Formulation and characterization of mouth dissolving mucoadhesive buccal film of Zolmitriptan

Abstract

http://dx.doi.org/10.21276/IJRDPL.22780238.2017.6(3).2625-2630 ABSTRACT: Fast dissolving buccal film drug delivery system is an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience in difficulties of swallowing traditional oral solid dosage forms. It improves the efficacy of API by dissolving within minute in oral cavity after the contact with less saliva as compared to fast dissolving tablets, without chewing and no need of water for administration. Oral films provide better drug utilization by avoiding the first pass metabolism, enhance drug bioavailability. Fast dissolving buccal films of zolmitriptan were prepared by solvent casting method using Polymers (E4, E10, E15) in different ratio as film forming agent, PEG 400 as plasticizer, Tween 80 as permeation enhancer, glycerin as surfactant.