A Review for Heart Regeneration

Abstract

Heart disease is one of the diseases with high mortality. When heart disease occurs, a large number of cardiomyocytes die and the heart function is severely damaged. In severe cases, it may lead to death. The research on heart regeneration has become a key issue in the treatment of heart diseases. This review article discusses the factors that influence heart regeneration. Promoters include ERBB2, NRG1, estrogen, and miRNA 19-72 clusters whereas inhibitors consist of innervation, thyroid T4 and miRNA-128. The recognition of factors that influence cardiomyocyte proliferation and heart regeneration may provide reveal new therapeutic possibilities in the treatment of cardiovascular diseases.