International Journal of Research and Development in Pharmacy and Life Sciences最新文献

{"title":"Preparation and in vitro and in vivocharacterization of Solid Dispersions tablets of Azithromycin by melting method","authors":"Pawan Kumar, R. Mazumder","doi":"10.21276/IJRDPL.2278-0238.2017.6(5).2769-2772","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2769-2772","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(5).2769-2772 ABSTRACT:Azithromycin is a cyclic-structure macrolide, shows prolonged antibacterial, anti-inflammatory and immunomodulatory effects. Azithromycin belongs to BCS class II drug i.e. drug with poor solubility and good permeability. The major problems with this drug is its very poor solubility in biological fluids that results into poor bioavailability after oral administration. The objectives of the present research work were to develop the formulation with enhanced dissolution rate of poorly soluble azithromycin. The solid dispersion of azithromycin was prepared using carrier PEG 6000 by melting method. Tablets were formulated containing solid dispersion products and compared with tablet formulated by pure drug without any carrier. The in vitro dissolution studied showed improved dissolution rate and it was compared with in vivo studied using animal model. Dissolution enhancement of the drug being caused by change in crystalline nature of drug in to amorphous nature.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"1 1","pages":"2769-2772"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89840204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer: An Overview","authors":"N. Tyagi, G. Sharma, B. Shrivastava, Nitin Chaudhary, N. Sahu","doi":"10.21276/IJRDPL.2278-0238.2017.6(5).2740-2747","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2740-2747","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(5).2740-2747 ABSTRACT:Cancer is the second leading causes of deaths in western countries after heart disease. In US alone more than one million people are diagnosed with cancer annually and more than half result in death. Cancer is a medical condition where abnormal cells in body divided without any control. Cancers cells do not respond normally to the body’s control mechanism, so they divide excessively and invade the neighboring tissues. Cancer starts when a normal cell is instantly detected by body immune system. However, if the abnormal cells remain at the original site, it will result in the less severe condition termed as benign tumor. Benign tumor can be completely removed by surgery and pose little threat. Malignant tumors have capability to enter the blood stream invading other tissues and disrupting the normal function of various systems in the body. They are difficult to treat may become life threatening. Cancer cells can spread to distinct locations from the original site by a process called metastasis.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"16 1","pages":"2740-2747"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88450361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Synergistic Anti-microbial efficacy of plant extracts and their formulation as Topical Agents","authors":"Z. Afsar, S. Khanam, A. Ram","doi":"10.21276/IJRDPL.2278-0238.2017.6(5).2779-2785","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2779-2785","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(5).2779-2785 ABSTRACT:The objective of the present study was to evaluate the antimicrobial activity of Cassia fistula, Ficusreligiosa, Milletiapinnataand Wendlandiathyrsoideaand to check the synergistic efficacy of these extracts when combined. The individual extracts and their combinations were evaluated against E coli (MTCC-1698), S aureus (MTCC-1143)and P aeruginosa (MTCC-2453) by agar diffusion method. The percentage growth inhibition of the combined extracts was determined by ditch plate method. The most active extract combinations were formulated as cream and gel including citronella oil and without oil in it. The prepared formulations were evaluated for their antimicrobial effect against two acne causing organisms viz; Propionibacterium acnes and Staphylococcus epidermidis at various concentrations. The extracts exhibited significant antimicrobial effect in combined form when compared to individual extracts in terms of zones of inhibition as well as percentage inhibition. The prepared cream and gel also exhibited significant antimicrobial effect against the selected strains. The physicochemical parameters of the prepared cream and gel also exhibited satisfactory results.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"87 1","pages":"2779-2785"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81261133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the effects of different surfactants on morphology and drug release of Repaglinide Microspheres","authors":"V. Yadav, A. Rai, A. Ghosh","doi":"10.21276/IJRDPL.2278-0238.2017.6(5).2786-2792","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2786-2792","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(5). 2786-2792 ABSTRACT: Objectives: To rationalize the use of surfactants by preparing Repaglinide Microspheres using two types of Surfactants, Tween 80 and Span 80 and study their effects on different characteristics of the microspheres. Methods: The microspheres were produced by emulsion solvent evaporation method, using the Eudragit RS100, Ethylcellulose, Tween 80 and Span80. Results and discussion: The microspheres were free flowing in nature. The surfactant concentration was found to be greatly affected the microspheres size distribution and dissolution. Scanning Electron Microscopy was done to study the surface morphology of the microspheres. Results have indicated that the incorporation of hydrophilic surfactant (Tween 80) gave larger microspheres, where as incorporation of the hydrophobic surfactant (Span 80) gave smaller microspheres and hydrophilic surfactant containing microspheres had higher drug release rate compared to hydrophobic surfactant containing microspheres. Conclusion: Microspheres containing repaglinide was prepared successfully by using an emulsion solvent evaporation technique.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"45 1","pages":"2786-2792"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81446964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute toxicity study of Mesenchymal Stromal cells derived from Wharton’s Jelly in mouse by intravenous and subcutaneous route","authors":"Jaianand Kannaiyan, S. Narayanan, A. Pandey","doi":"10.21276/IJRDPL.2278-0238.2017.6(5).2748-2756","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2748-2756","url":null,"abstract":": Aim: The present study was to evaluate the acute toxicity of WJ-MSCs in mouse by intravenous and subcutaneous route and to assess their potential for side effects, MLD, MTD and LD 50 . Objectives: Wide ranges of clinical and preclinical trials have suggested exploitation of adult MSCs for the cell-based reparative therapeutic approach; considering pros and cons of embryonic stem cells. However, for the clinical use existing adult stem cells source such as bone marrow, adipose tissue may be detrimental due to invasiveness in the procedure, less number of initial isolation and unsuitability for allogenic transplants. Recently fetal tissues such as Placenta, WJ have attracted as a good stem cell source due to its easy accessibility, ethical safety, immunological tolerance and large number of initial isolation of homogenous population necessary for increasing current market demand. Methods: In present study, we tried to work on complete characterization and up-scaling profiling of cells isolated from WJ, along with assessment of possible toxic effects of these cells when administered in-vivo and optimizing the route of administration with other clinical evaluation been addressed. Results: We confirmed that cells isolated from WJ exhibit morphologically and phenotypically similar properties as MSCs. The animal study also reveled that no mortality, no abnormal clinical signs and no remarkable pathological changes. Conclusion: Our animal toxicity study along with attempted rapid expansion of these cells to meet large clinical demands would allow them to be a lucrative candidate for clinical therapy.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"54 1","pages":"2748-2756"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74620062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A validated analytical method for the estimation of Oxetacaine from its pharmaceutical formulation by RP-HPLC","authors":"S. T. Narenderan, B. Babu, S. N. Meyyanthan, B. Gowramma","doi":"10.21276/IJRDPL.2278-0238.2017.6(5).2764-2768","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2764-2768","url":null,"abstract":"OBJECTIVE: The aim of the current study was to develop an analytical procedure for the determination and quantification of Oxetacaine, from its marketed formulation which is simple, precise, accurate and a validated, reverse phase high performance liquid chromatography (RP-HPLC) method. METHOD: The optimized chromatographic condition was achieved on a kromasil C18 (150 X 4.6 mm i.d., 5μ) as stationary phase and Acetonitrile: 10mM Potassium dihydrogen-ortho-phosphate (pH 3.5) in the ratio 30:70 % v/v as mobile phase, with a flow rate of 1.0 ml/min. The detector response for the method was determined, and the quantification was carried out at 214 nm. RESULT: Oxetacaine was eluted at 6.0 min. The quantification was performed using calibration curve method, and the linearity was achieved from 10-50 μg/ml. The percentage recovery was found to be 98.0 ± 1.20 respectively. The correlation coefficient was found to be 0.9954 respectively. The limit of detection (LOD) and limit of quantification (LOQ) for the current method was achieved at 1μg/mL and 5μg/mL respectively. CONCLUSION: The current study was performed at ambient temperature, and the method is simple, selective, linear, precise, accurate and sensitive which can be used for the routine analysis of Oxetacaine tablets. The developed method was validated as per ICH guidelines. ⇑ Corresponding author at: S.T. Narenderan, Department of Pharmaceutical Analysis, JSS College of Pharmacy (A Constituent College of Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, India E-mail address:mail2narenderan@gmail.com INTRODUCTION Most manufacturing industries rely upon quantitative chemical analysis to ensure that the raw materials used and the final products obtained meet certain specifications in the final product. Chromatography is the method by which a mixture is separated into its individual components as a result of the relative ability of each component to be flushed along or through a stationary phase and mobile phase [1-7]. Alumina gel and magnesium hydroxide react chemically to neutralize or buffer existing quantities of acid. It has no direct effect on the production of gastric acid. Gastroscopic observations have shown that alumina gel, if taken undiluted, forms a coating over the inflamed mucosa for a variable period. Oxetacaine is a topical potent anesthetic. Combining Oxetacaine with alumina gel exerts a prolonged topical anesthetic action when applied to mucous membranes Oxetacaine chemically known as (2,2'-(2hydroxyethylimino)bis[N-(1,1-dimethyl-2-phenylethyl)-Nmethylacetamide]) is a potent safe topical anesthetic drug substance having a molecular formula of C28H41N3O3 and a molecular weight 467.64 g/mol(fig.1). Narenderan et al., August September 2017; 6(5): 2764-2768 ©SRDE Group, All Rights Reserved. Int. J. Res. Dev. Pharm. L. Sci. 2765 O","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"34 1","pages":"2764-2768"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87819779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants: used in Anti-cancer treatment","authors":"N. Tyagi, G. Sharma, B. Shrivastava, P. Saxena, Nitin Kumar","doi":"10.21276/IJRDPL.2278-0238.2017.6(5).2732-2739","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2732-2739","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(5).2732-2739 ABSTRACT: Globally cancer is a disease which severely effects the human population. There is a constant demand for new therapies to treat and prevent this life – threatening disease. The plant kingdom produces naturally occurring secondary metabolites which are being investigated for the anticancer activities for the development of new clinical drugs. For many years herbal medicines have been used and are still used in developing countries as the primary source of medical treatment. Plants have been used in the medicine for their natural antiseptic properties. Thus, research has developed into the investigating the potential properties and uses of terrestrial plants extracts for the preparation of potential nanomaterial drugs for diseases including cancer. Many plant species are already being used to treat or prevent development of cancer. This review discusses the demand for naturally derived compounds from medicinal plants and their properties which make them targets for potential anticancer treatments.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"123 1","pages":"2732-2739"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88998314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation development and evaluation of Telmisartan Nanoemulsion","authors":"R. Kumar, G. Soni, S. Prajapati","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2711-2719","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2711-2719","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2711-2719 ABSTRACT:The aim of the present study was to development of oral nanoemulsion formulation of telmisartan belong to BCS class 2nd, It have low solubility and low permeability. Therefore, oral nanoemulsion containing Telmisartan was prepared to increase its solubility and bioavailability rate. The o/w nanoemulsion was prepared by screening the excipients from the nanoemulsion region of pseudo-ternary phase diagram. Oleic acid optimized as an oil phase based on higher solubility study. Surfactant (Tween 80) and co-surfactant (PEG 200) were mixed (Smix) in different volume ratios (1:1, 1:2, 1:3, 1:4, 2:1, 3:1..). The optimized formulation containing Oleic acid (13.6%), Tween 80 (23.9%), PEG 200 (7.9%) and Methanol (54.6%) as oil, surfactant, co-surfactant and aqueous phase in Smix was prepared. Formulated nanoemulsions has to be evaluated for UV, FTIR, in vitro drug release, viscosity, particle size, product stability at accelerated conditions compared to the conventional formulation. Optimized oral nanoemulsion showed increase bioavailability.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"115 1","pages":"2711-2719"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77919117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and modifying drug release from Hard and Soft Gelatin Capsules for Oral drug delivery","authors":"V. Prasad","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2663-2677","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2663-2677","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2663-2677 ABSTRACT: Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. There are two types of capsules, “hard” and “soft”. The hard capsule is also called “two pieces” as it consists of two pieces in the form of small cylinders closed at one end, the shorter piece is called the “cap” which fits over the open end of the longer piece, called the “body”. The soft gelatin capsule is also called as “one piece”. Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. The administration of liquid and solid drugs enclosed in hard gelatin capsules is one of the most frequently utilized dosage. This proves the oral bioavailability of poorly soluble compounds, delivery of low and ultra-low doses of a compound using softgel also ensures decreased plasma variability. This has led to the commercial pharmaceutical and nutraceutical industries opting for the development of alternative shell forming materials instead of the traditional capsule shell material gelatin. This review discusses establishment and the ongoing development of the manufacturing technology for liquid and semisolid capsules with focus on progress and challenges of soft and hard gelatin capsules formulation in oral administration for improved solubility and as an absorption-enhancing technique. These considerations form a basis for new applications in oral drug delivery. ⇑ Corresponding author at: V. Deva Prasad, Council of scientific and Industrial Research (CSIR), Indian Institute of Integrative Medicine (IIIM) Jammu, India E-mail address: dev25648@gmail.com INTRODUCTION","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"17 1","pages":"2663-2677"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80965454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and evaluation of Matrix Transdermal therapeutic system of Repaglinide","authors":"M. Sahu, M. Bhowmick, J. Rathi","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2697-2705","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2697-2705","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2697-2705 ABSTRACT:The present study is an attempt to develop a Matrix type transdermal system capable of delivering the selected antidiabetic drug Repaglinide in the desired therapeutic concentration for prolong period. The principle of transdermal drug delivery systems is to deliver drug across epidermis to achieve systemic effect over a prolonged period of time. Because of these attributes, transdermal drug delivery systems offer many advantages such as reduced side effects, improved patient compliance, elimination of first-pass metabolism, and sustained drug delivery. Antidiabetic drug which is important for the treatment of hyperglycemic disorders. This category of anti-diabetic drugs is rapid and almost completely absorbed from the GIT following oral administration, but undergoes extensive first pass metabolism. Therefore, the peak plasma concentration occurs rapidly and after a single oral dose and bioavailability is 56%, the half-life of elimination is 1 hour in normal subject. Hence, it is required to design a drug delivery system which may deliver antidiabetic drug Repaglinide in controlled manner for a prolonged period to circumvent the drug related side effects. Considering all these problems associated with oral administration of anti-diabetic drug Repaglinide, attempt has been made to develop transdermal drug delivery system in order to achieve a better release pattern. ⇑ Corresponding author at: MithileshSahu, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India E-mail address: mithun211@gmail.com INTRODUCTION","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"164 1","pages":"2697-2705"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86201659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}