The Effect of High Fat Diets on Organic Acids in Mice

Abstract

The high fat diet (HFD) is the main cause of obesity and can lead to some severe complications associated with metabolic disorder. The content of metabolic intermediates will change caused by HFD. In this review, we will report studies about the change of certain organic acids in high fat diet fed mice. In the research about HFD's effect on glycolysis, HFD has a great influence on the content of pyruvate lactic acid. Different hypotheses are proposed by researchers for this change. The effect of HFD on citric cycle (TCA cycle) seems not clear needing further studies in related directions. Based on studying the change of organic acid in HFD fed mice, researchers provided some treatments to mitigate the negative impacts of HFD and the severe complications.