International Journal of Research and Development in Pharmacy and Life Sciences最新文献

Preliminary phytochemical screening of bark (powder) extracts of Ficus religiosa (peepal) plant 榕(皮)皮(粉)提取物的初步化学筛选

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2020-06-15 DOI: 10.47128/IJRDPL.2278-0238.2020.9(1).1-9

P. Tiwari, R. Gupta

引用次数: 2

A prospective observational study on the effect of Erythropoiesis stimulating agents in chronic kidney disease Anemia patients 促红细胞生成素对慢性肾病贫血患者影响的前瞻性观察研究

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2020-06-15 DOI: 10.47128/IJRDPL.2278-

M. Jose, S. Singh, Vinson Achankunju, Punitha Sundaraswamy, S. Sherief, Sivakumar Thangaval

{"title":"A prospective observational study on the effect of Erythropoiesis stimulating agents in chronic kidney disease Anemia patients","authors":"M. Jose, S. Singh, Vinson Achankunju, Punitha Sundaraswamy, S. Sherief, Sivakumar Thangaval","doi":"10.47128/IJRDPL.2278-","DOIUrl":"https://doi.org/10.47128/IJRDPL.2278-","url":null,"abstract":"Background and Objectives: Anemia is a frequent complication, and significant morbidity and mortality in patient with chronic kidney disease (CKD). Erythropoiesis Stimulating Agents (ESAs) have become the standard care for anemia t erapy and reduces need for blood transfusions. The bjective of the study was to evaluate the safety and effect of ESAs and to create the awareness among patients regarding the Erythropoiesis stimulating agents through patient i formation leaflets. Methods: The prospective observational study of 6-month duration was conducted in a tertiary care hospital. A total of 162 patients on ESAs were enrolled in the study. Patients were followed for continuously and the mean difference is assessed by monitoring the primary and secondary hematological parameters before and after ESAs administration. Patient information leaflet was given t the patients for education and awareness about ESAs. Results: Out of 162 patients, after the administration of ESAs mean value increase in hemoglobin level was found from base line 6.9g/dL to 11.6g/dL. Significant improvement was noted in CKD anemia patient indicating impact of patient counseli g. Conclusion: It can be concluded that Erythropoiesis Stimulating Agents in treatment of anemia along with effective counseling from clinical pharmacist benefits CKD patients and improves the health outcomes.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"9 1","pages":"07-12"},"PeriodicalIF":0.0,"publicationDate":"2020-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78432185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catheter associated urinary tract infections in intensive care units patients in a tertiary care hospital 某三级医院重症监护病房患者尿路感染的研究

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2020-02-15 DOI: 10.4712821276/IJRDPL.2278-

M. Goel, D. Chhina, Veenu Gupta

{"title":"Catheter associated urinary tract infections in intensive care units patients in a tertiary care hospital","authors":"M. Goel, D. Chhina, Veenu Gupta","doi":"10.4712821276/IJRDPL.2278-","DOIUrl":"https://doi.org/10.4712821276/IJRDPL.2278-","url":null,"abstract":"Introduction: Catheter associated urinary tract infections (CAUTI) is the most common health care associated infection (HAI), accounting for 40% of all HAIs in particularly in patients admitted to intensive care units (ICU) due to their more frequent necessity of urinary catheterization and longer duration of catheter use. Knowledge about Microbiological profile and antimicrobial sensitivity pattern of CAUTI is essential to implement the infection control system in a proper manner. \u0000Aims and objectives: To study the rate and microbiological profile of catheter associated urinary tract infections and in patients admitted in Intensive Care Units. \u0000Materials and methods: A one-year prospective study was conducted in which urine samples were collected from patients admitted in Medical ICUs on indwelling urinary catheter for >48 hours and processed in Microbiology Department according to standard procedures. CA-UTI rate was calculated and their microbiological profile and various resistance patterns were studied as per CLSI guidelines. \u0000Results: Out of 1406 enrolled patients, 64 patients developed CAUTI. Overall CAUTI rate was 4.06/1000 catheter days. Most common isolate in CAUTI cases was Klebsiella spp. (32.3%), followed by Escherichia coli (24.6%). Gram negative isolates showed higher sensitivity to aminoglycosides, imipenam and nitrofurantoin as compared to cephalosporins The Enterococcus spp. were 100% sensitive to linezolid and 71.4% sensitive to both vancomycin and teicoplanin. \u0000Conclusion: CAUTI rate in our ICUs was high compared to the benchmarks. Antibiotic sensitivity pattern of the pathogens involved was also low. This study provides the data of predisposing risk factors and its causative microbial flora for CAUTI in our tertiary care.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"65 1","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81478127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal plants used for Diabetes mellitus: An Overview 治疗糖尿病的药用植物综述

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-08-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(4).3022-3029

Nitin Chaudhary, N. Tyagi

引用次数: 4

Preparation and evaluation of an Emulgel of Hydroxyzine hydrochloride 盐酸羟嗪乳状液的制备及评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-03-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(2).2962-2968

P. Lakshmi, K. Mounika, K. Kalyani

{"title":"Preparation and evaluation of an Emulgel of Hydroxyzine hydrochloride","authors":"P. Lakshmi, K. Mounika, K. Kalyani","doi":"10.21276/IJRDPL.2278-0238.2018.7(2).2962-2968","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(2).2962-2968","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(2).2962-2968 ABSTRACT: Hydroxyzine hydrochloride is effective in the treatment of urticaria and other allergic skin disorders. Hydroxyzine hydrochloride emulgel potentially enhances drug penetration into the stratum corneum and localizes the drug within the dermoepidermal layers. Emulgel was formulated by first preparing the emulsion using fixed oils and non-ionic surfactants, and then incorporated into a gel base. Emulsions were primarily optimized using non-ionic surfactants, Span 60 and Tween 20 and gel was optimized using Carbopol 940, HPMC K100M and xanthan gum. These optimized formulations were studied for in vitro drug release studies followed by ex vivo, skin irritation and stability studies. The optimized o/w emulgel was compared with the w/o emulgel which showed the in vitro release of 76.7% and ex vivo studies showed 42.3% release at the end of 8th hr. The ex vivo release of optimized HESX (o/w emulgel) formulation was compared with the HESX1 (w/o emulgel) formulation which showed the release of 53% and 42.3% release respectively. The emulgel formulation HESX showed irritation potential of ‘0’, thus proving to be non-irritant. Hence, it can be concluded that o/w emulgel formulation of hydroxyzine hydrochloride showed better release than the w/o emulgel.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"7 1","pages":"2962-2968"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81816713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Clinical and Laboratory evaluation of patients presenting with fever with Thrombocytopenia in a tertiary care hospital of North India 北印度三级医院出现发热伴血小板减少症患者的临床和实验室评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-03-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(2).2959-2961

D. Soin, P. Grover, H. Khutan, R. Malhotra

{"title":"Clinical and Laboratory evaluation of patients presenting with fever with Thrombocytopenia in a tertiary care hospital of North India","authors":"D. Soin, P. Grover, H. Khutan, R. Malhotra","doi":"10.21276/ijrdpl.2278-0238.2018.7(2).2959-2961","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2018.7(2).2959-2961","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(2).2959-2961 ABSTRACT: Introduction: Fever with thrombocytopenia is a common condition that is associated with an increased risk of morbidity and mortality. Aims & Objectives: The study was designed to assess the etiology, clinical features and laboratory profile of fever with thrombocytopenic patients which is of great value in determining the outcome and prognosis in these patients. Material & Methods: A total number of 50 patients who were admitted with the history of fever with thrombocytopenia were studied. Detailed examination of various systems was done. Routine investigations were done, Specific and Special investigations (Blood & Urine culture, Widal, Antigen test for malaria, IgM ELISA Dengue, Bone marrow examination etc.,) were done as and when indicated. Results: From this study it was observed that infections (98%) were the most common cause and among infections malaria (36%)was the commonest cause followed by viral illness (34%). Definitive increase in platelet counts was noted after treating the underlying cause. Conclusion: Thrombocytopenia was the commonest laboratory finding in many fever cases. It is better to do platelet count in all fever cases whether they have bleeding manifestations or not.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"18 1","pages":"2959-2961"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77223940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyrazole: A potent drug candidate with various Pharmacological activities 吡唑:一种具有多种药理活性的有效候选药物

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-03-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(2).2941-2948

Anandi Kapri, G. Raj, Nitin Gupta

引用次数: 0

Antibiotic Susceptibility in metal tolerant Pseudomonas Spp. from Tannery waste water 制革厂废水中耐金属假单胞菌的抗生素敏感性

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-03-01 DOI: 10.21276/ijrdpl.2278-0238.2018.7(2).2954-2958

Z. Hasan, Seema Singh, Ras Khuswaha, Santosh Kumar, Supriya Karpathak, Rajeev Kumar

引用次数: 0

Assessment of Phytochemical and Antiulcer activity of Curcuma longa leaves 姜黄叶的植物化学和抗溃疡活性评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-03-01 DOI: 10.21276/IJRDPL.2278-0238.2018.7(2).2949-2953

Sandhya Sujane, N. Shukla, N. Shukla, M. Bhowmick, J. Rathi

引用次数: 0

Study of miRNA based gene regulation involved in Squamous Lung Carcinoma by assistance of Argonaute Protein Argonaute蛋白辅助下肺鳞癌miRNA基因调控的研究

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-01-25 DOI: 10.21276/IJRDPL.2278-0238.2018.7(1).2913-2917

Roma Chandra, Sumit Kumar, M. Khan

引用次数: 0