Formulation and Evaluation of Ritonavir Solid Dispersions

Abstract

Ritonavir is an antiretroviral agent used in the treatment of AIDS having lowest water solubility of about 0.01mg/ml, indicates class IV drug bio-pharmaceutical classification systems, make an objective to study the solubility and dissolution by solid dispersion technique. Ritonavir solid dispersions are prepared using maltodextrin and poloxamer by solvent evaporation and kneading method at 1:1 and 1:3 drug: carrier and were evaluated for drug content, solubility, saturation solubility, FTIR, XRD, DSC and in-vitro dissolution. ⇑ Corresponding authors at: Professor (Dr.). Y. Anand Kumar, Department of Pharmaceutics, V.L. College of Pharmacy, Manik Prabhu Temple Road, Raichur 584103, India E-mail address: