Development and in-vitro evaluation of Furosemide Solid Dispersion using different Water Soluble Carriers

Abstract

Objective: The objective of the present investigation was to improve solubility and dissolution characteristics of Furosemide, which might offer improved bioavailability. The bioavailability of the drug when taken orally is limited by the relatively low solubility. Furosemide is a loop diuretic (a ‘water pill’) used to treat congestive heart failure, oedema and sometimes hypertension. Method: The solid dispersion of Furosemide was prepared by Solvent evaporation method by using 1:1, 1:2 and 1:3 ratios of drug and polymers (PVP K-30, PEG6000). The solid dispersion was prepared by solvent evaporation method. The prepared solid dispersion was evaluated for various parameters like uniformity of drug content, in-vitro drug release and short term stability studies. Results: The prepared dispersion showed marked increase in the dissolution rate of Furosemide than that of pure drug and the in vitro release studies revealed that there was an improvement in the dissolution characteristics of drug when prepared as solid dispersions. Solid dispersion with PEG 6000 and PVPK30 gave better rate and extent of dissolution. Conclusion: It can be concluded that the solid dispersions prepared with PEG6000 and PVP K30 and among all the formulations, F6 has highest solubility and in vitro dissolution rate.