Modified solvent evaporation technique for purpose and categorization of Novel Floating Microspheres of Metronidazole: Optimization of pharmacokinetics, in-vitro and stability study using special process capricious like Emulsifier concentration, stirring rate

Quick Response Code DOI Link: http://dx.doi.org/10.21276/IJRDPL. 2278.0238.2017; 6(2): 2559-2570 Abstract: Purpose of present study involves the development of floating microspheres of metronidazole as a model drug, using the modified solvent diffusion evaporation technique. Eudragit S100 and Eudragis RS100 were used in the different ratio as polymers for development of microspheres. The microspheres were characterized for surface morphology by SEM, yield, buoyancy, incorporation efficiency and micromeritic properties. The in-vitro drug release studies were performed in simulated gastric fluid at pH 1.2. Different kinetic models were also applied on drug release from selected formulations. Stability studies were additionally subjected for optimized formulations. The yield of microspheres was good. Microspheres showed satisfactory flow properties. SEM confirmed the spherical size, perforated smooth surface and a hollow cavity in them. Microspheres exhibited floating properties for more than 10 hours. Stability studies showed no significant change in residual drug content of floating Microspheres.