Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus

Abstract

DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2530-2534 Abstract: A series of phenyl pyrazoline derivatives have been synthesized from chalcones of indane-1,3-dione. The substituted chalcones have already been synthesized and reported by us. The phenyl pyrazoline derivatives were synthesized by condensation of chalcone of indane-1,3-dione with phenyl hydrazine in basic medium in the presence of ethanol. The newly synthesized compounds (7a-f) have been characterized by IR and H-NMR Spectroscopy and TLC. The new compounds have been evaluated for their antibacterial, antifungal and antitubercular activities.