International Journal of Research and Development in Pharmacy and Life Sciences最新文献_第2页

Formulation and evaluation of an Anti-pyretic (Paracetamol) syrup for Paediatric 小儿退热(扑热息痛)糖浆的配方及评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-01-25 DOI: 10.21276/ijrdpl.2278-0238.2018.7(1).2924-2930

Pawan Singh, Prevesh Kumar, N. Prasad

引用次数: 2

Smilax zeylanica: An overview 菝葜:概述

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-01-25 DOI: 10.21276/IJRDPL.2278-0238.2018.7(1).2893-2895

Sunaina Sharma, N. Tyagi, Sagarika Majhi

{"title":"Smilax zeylanica: An overview","authors":"Sunaina Sharma, N. Tyagi, Sagarika Majhi","doi":"10.21276/IJRDPL.2278-0238.2018.7(1).2893-2895","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(1).2893-2895","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(1).2893-2895 ABSTRACT: Smilax zeylanica is a plant species in the genus smilax. Its leaves and roots are used for medicinal purposes. The plant is widespread in India, and native in other parts of the Indian subcontinent as well as in Myanmar, Malaysia, java and islands. It is perennial, dioecious shrub of climbing nature. Leaves of Smilax zeylanica are found in various shapes like ovate, elliptic, oblanceolate which are generally round at base. It is known with different names like in HindiChobchini, Bhitura, Kumarika and Ramdatun; Sanskrit: Chopachinee, Vanamadhusnuhi: Tamilayadi, Tirunamappalai. The plants contain 1-3% steroidal Saponins, phytosterols, starch, resin, sarsapic acid and minerals. Leaves and roots contain diosgenin. It is traditionally used for ulcers. Antiulcer activity of Smilax zeylanica it is one of the larval host plants of the butterfly Zesius chrysomallus. It is one of the safe and efficacious medicinal used traditionally for the treatment of various ailments. As per Ayurveda the plant is useful against skin diseases pitta, insanity, diarrhea, colic, vata, syphilis, gonorrhea, fever, arthritis, leucorrhoea, impotency and general weakness etc. its roots are used as substitute for sarsaparilla. It also possesses many pharmacological activities such as antidiabetic, anticancer, anthelmintic, antioxidant, antiepileptic, hepatoprotective, pesticidal, immunomodulatory, antibacterial and antarthritic.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"210 1","pages":"2893-2895"},"PeriodicalIF":0.0,"publicationDate":"2018-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74435397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A QSAR study of some Phenoxyacetamide derivatives as a MAO-A inhibitor

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-01-25 DOI: 10.21276/IJRDPL.2278-0238.2018.7(1).2931-2940

Kanhiya Lal Bais, L. Lal, Rajmani Mafidar, Anjita Singh, R. Mathur, M. Bhowmick, J. Rathi

{"title":"A QSAR study of some Phenoxyacetamide derivatives as a MAO-A inhibitor","authors":"Kanhiya Lal Bais, L. Lal, Rajmani Mafidar, Anjita Singh, R. Mathur, M. Bhowmick, J. Rathi","doi":"10.21276/IJRDPL.2278-0238.2018.7(1).2931-2940","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(1).2931-2940","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(1).2931-2940 ABSTRACT: Antidepressants are the most prescribed therapy for depression. The prevailing theory is that antidepressants increase the concentration of one or more brain chemicals (neurotransmitters) that nerves in the brain use to communicate with one another. The neurotransmitters affected by antidepressants are norepinephrine, serotonin, and dopamine. In order to address the need for new MAO inhibitors with less side effects, we can aim compounds previously discovered for their potential as MAOIs. Among them, safinamide was reported to be a potent anti-MAO B agent, and milacemide, which was found to be a potent MAO inhibitor and a prodrug for glycine. The present work deals with the aim because Currentely available MAO inhibitors {Isocarboxazid (Marplan), Phenelzine (Nardil), Selegiline (Emsam), Tranylcypromine (Parnate) etc} develop side effects because they do not selectively for MAO-A and MAO-B. So, the present study is focused to develop potent selective MAO-A inhibitors, to treat depression, that may be of better pharmacological activity with less adverse effect.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"34 1","pages":"2931-2940"},"PeriodicalIF":0.0,"publicationDate":"2018-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77828871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perception regarding skewed sex ratio among reproductive age group females in an urban slum of Haryana 对哈里亚纳邦城市贫民窟育龄女性性别比例失衡的看法

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-01-25 DOI: 10.21276/ijrdpl.2278-0238.2017.6(7).2901-2905

R. Verma, K. Bhalla, V. Chayal, Raj Kumar, Mukesh Dhankar, Rohit Dhaka, Ginni Agrawal

{"title":"Perception regarding skewed sex ratio among reproductive age group females in an urban slum of Haryana","authors":"R. Verma, K. Bhalla, V. Chayal, Raj Kumar, Mukesh Dhankar, Rohit Dhaka, Ginni Agrawal","doi":"10.21276/ijrdpl.2278-0238.2017.6(7).2901-2905","DOIUrl":"https://doi.org/10.21276/ijrdpl.2278-0238.2017.6(7).2901-2905","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(7).2901-2905 ABSTRACT: Objective: The steep downfall in the child sex ratio is a prime indicator of lack of women empowerment, respect and esteem or worth in the society. Women make up for almost half of the total population of India, but they still lag behind men in a lot of areas. The present study assessed the perception of reproductive mothers about declining sex ratio. Methods: The study was a community based epidemiological study with cross‐sectional design and carried out by house to house visit in an urban slum of district Rohtak and duration was January to June 2017. The study recruited 500 reproductive age group female having age 15-49 years. Results: The present study found that that most of the participants (49%) were in the age group of 25–35 years, 35% of subjects were either illiterate or literate up to primary class and nearly half (55%) of study subjects were belonged to upper caste and 31% of individuals from backward class. Conclusion: The study concluded that factors mainly responsible for down sex ratio are dowry culture and son preference. Besides, poor female literacy and sharp increase in number of ultrasound machines have also contributed to the skewed sex ratio.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"2 1","pages":"2901-2905"},"PeriodicalIF":0.0,"publicationDate":"2018-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81718905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic analysis of MTR and MTRR gene polymorphisms in healthy mothers from Eastern part of India 印度东部健康母亲MTR和MTRR基因多态性的遗传分析

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-01-25 DOI: 10.21276/IJRDPL.2278-0238.2018.7(1).2896-2900

Susanta Sadhukhan, Silpita Paul, B. Bankura, Dinesh Munian, Sudakshina Ghosh, M. Das

{"title":"Genetic analysis of MTR and MTRR gene polymorphisms in healthy mothers from Eastern part of India","authors":"Susanta Sadhukhan, Silpita Paul, B. Bankura, Dinesh Munian, Sudakshina Ghosh, M. Das","doi":"10.21276/IJRDPL.2278-0238.2018.7(1).2896-2900","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2018.7(1).2896-2900","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(1).2896-2900 ABSTRACT: The polymorphic variation of MTR and MTRR genes can influence the folate metabolism and homeocysteine remethylation processes and consequently has strong impact on Neural Tube Defects (NTD). The SNP of MTR and MTRR genes has been reported in some populations, but in the Indian population has never been explored. This study is focused on the frequency distributions of rs1805087 (D919G/A2756G) and rs1801394 (I22M/A66G) of these genes in the West Bengal population, India for the first time. The G allele frequencies of rs1085087 and rs1801394 were 8% and 47% respectively. The G allele frequency of MTR rs1085087 in Indian population is less than the other major population; such as, in European (17%), American (18%), African (28%) and South Asian (32%) population. The G allele frequency of MTRR rs1801394 is quite like the European and south Asian population (G=52%) but greatly differs from African (25%), East Asian (26%) and mixed American (28%) population. This observation might help us to understand pattern of genetic alteration and development of single screening protocol for early detection and better prognosis in future.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"30 1","pages":"2896-2900"},"PeriodicalIF":0.0,"publicationDate":"2018-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79351408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Serum CRP levels in healthy controls and stable COPD and its correlation with different stages of COPD in north Indian population 印度北部人群健康对照和稳定期COPD血清CRP水平及其与COPD不同阶段的相关性

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2018-01-25 DOI: 10.21276/IJRDPL.2278-0238.2018.7(1).2918-2923

Sarika Pandey, R. Garg, S. Kant, A. Verma, Iqbal Ahmad, M. Ahmad

引用次数: 0

Preparation of Sustained Release Microspheres of Aceclofenac: Characterization & in-vivo studies 乙酰氯芬酸缓释微球的制备:表征及体内研究

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-12-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(7).2862-2866

Rakesh Sharma, Anil Midda

{"title":"Preparation of Sustained Release Microspheres of Aceclofenac: Characterization & in-vivo studies","authors":"Rakesh Sharma, Anil Midda","doi":"10.21276/IJRDPL.2278-0238.2017.6(7).2862-2866","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(7).2862-2866","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(7).2862-2866 ABSTRACT:Objective: To explore the sustained drug release model of Aceclofenac from microspheres to establish the result of hydrogel forming mucoadhesive polymers on drug release. Methods: Microspheres were produced by Emulsion solvent evaporation method using Carboxy Methyl cellulose (CMC) and Carbopol 934P (CP) as hydrogel forming polymers. Results and Discussion: Mucoadhesive sustained release microspheres of Aceclofenac were prepared using carboxymethyl cellulose sodium and carbomer 934P hydrogel forming polymers. Carboxymethyl cellulose sodium and Carbomer 934P were used in 1/3 and 1/6w/w proportion in the preparation. Scanning electron microscopy revealed the uneven outer surface of the microspheres. Invitro dissolution test was carried out in simulated gastric fluid pH 1.2 and simulated intestinal fluid pH 6.8. Release of Aceclofenac from microspheres was found sustained, dependent on the erosion of crosslinking of carbopol 934P. Invitro mucoadhesive study was done on fresh stomach mucosa of chicken and chicken egg shell membrane. Invivo gastroenteric conveyance of microspheres was done in Male Sprague-Dawley rats. Conclusion: Invitro drug release is sustained for the period of 14 hrs. In-vitro Mucoadhesion evaluation can be done either on chicken stomach mucous membrane or chicken eggshell membrane.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"36 1","pages":"2862-2866"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77427276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In-vitro evaluation of Anti-bacterial and Anti-fungal activity of different Explant extracts of Thespesia populnea L. 不同外植体提取物的体外抗菌和抗真菌活性评价。

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-12-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(7).2874-2880

Narendar Vankudothu, R. Chandrashekhar, N. Bhavani, Sudhakar Chekuri, S. Anwar

引用次数: 0

Birth Preparedness and Knowledge of ASHAs regarding danger signs of pregnancy in rural India: A cross sectional study 出生准备和ASHAs关于印度农村怀孕危险迹象的知识:一项横断面研究

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-12-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(7).2850-2855

K. Grover, P. Khanna, Raj Kumar, R. Verma, V. Chayal

{"title":"Birth Preparedness and Knowledge of ASHAs regarding danger signs of pregnancy in rural India: A cross sectional study","authors":"K. Grover, P. Khanna, Raj Kumar, R. Verma, V. Chayal","doi":"10.21276/IJRDPL.2278-0238.2017.6(7).2850-2855","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(7).2850-2855","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(7).2850-2855 ABSTRACT:Background: Birth preparedness and complication readiness (BPCR) strategy based on the premise that preparing for childbirth reduces delays in obtaining timely, skilled maternal and neonatal care. Study was undertaken with objective to assess the knowledge of Accredited Social Health Activists (ASHAs), considered key frontline workers, regarding danger signs of pregnancy and birth preparedness services provided. Material and Methods: Cross-sectional descriptive study, undertaken in Community Health Centre, Dubaldhan, rural field practice area of PGIMS, Rohtak. 60 ASHAs of total 120 posted in the area were recruited for study. Results: More than three fourth ASHAs (78.3%) identified swollen hands and feet as danger sign while only 28% considered blurred vision as danger sign during antenatal period. Almost 40% knew about all 3 key danger signs of post-natal period followed by ante natal (15%) and natal period (6.7%). Knowledge score about danger signs of pregnancy was higher in ASHAs who were graduates as compared to those educated up to middle class. Conclusion: The knowledge of danger signs and birth preparedness services provided by ASHAs is poor, emphasizing the need to raise the knowledge and awareness about components of BPCR towards reducing maternal and infant mortality.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"61 1","pages":"2850-2855"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83430050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preparation and evaluation of Maltodextrin based Proniosomes containing Capecitabine 含卡培他滨麦芽糖糊精原体的制备及评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-12-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(7).2856-2861

S. Srikanth, Anand Kumar, C. MallikarjunaSetty

引用次数: 3