International Journal of Research and Development in Pharmacy and Life Sciences最新文献_第5页

Medicinal plants: used in Anti-cancer treatment 药用植物:用于抗癌治疗

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-08-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(5).2732-2739

N. Tyagi, G. Sharma, B. Shrivastava, P. Saxena, Nitin Kumar

{"title":"Medicinal plants: used in Anti-cancer treatment","authors":"N. Tyagi, G. Sharma, B. Shrivastava, P. Saxena, Nitin Kumar","doi":"10.21276/IJRDPL.2278-0238.2017.6(5).2732-2739","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(5).2732-2739","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(5).2732-2739 ABSTRACT: Globally cancer is a disease which severely effects the human population. There is a constant demand for new therapies to treat and prevent this life – threatening disease. The plant kingdom produces naturally occurring secondary metabolites which are being investigated for the anticancer activities for the development of new clinical drugs. For many years herbal medicines have been used and are still used in developing countries as the primary source of medical treatment. Plants have been used in the medicine for their natural antiseptic properties. Thus, research has developed into the investigating the potential properties and uses of terrestrial plants extracts for the preparation of potential nanomaterial drugs for diseases including cancer. Many plant species are already being used to treat or prevent development of cancer. This review discusses the demand for naturally derived compounds from medicinal plants and their properties which make them targets for potential anticancer treatments.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"123 1","pages":"2732-2739"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88998314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Formulation development and evaluation of Telmisartan Nanoemulsion 替米沙坦纳米乳的研制与评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2711-2719

R. Kumar, G. Soni, S. Prajapati

{"title":"Formulation development and evaluation of Telmisartan Nanoemulsion","authors":"R. Kumar, G. Soni, S. Prajapati","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2711-2719","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2711-2719","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2711-2719 ABSTRACT:The aim of the present study was to development of oral nanoemulsion formulation of telmisartan belong to BCS class 2nd, It have low solubility and low permeability. Therefore, oral nanoemulsion containing Telmisartan was prepared to increase its solubility and bioavailability rate. The o/w nanoemulsion was prepared by screening the excipients from the nanoemulsion region of pseudo-ternary phase diagram. Oleic acid optimized as an oil phase based on higher solubility study. Surfactant (Tween 80) and co-surfactant (PEG 200) were mixed (Smix) in different volume ratios (1:1, 1:2, 1:3, 1:4, 2:1, 3:1..). The optimized formulation containing Oleic acid (13.6%), Tween 80 (23.9%), PEG 200 (7.9%) and Methanol (54.6%) as oil, surfactant, co-surfactant and aqueous phase in Smix was prepared. Formulated nanoemulsions has to be evaluated for UV, FTIR, in vitro drug release, viscosity, particle size, product stability at accelerated conditions compared to the conventional formulation. Optimized oral nanoemulsion showed increase bioavailability.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"115 1","pages":"2711-2719"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77919117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Formulation and modifying drug release from Hard and Soft Gelatin Capsules for Oral drug delivery 口服给药用软硬明胶胶囊的配方及药物释放改性

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2663-2677

V. Prasad

{"title":"Formulation and modifying drug release from Hard and Soft Gelatin Capsules for Oral drug delivery","authors":"V. Prasad","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2663-2677","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2663-2677","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2663-2677 ABSTRACT: Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. There are two types of capsules, “hard” and “soft”. The hard capsule is also called “two pieces” as it consists of two pieces in the form of small cylinders closed at one end, the shorter piece is called the “cap” which fits over the open end of the longer piece, called the “body”. The soft gelatin capsule is also called as “one piece”. Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. The administration of liquid and solid drugs enclosed in hard gelatin capsules is one of the most frequently utilized dosage. This proves the oral bioavailability of poorly soluble compounds, delivery of low and ultra-low doses of a compound using softgel also ensures decreased plasma variability. This has led to the commercial pharmaceutical and nutraceutical industries opting for the development of alternative shell forming materials instead of the traditional capsule shell material gelatin. This review discusses establishment and the ongoing development of the manufacturing technology for liquid and semisolid capsules with focus on progress and challenges of soft and hard gelatin capsules formulation in oral administration for improved solubility and as an absorption-enhancing technique. These considerations form a basis for new applications in oral drug delivery. ⇑ Corresponding author at: V. Deva Prasad, Council of scientific and Industrial Research (CSIR), Indian Institute of Integrative Medicine (IIIM) Jammu, India E-mail address: dev25648@gmail.com INTRODUCTION","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"17 1","pages":"2663-2677"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80965454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Design and evaluation of Matrix Transdermal therapeutic system of Repaglinide 瑞格列奈基质透皮治疗系统的设计与评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2697-2705

M. Sahu, M. Bhowmick, J. Rathi

{"title":"Design and evaluation of Matrix Transdermal therapeutic system of Repaglinide","authors":"M. Sahu, M. Bhowmick, J. Rathi","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2697-2705","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2697-2705","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2697-2705 ABSTRACT:The present study is an attempt to develop a Matrix type transdermal system capable of delivering the selected antidiabetic drug Repaglinide in the desired therapeutic concentration for prolong period. The principle of transdermal drug delivery systems is to deliver drug across epidermis to achieve systemic effect over a prolonged period of time. Because of these attributes, transdermal drug delivery systems offer many advantages such as reduced side effects, improved patient compliance, elimination of first-pass metabolism, and sustained drug delivery. Antidiabetic drug which is important for the treatment of hyperglycemic disorders. This category of anti-diabetic drugs is rapid and almost completely absorbed from the GIT following oral administration, but undergoes extensive first pass metabolism. Therefore, the peak plasma concentration occurs rapidly and after a single oral dose and bioavailability is 56%, the half-life of elimination is 1 hour in normal subject. Hence, it is required to design a drug delivery system which may deliver antidiabetic drug Repaglinide in controlled manner for a prolonged period to circumvent the drug related side effects. Considering all these problems associated with oral administration of anti-diabetic drug Repaglinide, attempt has been made to develop transdermal drug delivery system in order to achieve a better release pattern. ⇑ Corresponding author at: MithileshSahu, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India E-mail address: mithun211@gmail.com INTRODUCTION","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"164 1","pages":"2697-2705"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86201659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and evaluation of Buccal patches of Furosemide 速尿口腔贴剂的研制与评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2726-2731

U. Sharma

{"title":"Formulation and evaluation of Buccal patches of Furosemide","authors":"U. Sharma","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2726-2731","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2726-2731","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2726-2731 ABSTRACT:This study is mainly focused on the ability of polymer to increase the bioavailability of Furosemide and to release the drug in controlled predetermined manner. The polymers selected for the study include natural and synthetic polymer like Chitosan and sodium HPMC based on their physicochemical properties. The mucoadhesive buccal patches were prepared by solvent casting method. The prepared patches were subjected to physical evaluations, in vitro diffusion studies and stability study. All the formulations have shown good adhesive property, tensile strength, folding endurance, thickness, pH and moisture content. The diffusion studies have shown that the percentage drug release is from natural polymer (chitosan) based patches is more than the synthetic polymer (sodium HPMC) (89.5% to 97.89%) with chitosan based mucoadhesive patches and 72.97 to 88.75 patches prepared with sodium HPMC in 6 hours. The In vitro drug release, evaluation, stability and accelerated stability studies of the mucoadhesive patches shown that the formulation containing natural polymer 2% has the promising results with 97.89% drug release within 6 hours, folding endurance 211+2, patch thickness 0.7mm, surface pH 6.7, % swelling index 36% moisture content 3.3,tensile strength 2.94+3kg/cm. ⇑ Corresponding author at: Aspee Singh, Department Institute of Pharmacy, Bundelkhand University Jhansi, Uttar Prades, India E-mail address: aspeesingh786@gmail.com INTRODUCTION","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"74 1","pages":"2726-2731"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75074495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation and evaluation of Phytosomesyrup for Hepato-protective activity of Clerodendroninfortunatum Linn., root extract 石斛保肝植物体糖浆的研制与评价。、根提取物

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2678-2681

R. Sundaraganapathy, P. Leena

引用次数: 0

Pharmacological investigation of leaves of Polypodium decumanum for anti-bacterial activity against gram-positive and gram-negative bacteria 蓼叶对革兰氏阳性菌和革兰氏阴性菌抑菌活性的药理研究

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2685-2688

P. Niranjan, Chandrul Koushal, S. Jain

{"title":"Pharmacological investigation of leaves of Polypodium decumanum for anti-bacterial activity against gram-positive and gram-negative bacteria","authors":"P. Niranjan, Chandrul Koushal, S. Jain","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2685-2688","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2685-2688","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2685-2688 ABSTRACT:The widespread use of antibiotics has led to an increase in multidrugresistant bacteria, which represent a serious risk of infection, in view of this problem the aim of this research was performed to characterize the antibacterial effect of ethanolic and petroleum ether extract of Polypodium decumanum leaves against three gram-positive bacteria(Staphylococcus aureus, Bacillus subtilius, and Streptococcus pyogenes) and three gram-negative bacteria(Pseudomonas aeruginosa, Escherichia coli, and Pseudomonas alcaligenes) in vitro by disc-diffusion method. In this study, we have taken 3 concentrations of Polypodium decumanumplant extract (ethanolic and petroleum ether) viz. 50 mg/ml, 100 mg/ml, and 200 mg/ml, and observed that the ethanolic extract of Polypodium decumanumof the concentration of 200 mg/ml showed higher antibacterial effect compare to other concentration against all 3 gram-positive bacteria and all 3 gram-negative bacteria, but not higher than standard drug Ampicillin.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"25 1","pages":"2685-2688"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81496353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthesis and biological activity of some novel Combretastatin analogues and related compounds 几种新型复方蒿甲素类似物及相关化合物的合成及生物活性研究

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2720-2725

Shailendra Kumar, Chandrul Koushal, S. Jain

引用次数: 0

Pharmacological aspects of Turbinaria 杜鹃的药理学方面

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2648-2653

Alka Alka, N. Tyagi, S. Kumar

引用次数: 1

Evaluation of anti-obesity activity of Centratherum anthelminticum in obese rats 驱虫草对肥胖大鼠的抗肥胖作用评价

International Journal of Research and Development in Pharmacy and Life Sciences Pub Date : 2017-07-01 DOI: 10.21276/IJRDPL.2278-0238.2017.6(4).2689-2692

Ramji Swarnkar, Chandrul Koushal, S. Jain

{"title":"Evaluation of anti-obesity activity of Centratherum anthelminticum in obese rats","authors":"Ramji Swarnkar, Chandrul Koushal, S. Jain","doi":"10.21276/IJRDPL.2278-0238.2017.6(4).2689-2692","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2689-2692","url":null,"abstract":"http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4).2689-2692 ABSTRACT: The effect of Ethanolic extracts of Centratherum anthelminticum on adiposity index serum levels of liver enzyme in obese rats investigated. twenty mature (180-210gm body weight) Swiss albino rats either sex randomly distributed into 5 equal groups.group1 was fed on basal diet and kept negative control, while the other 4 group were fed on HFD for 6 week to induce obesity .there after group2 as normal control while group 3,4,5, were orally given ethanolic extract of Centratherum anthelminticum at 0.25gm, 0.50gm, 0.75gm / kg b.w/ respectively once daily for 4 week at the end of feeding period final body weight of rats was recorded and the adiposity index was calculated. Feeding of male rats on high fat diet (HFD) for 6 weeks significantly (P˂0.05) increased the final body weight, fat weight, and adiposity index as compared to negative control rats fed on basal diet oral administration of CAEt at doses 0.25 gm, 0.50 gm, and 0.75 gm/kg obese rats for 4 weeks caused significant (P˂0.05) decreases in the final body weight, fat weight, and adiposity index compared to normal control /rats in a dose dependent manner.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"7 1","pages":"2689-2692"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89438191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0