Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering最新文献

Study on Traditional Chinese Medicine for Treating COVID-19 中医药治疗新冠肺炎的研究

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444920

Jianqiu Wang

引用次数: 0

Improved Robustness in Water-Fat Separation in MRI using Conditional Adversarial Networks 基于条件对抗网络的MRI水脂分离鲁棒性改进

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444891

Chen Shen, H. She, Yiping P. Du

{"title":"Improved Robustness in Water-Fat Separation in MRI using Conditional Adversarial Networks","authors":"Chen Shen, H. She, Yiping P. Du","doi":"10.1145/3444884.3444891","DOIUrl":"https://doi.org/10.1145/3444884.3444891","url":null,"abstract":"Water-fat separation is a post-processing method to obtain water/fat only images and parametric maps from multi-echo magnetic resonance (MR) images. Due to multi-parametric analytic models and optimization algorithm, the water-fat separation problem is complicated and time-consuming to solve. Traditional model-based techniques require a known field map to make the problem becomes “almost linear”, which results in the dependence on the accuracy of field map estimation and the decrease of computing efficiency. In this study, we proposed a deep learning based method to solve the inverse problem and simultaneously obtain the water/fat images, field map and R2* map without iteration process and field map estimation in advance. Conditional GAN was utilized in this work to preserve the structural details and ground truth was obtained using a graph cut method. The results showed that our method had a more robust performance and higher structural similarity in water-fat separation compared to U-Net based method. The proposed deep learning method is field map free and effective to separate fat/water.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114883733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Secretome And Ramiprilat Effects On Endothelial Progenitor Cells Proliferation In Chronic Coronary Syndrome Patient 分泌组和雷米普利特对慢性冠脉综合征患者内皮祖细胞增殖的影响

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444910

Y. Oktaviono, F. Sandra, A. Lefi, C. P. Budianto

{"title":"Secretome And Ramiprilat Effects On Endothelial Progenitor Cells Proliferation In Chronic Coronary Syndrome Patient","authors":"Y. Oktaviono, F. Sandra, A. Lefi, C. P. Budianto","doi":"10.1145/3444884.3444910","DOIUrl":"https://doi.org/10.1145/3444884.3444910","url":null,"abstract":"It is known, that patients with chronic coronary syndrome (CCS) have lower endothelial progenitor cells (EPC) levels compared with healthy people. Secretome is a paracrine product from human umbilical cord blood mesenchymal stem cells (hUCB-MSC) that contains growth factors that enhanced the neovascularization and angiogenesis. Ramiprilat is an active form of ramipril which acts as an angiotensisn-converting enzyme inhibitor (ACE-I). Ramipril has been shown to have an effect on EPC proliferation. The effect of secretome alone or combination with ramiprilat is not yet elucidated. This study aimed to identify the effect of secretome compared with ramiprilat on EPC proliferation. The EPC was collected from a CCS person and cultered in stemline II medium for seven days. Cultured EPC were then divided into 8 groups of control, various doses of secretome (2, 10, and 20%), ramiprilat 10 μmol, and combination of various doses of secretome and ramiprilat. Three days after the treatement, the EPC proliferation measured by MTT assay in 96-well plated. The result of this study shown the higher the dose of secretome (2,10, and 20%) increase the proliferation of EPC better than ramiprilat (0.7128; 1.2417; 1.585 OD vs 0.7 OD; p<0.001). in conclusion secretome works in dose-dependent manner, the higher the concentration of secretome, the higher the EPC proliferation.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114871507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4th order tensors for multi-fiber resolution and segmentation in white matter 四阶张量在白质多纤维分辨和分割中的应用

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444892

Temesgen Bihonegn, Avinash Bansal, J. Slovák, Sumit Kaushik

{"title":"4th order tensors for multi-fiber resolution and segmentation in white matter","authors":"Temesgen Bihonegn, Avinash Bansal, J. Slovák, Sumit Kaushik","doi":"10.1145/3444884.3444892","DOIUrl":"https://doi.org/10.1145/3444884.3444892","url":null,"abstract":"Since its inception, DTI modality has become an essential tool in the clinical scenario. In principle, it is rooted in the emergence of symmetric positive definite (SPD) second-order tensors modelling the difusion. The inability of DTI to model regions of white matter with fibers crossing/merging leads to the emergence of higher order tensors. In this work, we compare various approaches how to use 4th order tensors to model such regions. There are three different projections of these 3D 4th order tensors to the 2nd order tensors of dimensions either three or six. Two of these projections are consistent in terms of preserving mean diffusivity and isometry. The images of all three projections are SPD, so they belong to a Riemannian symmetric space. Following previous work of the authors, we use the standard k-means segmentation method after dimension reduction with affinity matrix based on reasonable similarity measures, with the goal to compare the various projections to 2nd order tensors. We are using the natural affine and log-Euclidean (LogE) metrics. The segmentation of curved structures and fiber crossing regions is performed under the presence of several levels of Rician noise. The experiments provide evidence that 3D 2nd order reduction works much better than the 6D one, while diagonal components (DC) projections are able to reveal the maximum diffusion direction.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130114576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Molecular Dynamics Study on the PATHOGENICITy of Cystatin C Mutant 胱抑素C突变体致病性的分子动力学研究

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444905

Luying Pan

{"title":"The Molecular Dynamics Study on the PATHOGENICITy of Cystatin C Mutant","authors":"Luying Pan","doi":"10.1145/3444884.3444905","DOIUrl":"https://doi.org/10.1145/3444884.3444905","url":null,"abstract":"Cystatin C can inhibit cysteine proteases and performs important physiological functions in cells. This protein is involved in the formation of amyloid fibers, and usually found in patients with Alzheimer's diseases or Down syndromes. Experimental evidence indicates that the mutation of human cystatin C 66th position, named L66Q is more likely to form dimers, which self-assemble subsequently to form amyloid deposits. However, the details about how the L66Q forms amyloid deposits are not clear. Here we used MD simulations and revealed that the single-site mutation in the 68th position of chicken cystatin C will cause changes in structural characteristics. The I68Q mutant has a higher fibro genic tendency than the wt, and the I68Q mutant has a tendency to “open” compared to the wt. The Loop1 region of I68Q has greater flexibility, and are easier to form dimers through domain exchange than wt, followed by further forming amyloid fiber deposits. Our study results are consistent with previous experimental conclusions, and provide a new idea for the future research of similar proteins. Besides, our conclusions also afford a solid theoretical basis for conquering amyloid diseases caused by cystatin C from a structural perspective.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114676609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of Tumor Immunotherapy based on Indoleamine 2,3 Dioxygenase Inhibitors 基于吲哚胺2,3双加氧酶抑制剂的肿瘤免疫治疗综述

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444917

Xiangyu Hao

引用次数: 1

The Effect of High Fat Diets on Organic Acids in Mice 高脂肪饮食对小鼠体内有机酸的影响

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444903

Si-Cheng Li

引用次数: 0

Expression and Methylation of Tumor Suppressor Gene DKK3 in Nasopharyngeal Carcinoma: A Datamining Study 肿瘤抑制基因DKK3在鼻咽癌中的表达和甲基化:一项数据挖掘研究

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444887

Xinyuan Zheng, Dongzhi Cen

{"title":"Expression and Methylation of Tumor Suppressor Gene DKK3 in Nasopharyngeal Carcinoma: A Datamining Study","authors":"Xinyuan Zheng, Dongzhi Cen","doi":"10.1145/3444884.3444887","DOIUrl":"https://doi.org/10.1145/3444884.3444887","url":null,"abstract":"Objectives: To study the relationship between the expression level of tumor suppressor gene DKK3 in nasopharyngeal carcinoma tissues and the methylation of the promoter region, and to explore the methylation of DKK3 gene promoter as a potential epigenetic intervention target for nasopharyngeal carcinoma. Methods: First, download the nasopharyngeal carcinoma expression profile chip, RNA-Seq sequencing and methylation chip data from the GEO database, use the R software to analyze the difference of DKK3 expression and promoter methylation in nasopharyngeal carcinoma and adjacent tissues and normal control tissues; then, select cancer tissue specimens and corresponding adjacent tissue specimens from 50 patients with nasopharyngeal carcinoma, use RT-PCR to detect the mRNA expression of DKK3 gene and methylation-specific PCR (MSP) to detect the promoter methylation level, and analyze the relationship between the two. Results: The mRNA level of DKK3 gene was found significantly down-regulated (|log2FC|> 1.0) by three different expression profiling platforms of AffymetrixU133 Plus2.0, IlluminaHiSeq 2000 and 4000. Methylation chip analysis found that the methylation status of 4 CpG sites in nasopharyngeal carcinoma tissues was significantly higher than that of normal control tissues. 2 CpG sites in nasopharyngeal carcinoma tissues was significantly higher than that of adjacent tissues (GSE62336). Conclusions: Hypermethylation in the promoter region caused down-regulation of the tumor suppressor gene DKK3 expression in nasopharyngeal carcinoma tissues, which was a potential target for epigenetic intervention.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130446217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of Repetitive Transcranial Magnetic Stimulation on Mood and Cognitive Function in Simulated Weightlessness Rats 重复经颅磁刺激对模拟失重大鼠情绪和认知功能的调节

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444902

Ling Wang, Jiajia Yang, Xi Xiao, C. Zheng, Dong Ming

{"title":"Modulation of Repetitive Transcranial Magnetic Stimulation on Mood and Cognitive Function in Simulated Weightlessness Rats","authors":"Ling Wang, Jiajia Yang, Xi Xiao, C. Zheng, Dong Ming","doi":"10.1145/3444884.3444902","DOIUrl":"https://doi.org/10.1145/3444884.3444902","url":null,"abstract":"During spaceflight, microgravity can cause negative impact on emotion and cognitive function. However, few effectively preventive methods have been developed yet. Previous studies showed that repetitive transcranial magnetic stimulation (rTMS), as a novel non-invasive technique, alleviated depression and cognitive dysfunctions. In the present study, the hindlimb unloading (HU) rat model was used to simulate microgravity. And then, in experiment 1 we investigated whether 3-week HU induced anxiety and memory impairment. Behavioral tests including open field test, elevated plus maze test, Y maze test, and Morris water maze were performed. In experiment 2, during the simulated microgravity, HU rats were exposed to a 2-week rTMS (10Hz). After that, the same behavioral experiments were carried out. The results showed that spontaneous activity of HU rats decreased, reflected in the fewer entries to the central area in open field test, while rTMS protected against the harmful effect. No difference was observed in the behavioral performance of spatial cognition between control and HU rats. Our data suggests that rTMS-treatment during simulated microgravity plays a role in protecting against anxious emotion induced by microgravity simulation.","PeriodicalId":142206,"journal":{"name":"Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114268709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

View from Public Health to Molecular Biology on Coronavirus Disease 2019 (COVID-19) 2019冠状病毒病(COVID-19)从公共卫生到分子生物学的视角

Proceedings of the 2020 7th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2020-11-06 DOI: 10.1145/3444884.3444922

Yuru Li

引用次数: 0