Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering最新文献_第2页

The Molecular Dynamics Study on the stability of Elk Prion Protein 麋鹿朊病毒蛋白稳定性的分子动力学研究

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444904

Ye Wang

{"title":"The Molecular Dynamics Study on the stability of Elk Prion Protein","authors":"Ye Wang","doi":"10.1145/3444884.3444904","DOIUrl":"https://doi.org/10.1145/3444884.3444904","url":null,"abstract":"Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are fatal and highly contagious neurodegenerative diseases, of which the misfolding and aggregation of the prion protein is the only pathogenic factor. After undergoing a specific conformational change. the ubiquitous intracellular prion protein (PrPC) can transform into a pathogenic conformation PrPSc, and subsequently leads to these devastating diseases. However, the details of the conformational conversion from PrPC to PrPSc are still undiscovered. In this work, molecular dynamics (MD)and steered molecular dynamics (SMD)simulations were combined to study the stability of elk prion protein (ePrPC). There is a coiled structure with the helical tendency and the random distortion of the β-sheets in the elk prion protein and these changes can provide a structural basis for the study of the transformation from PrPC to PrPSc. The elk prion protein, in the meantime, maintains its structural stability through the formation of a rigid mesh structure and the coordination of the loose loop structure, and achieves the purpose of supporting its biological activity. Our results can help to further understanding of the pathogenic mechanism of prion protein and contribute to designing and screening drugs against TSE diseases from a structural perspective.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122279544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gait Stability Analysis with a Two-dimensional Dynamic Parameter 基于二维动态参数的步态稳定性分析

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444901

Xing Gao, Fei Shen, Li Wang, Yingnan Ma, Haijun Niu, Yu-Bo Fan

{"title":"Gait Stability Analysis with a Two-dimensional Dynamic Parameter","authors":"Xing Gao, Fei Shen, Li Wang, Yingnan Ma, Haijun Niu, Yu-Bo Fan","doi":"10.1145/3444884.3444901","DOIUrl":"https://doi.org/10.1145/3444884.3444901","url":null,"abstract":"Objective: To define a two-dimensional (2-D) region of stability derived by center of mass (COM) velocity, and to assess the dynamic walking stability with COM position and velocity. Methods: The 2-D base of support (BOS) was determined by the intersection between the vector of the 2-D COM velocity and the envelope of the foot pressure. The region of stability for velocity (ROSv) in 2-D were determined using normalized COM position and velocity at toe off (TO). In order to exam the utility of this new parameter, fourteen elderly females with and without history of falls participated into a walking experiment. Results: The results showed that the 2-D ROSv could distinguish the coordinates difference between two groups much better than 1-D form in antero-posterior. COM position of elderly fallers demonstrated significant closer to the foot supporting boundary than that of healthy elderly adults at TO. Conclusion: The parameter of 2-D ROSv could differentiate among dynamic stability for healthy elderly adults and fallers. The results of walking experiment revealed elderly fallers tend to walk more conservatively compared to healthy subjects, to relieve the pressure of controlling their momentum.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124736110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Viability Differences on Oocyte Vitrification Surrounded by Cumulus Cells and Oocyte Vitrification not Surrounded by Cumulus Cells after In Vitro Maturation 卵母细胞体外成熟后被积云细胞包围的玻璃化与未被积云细胞包围的玻璃化卵母细胞存活率的差异

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444912

A. Kasman, B. Santoso, W. Widjiati, A. Hinting, Ni Wajan Tirthaningsih, R. I’tishom, B. Utomo, M. Djati

{"title":"The Viability Differences on Oocyte Vitrification Surrounded by Cumulus Cells and Oocyte Vitrification not Surrounded by Cumulus Cells after In Vitro Maturation","authors":"A. Kasman, B. Santoso, W. Widjiati, A. Hinting, Ni Wajan Tirthaningsih, R. I’tishom, B. Utomo, M. Djati","doi":"10.1145/3444884.3444912","DOIUrl":"https://doi.org/10.1145/3444884.3444912","url":null,"abstract":"This study aims to evaluate the viability differences on oocyte vitrification surrounded by cumulus cells and oocyte vitrification not surrounded by cumulus cells after in vitro maturation. The oocyte collection was through the aspiration technique of puncturing the 10 cc disposable syringe with 18 G needle filled with oocyte medium on follicle 2-6mm. Oocytes with intact cytoplasm were chosen and divided into two treatment groups; oocytes surrounded by cumulus cells and not surrounded by cumulus cells. The oocyte vitrification used hemi-straw into liquid nitrogen for ten days and continued with warming. In vitro maturation, each was with 50 μl drop for 5-10 oocytes covered with mineral oil in incubator for 22 hours under environmental condition of 5% CO2 , temperature of 38 °C, and humidity of 95-99%. This study resulted in the morphological proportion of normal oocytes was 83.3% in the oocyte group surrounded by cumulus cells and 70% in the oocyte group not surrounded by cumulus cells. The oocyte viability on groups of oocyte surrounded by cumulus cells was insignificantly higher compared to the groups of oocyte not surrounded by cumulus cells after the vitrification and warming followed by in vitro maturation.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128326526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of Cancer Immunotherapy 癌症免疫治疗概述

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444919

Zihan Wang

引用次数: 0

Orientation and Distance Dependence of Pairwise Correlation in Macaque V1 猕猴V1成对相关的方向和距离依赖

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444893

Lisha Hu, Qiyi Hu, Yao Chen

{"title":"Orientation and Distance Dependence of Pairwise Correlation in Macaque V1","authors":"Lisha Hu, Qiyi Hu, Yao Chen","doi":"10.1145/3444884.3444893","DOIUrl":"https://doi.org/10.1145/3444884.3444893","url":null,"abstract":"Neuronal responses to sensory stimuli are not independent from each other. For instance, trial-to-trial fluctuations in response strength are shared between neurons. Understanding the mechanisms that underlie these pairwise correlation is critical for determining their role in encoding sensory information. Our goal was to measure the effects of different orientation preferences and electrode recording distances on the correlation of paired neurons under different task difficulty. We simultaneously recorded single-unit activities from V1 neuronal pairs with non-overlapping receptive fields separating in different millimeter scales (up to 7.5 mm), while rhesus monkeys performed a detection task under two levels of task difficulty. We found that correlation of distant neurons is dependent on distances, but not sensitive to differences of orientation preference and task difficulty. These findings suggest that correlation of distant neurons likely involves feedback from extra-striate cortex. The circuit mechanism they imply provides new constraints on the functional connectivity that correlation may play in visual processing.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126290471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Anti-Müllerian Hormone (AMH) in Regulating Hypothalamus-Pituitary Function 抗<s:1> lerian激素(AMH)在调节下丘脑-垂体功能中的作用

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444899

Bin-bin Yan

引用次数: 0

The Research of Autophagy and Anti-Aging 自噬与抗衰老的研究

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444915

Baoshuai An

引用次数: 0

Biosensor-based Rapid Detection for Harmful Foodborne Pathogens 基于生物传感器的有害食源性病原体快速检测

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444906

Pei-lei Xu

{"title":"Biosensor-based Rapid Detection for Harmful Foodborne Pathogens","authors":"Pei-lei Xu","doi":"10.1145/3444884.3444906","DOIUrl":"https://doi.org/10.1145/3444884.3444906","url":null,"abstract":"With the rapid development of the food industry, food safety has received more and more attention from various countries. There are many factors affecting food safety, among which foodborne pathogens are one of the main factors. Therefore, it is becoming more and more important to develop rapid detection methods for foodborne pathogens. Biosensors have the advantages of simplicity, small size, low cost, high sensitivity, strong specificity, strong anti-interference ability, and quick response. To better understand the roles of biosensors in the detection of foodborne pathogens, this review focuses on latest development of pathogens rapid detection with biosensors. We introduced three types biosensors including optical, electrochemical, mass sensitive biosensors and discussed the application of nanobiotechnology in biosensors. We found that the optical and electrochemical biosensors have been studied for quite periods of time, therefore their better performance is accepted and appreciated during commercialization. Beyond that, monitoring viable cells are of great importance for food quality control and people's health supervision. We believe that the potential of various biosensors may shed new light on viable cell measurement and counting in the future.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117143927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viewing the Development Process of Coronavirus from the Diagnosis and Treatment of New Coronavirus 从新型冠状病毒的诊治看冠状病毒的发展历程

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444921

S. Wan

引用次数: 0

A Review for Heart Regeneration 心脏再生研究进展

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444897

Flora Chen

引用次数: 0