eyes. Because this post-mortem model cannot adequately assess hemorrhagic complications, procedural safety and clinical performance require further in vivo evaluation. </p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Clinical outcomes of fibrin glue assisted hemostasis in persistent intraoperative optic disc bleeding.","authors":"Saarang Hansraj, Thirumalesh Mb, Brijesh Takkar, Vivek Pravin Dave, Ritesh Narula, Srishti Raksheeth Ramamurthy, Mudit Tyagi","doi":"10.1186/s40942-026-00827-0","DOIUrl":"10.1186/s40942-026-00827-0","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"12 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injecting OVD temporarily seal the edge of the retinectomy to prevent subretinal perfluorocarbon liquid droplets retention and retinal slippage during fluid-air exchange.","authors":"Zifang He, Yinong Guo, Yilinuer Yilihaer, Suyu Liu, Yifei Tang, Lv Xie, Ye Zhang, Yajun Liu, Zhenggao Xie","doi":"10.1186/s40942-026-00828-z","DOIUrl":"10.1186/s40942-026-00828-z","url":null,"abstract":"<p><p>BACKGROUND: To investigate effect of the injection of ophthalmic viscosurgical device (DisCoVisc) temporarily seal the edge of the retinectomy to prevent subretinal perfluorocarbon liquid (PFCL) droplets retention and retinal slippage during fluid-air exchange. METHODS: PFCL was injected, with the fluid level extended 3–5 mm above the posterior edge of the retinectomy. Laser photocoagulation was applied around the edge of the retinectomy. DisCoVisc was then injected under PFCL and evenly applied along the edge of the retinectomy to achieve temporary and complete sealing. Under infusion fluid, PFCL was completely removed. Then fluid-air exchange was applied. Finally, silicone oil was injected for intravitreal tamponade. RESULTS: A total of 9 patients (9 eyes) were included in this study, all of whom underwent retinectomy. On postoperative day 1, the retinas of all patients remained fully attached without any flap inversion or slippage. No subretinal PFCL droplets were detected. At last visit, the mean IOP was 15.61 ± 7.18 mmHg, without significant difference compared to preoperative IOP (13.39 ± 4.97 mmHg) (P = 0.455), but the mean post-operative BCVA (1.01 ± 0.62) logMAR (Snellen equivalent 20/200) with a significant difference compared to preoperative BCVA (2.04 ± 1.42) logMAR (Snellen equivalent 20/2190) (P = 0.031). CONCLUSIONS: Injecting DisCoVisc under PFCL to temporarily seal the edge of the retinectomy effectively prevents infusion fluid and PFCL droplets from entering the subretinal space during fluid–air exchange, thereby reducing the risk of retinal slippage and subretinal PFCL retention. CLINICAL TRIAL NUMBER: Not applicable. </p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious retinitis associated with JAK inhibitors: the ongoing duality of JAK inhibitors.","authors":"Jose S Pulido, Fukutaro Mano, Marcello Casella, Susumu Ishida","doi":"10.1186/s40942-026-00823-4","DOIUrl":"10.1186/s40942-026-00823-4","url":null,"abstract":"<p><p>PURPOSE: To discuss the recent evidence that Janus kinase (JAK) inhibitors can cause viral retinitis. METHODS: A commentary on the case report in this issue and a review of cases in the literature. RESULTS: A total of 6 cases have now been reported of cytomegalovirus retinitis associated with Jak inhibitors. Additionally, there was a case of bilateral toxoplasma retinitis and a case of herpetic scleritis. DISCUSSION: It is important to be aware of the potential blinding complications associated with JAK inhibitors and if the patient complains of acute vision loss and/or floaters, the patient should be emergently referred to a retina specialist. </p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":"12 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12964922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of glycemic control among patients undergoing surgical treatment for advanced diabetic retinopathy in Saudi Arabia.","authors":"Ahmed Radi Algethami, Thuraya Zaki Jastaniah, Jouri Khalid Futaini, Abeer Saleh Fallatah, Shahad Aref Almatrafi, Sally Farahat Elsehimy, Ali Mohammed Bin Mahfodh","doi":"10.1186/s40942-026-00826-1","DOIUrl":"10.1186/s40942-026-00826-1","url":null,"abstract":"<p><strong>Background: </strong>Glycemic Control and its most common complication Diabetic retinopathy are a leading cause of visual impairment among diabetic patients which has a significant effect on patients' quality of life.</p><p><strong>Aim: </strong>This study aims to determine the impact of poor glycemic control (HbA1c) in preoperative tests and how it will affect the surgical outcome for advanced diabetic retinopathy.</p><p><strong>Methods: </strong>A retrospective case series study was employed at King Abdullah Medical City, Makkah. Analyzing 91 patients who underwent surgical treatment for advanced diabetic retinopathy from January 1, 2021, to 31 December 2021. Data were collected using the Track Care system, targeting patients whose preoperative level of glycemic control (HbA1c) was uncontrolled.</p><p><strong>Results: </strong>The final outcome determined that preoperative vision was poor in 18 patients with controlled HbA1c (≤7), and 52 patients (57%) had uncontrolled HbA1c (>7%). Compared with postoperative vision, it was poor in 20 patients with controlled HbA1c and 49 with uncontrolled HbA1c, and good in only 4 patients with controlled HbA1c and 18 with uncontrolled HbA1c (p>0.05). The average level of poorly controlled HbA1c in preoperative tests reaches 8.13 in our referred patients.</p><p><strong>Conclusion: </strong>This study concluded that the elevated HbA1c levels were associated with poor perioperative outcomes in diabetic patients undergoing surgical management for advanced retinopathy, highlighting the importance of optimizing glycemic control prior to surgery.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19-related acute macular neuroretinopathy in China: a retrospective study of 90 cases (152 eyes).","authors":"Hua Fu, Boya Chen, Yanming Xu, Houyue Liu, Zeyu Cai, Qiannan Chai, Nalei Zhou, Xuejing Li, Jialiang Duan","doi":"10.1186/s40942-026-00825-2","DOIUrl":"10.1186/s40942-026-00825-2","url":null,"abstract":"<p><p>BACKGROUND: Acute macular neuroretinopathy (AMN), a rare retinal disorder, is characterized by mild visual impairment that is associated with macular lesions. AMN cases increased during the coronavirus disease 2019 (COVID-19) pandemic. Chinese ophthalmology clinics have also observed an increase in cases since the end of 2022. We analyzed the clinical and epidemiological characteristics of COVID-19-related AMN cases in China. METHODS: This retrospective study included 90 patients (152 eyes). Information regarding COVID-19-related AMN cases was collected from online consultations and local clinics. Cases were diagnosed using multimodal fundus imaging. Statistical analyses were performed to evaluate clinical features and prognostic characteristics. RESULTS: Most patients were female (n = 70; 78%) and young (mean age, 28.6 ± 6.0 years). Bilateral AMN lesions were observed in 69% (n = 62) of patients. Most patients (n = 79; 88%) experienced a peak in ocular symptoms on the second to third day after COVID-19 symptoms, following a high fever. The most common ocular symptom was scotomas (n = 63 eyes; 41%). Most eyes (n = 112; 74%) had a baseline best-corrected visual acuity of ≥ 20/40. Among 56 patients (96 eyes) with follow-up durations of 3–15 months, changes in patient-reported visual symptoms were observed, with improvement in 41% of eyes (n = 39), no change in 46% (n = 44), and worsening in 13% (n = 13). CONCLUSIONS: Recognizing and addressing COVID-19-related retinal complications, particularly AMN, are important. Follow-up is crucial for monitoring the progression and evolution of visual symptoms and retinal changes over time. </p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and microvascular retinal changes following bariatric surgery: a prospective study.","authors":"Lívia da Silva Conci, Leandro Bortolon Bissoli, Davi Paraguassu de Sousa Martins, Cleide Guimarães Machado, André Carvalho Kreuz, Rony Carlos Preti, Leonardo Proveti Cunha, Alexandre Grobberio Pinheiro, Marco Aurelio Santo, Mario Luiz Ribeiro Monteiro, Leandro Cabral Zacharias","doi":"10.1186/s40942-026-00819-0","DOIUrl":"10.1186/s40942-026-00819-0","url":null,"abstract":"<p><p>BACKGROUND: This study sought to evaluate structural retinal changes, mainly microvascular ones, in obese patients undergoing bariatric surgery. METHODS: Obese patients who were candidates for bariatric surgery at University of São Paulo Medical School Clinics Hospital were recruited. Each participant underwent ophthalmic evaluation with ultra-widefield retinography, optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) obtained within one month before and six months following the surgical procedure. Structural OCT parameters (subfoveal choroidal thickness, mean peripapillary nerve fiber layer thickness, central foveal thickness, and macular volume) and OCTA parameters (peripapillary vascular density, macular vascular density, area, perimeter and circularity of the foveal avascular zone - FAZ - of both superficial and deep vascular complexes) were calculated and compared. RESULTS: 42 participants were included (83.3% female, mean age 47 years) of whom 24 (57.14%) were diabetic and 18 (42.86%) were non-diabetic. Of this sample, 81 eyes were evaluated. Six months after bariatric surgery, a significant increase in central foveal thickness (from 258±26 μm to 260±25 μm, p < 0.001), macular volume (from 8.6 ± 0.4 mm³ to 8.7 ± 0.4 mm³, p < 0.001), peripapillary vascular density (from 63 ± 8% to 65 ± 8%, p = 0.003) and macular vascular density in the superficial (from 27 ± 4.7% to 28 ± 4.4%, p = 0.005) and deep vascular complexes (29 ± 3.9% to 31 ± 3.5%, p < 0.001) were observed. No significant changes were detected in the metrics of the FAZ, subfoveal choroidal thickness and mean peripapillary nerve fiber layer thickness. CONCLUSIONS: In this study, bariatric surgery was associated with improved retinal microvascular perfusion, as demonstrated by the increase in macular and peripapillary vascular density. The increase in central foveal thickness and macular volume may be secondary to improved microvascular perfusion. </p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}