International Journal of Research and Development in Pharmacy and Life Sciences最新文献

{"title":"Design and evaluation of a Sustained Release Gastroretentive Dosage form of Captopril","authors":"Hakim Singh Rajput, M. Bhowmick, V. Rathi, J. Rathi","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2535-2547","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2535-2547","url":null,"abstract":"Quick Response Code DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2535-2547 Abstract: Sustained drug delivery means not only prolonged duration of drug delivery but also implies predictability and reproducibility of drug release kinetics. In the present study gastroretentive dosage form (tablet) was selected as a method to design sustained release dosage forms because it is a rapidly expanding technology. The objective of the work was to design sustained release tablets of Captopril as gastroretentive drug delivery dosage form of a drug meant for management of treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack. Formulation of gastroretentive drug delivery dosage forms are done based on optimization under factorial design of formula and classed formulation batches in which concentration of polymer HPMC of various grades (HPMC K15 M, HPMC K100M and HPMC K4M) varied with the ration of sodium bi carbonate and microcrystalline cellulose. Therefore, the Aim of the present work is design to formulate and evaluate gastroretentive dosage form (tablets) of Captopril for efficient sustained release after oral administration in case of congestive heart failure, kidney problems caused by diabetes.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"1 1","pages":"2535-2547"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88755428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified solvent evaporation technique for purpose and categorization of Novel Floating Microspheres of Metronidazole: Optimization of pharmacokinetics, in-vitro and stability study using special process capricious like Emulsifier concentration, stirring rate","authors":"P. Bhardwaj, R. Gupta, D. Chaurasia, Preeti Eiron","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2559-2570","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2559-2570","url":null,"abstract":"Quick Response Code DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2559-2570 Abstract: Purpose of present study involves the development of floating microspheres of metronidazole as a model drug, using the modified solvent diffusion evaporation technique. Eudragit S100 and Eudragis RS100 were used in the different ratio as polymers for development of microspheres. The microspheres were characterized for surface morphology by SEM, yield, buoyancy, incorporation efficiency and micromeritic properties. The in-vitro drug release studies were performed in simulated gastric fluid at pH 1.2. Different kinetic models were also applied on drug release from selected formulations. Stability studies were additionally subjected for optimized formulations. The yield of microspheres was good. Microspheres showed satisfactory flow properties. SEM confirmed the spherical size, perforated smooth surface and a hollow cavity in them. Microspheres exhibited floating properties for more than 10 hours. Stability studies showed no significant change in residual drug content of floating Microspheres.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"166 1","pages":"2559-2570"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75140616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative utility of C reactive protein and Blood culture for diagnosis of neonatal septicaemia","authors":"Shipra Galhotra, Veenu Gupta, D. Chhina, H. Bains, A. Chhabra","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2586-2589","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2586-2589","url":null,"abstract":"Quick Response Code DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2586-2589 Abstract: Introduction: Neonatal septicaemia constitutes a significant cause of morbidity and mortality of neonates in India. The diagnosis of neonatal septicemia based on clinical manifestations is nonspecific which leads to initiation of unnecessary antibiotic treatment. Blood culture remains the gold standard for the diagnosis of neonatal sepsis. But many times, culture may be negative in symptomatic neonates, preterm neonates or very low birth weight babies. Further difficulty with blood culture is turnaround time of at least 18-24hrs and this facility is available only in wellequipped centers. C-reactive protein (CRP) production is a nonspecific response to a disease but along with clinical symptoms, it is helpful for the diagnosis of neonatal septicaemia. Methods: In this one year prospective study, 257 clinically suspected cases of neonatal septicaemia were enrolled. Screening for CRP was done by quantitative method and cut off value of CRP was taken as 6mg/l. Simultaneously, blood culture was done by automated BACTEC 9240 system. Results: Out of 257 cases, 67 showed positive CRP and 20 cases showed positive blood culture. The predominant organisms were Staphylococcus species followed by Escherichia coli. CRP test showed 50% sensitivity and 77%specificity, considering blood culture as gold standard method. Conclusion: CRP is a rapid tool for screening of neonatal septicaemia and a reliable marker in the absence of positive blood cultures. The use of both CRP and blood culture in combination would increase the yield of laboratory confirmed neonatal septicaemia cases.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"80 1","pages":"2586-2589"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86968145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speciation, biofilm formation and antifungal susceptibility of Candida isolates","authors":"S. Arora, Nitika Dhuria, N. Jindal, Shilpa Galhotra","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2517-2521","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2517-2521","url":null,"abstract":"DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278-0238.2017.6(2).2517-2521 Abstract: Recently, an increase in the incidence of infections caused by fungi especially non-albicans Candida species has been reported. Several virulence factors like biofilm formation, toxin production and presence of adhesins contribute to its pathogenesis. This study was undertaken to determine species distribution, biofilm formation and in-vitro antifungal susceptibility of Candida isolated in our tertiary care hospital. One hundred and forty-two clinical isolates obtained from various clinical specimens were subjected to KOH smear and cultured on Sabouraud’s Dextrose agar medium. Conventional methods and automated identification system (Vitek 2 Compact) for yeast identification were done. Biofilm forming ability of each isolate was detected using microtitre plate method. Antifungal susceptibility against fluconazole, voriconazole, flucytosine, amphotericin B and caspofungin was tested using Vitek 2 Compact. Out of 142 Candida isolates, 90 (63.4%) were C. albicans and 52 (36.6%) were non-albicans Candida species. Among 52 nonalbicans Candida, C. parapsilosis was found in 20 (38.5%) cases followed by C. tropicalis 16 (30.8%). Among all isolates, 52 (36.6%) were biofilm producers and biofilm positivity was more among non-albicans Candida 28 (53.8%) as compared to C. albicans 24 (26.7%) (p-value <0.002). The maximum positivity was observed with isolates from plastic devices (60%). The minimum inhibitory concentrations of all isolates against antifungal drugs were within susceptible range. Although C. albicans remains the major isolate from various clinical specimens, infections caused by non-albicans. Candida is on the rise and biofilm formation as a virulence factor might have a higher significance for nonalbicans Candida species than for C. albicans. The changing epidemiology of Candida infections highlights the need for close monitoring on the distribution, biofilm production and susceptibility to optimize therapy and outcome. ⇑ Corresponding authors at: Dr. Shilpa Arora, Department of Microbiology, Guru Gobind Singh Medical College & Hospital, Faridkot, India E-mail address: s.arora49@yahoo.com, drnitikadhuria@gmail.com, neerjarajender@hotmail.com, shipragalhotra@gmail.com","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"18 1","pages":"2517-2521"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80705588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and characterization of Vasicine from Adhatoda vasica (Adusa)","authors":"Bali Reddy Keesara, R. Jat","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2590-2596","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2590-2596","url":null,"abstract":"QR Code DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2590-2596 Abstract: The research work is related to an improved process of isolation & characterization of Vasicine from Adhatodha Vasica (Sanskrit: Adusa). Adhatodha vasica, commonly known as Arusa, is a valued herb in Ayurvedic medicine. Roots, leaves and preparations of the plant are traditionally used as tonic, antiasthmatic, analgesic, antiinflammatory and diuretic. A. vasica mainly contains Vasicine alkaoids including Vasicine which are specific to the Acantheceae family. Vasicinosides are biologically active secondary metabolites present in roots and leaves of A. vasica. In the present study, we have standardized the protocol for the isolation of Vasicine from the Adhatodha vasica punchang. Vasicine possess anti-inflammatory and antistress properties. This study contains newer and conventional method of isolation of Vasicine from Adhatodha vasaka as well Quantitative and qualitative techniques involved in purification of compound was followed throughout this research work. In this study, we have taken different trials based on hydro-alcoholic solvent composition. Based on different solvent extraction process pure 95% Vasicine was successfully isolated.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"6 1","pages":"2590-2596"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84988741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study to assess high demand and high commercial value Medicinal Plants of Jammu and Kashmir India - with special focus on routes of procurement and identification","authors":"A. Dar, Wahid Hassan, A. Lone, A. Haji, N. Manzoor, A. I. Mir","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2576-2585","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2576-2585","url":null,"abstract":"Quick Response Code DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2576-2585 Abstract: Despite ancient nature of the tradition, medicinal plants still form the basis of traditional or indigenous health systems and are reported by the World Health Organization (WHO) to still be used by the majority of the populations in most developing countries. Medicinal and aromatic plants (MAPs) play a significant role in meeting the demands of the traditional medicine markets which are found both domestically in the producing and in overseas markets. Demand for a wide variety of wild species is increasing with growth in human needs, numbers and commercial trade. With the increased realization that some wild species are being over-exploited, several agencies are recommending that wild species be brought into cultivation systems. The present pharmacognostical study was conducted with the objectives to assess the high demand and high commercial value Medicinal Plants in Jammu and Kashmir and to assess the source of identification of Medicinal raw herbs in Jammu and Kashmir. The study was conducted by randomly selecting 10 districts of two provinces (Jammu and Kashmir) of Jammu and Kashmir. The study was aimed at distributors, retailers and traders of raw herbs and Medicinal Plants. The study was carried out thorough a team of experts who visited the traders of raw medicinal herbs in the identified areas of study. Their feedback was recorded in the form of a questionnaire designed for the said purpose. It was observed that the trade of raw medicinal herbs in J&K is haphazard and erratic with negligible authoritarian control. The high demand species are distinctive with their local availability and the popularity of the herb is directly proportional to availability of the herb in the area. The source of identification of herbs is also erratic, with no expert identification.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"24 1","pages":"2576-2585"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86983286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus","authors":"Siddharth Desai, V. G. Sastry, A. Malpani, Kishore Singh","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2530-2534","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2530-2534","url":null,"abstract":"DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2530-2534 Abstract: A series of phenyl pyrazoline derivatives have been synthesized from chalcones of indane-1,3-dione. The substituted chalcones have already been synthesized and reported by us. The phenyl pyrazoline derivatives were synthesized by condensation of chalcone of indane-1,3-dione with phenyl hydrazine in basic medium in the presence of ethanol. The newly synthesized compounds (7a-f) have been characterized by IR and H-NMR Spectroscopy and TLC. The new compounds have been evaluated for their antibacterial, antifungal and antitubercular activities.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"127 1","pages":"2530-2534"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79587146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and in-vitro evaluation of Furosemide Solid Dispersion using different Water Soluble Carriers","authors":"L. Soni, M. Ansari, Nisha Thakre, Anjita Singh, M. Bhowmick, J. Rathi","doi":"10.21276/IJRDPL.2278-0238.2017.6(2).2571-2575","DOIUrl":"https://doi.org/10.21276/IJRDPL.2278-0238.2017.6(2).2571-2575","url":null,"abstract":"Objective: The objective of the present investigation was to improve solubility and dissolution characteristics of Furosemide, which might offer improved bioavailability. The bioavailability of the drug when taken orally is limited by the relatively low solubility. Furosemide is a loop diuretic (a ‘water pill’) used to treat congestive heart failure, oedema and sometimes hypertension. Method: The solid dispersion of Furosemide was prepared by Solvent evaporation method by using 1:1, 1:2 and 1:3 ratios of drug and polymers (PVP K-30, PEG6000). The solid dispersion was prepared by solvent evaporation method. The prepared solid dispersion was evaluated for various parameters like uniformity of drug content, in-vitro drug release and short term stability studies. Results: The prepared dispersion showed marked increase in the dissolution rate of Furosemide than that of pure drug and the in vitro release studies revealed that there was an improvement in the dissolution characteristics of drug when prepared as solid dispersions. Solid dispersion with PEG 6000 and PVPK30 gave better rate and extent of dissolution. Conclusion: It can be concluded that the solid dispersions prepared with PEG6000 and PVP K30 and among all the formulations, F6 has highest solubility and in vitro dissolution rate.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"45 1","pages":"2571-2575"},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85782761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CREATE A LEADERSHIP LEGACY (L2) BY DEVELOPING A PHARMACY PRACTICE VISION","authors":"Kerry K. Fierke","doi":"10.4172/2278-0238.10001577","DOIUrl":"https://doi.org/10.4172/2278-0238.10001577","url":null,"abstract":"Objective: This article explores the importance of having a vision within pharmacy practice to create a Leadership Legacy (L2). This is shown through the study of current literature and data gathered by the researcher from prominent pharmacists who hold or have held national positions within the profession. The article includes a leadership vision activity that pharmacists can implement. \u0000Setting: The research was conducted through extensive one hour interviews with national and international pharmacist practitioners. This data was reviewed for themes and the highlights of the results from four U.S. pharmacists are provided in the article. Practice description: Pharmacists who hold or have held national positions within the profession share their thoughts on their Leadership Legacy (L2). The information pertaining to their specific vision is incorporated into the article. \u0000Practice intervention: A vision can guide a pharmacist’s practice and provide ways to navigate goals and outcomes within the profession. Evaluation: Four US pharmacists were asked about their Leadership Legacy (L2). The aspects of an L2 include vision, foundation, intentional focus, meaningful relationships, resiliency, and sustainability. The qualitative data and comments provided by the pharmacists explore their ideas and ways they have incorporated a vision into professional practice. \u0000Results: The pharmacists interviewed offered insight into how their specific visions, as well as how they incorporated it into their professional lives. These highlights include wisdom from the various pharmacists and ways to continuously improve the profession in various areas with a vision. \u0000Conclusion: Incorporating a vision into practice can allow a pharmacist to have a focus for the intended future. It is a way to ensure that the practice and profession are on track for better outcomes for patients.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90319855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and In-Vivo Pharmacological Evaluation of Some Novel 4(3H)- Quinazolinone Derivatives as Potential Anti-malarial Agents","authors":"M. Bule, Ariaya Haymete, Belayneh Kefale","doi":"10.4172/2169-0138.1000121","DOIUrl":"https://doi.org/10.4172/2169-0138.1000121","url":null,"abstract":"In this work six 3-aryl-2-(substituted styryl)-4(3H)-quinazolinones derivatives were synthesized by the reaction of 3-aryl-2-methyl-4(3H)-quinazolinone (intermediate products) with different substituted aromatic aldehydes. Three intermediate products were synthesized by reacting 2-methyl-3,1-benzoxazin-4-one, which was initially prepared by cyclizing anthranilic acid using acetic anhydride, with three aromatic amines. Their structures were confirmed using IR, 1HNMR, 13CNMR spectroscopic methods and elemental microanalyses. The synthesized compounds were evaluated for their in vivo antimalarial activity against P. berghei. Four of the synthesized compounds (IIIc, IVa, IVb and IVf) exhibited activity against the parasite. Among these compound IVa was found to be the most active compound. Results of acute toxicity study showed that oral administration of the synthesized compounds in single doses (100, 250 and 500 mg/kg) had no adverse effects, indicating that the compounds have high safety margin and their LD50 is higher than 500 mg/kg.In general this study indicates that 4(3H)-quinazolinones derivatives are potential sources of lead compounds for anti malarial drugs.","PeriodicalId":14206,"journal":{"name":"International Journal of Research and Development in Pharmacy and Life Sciences","volume":"13 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2015-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75275024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}