International Journal of Research and Development in Pharmacy and Life Sciences最新文献

{"title":"A review on Mucoadhesive Buccal Patches","authors":"Aspee Singh, Upendra Prajapati","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2654-2660","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2654-2660","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2654-2660 ABSTRACT: The oral cavity is an attractive site for the delivery of drugs. Through this route it is possible to realize mucosal (local effect) and transmucosal (systemic effect) drug administration. In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrier to reach the systemic circulation.Absorption through the buccal mucosa overcomes premature drug degradation due to the enzyme activity and pH of gastro intestinal tract, avoids active drug loss due to presystemic metabolism, acid hydrolysis and therapeutic plasma concentration of the drug can be rapidly achieved. The adhesive properties of such drug delivery platforms can reduce the enzymatic degradation due to the increased intimacy between the delivery vehicle and the absorbing membrane. However, per oral administration of drugs has disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract, that prohibit oral administration of certain classes of drugs especially peptides and proteins. Consequently, other absorptive mucosa is considered as potential sites for drug administration. Transmucosal routes of drug delivery offer distinct advantages over per oral administration for systemic drug delivery.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"2 1","pages":"2654-2660"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75490397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Yogic exercise on static Spirometery values in normal healthy individuals","authors":"K. Ambareesha, B. M. Rao, M. Suresh, K. Rani, M. Chandrasekar","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2682-2684","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2682-2684","url":null,"abstract":"Introduction: Yogic practices can be a very good exercise for maintaining proper health and has a profound effect on the lung functions of an individual. They are also used as psycho-physiological stimuli to increase the physiological functionsand human performance. Materials & Methods: The present study was conducted on 60 male medical students in first yearM.B.B.S, who came voluntarily as subjects for the project with written consent. Their age ranged between 18-24 years. All the participants were given training for 15 days by a certified yoga teacher and were allowed to practice pranayama and suryanamaskar exercise for one hour every day in the evening for a duration of six months. Five types of pranayama namely; Bhastrika pranayama, Anulomavilom pranayama, Bhramari pranayama and Pranava pranayama were chosen for this study. Various static spirometry tests were done to measure the Tidal volume (TV), Slow vital capacity (SVC), Inspiratory reserve volume (IRV), Expiratory reserve volume (ERV). Pulmonary function test was performed in all the participants using computerized pulmonary testing machine (Helios401, RMS).Results:The obtained data was analyzed for statistical significance using SPSS software of 22.0 version followed by students t test and p<0.005 was considered the level of significance. There was significant increase in all these variables(p<0.001) in the study group after six months of yoga. Conclusion: From this study we concluded that, the practice of yoga can be advocated to improve respiratory efficiency for healthy individuals as well as an alternative therapy or as adjunct to conventional therapy in respiratory diseases and improve the anesthetic fitness for cardiothoracic surgery. ⇑ Corresponding author at: K. Ambareesha Assistant Professor, Department of Physiology, MNR Medical College & Hospital, Sangareddy, Telangana, India E-mail address: drambreeshphysio@gmail.com","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"19 1","pages":"2682-2684"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87346446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of Rifamycin using Nocardia mediterranea (ATCC 13865)","authors":"S. Niranjan, Chandrul Koushal, S. Jain","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2693-2696","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2693-2696","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4). 2693-2696 ABSTRACT: The U.V. irradiation to Nocardia mediterranea ATCC 13865 for 10, 20, 30, 40, 50, 60, 70, up to 120 minute the maximum (581μgml) production of rifamycin was found developed S-10 strain for maximum production of rifamycin antibiotics (optimum time 15 minute) for further enhancement of rifamycin various parameter like age and size inoculum, pH of the culture medium, various carbohydrate, various amino acids, temperature, various Carbone sources, aeration were optimized. The maximum rifamycin conc. of 570 μgml at 4.50 inoculums % with the age of 48 hrs. Inoculum was given even maximum rifamycin production with various age of inoculums (24, 36, 48, 60, 72 hrs.) with corresponding inoculums % (1.5, 2.5, 3.5, 4.5) in culture media, the optimum rifamycin 485 and 480 μgml of rifamycin was producing M-6 and M-8 respectively medium amongst M-1, 2, 3, 4, 5, 6, 7, 8, 9 and M-10.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"76 1","pages":"2693-2696"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79949303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of roots of Calotropisprocera and Calotropis gigantean via evaluation of morphological and physicochemical parameters","authors":"Pratibha Mishra, K. Yadav, G. Gautam","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2706-2710","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2706-2710","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2706-2710 ABSTRACT: BothCalotropis giganteanand Calotropisprocera are medicinal shrub, belongs to the family Asclepiadaceae. Both plants are used in Ayurvedic system of medicine for healing various diseases. However, the present study was aimed to evaluate the parameters to determine the identity, purity and strength of the plant. This study comprises of Morphological and Preliminary physio-chemical investigations of the shrub. Organoleptic characteristics such as color, taste, odour, powder microscopy,etc. were studied. The fluorescent behavior of the powdered root part of Calotropis giganteanand Calotropisprocera in different solutions towards ordinary light and ultraviolet light (both long and short wavelengths) were found out. Total Ash Value, Acid insoluble ash, Water & Alcohol soluble extractive values were determined.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"2016 1","pages":"2706-2710"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74275721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant properties of polyphenolic rich HPLC standardized extract of Beta vulgaris L. roots","authors":"R. Indu, A. Adhikari, M. Ray, A. Hazra, T. Sur, A. Das","doi":"10.21276/IJRDPL.2278-0238.2017.6(3).2619-2624","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(3).2619-2624","url":null,"abstract":"OBJECTIVES: The present study was planned to evaluate the antioxidant effects of standardized Beta vulgaris L. or beetroot. METHODS: The polyphenols present in lyophilized water extract of beetroot (BR) were quantified and standardized by HPLC. Deactivation of free radicals by BR was studied by in vitro biochemical assays including 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide and superoxide radical scavenging activities. Nitrite content of BR was estimated. Moreover, inhibition of protein denaturation properties of BR was carried out. RESULTS : HPLC chromatogram revealed presence of nine bioactive polyphenols in BR. Further, strong dose-dependent antioxidant properties were noted. IC50 (Inhibitory Concentration) of BR for DPPH, hydrogen peroxide and superoxide radical were 104.44μg/ml, 4.06μg/ml and 71.43μg/ml respectively. BR also showed enriched in nitrite content 3.359 mM/mg and it inhibited protein denaturation (IC50 594μg/ml). CONCLUSION: Beetroot was found to possess strong antioxidant property that may be due to presence of polyphenols.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"60 1","pages":"2619-2624"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77181306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review on Buccal DrugDelivery System","authors":"P. Singh, Devender Singh, Rohit Kumar Kumar Bijauliya","doi":"10.21276/IJRDPL.2278-0238.2017.6(3).2606-2618","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(3).2606-2618","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(3).2606-2618 ABSTRACT: Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity. The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief description of advantages, limitations of buccal drug delivery and theories involved in mucoadhesion along with method of preparation mucoadhesive system, mucoadhesive polymer, and classification of buccal system.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"3 1","pages":"2606-2618"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87097582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and characterization of mouth dissolving mucoadhesive buccal film of Zolmitriptan","authors":"P. Singh, Devender Singh, Rohit Kumar Kumar Bijauliya","doi":"10.21276/IJRDPL.2278-0238.2017.6(3).2625-2630","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(3).2625-2630","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(3).2625-2630 ABSTRACT: Fast dissolving buccal film drug delivery system is an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience in difficulties of swallowing traditional oral solid dosage forms. It improves the efficacy of API by dissolving within minute in oral cavity after the contact with less saliva as compared to fast dissolving tablets, without chewing and no need of water for administration. Oral films provide better drug utilization by avoiding the first pass metabolism, enhance drug bioavailability. Fast dissolving buccal films of zolmitriptan were prepared by solvent casting method using Polymers (E4, E10, E15) in different ratio as film forming agent, PEG 400 as plasticizer, Tween 80 as permeation enhancer, glycerin as surfactant.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"75 1","pages":"2625-2630"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91170618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of natural oils for the development of cheap and sustainable solution for mosquito problem in the poor community","authors":"Hrishikesh Badrike, M. Sampat, S. More, Wilma D. Cunha","doi":"10.21276/IJRDPL.2278-0238.2017.6(3).2641-2647","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(3).2641-2647","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(3).2641-2647 ABSTRACT: Mosquitoes and their increasing number are responsible for causing millions of deaths around the world. Another important aspect is global warming that has already altered the distribution of vector borne diseases (IPCC fourth assessment report). Uses of synthetic insecticides to control vector mosquitoes has not only affected humans but has also caused adverse environmental effects in addition to high operational cost. Chemical mosquito repellent has a remarkable safety profile, but they are toxic to human health causing various side effects. Hence giving importance to health of human beings together with the environment, a mosquito repellent solution was prepared. The solution was prepared using the natural oils such as neem (Azadirachta indica), lemon grass (Cymbopogon flexuosus). All the oils were experimented using different concentrations. The experiment was conducted in a society where the people were already suffering from vector borne diseases such as malaria, dengue and chikungunya. The solution proved to be very effective for repelling of the mosquitoes and also did not cause any effect on the human beings. In addition to this, the solution is affordable by the poor communities.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"33 1","pages":"2641-2647"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82558989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of Tadalafil oral disintegrating tablets with enhanced dissolution rate by complexation","authors":"Ashok Thulluru, K. Kumar, E. C. Priya, R. Mounika, K. Munichandra, Sree Vidyanikethan","doi":"10.21276/IJRDPL.2278-0238.2017.6(3).2631-2640","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(3).2631-2640","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(3).2631-2640 ABSTRACT: Aim: In the present study was to enhance the solubility of Tadalafil (TDF) by forming inclusion complexes with β-cyclodextrin (βCD) and further to enhance its dissolution rate by formulating orally disintegrating tablet (ODT) by direct compression technique. Objectives: To perform the phase solubility studies, for to determine the ratio of drug: carrier ratio in the formation of complexes. Physico-chemical characterization of complexes by DSC and X-ray diffraction studies. To check the superiority of selected superdisintegrants [sodium starch glycolate (SSG), croscarmellose sodium (CCS), crospovidone (CPV)] in enhancing the dissolution rate of TDF. To fasten the onset of action and thereby increasing TDF’s bioavailability in comparison to its conventional tablets. Methods: Standard calibration curve of TDF in pH 6.8 phosphate buffer was constructed by spectrophotometric method, drug-excipient compatibility was checked by FT-IR studies. All the Formulations were evaluated for pre& post-compression studies. Accelerated stability studies up to 3 months were conducted for the optimized formulation, as per ICH guidelines. Results and Discussions: polymers used in the study are compatible with TDF. Pre& postcompression parameters were within the acceptable limits for all formulations. In vitro dissolution kinetic studies indicate the release of TDF from ODT increases with the increased concentration of superdisintegrants. The order of superdisintegrants in enhancing the dissolution rate of TDF is CPV>SSG>CCS. Formulation F6, had the highest dissolution efficiency at 5 min (DE5=39.55 %); first order dissolution rate constant (K1 =0.1052 min-1) with a regression coefficient (r2=0. 9844) and lesser time for 50% of drug release (t50=4 min), was considered as the optimal ODT. It passed the test for stability as per ICH guidelines. Conclusion: The optimized TDF ODT with its 1:4 βCD complex was formulated by the direct compression technique, with 6% w/w CPV as superdisintegrant, which will fasten the onset of action and enhances the bioavailability of TDF in comparison to its conventional tablets.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"38 1","pages":"2631-2640"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88507220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Ritonavir Solid Dispersions","authors":"P. Swathi, Y. Kumar","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2522-2529","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2522-2529","url":null,"abstract":"Ritonavir is an antiretroviral agent used in the treatment of AIDS having lowest water solubility of about 0.01mg/ml, indicates class IV drug bio-pharmaceutical classification systems, make an objective to study the solubility and dissolution by solid dispersion technique. Ritonavir solid dispersions are prepared using maltodextrin and poloxamer by solvent evaporation and kneading method at 1:1 and 1:3 drug: carrier and were evaluated for drug content, solubility, saturation solubility, FTIR, XRD, DSC and in-vitro dissolution. ⇑ Corresponding authors at: Professor (Dr.). Y. Anand Kumar, Department of Pharmaceutics, V.L. College of Pharmacy, Manik Prabhu Temple Road, Raichur 584103, India E-mail address:","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"62 1","pages":"2522-2529"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81321153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}